CN103202780A - Nano essence for cosmetic and preparation method thereof - Google Patents
Nano essence for cosmetic and preparation method thereof Download PDFInfo
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- CN103202780A CN103202780A CN2013101321166A CN201310132116A CN103202780A CN 103202780 A CN103202780 A CN 103202780A CN 2013101321166 A CN2013101321166 A CN 2013101321166A CN 201310132116 A CN201310132116 A CN 201310132116A CN 103202780 A CN103202780 A CN 103202780A
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Abstract
The invention provides nano essence for cosmetic and a preparation method thereof. The nano essence is prepared from nano solution, licoflavone, base stock and an additive, wherein the additive comprises one or more of a cell growth factor, arbutin, collagen, vitamin b5, salicyloyl phytosphingosine, levorotation vitamin C and hyaluronic acid; the base stock is prepared from a water-phase material and an oil-phase material; the water-phase material comprises one or more of a water-soluble polymer, deionized water and quaternary ammonium; and the oil-phase material comprises one or more of animal oil, plant oil, mineral oil, fatty alcohol, polyol ester, silicon oil and stearic acid. By adopting the nano essence for cosmetic and the preparation method thereof, the licoflavone and the nano solution are compounded; and the substances such as licoflavone are encapsulated inside nano-particles, so that active substances such as licoflavone are isolated with the air; the retention period of the active substances is prolonged; and the utilization rate of the active substances such as licoflavone is also improved.
Description
Technical field
The invention belongs to cosmetic field, be specifically related to a kind of used for cosmetic nanometer essence and preparation method thereof.
Background technology
Along with the increase at age, the growth rate of collagen protein and elastin laminin is slack-off in the skin, as can not in time replenishing, can cause skin aging, and mottle occurs, and develops into senile plaque then; Simultaneously, skin follows the string, and becomes lax thereupon, wrinkle occurs.Along with enriching of human material life, just more and more higher for the pursuit of U.S..Given this, the whitening anti-wrinkling product just more and more is subjected to popular favor.The whitening anti-wrinkling of skin is a comprehensive process, needs to replenish fast the collagen protein that loses in the ageing processes of skin etc. on the one hand, needs effectively to remove the free radical that causes these skin aginges on the other hand, also needs speckle dispelling or suppresses the appearance of mottle.Oxygen-derived free radicals can effectively be removed or suppress to licoflavone as the Natural antioxidant that is present in the plant, suppresses lipid peroxidation, and can suppress the formation of mottle, and licoflavone mainly comes from the Radix Glycyrrhizae.But this antioxidant poorly water-soluble, and unstable, be easy to oxidation, thereby limited its application.
Summary of the invention
The invention provides a kind of used for cosmetic nanometer essence and preparation method thereof, a kind of energy load licoflavone is provided, solves the water miscible nanometer liquid of licoflavone, can well overcome the above problems.
The invention provides a kind of used for cosmetic nanometer essence, described nanometer essence is by nanometer liquid, licoflavone, base material and additive are formed, additive comprises: cell growth factor, arbutin, collagen protein, vitamin b5, the salicyloyl phytosphingosine, in L-vitamin C and the hyaluronic acid one or more, base material is made up of water raw material and oil phase raw material, the water raw material comprises: water-soluble polymer, in deionized water and the quaternary amine one or more, the oil phase raw material comprises: animal oil, vegetable oil, mineral oil, aliphatic alcohol, polyol ester, silicone oil, in the stearic acid one or more.
According to concrete technical scheme of the present invention, wherein, by nanometer essence total weight percent, nanometer liquid is 0.01%-3%.
According to concrete technical scheme of the present invention, wherein, by nanometer essence total weight percent, licoflavone is 0.1%-5%.
According to concrete technical scheme of the present invention, wherein, by nanometer essence total weight percent, additive is 5%-15%.
According to concrete technical scheme of the present invention, wherein, by nanometer essence total weight percent, the water raw material is 50%-80%.
According to concrete technical scheme of the present invention, wherein, by nanometer essence total weight percent, the oil phase raw material is 5%-25%.
According to concrete technical scheme of the present invention, wherein, the oil phase raw material also comprises: one or more in pH regulator agent, spice and the surfactant.
According to concrete technical scheme of the present invention, wherein, surfactant is the Pilus Caprae seu Ovis isopropyl fatty acid ester.
