CN101214199A - Nano active acne-eliminating cosmetic composition - Google Patents
Nano active acne-eliminating cosmetic composition Download PDFInfo
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- CN101214199A CN101214199A CNA2007100330514A CN200710033051A CN101214199A CN 101214199 A CN101214199 A CN 101214199A CN A2007100330514 A CNA2007100330514 A CN A2007100330514A CN 200710033051 A CN200710033051 A CN 200710033051A CN 101214199 A CN101214199 A CN 101214199A
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Abstract
The present invention relates to an anti-acne cosmetic combination containing nanometer active component. The combination comprises the active component of nanometer latex taking 5 to 45wt percent of the combination, antioxidant taking 0.01 to 0.10wt percent of the combination and thickening agent taking 0.01 to 0.10wt percent of the combination, and the rest are carrier and deionized water which are acceptable to the cosmetic, wherein, the nanometer latex of the active component comprises at least one kind of vitamin A, C and E fatty acid ester, organic acid, anti-inflammatory agent and fat soluble anticorrosion bactericide and also comprises emulsifying agent, grease, stabilizing agent, etc.; the nanometer latex is prepared under certain pressure temperature and time, and the uniform and stable nanometer latex is formed inside a high pressure viscolizer. The combination of the present invention can eliminate the acne, has good skin slow-release effect, does not stimulate skin easily and can be absorbed by the skin easily.
Description
Technical field
The invention belongs to household chemicals field, relate to a kind of acne-eliminating cosmetic composition that contains the nano active composition specifically.
Background technology
Acne are that the people is in the disorderly phenomenon of common a kind of skin physiology of adolescence stage of development. normal sending out in patient's face. and the initial form of expression is exactly that skin growth goes out indivedual acne, a kind of by the excretory material of hair follicle gland, claimed " blackhead ". show as when developing into mid-term stage and several blackheads occur, develop into the serious stage in various degree at last, show as acne and do not move back lastingly and form cicatrix.
Acne are to produce when alluvial in the skin folliculus has excessive horn shape material. this horn shape material is exactly the main component of so-called hoary hair and blackhead. because the growth of antibacterial in the horn shape material, the generation swelling of skin folliculus is also broken, cause inflammatory reaction and pustule occurs, pimple, cyst and joint knot etc.
There are many methods to be used to treat acne, comprising the retinoic acid method, organic acid (salicylic acid) method, estrogen method, antibiotic method and operation on skin method etc.
Although the employing hormone of system and antibiotic method treatment acne have also obtained some successes, there also do not have a kind of Therapeutic Method to accomplish till now to be effectively real.
Tretinoin A (tretinoin) has been used to partial treatment, British patent, BR906000 has disclosed the keratinization process that the cosmetic composition that contains Vitamin A is used to control skin, but there are two problems in the product that contains Tretinoin A, the one, the Tretinoin A instability, be difficult to compatibility in the prescription, the 2nd, Tretinoin A has skin irritation.
Salicylic acid, also be the BHA fruit acid, to compare mildness good with the AHA fruit acid, its action principle is the dissolving horn cell and quickens to come off, but work as the skin fragility or situation hypersensitive is arranged, as tan severely, be not suitable for using salicylated product during phenomenon such as pruritus, twinge, decortication, contain salicylic product generally speaking and only be suitable for local skin and use.
The antibiotic method, as using penicillin, methods such as chloromycetin treatment acne can have antiinflammatory effect preferably in the first processing procedure to acne, but be easy to develop immunity to drugs, and can not thoroughly treat acne.
In addition, according to the difference of use active component, treatment acne best prescription dosage form has two kinds, and a kind of is the tincture type, and a kind of is water aqua type, and often the curative effect of tincture type is good than water aqua type in two kinds of dosage forms.
As everybody knows, the solid kind medicine that is used for skin treating is not directly by skin absorbs but be used for realizing by medicine dissolution is made at medium.Same reason, the medicine that micro situation exists is easy to skin absorbs.Medicine is distributed on the skin as crystal or thin film-forming method with multi-form after the solvent evaporates of dissolved substance.Some active component such as Tretinoin A water insoluble but dissolve in alkalescence aqueous solution in, yet Tretinoin A is unsettled in alkaline aqueous solution, and unique to satisfy the Tretinoin A solvent that both dissolubility was well stable be exactly organic solvent, after the use, organic solvent almost all volatilizees and stays the crystal of tretinoin.Then these crystal of leaving over depend in the skin fluid dissolving and by skin absorbs, the speed of absorption depends primarily on the dissolubility of crystal in the skin fluid.Obviously, medicine crystal is big more, and the dissolubility in the skin fluid is more little, thereby the percutaneous absorption is casual more.What can be sure of is, after the solvent evaporates in the tincture formulation, the Tretinoin A active matter that is evenly distributed on skin surface is that the form with subparticle exists, the Tretinoin A that this fine form exists relies on himself than bulky grain crystal easier dissolved advantage in the skin fluid, performance therapeutical effect in penetrating to the skin preferably.
