CN101175476B - 包含眼科药物、泊洛沙明和二醇张力调节剂的眼科混悬剂，所述组合物用于生产治疗眼科病症的药物的用途 - Google Patents

包含眼科药物、泊洛沙明和二醇张力调节剂的眼科混悬剂，所述组合物用于生产治疗眼科病症的药物的用途 Download PDF

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Publication number
CN101175476B
CN101175476B CN200680016190XA CN200680016190A CN101175476B CN 101175476 B CN101175476 B CN 101175476B CN 200680016190X A CN200680016190X A CN 200680016190XA CN 200680016190 A CN200680016190 A CN 200680016190A CN 101175476 B CN101175476 B CN 101175476B
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CN
China
Prior art keywords
composition
poloxamine
ophthalmic
nonionic surfactant
proviso
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN200680016190XA
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English (en)
Chinese (zh)
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CN101175476A (zh
Inventor
G·R·欧文
A·C·布鲁克斯
G·格拉夫
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Alcon Inc
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Alcon Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN200680016190XA 2005-05-10 2006-05-08 包含眼科药物、泊洛沙明和二醇张力调节剂的眼科混悬剂，所述组合物用于生产治疗眼科病症的药物的用途 Expired - Fee Related CN101175476B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67951005P 2005-05-10 2005-05-10
US60/679,510 2005-05-10
PCT/US2006/017607 WO2006121964A2 (en) 2005-05-10 2006-05-08 Ophthalmic suspension comprising an ophthalmic drug, a poloxamine and a glycol tonicity-adjusting agent, use of said composition for the manufacture of a medicament for treating ophthalmic disorders

Publications (2)

Publication Number Publication Date
CN101175476A CN101175476A (zh) 2008-05-07
CN101175476B true CN101175476B (zh) 2011-11-16

Family

ID=37087751

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200680016190XA Expired - Fee Related CN101175476B (zh) 2005-05-10 2006-05-08 包含眼科药物、泊洛沙明和二醇张力调节剂的眼科混悬剂，所述组合物用于生产治疗眼科病症的药物的用途

Country Status (19)

Country Link
US (1) US20060257486A1 (OSRAM)
EP (1) EP1906916B1 (OSRAM)
JP (1) JP4968955B2 (OSRAM)
KR (1) KR20080011311A (OSRAM)
CN (1) CN101175476B (OSRAM)
AT (1) ATE412402T1 (OSRAM)
AU (1) AU2006244245B2 (OSRAM)
BR (1) BRPI0608774A2 (OSRAM)
CA (1) CA2607014A1 (OSRAM)
CY (1) CY1108676T1 (OSRAM)
DE (1) DE602006003438D1 (OSRAM)
DK (1) DK1906916T3 (OSRAM)
ES (1) ES2313670T3 (OSRAM)
MX (1) MX2007014084A (OSRAM)
PL (1) PL1906916T3 (OSRAM)
PT (1) PT1906916E (OSRAM)
SI (1) SI1906916T1 (OSRAM)
WO (1) WO2006121964A2 (OSRAM)
ZA (1) ZA200709296B (OSRAM)