According to concrete technical scheme of the present invention, wherein, water-soluble polymer comprises: hydroxyethyl-cellulose, polyoxyethylene alcohol ester, glycerol, polyacrylic acid 934 and molecular weight are one or more in the Polyethylene Glycol of 2000-50000, and quaternary amine comprises: one or more in triethanolamine and the acetylamino oxypropyl trimethyl ammonium chloride.
The present invention also provides a kind of preparation method of above-mentioned used for cosmetic nanometer essence, and the water raw material is put into vessel in heating to 70-90 ℃, stirs 5-15 minute with the speed of propeller agitator with 500-700 rev/min, stirs; The oil phase raw material is put into vessel in heating to 80-90 ℃, and fusing was stirred 5-15 minute with the speed of propeller agitator with 500-700 rev/min, stirred; The water raw material is added in the oil phase raw material, stir when being cooled to 30-40 ℃, add additive, licoflavone and nanometer liquid, stir, namely get the nanometer essence.
The present invention also provides a kind of skin care item, and described skin care item comprise above-mentioned used for cosmetic nanometer essence, and it is 0.1-10% that the nanometer essence accounts for the skin care item gross weight.
The advantage of a kind of used for cosmetic nanometer essence of the present invention and preparation method thereof is: carry out licoflavone and nanometer liquid composite, utilize nanotechnology, by selecting suitable matrix material and emulsifying agent, through simple processing, can be with licoflavone, the salicyloyl phytosphingosine, materials such as cell growth factor are encapsulated in nano-particle inside, make licoflavone isoreactivity material and air isolated, increased the storage life of active substance, improved the utilization rate of this class active substance of licoflavone, this nanometer essence good stability, can preserve under 45 ℃ of environment 3 months not stratified, invariant color, normal temperature storage 3 years is not stratified, good stability, thus the problem that runs in the licoflavone application process solved; This nanometer essence has the whitening anti-wrinkling of raising trap, increases the effect of whitening anti-wrinkling effect, and this nanometer essence can directly be coated on the skin, also can coldly join to join in the different cosmetic formulations, convenient use in all kinds of cosmetics; Preparation method is scientific and reasonable, good stability.
The specific embodiment
Mode with specific embodiment illustrates the present invention below, but the present invention never only limits to the following example.
A kind of used for cosmetic nanometer essence, described nanometer essence is by nanometer liquid, licoflavone, base material and additive are formed, additive comprises: cell growth factor, arbutin, collagen protein, vitamin b5, the salicyloyl phytosphingosine, in L-vitamin C and the hyaluronic acid one or more, base material is made up of water raw material and oil phase raw material, the water raw material comprises: water-soluble polymer, in deionized water and the quaternary amine one or more, the oil phase raw material comprises: animal oil, vegetable oil, mineral oil, aliphatic alcohol, polyol ester, silicone oil, in the stearic acid one or more.
The mechanism that forms at wrinkle, pigment, mottle adopts nanometer liquid and licoflavone, additive compound to form, can finish the deep layer nursing to skin efficiently, accelerate the metabolism of skin, reparation is undermined keratinized skin, recover the elasticity of skin, thereby reach the effect of deep layer reduce wrinkle and skin whitening.
L-vitamin C, hyaluronic acid, collagen protein etc. are the cosmetic active raw material of natural origin, can help skin to resist the ultraviolet infringement, avoid black speck, freckle to produce, and enhance metabolism, and allow established melanin discharge spot fading; Can also help skin to pin necessary moisture, avoid the decortication that causes because of too much evaporation and tight, strengthen the ability that skin opposing extraneous contamination is encroached on, avoid skin tired, wax yellow ugly; This nanometer essence component is reasonable, comprehensive effect height; Have very strong affinity with skin, be easy to skin and absorb.
Human experimentation proves, add the 10%(percentage by weight) nanometer essence (not having any active component) in the blank mastic of cosmetics, activity substance content is 10% in this nanometer essence, licoflavone, salicyloyl phytosphingosine, L-vitamin C by weight, the 2.0:7.0:1.0 proportioning.Use after 60 days, consumer's readme and dermatologist's visual report confirm that all this nanometer essence effect is better than using separately the cosmetics that contain above-mentioned active substance.Place after 3 months, find that by liquid chromatographic detection the storage rate of the above-mentioned active substance in this nanometer essence is all more than 98%, and deposit the alcoholic solution that contains above-mentioned active substance separately, its activity substance content all is lower than 20%, this shows prepared nanometer essence stable performance.
By nanometer essence total weight percent, nanometer liquid is 0.01%-3%.