On curative effect, the tincture product has certain advantage than aqua product really, and is good as the active component dissolubility, when made product uses volatilization fast, be easy to the fine distribution of active component and absorption etc.
Yet the tincture product often contains percent 80 percent 99 ethanol, as easy as rolling off a log generation skin negative interaction, thereby be not suitable for full face and use, can only use at acne are local.
The purpose of this invention is to provide a kind of cosmetic composition that contains the nanometer coating active composition, said composition energy anti-acne has skin slow release effect preferably, and being not easy to produce stimulates, and skin absorbs easily.
Summary of the invention
The present invention is achieved by the following technical solutions, and a kind of acne-eliminating cosmetic composition that contains the nano active composition is characterized in that said composition is made up of following component and content:
I contains the nanoemulsions of active component, accounts for compositions 5-45wt%;
Consisting of of the nanoemulsions of active component:
A) active component, be taken from wherein at least a kind of of Vitamin A fatty acid ester, vitamin C fatty acid ester, vitamin e fatty acid ester, organic acid, antiinflammatory, fat-soluble anticorrosion and bactericidal agent, its content in nanoemulsions is respectively: the Vitamin A fatty acid ester is 0.1-2.0wt%; The vitamin C derivant is 2-25wt%; The vitamin e fatty acid ester is 2-25wt%; Organic acid is 2-30wt%; Fat-soluble anticorrosion and bactericidal agent is 1-10wt%; Antiinflammatory is 0.5-30wt%;
B) emulsifying agent is selected from hydrogenation egg lecithin or hydrogenated soy phosphatidyl choline, and its content in nanoemulsions is 1-10wt%;
C) oils and fats is selected from wherein at least a of squalane, isopropyl palmitate, isopropyl myristate, Oleum Glycines, and its content in nanoemulsions is 2-15wt%,
D) stabilizing agent is selected from wherein at least a kind of of Yoshinox BHT, butylated hydroxyanisol, propylated gallate or a-tocopherol, and its content in nanoemulsions is 0.01-0.1wt%,
The nanoemulsions of active component adopts following method preparation:
I adds active component, oils and fats, emulsifying agent and stabilizing agent successively in the ratio in the prescription in circular flask,
Ii adds ethanol then and rocks dissolving, afterwards, with rotary evaporator with ethanol evaporation,
The iii precentagewise adds deionized water and vibrations are stirred up to the mixed liquor that forms homogeneous, promptly elementary emulsion,
The elementary emulsion that iv will go up the step preparation imports in the high pressure homogenisers, the circulation homogenizing also obtains required emulsion particle diameter, pressure during homogenizing in the high pressure chest is the 500-1500 crust, homogenizing time 10-30 minute, carry out under temperature 30-40 ℃ the constant temperature, form the nanoemulsions of distribution homogeneous, stable particle diameter 50 nanometer to 500 nanometers;
II antioxidant is selected from wherein at least a kind of of Yoshinox BHT, butylated hydroxyanisol, propylated gallate or a-tocopherol, and its content accounts for the 0.01-0.10wt% of compositions;
The III thickening agent is selected from wherein at least a kind of of HANSHENGJIAO, hydroxyethyl-cellulose, hydroxypropyl cellulose, tart hydroxy polymer, and its content accounts for the 0.1-1.0wt% of compositions;
All the other are cosmetics acceptable carrier and deionized water for IV.
