CN101195017A

CN101195017A - Chinese medicine patch for treating ache

Info

Publication number: CN101195017A
Application number: CNA2006101299285A
Authority: CN
Inventors: 牛品中
Original assignee: TIANJIN KANGJIALI SCIENCE AND TECHNOLOGY DEVELOPMENT Co Ltd
Current assignee: TIANJIN KANGJIALI SCIENCE AND TECHNOLOGY DEVELOPMENT Co Ltd
Priority date: 2006-12-08
Filing date: 2006-12-08
Publication date: 2008-06-11

Abstract

The invention relates to a traditional medicine preparation field. The traditional Chinese medical plaster for curing pain comprises the following medicaments and proportion by weight: fried materials comprise nidus vespae 10-30, hedyotis diffusa willd 10-30, cochinchia momordica 10-30, zedoary root 10-30, duck eggs 10-30, solanum nigrum 10-30 and sweetautumn clematis 10-30, fines comprise panax notoginseng 5-20, scorpion 5-20, centipede 5-20, olibanum 5-20, myrrh 5-20, musk 0.2-1.5 and borneol 5-20, and auxiliary materials comprise cheung cinnadar 250-450 and sesame oil 500-1000. The process for preparation comprises putting the seven fried materials into the sesame oil to fry, taking out the fried materials after over fried, heating the sesame oil to 240 degrees, decocting the sesame until the water is formed bead after dropping into the sesame oil, putting cheung cinnadar to collect paste, drawing lump, then putting the paste into cold water to immerse for 30 days, grinding the seven fines into 120 orders, and heating the paste and adding the fines powder into the paste, then forming the plaster which is 10g in each dose.

Description

A kind of Chinese herbs paste for the treatment of pain

Technical field

The invention belongs to field of traditional Chinese, particularly pain relieving patch field.

Background technology

Cancerous pain is one of cardinal symptom of advanced malignant tumor patient, and violent human body pain is brought insufferable human body misery and mental suffering to the patient, also makes family numbers of patients agonizing.How effectively alleviating and eliminating cancerous pain is ten minutes stubborn problem in the clinical tumor work, also is one of four emphasis problems in World Health Organization's cancer unified plan.Analgesic commonly used is easy to addiction, and curative effect lasting time is shorter, and bigger toxic and side effects is arranged.Therefore, explore easy effect good, have no side effect and addicted Therapeutic Method, be very necessary and urgent.

Chinese medicine is artificial, and tumor is owing to reason such as imbalance of YIN and YANG, mood pent-up, internal organs be impaired, causes qi depression to blood stasis, with the passing of time forms the “ mass in the abdomen ", " gathering ", although cancerous protuberance is of a great variety, symptom is different, its pathogenesis is nothing more than " empty stasis of blood heresy ".The main of cancerous pain rises because the cancer poison is coalescent, qi depression to blood stasis, retardance meridians, stagnation of QI and blood may bring about pain.

Summary of the invention

The objective of the invention is to overcome the deficiencies in the prior art, a kind of Chinese herbs paste of the simple and effective treatment pain according to the theory of Chinese medical science prescription is provided.

A kind of Chinese herbs paste for the treatment of pain comprises following medicine and weight ratio thereof, fried material: Nidus Vespae 10-30, Herba Hedyotidis Diffusae 10-30, Semen Momordicae 10-30, Rhizoma Curcumae 10-30, the sub-10-30 of Ovum Anas domestica, Herba Solani Nigri 10-30, Rhizoma Dioscoreae Bulbiferae 10-30, fines: Radix Notoginseng 5-20, Scorpio 5-20, Scolopendra 5-20, Olibanum 5-20, Myrrha 5-20, Moschus 0.2-1.5, Borneolum Syntheticum 5-20; Adjuvant: Plumbum preparatium 250-450, Oleum Sesami 500-2000, make by following technology: the fried material of above 7 flavors is put into Oleum Sesami, friedly take out fried material to burnt the paste, Oleum Sesami is heated to 240 degree, endure and drip into pearl, put into Plumbum preparatium and receive cream, pulling out sticks together cooled the water logging bubble 30 days; Above 7 flavor fineves are ground into 120 orders, and reheat spreads out into the plaster of every part 10 gram to going into the fines powder.