By nanometer essence total weight percent, licoflavone is 0.1%-5%.
By nanometer essence total weight percent, additive is 5%-15%.
By nanometer essence total weight percent, the water raw material is 50%-80%.
By nanometer essence total weight percent, the oil phase raw material is 5%-25%.
The oil phase raw material also comprises: one or more in pH regulator agent, spice and the surfactant.
Surfactant is the Pilus Caprae seu Ovis isopropyl fatty acid ester.
Water-soluble polymer comprises: hydroxyethyl-cellulose, polyoxyethylene alcohol ester, glycerol, polyacrylic acid 934 and molecular weight are one or more in the Polyethylene Glycol of 2000-50000, and quaternary amine comprises: one or more in triethanolamine and the acetylamino oxypropyl trimethyl ammonium chloride.
A kind of preparation method of above-mentioned used for cosmetic nanometer essence is put into vessel in heating to 70-90 ℃ with the water raw material, stirs 5-15 minute with the speed of propeller agitator with 500-700 rev/min, stirs; The oil phase raw material is put into vessel in heating to 80-90 ℃, and fusing was stirred 5-15 minute with the speed of propeller agitator with 500-700 rev/min, stirred; The water raw material is added in the oil phase raw material, stir when being cooled to 30-40 ℃, add additive, licoflavone and nanometer liquid, stir, namely get the nanometer essence.
A kind of skin care item, described skin care item comprise above-mentioned used for cosmetic nanometer essence, and it is 0.1-10% that the nanometer essence accounts for the skin care item gross weight.
These skin care item are mixed with oil preparation, Emulsion, water preparation, unguentum, emulsion, cream etc. on demand.
Described skin protectant is used for the purposes of whitening anti-wrinkling.
Embodiment 1
| ? | Weight % |
| Licoflavone | 2.0 |
| Nanometer liquid | 3.0 |
| Component A | ? |
| Polyoxyethylene (20) ether tristerin | 5.0 |
| Cetyl stearic | 15 |
| Semen Tritici aestivi germ oil | 2.0 |
| Polydimethylsiloxane | 0.3 |
| Propyl p-hydroxybenzoate | 0.02 |
| B component | ? |
| Glycerol | 3.0 |
| Deionized water | 57.68 |
| Component C | ? |
| Cell growth factor | 2.0 |
| Hyaluronic acid | 5.0 |
| The salicyloyl phytosphingosine | 5.0 |
Water raw material (B component) is put into vessel in heating to 75 ℃, stirred 10 minutes with the speed of propeller agitator with 600 rev/mins, stir; The oil phase raw material is put into vessel in heating to 80 ℃, and fusing was stirred 10 minutes with the speed of propeller agitator with 600 rev/mins, stirred; The water raw material is added in the oil phase raw material, when stirring is cooled to 35 ℃, add additive (component C), licoflavone and nanometer liquid, stir, namely get the nanometer essence, in the time of 25 ℃ the nanometer essence is transferred in the suitable containers, this moment, emulsion was flow regime, and viscosity reaches peak after several hours.
Embodiment 2
| ? | Weight % |
| Licoflavone | 5.0 |
| Nanometer liquid | 3.0 |
| Component A | ? |
| The Pilus Caprae seu Ovis isopropyl fatty acid ester | 1.0 |
| Mineral oil | 3.5 |
| Stearic acid | 1.5 |
| Tristerin | 2.0 |
| B component | ? |
| Glycerol | 3.0 |
| Polyacrylic acid 934,3% | 10.0 |
| Triethanolamine 10% | 10.0 |
| Deionized water | 52.0 |
| Component C | ? |
| Arbutin | 2.0 |
| The salicyloyl phytosphingosine | 2.0 |
| Hyaluronic acid | 5.0 |
Water raw material (B component) is put into vessel in heating to 70 ℃, stirred 15 minutes with the speed of propeller agitator with 700 rev/mins, stir; The oil phase raw material is put into vessel in heating to 85 ℃, and fusing was stirred 15 minutes with the speed of propeller agitator with 700 rev/mins, stirred; The water raw material is added in the oil phase raw material, stir when being cooled to 30 ℃, add additive (component C), licoflavone and nanometer liquid, stir, namely get the nanometer essence, transfer to subsequently in the suitable containers.
Experiment effect 1
Hydroxyl radical free radical removing ability is measured
The configuration of experiment reagent
The phosphate buffer of pH=7.4: take by weighing 13.609gKH
2PO
4, the adding distil water dissolving is settled to 250ml, is A liquid; Take by weighing 45.644gK
2HPO
4, add water and be settled to 500mL, be B liquid.Ratio with volume ratio A:B=19:81 disposes the phosphate buffer that obtains pH=7.4,0.2mol/L again.