Active nano emulsion Vitamin A fatty acid ester described in the present invention is selected from the Vitamin A acetate, and its content in nanoemulsions is 0.5%-1wt%; The vitamin C derivant is selected from a kind of in L-ascorbic acid 2-hexyl certain herbaceous plants with big flowers four esters, the L-Ascorbyl Tetraisopalmitate, and its content in nanoemulsions is 5-20t%; The vitamin e fatty acid ester is selected from a kind of in a-tocopherol three plough acid esters and the a-tocopherol acetate, and its content in nanoemulsions is 5-20wt%; Organic acid is selected from a kind of in malic acid, citric acid, Azelaic Acid and the salicylic acid, and its content in nanoemulsions is 5-20wt%; Fat-soluble anticorrosion and bactericidal agent is selected from propylparaben, butoben and 2,4, a kind of in the 4-three chloro-2-dihydroxy diphenyl ethers, and it is 3-8wt% at nanoemulsions content; Antiinflammatory is selected from licoflavone or a-bisabolol, and its content in nanoemulsions is 2-20wt%;
Emulsifying agent preferably uses hydrogenated soy phosphatidyl choline in the nanoemulsions, and its preferred content accounts for the 2.5-5wt% of nanoemulsions; Oils and fats preferably uses Oleum Glycines or isopropyl myristate, and wherein the Oleum Glycines preferred content accounts for the 5-8wt% of nanoemulsions, and the preferred content of isopropyl myristate accounts for the 5-15wt% of nanoemulsions; Stabilizing agent preferably uses Yoshinox BHT, and its preferred content accounts for the 0.03-0.06wt% of nanoemulsions;
The vitamin C derivant is preferably used the L-Ascorbyl Tetraisopalmitate in the active nano emulsion described among the present invention, and its content in nanoemulsions is preferably 8-15wt%; The vitamin e fatty acid ester preferably uses the a-tocopherol acetate, and its content in nanoemulsions is preferably 8-15wt%; Organic acid preferably uses salicylic acid, the preferred 8-15wt% of its content in nanoemulsions; Fat-soluble anticorrosion and bactericidal agent preferably uses 2,4,4-three chloro-2-dihydroxy diphenyl ethers, and its content in nanoemulsions is preferably 5wt%; The preferred a-bisabolol of antiinflammatory, its content in nanoemulsions is preferably 5-15wt%.
The nanoemulsions most preferred content of active component is among the present invention: the nanoemulsions 10wt% of Vitamin A fatty acid ester; The nanoemulsions 10wt% of vitamin C derivant; The nanoemulsions 10wt% of vitamin e fatty acid ester; Salicylic nanoemulsions 10wt%; The nanoemulsions 10wt% of a-bisabolol.
Antioxidant preferably uses butylated hydroxyanisol among the present invention, and its content accounts for compositions 0.04-0.08wt%'s; Amount of thickener accounts for the 0.4-0.8wt% of compositions, the cosmetics acceptable carrier is a glycerol, propylene glycol, a kind of in the ethanol, content accounts for the 3-13wt% of compositions, and other component also comprises tea tree ethereal oil and the balance of deionized water that accounts for total composition 0.05-5wt%.
The compositions of treatment acne provided by the invention contains the nanoemulsions of active component, do not contain or contain small amount of ethanol (less than percent 5), and the physical and chemical stability of said composition prescription is good, and safety is fit to full face and uses, and can not produce negative interaction.
The specific embodiment
Below in conjunction with embodiment the present invention is done further detailed description:
In the nanoemulsions of the present invention, the nanoemulsions of Vitamin A fatty acid ester, particle diameter are controlled at the 100-500 nanometer, are preferable over the 300-500 nanometer; Its particle diameter of vitamin C derivates nanometer emulsion is controlled at the 50-500 nanometer, is preferable over the 100-300 nanometer; Its particle diameter of vitamin e fatty acid ester nanoemulsions is controlled at the 100-500 nanometer, is preferable over the 200-500 nanometer; The organic acid nanoemulsions, particle diameter is controlled at the 100-500 nanometer, be preferable over the 200-400 nanometer, fat-soluble anticorrosion and bactericidal agent nanoemulsions, its particle diameter is controlled at the 50-300 nanometer, is preferable over the 100-200 nanometer, and fat-soluble anticorrosion and bactericidal agent preferably uses 2 among the present invention, 4,4-chlorine three-2-dihydroxy diphenyl ether (trade name: An Jieqing); The antiinflammatory nanoemulsions, its particle diameter is controlled at the 100-300 nanometer, is preferable over the 150-250 nanometer.
In the present composition acceptable carrier comprise thickening agent as and the organic amine nertralizer that is used for the acidic polymer thickening, thickening agent such as HANSHENGJIAO, hydroxyethyl-cellulose; As commercially available trade name CARBOPOL 934 and CARBOPOL940 and use organic amine neutralization to form colloid, as β-alanine, 2-isopropanolamine, triethanolamine.Acidic polymer such as carbomer 934 and carbomer 940 use organic amine β-alanine then, or 2-isopropanolamine or three hydramine neutralization.The cosmetics acceptable carrier has glycerol, and propylene glycol, ethanol, antiseptic such as methyl hydroxybenzoate, propylparaben, deionized water are the needs interpolations according to prescription and surplus.