Pharmacology:

According to the traditional Chinese medical science " stagnation of QI and blood may bring about pain, general rule are not bitterly " theory, the basic rule of treatment that we have established the treatment cancerous pain by brainstrust, promptly " removing obstruction in the collateral to relieve pain through long-felt, improves repeatedly for anticancer healing, blood stasis dispelling circulation of qi promoting, develops " Chinese mugwort pain card ".This ointment is based on Scorpio, Nidus Vespae, Scolopendra, Eupolyphaga Seu Steleophaga etc., anticancer healing, the eliminating stagnation of stimulating the menstrual flow, removing blood stasis with potent drugs detumescence; Be aided with Olibanum, Myrrha, Moschus etc., strengthen its eliminating stagnation removing blood stasis with potent drugs, inducing menstruation to relieve menalgia effect; Help again with Herba Solani Nigri, Rhizoma Dioscoreae Bulbiferae etc., can reach the purpose of " removing blood stasis with potent drugs and just not hindering, counteracting toxic substances and do not poison ".This ointment takes to distinguish that the cancer acupoint selection sticks, and the anticancer analgetic effect can be constantly accumulated in periodic replacement, and longer-term is to discharge its anticancer blood-activating analgetic of accumulating to render a service constantly, thereby obtains remarkable and stable clinical effectiveness.

Through the clinical application verification that exceedes thousand examples, this ointment can obtain good and clinical curative effect, and its obvious effective rate reaches 80.32%, and total effective rate is 95.53%.Clinical control is observed and shown that this ointment curative effect obviously is better than analgesic pethidine commonly used etc., and following characteristics are arranged: 1. early (coming into force in 15～30 minutes) appears in the anticancer analgetic effect, and the persistent period is grown (more than 48 hours).2. distinguish cancer subsides cave, easy to use, patient or family members can use voluntarily.3. economical efficacious, safety is easily gone, and analgesic effect is reliable.4. non-stimulated to skin, do not have irritated phenomenon, have no side effect, also do not have addiction.Thereby can extensively promote the use of.

The specific embodiment

Example 1:

Prescription: fried material: Nidus Vespae 20g, Herba Hedyotidis Diffusae 20g, Semen Momordicae 20g, Rhizoma Curcumae 20g, the sub-20g of Ovum Anas domestica, Herba Solani Nigri 20g, Rhizoma Dioscoreae Bulbiferae 20g, fines: Radix Notoginseng 10g, Scorpio 10g, Scolopendra 10g, Olibanum 10g, Myrrha 10g, Moschus 1g, Borneolum Syntheticum 10g; Adjuvant: Plumbum preparatium 350g, Oleum Sesami 1kg makes by following technology: the fried material of above 7 flavors is put into Oleum Sesami, friedly take out fried material to burnt the paste, Oleum Sesami is heated to 240 degree, endure and drip into pearl, put into Plumbum preparatium and receive cream. and pulling out sticks together cooled the water logging bubble 30 days; Above 7 flavor fineves are ground into 120 orders, and reheat spreads out into the plaster of every part 10 gram to going into the fines powder.

It is as follows that the Chinese herbs paste that this method is made is used for clinical observation:

Effect observation

One, materials and methods

1. the cancer pain classification is according to the clinical scale standard of pain, and cancer pain is divided into following 4 grades: 0 grade: the painless feel of patient.I level (mild pain): though having pain, the patient can stand, and can orthobiosis, sleep is interference-free.II level (moderate pain): pain is obvious, is impatient at, and requires the clothes analgesic, and sleep is disturbed.III level (severe pain): sharp ache, be impatient at, need to use analgesic, sleep is seriously disturbed, and autonomic nervous dysfunction performance or positive position can be arranged.

2. case is selected to detect (CT and pathologic finding etc.) through modern medicine and is diagnosed as cancer, and the patient has moderate or severe pain, and pain is strictly by cancer and directly causes.

3. general clinical data is accepted 1290 routine all kinds of cancer pain patients altogether for medical treatment, is divided into ointment group and matched group at random, ointment group 940 examples, male 524 examples, women 416 examples, 29～82 years old age, 56.1 years old mean age.Matched group 350 examples, male 188 examples, women 162 examples, at 30～80 years old age, 54.8 years old mean age, two groups of patient's cancer kinds see table 1 for details.

Table 1 liang group patient's cancer kind alanysis (example)

4. using method

Ointment group acupuncture points external application Chinese mugwort pain is pasted, select the cave as follows by diseased region and cancer kind: pulmonary carcinoma is got the Ruzhong, big bag, region below the heart, fei shu, esophageal carcinoma is got canopy, Danzhong, Zhongting, the middle part of gastric cavity, gastric cancer is got the middle part of gastric cavity, Shenque, bl, hepatocarcinoma is got the middle part of gastric cavity, right Qimen, right bl, cancer of pancreas is got the middle part of gastric cavity, Shenque, Fuai, osteocarcinoma is got dazhu, local (focus), renal carcinoma is got Zhangmen, shen shu, gallbladder and cancer of biliary duct are got the middle part of gastric cavity, right Qimen, colon cancer is got Shenque, fu jie, rectal cancer is got cv, Yaoshu(Du 2), ovarian cancer and cervical cancer are got cv, water channel, except that above acupuncture point, need on lump or Ashi point adds deposited ZHITONG GAO, changed 1 time in 48 hours, 14 days was 1 course of treatment.