7.5mM FeSO
4Solution: take by weighing 1.0428gFeSO
47H
2O is settled to 500mL with dissolved in distilled water, obtains the FeSO that concentration is 7.5mM
4Solution.
5mM Phen aqueous solution: take by weighing Phen 0.2478g, be settled to 250mL with distilled water, getting concentration is the Phen aqueous solution of 5mM.
1%H
2O
2Solution: the hydrogenperoxide steam generator dilution with 30% had both got 1% hydrogenperoxide steam generator for 30 times.
Remove hydroxyl radical free radical OH
The phosphate buffer that adds 2mL pH=7.4 in test tube respectively, 0.3mL5mM Phen solution fully behind the mixing, adds 0.2mL7.5mM FeSO
4Solution whenever adds behind the pipe mixing immediately.Then to wherein add extracting solution, mixing adds 1% H again
2O
21mL replenishes volume at last to 8mL.Do again in addition with the skin protectant protecting tube with the skin protectant protecting tube, in pipe, respectively add 1mL1%H
2O
2, replenish each pipe volume at last to 8mL.Insulation 1h surveys the light absorption value under 536nm under 37 ℃, calculates clearance rate, and its computing formula is:
A
1Absorption value with skin protectant
A
0Absorption value with skin protectant
It is as shown in the table for the effect of two kinds of skin care item:
| Sample | Free radical scavenging activity |
| Embodiment 1 | 25% |
| Embodiment 2 | 33% |
Experiment effect 2
Skin protectant treatment patient cases of the present invention is as follows:
Miss Zou: 40 years old, people from Weihai, Shandong.The car detailing industry is engaged in Beijing, has a liking for spicy partially.It is irregular to live, and causes the endocrine disturbance, causes the wrinkle, wax yellow etc. of face, has a strong impact on attractive in appearance.Adopt one course for the treatment of of external of the present invention, symptom takes an evident turn for the better, and after continuing to use two courses for the treatment of, does not have recurrence.
Miss Tian: 45 years old, Shanghai people.Because of operating pressure, cause the endocrine disturbance, caused acne and butterfly spot etc., have a strong impact on attractive in appearance.After using external of the present invention course for the treatment of, symptom takes an evident turn for the better, and after continuing to use two courses for the treatment of, cures and does not have recurrence.
This product detects test through hygiology, and sanitary index meets 2007 editions " cosmetics health standard " regulation; The safety toxicological experiment shows and has no adverse effects.
Above-described only is principle of the present invention and preferred embodiment.Should be pointed out that to those skilled in the art, under the prerequisite that does not break away from the principle of the invention, can also make some distortion and improvement, also should be considered as belonging to protection scope of the present invention.
Claims (10)
1. used for cosmetic nanometer essence, it is characterized in that: described nanometer essence is by nanometer liquid, licoflavone, base material and additive are formed, additive comprises: cell growth factor, arbutin, collagen protein, vitamin b5, the salicyloyl phytosphingosine, in L-vitamin C and the hyaluronic acid one or more, base material is made up of water raw material and oil phase raw material, the water raw material comprises: water-soluble polymer, in deionized water and the quaternary amine one or more, the oil phase raw material comprises: animal oil, vegetable oil, mineral oil, aliphatic alcohol, polyol ester, silicone oil, in the stearic acid one or more.
2. used for cosmetic nanometer essence according to claim 1, it is characterized in that: by nanometer essence total weight percent, nanometer liquid is 0.01%-3%.
3. used for cosmetic nanometer essence according to claim 1, it is characterized in that: by nanometer essence total weight percent, licoflavone is 0.1%-5%.
4. used for cosmetic nanometer essence according to claim 1, it is characterized in that: by nanometer essence total weight percent, additive is 5%-15%.
5. used for cosmetic nanometer essence according to claim 1, it is characterized in that: by nanometer essence total weight percent, the water raw material is 50%-80%.
6. used for cosmetic nanometer essence according to claim 1, it is characterized in that: by nanometer essence total weight percent, the oil phase raw material is 5%-25%.
7. used for cosmetic nanometer essence according to claim 1, it is characterized in that: the oil phase raw material also comprises: one or more in pH regulator agent, spice and the surfactant.