The main component of using in the cosmetic composition of nano-encapsulated composition of the present invention is lecithin, it is the main naturally occurring emulsifying agent of nano-encapsulated composition, also be one of most important component in the human body cell, in cell metabolism and membrane permeation, playing the part of very important role.The active component such as the Vitamin A that by special technology existing potential or direct zest are difficult to compatibility with high-load soybean lecithin again, vitamin C and other oil-soluble active ingredient etc. are wrapped in the nano level microcapsule, be prepared into nanoemulsions, to improve the Transdermal absorption and the bioavailability of active matter greatly, make it really can bring into play effect.
Making of the present invention aspect adopts different methods before.Usually, the antioxidant in the prescription is dissolved in earlier in the deionized water, next adds the acidic polymer of respective amount for the system that needs thickening.Gel in the prescription, interpolation earlier is a small amount of and be dissolved into glue under stirring at low speed.When acid hydroxy group polymer such as carbomer 934 or carbomer 940 are used to thickening, need to add the organic amine nertralizer of respective amount and need the time enough stirring at low speed to disperse up to becoming glue, last active component and the quintessence oil that when 40-45 spends, adds nanoemulsions.
The nanoemulsions acne-removing composition of active component has been realized lipid or lipophile active matter are prepared into a kind of physiological safety, water miscible, crude among the present invention, formed a kind of optimal transmission system, has smaller particle size, the anti-acne of real performance active matter is repaired effect, and safe and non-stimulating, be fit to full face and use.
The stabilized nano emulsion has accurately, and homogeneous particle diameter distributes.Obtain the stabilized nano emulsion, need accurately to select emulsification times and pressure.Especially it is particularly important that the cavity pressure of high pressure homogenizer is selected (500 crust-1500 crust), and in addition, the geometry in homogenizing chamber is also extremely important in the selected high pressure homogenizer, and it directly influences homogenizing efficient.The range of choice of the nanoemulsions size of each active component is 50 nanometers-500 nanometers among the present invention, and emulsion particle diameter is more little, and percutaneous absorbs fast more, and potential skin irritation is then big more; Otherwise emulsion particle diameter is big more, and percutaneous absorbs casual more, potential zest is just more little, therefore, determines the size and the concentration of its emulsion particle diameter in compositions according to the zest size of active component, slow release absorbs the generation curative effect but both can play, and can not produce negative interaction to skin again.Active component by the zest size sequence is among the present invention: Vitamin A fatty acid ester＞salicylic acid＞vitamin C fatty acid ester＞a-bisabolol＞An Jieqing, therefore in preparation process, the size of the active component nanoemulsions of required preparation is followed successively by: the clean clear nano-emulsion liquid of Vitamin A fatty acid ester nanoemulsions＞salicylic acid nanoemulsions＞vitamin C fatty acid ester nanoemulsions＞a-bisabolol nanoemulsions＞peace.
The authentication method that nanoemulsions is commonly used:
Optical identification: emulsified body presents slight or strong milky outward appearance (emulsion with 200 nanometers is reference usually)
The laser transmissometer; Be used for measuring emulsion particle diameter and homogeneity,
Ultramicroscope; Observe freezing breaking and minus deviation; The laser turbidimetry is confirmed and particle shape is learned information)
The chemical analysis of nanoemulsions etc.
