CN101215274B - N取代吗啉类有机化合物的制备工艺 - Google Patents

N取代吗啉类有机化合物的制备工艺 Download PDF

Info

Publication number
CN101215274B
CN101215274B CN2007101733832A CN200710173383A CN101215274B CN 101215274 B CN101215274 B CN 101215274B CN 2007101733832 A CN2007101733832 A CN 2007101733832A CN 200710173383 A CN200710173383 A CN 200710173383A CN 101215274 B CN101215274 B CN 101215274B
Authority
CN
China
Prior art keywords
organic compounds
substituted morpholines
morpholines
substituted
preparation technology
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN2007101733832A
Other languages
English (en)
Chinese (zh)
Other versions
CN101215274A (zh
Inventor
李峰
李倩
孙婧
康立涛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHANGHAI BIOCOMPOUNDS CHEMLAB CO Ltd
Original Assignee
SHANGHAI BIOCOMPOUNDS CHEMLAB CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHANGHAI BIOCOMPOUNDS CHEMLAB CO Ltd filed Critical SHANGHAI BIOCOMPOUNDS CHEMLAB CO Ltd
Priority to CN2007101733832A priority Critical patent/CN101215274B/zh
Priority to PCT/CN2008/070072 priority patent/WO2009082884A1/fr
Publication of CN101215274A publication Critical patent/CN101215274A/zh
Application granted granted Critical
Publication of CN101215274B publication Critical patent/CN101215274B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN2007101733832A 2007-12-27 2007-12-27 N取代吗啉类有机化合物的制备工艺 Active CN101215274B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN2007101733832A CN101215274B (zh) 2007-12-27 2007-12-27 N取代吗啉类有机化合物的制备工艺
PCT/CN2008/070072 WO2009082884A1 (fr) 2007-12-27 2008-01-10 Procédés pour préparer des composés de morpholine n-substitués

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2007101733832A CN101215274B (zh) 2007-12-27 2007-12-27 N取代吗啉类有机化合物的制备工艺

Publications (2)

Publication Number Publication Date
CN101215274A CN101215274A (zh) 2008-07-09
CN101215274B true CN101215274B (zh) 2011-05-04

Family

ID=39621792

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2007101733832A Active CN101215274B (zh) 2007-12-27 2007-12-27 N取代吗啉类有机化合物的制备工艺

Country Status (2)

Country Link
CN (1) CN101215274B (fr)
WO (1) WO2009082884A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102675246B (zh) * 2012-05-18 2014-04-23 济南诚汇双达化工有限公司 一种盐酸普莫卡因的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1681796A (zh) * 2002-09-13 2005-10-12 阿斯利康(瑞典)有限公司 制备4－(3′－氯－4′－氟苯胺基)－7－甲氧基－6－(3－吗啉代丙氧基)喹唑啉的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3528548A1 (de) * 1985-08-08 1987-02-19 Dow Chemical Gmbh Herstellung eines allylamins und quaternaerer diallylammoniumverbindungen daraus
PL205557B1 (pl) * 1999-02-10 2010-05-31 Astrazeneca Ab Pochodne indolu
GB9922171D0 (en) * 1999-09-21 1999-11-17 Zeneca Ltd Chemical compounds
RU2320646C2 (ru) * 2002-06-24 2008-03-27 Акадиа Фармасьютикалз Инк. N-замещенные производные пиперидина в качестве агентов серотонинового рецептора

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1681796A (zh) * 2002-09-13 2005-10-12 阿斯利康(瑞典)有限公司 制备4－(3′－氯－4′－氟苯胺基)－7－甲氧基－6－(3－吗啉代丙氧基)喹唑啉的方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
张想竹，张继昌，吴明书.N-甲基吗啉的合成.应用化学20 9.2003,20(9),917-918，特别是917页的合成步骤.
张想竹,张继昌,吴明书.N-甲基吗啉的合成.应用化学20 9.2003,20(9),917-918,特别是917页的合成步骤. *

Also Published As

Publication number Publication date
CN101215274A (zh) 2008-07-09
WO2009082884A1 (fr) 2009-07-09

Similar Documents

Publication Publication Date Title
CN102307866B (zh) 一种利奈唑胺的制备方法及其中间体
CN101648978B (zh) 一种高纯度的六苯氧基环三磷腈的制造方法
CN102250076A (zh) 一种利伐沙班中间体及利伐沙班的制备方法
CN102276559A (zh) 3-羟甲基四氢呋喃的合成方法
Wang et al. Annulation of metallabenzenes: From osmabenzene to osmabenzothiazole to osmabenzoxazole
KR20170016894A (ko) 1,3-벤조디옥솔 헤테로사이클릭 화합물의 제조 방법
US20120165550A1 (en) Organoboron Compound and Method for Manufacturing the Same
CN101215274B (zh) N取代吗啉类有机化合物的制备工艺
CN106008366A (zh) 一种利匹韦林的制备方法
CN109535120B (zh) 7-取代-3,4,4,7-四氢环丁烷并香豆素-5-酮的制备方法
CN103554064B (zh) 3-羟基氧杂环丁烷类化合物的制备方法
CN101891693B (zh) 一种氟康唑的制备方法
EP2773210A1 (fr) Procédé de production d'un inhibiteur de la protéine de transfert des esters de cholestérol (cetp)
CN116284031A (zh) 一种r-光甘草定的制备方法
CN115894303A (zh) 一种(3-氨基双环[1.1.1]戊烷-1-基)氨基甲酸叔丁酯及其中间体的制备方法
CA3085475A1 (fr) Procede de preparation de crisaborole
CN102675294A (zh) 一种合成氯沙坦及其中间体的方法
CN102153521B (zh) 一种用于制备利奈唑胺的中间体及其制备方法
JP2818476B2 (ja) 塩素化ニコチンアルデヒドの製造法
JP3882495B2 (ja) ３−アルキル−３−ヒドロキシメチルオキセタンを原料とするエーテル類の製造方法
CA2867936C (fr) Procede industriel pour la fabrication de methiozolin de purete elevee
CN111302997B (zh) “一锅法”制备拉罗替尼中间体的方法
CN109496215A (zh) 一种福沙匹坦磷酸酯中间体及其制备方法
JP4361290B2 (ja) エスクレチン誘導体、その製造方法、ならびにエスクレチンの精製方法
CN101148447A (zh) 聚乙二醇-400催化硝酸舍他康唑的制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
EE01 Entry into force of recordation of patent licensing contract

Application publication date: 20080709

Assignee: Lianyungang Shenghe Biotechnology Co., Ltd.

Assignor: Shanghai BioCompounds ChemLab Co., Ltd.

Contract record no.: 2013320000513

Denomination of invention: Technique for preparing N-substituted morpholines organic compounds

Granted publication date: 20110504

License type: Exclusive License

Record date: 20130605

LICC Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model
PE01 Entry into force of the registration of the contract for pledge of patent right

Denomination of invention: Technique for preparing N-substituted morpholines organic compounds

Effective date of registration: 20131104

Granted publication date: 20110504

Pledgee: Pudong Development Bank of Huangpu Shanghai branch

Pledgor: Shanghai BioCompounds ChemLab Co., Ltd.

Registration number: 2013310000054

PLDC Enforcement, change and cancellation of contracts on pledge of patent right or utility model