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CA2607608A1 (en) * 2005-05-10 2006-11-16 Alcon, Inc. Suspension formulations of nepafenac and other ophthalmic drugs for topical treatment of ophthalmic disorders
TW200812575A (en) * 2006-04-28 2008-03-16 Alcon Inc Formulations containing amide derivatives of carboxylic acid NSAIDs for topical administration to the eye
TW201023912A (en) 2008-12-05 2010-07-01 Alcon Res Ltd Pharmaceutical suspension
CN102340993A (zh) * 2009-03-03 2012-02-01 爱尔康研究有限公司 向眼部递送受体酪氨酸激酶抑制性(RTKi)化合物的药物组合物
WO2010101989A1 (en) 2009-03-03 2010-09-10 Alcon Research, Ltd. PHARMACEUTICAL COMPOSITION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE
KR101543613B1 (ko) 2009-12-03 2015-08-11 알콘 리서치, 리미티드 카복시비닐 폴리머를 포함하는 나노입자 현탁액
EP2509596B1 (en) 2009-12-08 2019-08-28 Case Western Reserve University Gamma aminoacids for treating ocular disorders
JP5870459B2 (ja) * 2010-08-27 2016-03-01 わかもと製薬株式会社 点眼用水性組成物
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
CN104706579A (zh) * 2015-03-12 2015-06-17 广州仁恒医药科技有限公司 一种夫西地酸滴眼液及其制备方法
CN111285845B (zh) * 2020-02-11 2021-01-01 深圳厚存纳米药业有限公司 末端官能团化的泊洛沙胺衍生物
US12049606B2 (en) * 2021-01-12 2024-07-30 Johnson & Johnson Vision Care, Inc. Compositions for ophthalmologic devices
CA3206106A1 (en) * 2021-02-10 2022-08-18 Bhaskar Chaudhuri Methods for ophthalmic delivery of roflumilast
CN116867480A (zh) * 2021-02-10 2023-10-10 洛利克斯治疗有限公司 眼部递送罗氟司特的方法
US12263160B2 (en) 2021-09-22 2025-04-01 Iolyx Therapeutics, Inc. Methods of treating ocular inflammatory diseases
WO2024058848A1 (en) * 2022-09-15 2024-03-21 Arcutis Biotherapeutics, Inc. Pharmaceutical compositions of roflumilast and solvents capable of dissolving high amounts of the drug

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US20020107238A1 (en) * 2000-10-10 2002-08-08 Rebanta Bandyopadhyay Topical antibiotic composition for treatment of eye infection
US20040115270A1 (en) * 2002-12-13 2004-06-17 Dharmendra Jani Absorption and controlled release of polyethers from hydrogel biomaterials

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US5631005A (en) * 1994-09-21 1997-05-20 Alcon Laboratories, Inc. Use of amidoamines in ophthalmic compositions
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US5540930A (en) * 1993-10-25 1996-07-30 Pharmos Corporation Suspension of loteprednol etabonate for ear, eye, or nose treatment
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US20020107238A1 (en) * 2000-10-10 2002-08-08 Rebanta Bandyopadhyay Topical antibiotic composition for treatment of eye infection
WO2002048300A1 (en) * 2000-12-14 2002-06-20 Bausch & Lomb Incorporated Composition for cleaning and wetting contact lenses
US20040115270A1 (en) * 2002-12-13 2004-06-17 Dharmendra Jani Absorption and controlled release of polyethers from hydrogel biomaterials

Also Published As

Publication number Publication date
ATE412402T1 (de) 2008-11-15
ES2313670T3 (es) 2009-03-01
JP4968955B2 (ja) 2012-07-04
CN101175476A (zh) 2008-05-07
DK1906916T3 (da) 2009-01-19
WO2006121964A3 (en) 2007-03-22
CA2607014A1 (en) 2006-11-16
DE602006003438D1 (de) 2008-12-11
KR20080011311A (ko) 2008-02-01
ZA200709296B (en) 2009-01-28
WO2006121964A2 (en) 2006-11-16
BRPI0608774A2 (pt) 2010-01-26
EP1906916B1 (en) 2008-10-29
AU2006244245A1 (en) 2006-11-16
AU2006244245B2 (en) 2010-11-18
US20060257486A1 (en) 2006-11-16
EP1906916A2 (en) 2008-04-09
JP2008540533A (ja) 2008-11-20
PL1906916T3 (pl) 2009-02-27
MX2007014084A (es) 2008-02-07
SI1906916T1 (sl) 2009-02-28
CY1108676T1 (el) 2014-04-09
PT1906916E (pt) 2008-12-10

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Granted publication date: 20111116

Termination date: 20130508