Following embodiment is used for setting forth explanation formula for dispelling pox compositions of the present invention
Embodiment 1
| Component | Content wt% |
| Vitamin A acetate nanoemulsions butylated hydroxyanisol (BHA) carbomer 940 3 hexanol amine 1,3 butanediol tea tree oil methyl hydroxybenzoate deionized water | 15.0 0.05 1.2 1.0 5.0 0.2 0.08 surplus |
Embodiment 2
| Component | Content wt% |
| Vitamin e acetate nanoemulsions butylated hydroxyanisol carbomer 940 3 is hydramine tea tree oil methyl hydroxybenzoate | 5.0 0.05 1.2 1.0 0.2 0.10 |
| Deionized water | Surplus |
Embodiment 3
| Component | Content wt% |
| Salicylic acid nanoemulsions butylated hydroxyanisol 1,3 butanediol ethanol HANSHENGJIAO tea tree oil methyl hydroxybenzoate deionized water | 25.0 0.05 8.0 2.0 0.2 0.2 0.10 surplus |
Embodiment 4
| Component | Content wt% |
| A-bisabolol nanoemulsions butylated hydroxyanisol carbomer 940 3 hexanol amine tea tree oil methyl hydroxybenzoate deionized waters | 40.0 0.01 1.2 0.8 0.2 0.10 surplus |
Embodiment 5
| Component | Content wt% |
| Vitamin A acetate nanoemulsions 2,4,4-three chloro-2-dihydroxy diphenyl ether nanoemulsions (An Jieqing) butylated hydroxyanisol carbomers 940 3 hexanol amine 1,3 butanediol tea tree oil methyl hydroxybenzoate deionized water | 10.0 10.0 0.05 1.2 1.0 5.0 0.2 0.08 surpluses |
Embodiment 6
| Component | Content wt% |
| Vitamin A acetate nanoemulsions vitamin e acetate nanoemulsions 2,4,4-three chloro-2-dihydroxy diphenyl ether (An Jieqing) nanoemulsions butylated hydroxyanisol carbomers 940 3 hexanol amine tea tree oil methyl hydroxybenzoate deionized waters | 10.0 5.0 10.0 0.05 1.2 1.0 0.2 0.10 surpluses |
Embodiment 7
| Component | Content wt% |
| Salicylic acid nanoemulsions vitamin e acetate nanoemulsions 2,4,4-three chloro-2-dihydroxy diphenyl ether (An Jieqing) nanoemulsions butylated hydroxyanisols 1,3 butanediol ethanol HANSHENGJIAO tea tree oil methyl hydroxybenzoate deionized water | 10.0 20.0 10.0 0.05 8.0 2.0 0.2 0.2 0.10 surpluses |
Embodiment 8
| Component | Content wt% |
| A-bisabolol nanoemulsions vitamin e acetate nanoemulsions vitamin C four different cetylate nano-emulsion liquid 2,4,4-three chloro-2-dihydroxy diphenyl ether nanoemulsions (An Jieqing) butylated hydroxyanisol carbomers 940 3 hexanol amine tea tree oil methyl hydroxybenzoate deionized waters | 10.0 5.0 2.0 10.0 0.05 1.2 0.8 0.2 0.10 surpluses |
All the other formula examples
| Embodiment | 9 | 10 | 11 | 12 | 13 | 14 | |
| Component | Content wt% | ||||||
| The A phase | The vitamin A acetate nanoemulsions | 30.0 | 15.0 | ||||
| Vitamin e acetate nanoemulsions | 10.0 | 5.0 | 5.0 | ||||
| Vitamin C four different cetylate nanoemulsions | 10.0 | ||||||
| Pacify clean clear nanoemulsions | 15.0 | 10.0 | 10.0 | 5.0 | 20.0 | 5.0 | |
| The salicylic acid nanoemulsions | 30.0 | ||||||
| A-bisabolol nanoemulsions | 20.0 | 10.0 | 30.0 | ||||
| The B phase | BHT | 0.04 | 0.01 | 0.01 | |||
| BHA | 0.1 | 0.08 | 0.01 | 0.05 | |||
| Glycerol | 3.0 | 3.0 | |||||
| 1,3 butanediol | 5.0 | 5.0 | 5.0 | 6.0 | 10.0 | 10.0 | |
| HANSHENGJIAO | 0.5 | 0.1 | |||||
| Carbomer 934 | 0.5 | ||||||
| Carbomer 940 | 1.2 | 0.8 | 1.2 | ||||
| The C phase | Ethanol | 3.0 | 2.0 | 4.0 | 2.0 | ||
| Three hexanol amine | 1.0 | 0.8 | 1.0 | 0.4 | 0.10 | ||
| Tea tree ethereal oil | 0.1 | 0.1 | 0.1 | 0.5 | 0.05 | 0.05 | |
| Methyl hydroxybenzoate | 0.1 | 0.1 | 0.08 | 0.1 | 0.1 | 0.1 | |
| Propylparaben | 0.04 | ||||||
| Deionized water | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus |
The preparation method of active component nanoemulsions in the compositions
Preparation method is the preparation of (1) vitamin fatty acid ester esters and the blended nanoemulsions of soybean oil for example
| Composition | Content wt% emulsion particle diameter: 300-500nm |
| Lecithin Vitamin A fatty acid ester Yoshinox BHT (BHT) Oleum Glycines | 2.5 1.0 0.03 8.0 |
| Deionized water | Surplus |
Manufacture method: get 2.5 gram lecithin, 1 gram Vitamin A fatty acid ester, 0.01 gram Yoshinox BHT and 8 gram Oleum Glycines are in circular major diameter bottle, adding 10 gram ethanol dissolves, afterwards, with rotary evaporator ethanol evaporation is reclaimed, last, precentagewise adds deionized water and vibrations are stirred up to the mixed liquor (elementary emulsion) that forms homogeneous.