8. used for cosmetic nanometer essence according to claim 7, it is characterized in that: surfactant is the Pilus Caprae seu Ovis isopropyl fatty acid ester.
9. used for cosmetic nanometer essence according to claim 1, it is characterized in that: water-soluble polymer comprises: hydroxyethyl-cellulose, polyoxyethylene alcohol ester, glycerol, polyacrylic acid 934 and molecular weight are one or more in the Polyethylene Glycol of 2000-50000, and quaternary amine comprises: one or more in triethanolamine and the acetylamino oxypropyl trimethyl ammonium chloride.
10. the preparation method of the described used for cosmetic nanometer of a claim 1-9 essence is characterized in that: the water raw material is put into vessel in heating to 70-90 ℃, stirred 5-15 minute with the speed of propeller agitator with 500-700 rev/min, stir; The oil phase raw material is put into vessel in heating to 80-90 ℃, and fusing was stirred 5-15 minute with the speed of propeller agitator with 500-700 rev/min, stirred; The water raw material is added in the oil phase raw material, stir when being cooled to 30-40 ℃, add additive, licoflavone and nanometer liquid, stir, namely get the nanometer essence.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN2013101321166A CN103202780A (en) | 2013-04-16 | 2013-04-16 | Nano essence for cosmetic and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013101321166A CN103202780A (en) | 2013-04-16 | 2013-04-16 | Nano essence for cosmetic and preparation method thereof |
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| CN103202780A true CN103202780A (en) | 2013-07-17 |
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|---|---|---|---|
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103908424A (en) * | 2014-03-03 | 2014-07-09 | 奥思达干细胞有限公司 | Beautifying and nursing essence and preparation method thereof |
| CN105147560A (en) * | 2015-09-25 | 2015-12-16 | 夏放军 | Whitening, moisturizing and macula-removing body lotion and preparation method thereof |
| CN107080704A (en) * | 2017-04-27 | 2017-08-22 | 缪来耿 | Soluble cleaning tissue of a kind of skin whitening, moisturizing and preparation method thereof |
| CN109549864A (en) * | 2019-01-18 | 2019-04-02 | 花安堂生物科技集团有限公司 | A kind of emulsifying cosmetics and preparation method thereof |
| WO2019173584A1 (en) | 2018-03-09 | 2019-09-12 | Ocusoft, Inc. | Topical skin care compositions |
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| CN1660059A (en) * | 2004-02-25 | 2005-08-31 | 重庆华邦制药股份有限公司 | Composite liposome of vitaminaacid as well as preparation method and application |
| CN101214199A (en) * | 2007-12-29 | 2008-07-09 | 广东拉芳日化有限公司 | Nano active acne-eliminating cosmetic composition |
| CN102973425A (en) * | 2011-09-05 | 2013-03-20 | 张弘 | Whitening anti-aging nanoscale skin-care agent |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1660059A (en) * | 2004-02-25 | 2005-08-31 | 重庆华邦制药股份有限公司 | Composite liposome of vitaminaacid as well as preparation method and application |
| CN101214199A (en) * | 2007-12-29 | 2008-07-09 | 广东拉芳日化有限公司 | Nano active acne-eliminating cosmetic composition |
| CN102973425A (en) * | 2011-09-05 | 2013-03-20 | 张弘 | Whitening anti-aging nanoscale skin-care agent |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103908424A (en) * | 2014-03-03 | 2014-07-09 | 奥思达干细胞有限公司 | Beautifying and nursing essence and preparation method thereof |
| CN105147560A (en) * | 2015-09-25 | 2015-12-16 | 夏放军 | Whitening, moisturizing and macula-removing body lotion and preparation method thereof |
| CN107080704A (en) * | 2017-04-27 | 2017-08-22 | 缪来耿 | Soluble cleaning tissue of a kind of skin whitening, moisturizing and preparation method thereof |
| WO2019173584A1 (en) | 2018-03-09 | 2019-09-12 | Ocusoft, Inc. | Topical skin care compositions |
| EP3761952A4 (en) * | 2018-03-09 | 2021-12-15 | Ocusoft, Inc. | Topical skin care compositions |
| CN109549864A (en) * | 2019-01-18 | 2019-04-02 | 花安堂生物科技集团有限公司 | A kind of emulsifying cosmetics and preparation method thereof |
| CN109549864B (en) * | 2019-01-18 | 2022-03-29 | 花安堂生物科技集团有限公司 | Emulsified spot-removing cosmetic and preparation method thereof |
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Application publication date: 20130717 |