The general cancer patient of matched group takes the pethidine tablet, and 100mg/ time, 4～6 times/day, 14 days was 1 course of treatment.But the hard to bear person of severe pain is the intramuscular injection pethidine in case of necessity.

Two, result

1. efficacy assessment standard produce effects: the cancerous pain complete obiteration, patient's ordinary circumstance is good, and promptly cancer pain returns to 0 grade.Effectively: cancer pain obviously alleviates before than medication, and patient's sleep is interference-free substantially, and promptly cancer pain is relieved to 1 grade.Invalid: cancer pain does not have before the treatment and does not alleviate, though or have and alleviate, it is hard to bear that the patient still feels obvious pain, sleep is disturbed.

2. clinical curative effect analysis is after two course of therapy, and the clinical efficacy situation of ointment group and matched group sees Table 2, and processing (X 2 test), X are analysed in credit by statistics ²=65.79, p＜0.01, two group curative effect difference has significance.

Table 2 ointment group and matched group clinical efficacy be (X relatively ²)

Two groups of obvious effective rates are handled (t check between two percentage rate) by statistics, t=6.874, and p＜0.01, the two also has notable difference.The result shows that Chinese mugwort pain plaster obviously is better than the pethidine of matched group to the analgesic effect of cancerous pain.

Example 2:

Prescription: fried material: Nidus Vespae 10g, Herba Hedyotidis Diffusae 30g, Semen Momordicae 10g, Rhizoma Curcumae 30g, the sub-10g of Ovum Anas domestica, Herba Solani Nigri 30g, Rhizoma Dioscoreae Bulbiferae 10g, fines: Radix Notoginseng 20g, Scorpio 5g, Scolopendra 20g, Olibanum 5g, Myrrha 20g, Moschus 0.2g, Borneolum Syntheticum 20g; Adjuvant: Plumbum preparatium 250g, Oleum Sesami 0.5kg makes by following technology: the fried material of above 7 flavors is put into Oleum Sesami, friedly take out fried material to burnt the paste, Oleum Sesami is heated to 240 degree, endure and drip into pearl, put into Plumbum preparatium and receive cream. and pulling out sticks together cooled the water logging bubble 30 days; Above 7 flavor fineves are ground into 120 orders, and reheat spreads out into the plaster of every part 10 gram to going into the fines powder.

Example 3:

Prescription: fried material: Nidus Vespae 30g, Herba Hedyotidis Diffusae 10g, Semen Momordicae 30g, Rhizoma Curcumae 10g, the sub-30g of Ovum Anas domestica, Herba Solani Nigri 10g, Rhizoma Dioscoreae Bulbiferae 30g, fines: Radix Notoginseng 5g, Scorpio 20g, Scolopendra 5g, Olibanum 20g, Myrrha 5g, Moschus 1.5g, Borneolum Syntheticum 5g; Adjuvant: Plumbum preparatium 450g, Oleum Sesami 2kg makes by following technology: the fried material of above 7 flavors is put into Oleum Sesami, friedly take out fried material to burnt the paste, Oleum Sesami is heated to 240 degree, endure and drip into pearl, put into Plumbum preparatium and receive cream. and pulling out sticks together cooled the water logging bubble 30 days; Above 7 flavor fineves are ground into 120 orders, and reheat spreads out into the plaster of every part 10 gram to going into the fines powder.

Claims

1. a Chinese herbs paste for the treatment of pain comprises following medicine and weight ratio thereof, fried material: Nidus Vespae 10-30, Herba Hedyotidis Diffusae 10-30, Semen Momordicae 10-30, Rhizoma Curcumae 10-30, the sub-10-30 of Ovum Anas domestica, Herba Solani Nigri 10-30, Rhizoma Dioscoreae Bulbiferae 10-30, fines: Radix Notoginseng 5-20, Scorpio 5-20, Scolopendra 5-20, Olibanum 5-20, Myrrha 5-20, Moschus 0.2-1.5, Borneolum Syntheticum 5-20; Adjuvant: Plumbum preparatium 250-450, Oleum Sesami 500-2000, make by following technology: the fried material of above 7 flavors is put into Oleum Sesami, friedly take out fried material to burnt the paste, Oleum Sesami is heated to 240 degree, endure and drip into pearl, put into Plumbum preparatium and receive cream, pulling out sticks together cooled the water logging bubble 30 days; Above 7 flavor fineves are ground into 120 orders, and reheat spreads out into the plaster of every part 10 gram to going into the fines powder.