The elementary emulsion for preparing is imported in the high pressure homogenisers, and the circulation homogenizing also obtains required emulsion particle diameter, and the pressure during homogenizing in the high pressure chest is adjusted to 950 crust, homogenizing time 20 minutes.Whole all systems process is to carry out under the constant temperature of 35 degree, and prepared nanoemulsions particle size distribution homogeneous is stable.
The preparation of a-bisabolol and isopropyl myristate mixing nanoemulsions among the embodiment 4
| Composition | Content wt% emulsion particle diameter: 100-300nm |
| Lecithin a-bisabolol Yoshinox BHT isopropyl myristate deionized water | 5.0 10.0 0.03 15.0 surpluses |
Manufacture method: 5 gram lecithin, 10 gram a-bisabolols, 0.01 gram Yoshinox BHT and 15 gram isopropyl myristate oil are in circular major diameter bottle, adding 10 gram ethanol dissolves, afterwards, with rotary evaporator ethanol evaporation is reclaimed, last, precentagewise adds deionized water and vibrations are stirred up to the mixed liquor (elementary emulsion) that forms homogeneous.
The elementary emulsion for preparing is imported in the high pressure homogenisers, and the circulation homogenizing also obtains required emulsion particle diameter, and the pressure during homogenizing in the high pressure chest is adjusted to 950 crust, homogenizing time 30 minutes.
Whole homogenizing process is to carry out under the constant temperature of 40 degree, and prepared nanoemulsions particle size distribution homogeneous is stable.
In addition, above method is fit to vitamin e nanoemulsions, vitamin C nanoemulsions, salicylic acid nanoemulsions, and the preparation of pacifying clean clear nanoemulsions equally.Obtain required nanoemulsions particle diameter, one will regulate the pressure in the high pressure chest, and two will increase circulation homogenizing number of times, thereby obtain the emulsion particle diameter of 50 nanometer to 500 nanometers.
The acne-eliminating cosmetic composition preparation method is given an example:
Can use the method for any routine known in the art to prepare the acne-eliminating cosmetic composition of embodiment 1-14.Said composition
Preparation as follows.
With HANSHENGJIAO, carbomer 934 and carbomer 940 polymer (when comprising) are added to the water, and are stirred to dissolving, then, be heated to 70 degree, and add butylated hydroxyanisol, Yoshinox BHT, glycerol, 1,3 butanediol, (in being contained in compositions time).With above mixture be cooled to be not more than about 40 the degree, and (between about per minute rotating speed 10-30) adds ethanol, tea tree ethereal oil, methyl hydroxybenzoate, propylparaben, vitamin A acetate nanoemulsions, Vitamin E acetate nanoemulsions, vitamin C four different cetylate nanoemulsions, the clean clear nanoemulsions of peace, salicylic acid nanoemulsions, a-bisabolol nanoemulsions (when prescription comprises) under casual speed stirs, at last, with three in the hydramine and above mixture, the pH value that all compositionss have is between 3.5 and 7.5.
Acne-eliminating cosmetic composition of the present invention, be fit to full face or office's use, can use 2 to 6 times as required every day up to transference cure, the number of times that uses concrete every day is decided according to the position of patient's acne or the order of severity, usually will adhere to using 2-7 days time, the time that serious situation may need is longer.
The present composition can be prepared into the gel formula that does not contain or contain small amount of ethanol can also be prepared into distillate medicinal water or the water preparation prescription that does not contain or contain small amount of ethanol, use easily, and be retained in and smear the position, compare with the situation of often seeing in the past, only produce slight prodding and itching feeling, can not produce sensation of pricking or long discomfort etc. is arranged.
Claims (5)
1. nano active acne-eliminating cosmetic composition, said composition comprises:
I contains the nanoemulsions of active component, accounts for compositions 5-45wt%;
Consisting of of the nanoemulsions of active component:
A) active component, be taken from wherein at least a kind of of Vitamin A fatty acid ester, vitamin C fatty acid ester, vitamin e fatty acid ester, organic acid, antiinflammatory, fat-soluble anticorrosion and bactericidal agent, its content in nanoemulsions is respectively: the Vitamin A fatty acid ester is 0.1-2.0wt%; The vitamin C derivant is 2-25wt%; The vitamin e fatty acid ester is 2-25wt%; Organic acid is 2-30wt%; Fat-soluble anticorrosion and bactericidal agent is 1-10wt%; Antiinflammatory is 0.5-30wt%;
B) emulsifying agent is selected from hydrogenation egg lecithin or hydrogenated soy phosphatidyl choline, and its content in nanoemulsions is 1-10wt%;
C) oils and fats is selected from wherein at least a of squalane, isopropyl palmitate, isopropyl myristate, Oleum Glycines, and its content in nanoemulsions is 2-15wt%,
D) stabilizing agent is selected from wherein at least a kind of of Yoshinox BHT, butylated hydroxyanisol, propylated gallate or a-tocopherol, and its content in nanoemulsions is 0.01-0.1wt%,
E) surplus is a deionized water;
The nanoemulsions of active component adopts following method preparation:
I adds active component, oils and fats, emulsifying agent and stabilizing agent successively in the ratio in the prescription in circular flask,
Ii adds ethanol then and rocks dissolving, afterwards, with rotary evaporator with ethanol evaporation,
Iii adds deionized water in proportion and vibrations are stirred up to the mixed liquor that forms homogeneous, promptly elementary emulsion,
Iv imports the elementary emulsion of iii step preparation in the high pressure homogenisers, the circulation homogenizing also obtains required emulsion particle diameter, pressure is the 500-1500 crust during homogenizing, homogenizing time 10-30 minute, carry out under temperature 30-40 ℃ the constant temperature, form the nanoemulsions of distribution homogeneous, stable particle diameter 50 nanometer to 500 nanometers;
II antioxidant is selected from wherein at least a kind of of Yoshinox BHT, butylated hydroxyanisol, propylated gallate or a-tocopherol, and its content accounts for the 0.01-0.10wt% of compositions;
The III thickening agent is selected from wherein at least a kind of of HANSHENGJIAO, hydroxyethyl-cellulose, hydroxypropyl cellulose, tart hydroxy polymer, and its content accounts for the 0.1-1.0 wt% of compositions;
All the other are cosmetics acceptable carrier and deionized water for IV.
2. acne-eliminating cosmetic composition according to claim 1 is characterized in that: the Vitamin A fatty acid ester is selected from the Vitamin A acetate in the described active nano emulsion, and its content in nanoemulsions is 0.5%-1wt%; The vitamin C derivant is selected from a kind of in L-ascorbic acid 2-hexyl certain herbaceous plants with big flowers four esters, the L-Ascorbyl Tetraisopalmitate, and its content in nanoemulsions is 5-20t%; The vitamin e fatty acid ester is selected from a kind of in a-tocopherol three plough acid esters or the a-tocopherol acetate, and its content in nanoemulsions is 5-20wt%; Organic acid is selected from a kind of in malic acid, citric acid, Azelaic Acid and the salicylic acid, and its content in nanoemulsions is 5-20wt%; Fat-soluble anticorrosion and bactericidal agent is selected from propylparaben, butoben and 2,4, a kind of in the 4-three chloro-2-dihydroxy diphenyl ethers, and it is 3-8wt% at nanoemulsions content; Antiinflammatory is selected from licoflavone or a-bisabolol, and its content in nanoemulsions is 2-20wt%;
Emulsifying agent preferably uses hydrogenated soy phosphatidyl choline in the nanoemulsions, and its preferred content accounts for the 2.5-5wt% of nanoemulsions; Oils and fats preferably uses Oleum Glycines or isopropyl myristate, and wherein the Oleum Glycines preferred content accounts for the 5-8wt% of nanoemulsions, and the preferred content of isopropyl myristate accounts for the 5-15wt% of nanoemulsions; Stabilizing agent preferably uses Yoshinox BHT, and its preferred content accounts for the 0.03-0.06wt% of nanoemulsions;
3. acne-eliminating cosmetic composition according to claim 2, its feature will in: the vitamin C derivant is preferably used the L-Ascorbyl Tetraisopalmitate in the described active nano emulsion, and its content in nanoemulsions is preferably 8-15wt%; The vitamin e fatty acid ester preferably uses the a-tocopherol acetate, and its content in nanoemulsions is preferably 8-15wt%; Organic acid preferably uses salicylic acid, the preferred 8-15wt% of its content in nanoemulsions; Fat-soluble anticorrosion and bactericidal agent preferably uses 2,4,4-three chloro-2-dihydroxy diphenyl ethers, and its content in nanoemulsions is preferably 5wt%; The preferred a-bisabolol of antiinflammatory, its content in nanoemulsions is preferably 5-15wt%.
4. acne-eliminating cosmetic composition according to claim 3 is characterized in that: the nanoemulsions most preferred content of active component is: the nanoemulsions 10wt% of Vitamin A fatty acid ester; The nanoemulsions 10wt% of vitamin C derivant; The nanoemulsions 10wt% of vitamin e fatty acid ester; Salicylic nanoemulsions 10wt%; The nanoemulsions 10wt% of a-bisabolol.
5. acne-eliminating cosmetic composition according to claim 1, its feature will in: antioxidant preferably uses butylated hydroxyanisol, and its content accounts for compositions 0.04-0.08wt%; Amount of thickener accounts for the 0.4-0.8wt% of compositions, the cosmetics acceptable carrier is a glycerol, propylene glycol, a kind of in the ethanol, content accounts for the 3-13wt% of compositions, and other component also comprises tea tree ethereal oil and the balance of deionized water that accounts for total composition 0.05-5wt%.
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| CN101313883B (en) * | 2008-06-27 | 2010-06-02 | 东北农业大学 | Emulsifying agent for cosmetics and preparation method thereof |
| CN103202780A (en) * | 2013-04-16 | 2013-07-17 | 纪艺琼 | Nano essence for cosmetic and preparation method thereof |
| CN104755128A (en) * | 2012-11-02 | 2015-07-01 | 考司美德制药株式会社 | Retinoic acid microneedle |
| CN104958193A (en) * | 2015-07-08 | 2015-10-07 | 北京中海诚达科贸有限公司 | Composition method for sterilizing and acne removing preparation |
| CN106860050A (en) * | 2017-02-24 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment anti-acne emulsion |
| CN106890102A (en) * | 2017-04-26 | 2017-06-27 | 烟台新时代健康产业日化有限公司 | A kind of preparation method of Ascorbyl Tetraisopalmitate nano particle |
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| CN115414282A (en) * | 2022-09-21 | 2022-12-02 | 陕西慧康生物科技有限责任公司 | Composition containing ultramicro azelaic acid with acne-removing, anti-inflammatory, whitening and freckle-removing effects |
| US11540984B2 (en) | 2018-05-23 | 2023-01-03 | Conopco, Inc. | Nanoemulsions and a method for making the same |
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| CN101313883B (en) * | 2008-06-27 | 2010-06-02 | 东北农业大学 | Emulsifying agent for cosmetics and preparation method thereof |
| CN104755128A (en) * | 2012-11-02 | 2015-07-01 | 考司美德制药株式会社 | Retinoic acid microneedle |
| CN103202780A (en) * | 2013-04-16 | 2013-07-17 | 纪艺琼 | Nano essence for cosmetic and preparation method thereof |
| CN104958193A (en) * | 2015-07-08 | 2015-10-07 | 北京中海诚达科贸有限公司 | Composition method for sterilizing and acne removing preparation |
| CN106860050A (en) * | 2017-02-24 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment anti-acne emulsion |
| CN106890102A (en) * | 2017-04-26 | 2017-06-27 | 烟台新时代健康产业日化有限公司 | A kind of preparation method of Ascorbyl Tetraisopalmitate nano particle |
| CN110913828A (en) * | 2017-07-12 | 2020-03-24 | 荷兰联合利华有限公司 | Nanoemulsion with color-stabilized active substance |
| US11540984B2 (en) | 2018-05-23 | 2023-01-03 | Conopco, Inc. | Nanoemulsions and a method for making the same |
| WO2024032549A1 (en) * | 2021-08-22 | 2024-02-15 | 张天平 | Nanofiber supramolecular skincare composition |
| CN115414282A (en) * | 2022-09-21 | 2022-12-02 | 陕西慧康生物科技有限责任公司 | Composition containing ultramicro azelaic acid with acne-removing, anti-inflammatory, whitening and freckle-removing effects |
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| CN101214199B (en) | 2010-06-16 |
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