CN101164560A - Plant component aromatic preparation for relieving emotional stress, anxiety and depression and preparation method thereof - Google Patents
Plant component aromatic preparation for relieving emotional stress, anxiety and depression and preparation method thereof Download PDFInfo
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- CN101164560A CN101164560A CNA2006101405532A CN200610140553A CN101164560A CN 101164560 A CN101164560 A CN 101164560A CN A2006101405532 A CNA2006101405532 A CN A2006101405532A CN 200610140553 A CN200610140553 A CN 200610140553A CN 101164560 A CN101164560 A CN 101164560A
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- rhizoma atractylodis
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Abstract
The present invention relates to a plant component aromatic preparation for relieving emotional tonicity, anxiety and depression and its preparation method. It is made up by using volatile oil extracted from Chinese medicinal material bighead atractylodes rhizome, aromatic volatile oil extracted from one of Chinese medicinal materials of peppermint, atractylodes rhizome, cablin pacholi and folium eucalypti or more than one of them and any one of auxiliary materials of ethyl alohol, Tween-80, methylparaben, ethylparaben, propanediol, vitamin E, vitamin C, cysteine, citric acid and sodium sulfite or several kinds of them through a certain preparation process. Said invention can be made into spray, aerosol, nose drops, nose pigment, cream, ointment, liniment and oil solutions.
Description
Technical field
The invention belongs to the technical field of plant fragrance preparation, the plant component aromatic preparation that relates to a kind of relieving emotional stress, anxiety, depression, relate in particular to balm that comprises the volatile oil of producing by the Rhizoma Atractylodis Macrocephalae and be prepared from one or more the fragrant volatile oil produced that add in addition and preparation method thereof by in vegetable material Herba Menthae, Rhizoma Atractylodis, Herba Pogostemonis, the Folium eucalypti globueli (Eucalyptus globulus Labill.).
Background technology
Along with rapid economy development, when living standard improved, people's stress was also increasing, and in the face of more opportunity the time, competition also is growing more intense.The competition of school work, employment, occupation, modern's stress and psychological burden are strengthened, and various unhealthy emotions such as engender tension, anxiety, depression thus, and these unhealthy emotions not only influence the quality of life, it is not normal more the people to be brought into play, especially in activities such as examination, application, speech, performance often because unhappy and be difficult to show true horizon and miss opportunity.Almost everyone wishes and can keep good phychology in the occasion of key, overcome unhealthy emotions such as anxiety, anxiety, depression, however few people can really accomplish to control and regulate emotion by the oneself, most of people feel simply helpless to these unhealthy emotions.Though have some chemicalses can alleviate unhealthy emotion, chemicals is taken inconvenience, and toxic and side effects is big, untoward reaction is many, is difficult to be accepted by masses.
Summary of the invention
The objective of the invention is at the unhealthy emotion that causes by mental pressure, the plant component aromatic preparation of a kind of relieving emotional stress, anxiety, depression is provided, at present, domestic and international bibliographical information and patent of not seeing similar invention.
Patent application of the present invention discloses the plant component aromatic preparation of a kind of relieving emotional stress, anxiety, depression, this balm adopts the natural plant material to form through extracting the meticulous allotment of volatile oil component, wherein said vegetable material is except that the Rhizoma Atractylodis Macrocephalae, add in Herba Menthae, Rhizoma Atractylodis, Herba Pogostemonis, the Folium eucalypti globueli (Eucalyptus globulus Labill.) one or more in addition, this balm nature and flavor gentleness, nontoxic, environmental protection have refreshment, ventilate and have one's ideas straightened out, clear away heart-fire pleasant effect.Quiet the calming the nerves of energy effectively alleviated unhealthy emotion, is particularly useful for alleviating anxiety, anxiety, the depressive emotion that activities such as examination, application, performance lecture cause.
Patent application of the present invention discloses plant component aromatic preparation of a kind of relieving emotional stress, anxiety, depression and preparation method thereof, add adjuvant: any one or a few in ethanol, tween 80, beta-schardinger dextrin-, Buddhist nun uncle tortoise beetle ester, Ethyl Hydroxybenzoate, propylene glycol, polypropylene ketopyrrolidine, vitamin E, vitamin C, Borneolum Syntheticum, cysteine, citric acid and the sodium sulfite, make spray, aerosol, nasal drop, be coated with nose agent, ointment, ointment, liniment or oil preparation.The preparation character stable homogeneous of making, easy to use, be easy to carry about with one, can use in public.
Technical scheme of the present invention:
1. balm of the present invention is to be prepared from through conventional volatile oil extraction process with the Rhizoma Atractylodis Macrocephalae and one or more vegetable materials of being selected from Herba Menthae, Rhizoma Atractylodis, Herba Pogostemonis, the Folium eucalypti globueli (Eucalyptus globulus Labill.).The consumption that wherein is used to produce the vegetable material of volatile oil is a Rhizoma Atractylodis Macrocephalae 5-10 weight portion; Except that the volatile oil that the Rhizoma Atractylodis Macrocephalae is produced, add in addition by one or more the fragrant volatile oil produced in vegetable material Herba Menthae, Rhizoma Atractylodis, Herba Pogostemonis, the Folium eucalypti globueli (Eucalyptus globulus Labill.), above-mentioned vegetable material consumption be respectively: Herba Menthae 2-5 weight portion, Rhizoma Atractylodis 5-10 weight portion, Herba Pogostemonis 1-5 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 3-8 weight portion.In an embodiment preferred of the present invention, the consumption of vegetable material is the Rhizoma Atractylodis Macrocephalae by weight: Herba Menthae: Rhizoma Atractylodis: Herba Pogostemonis: Folium eucalypti globueli (Eucalyptus globulus Labill.) 6: 2: 6: 4: 4.
2. balm of the present invention is with the Rhizoma Atractylodis Macrocephalae, with be selected from one or more vegetable material such as Herba Menthae, Rhizoma Atractylodis, Herba Pogostemonis, Folium eucalypti globueli (Eucalyptus globulus Labill.) and extract through mixing water steam distillation, or extract back united extraction thing with vapor distillation respectively, dewater through acceptable dehydrant, thereby obtain comprising Rhizoma Atractylodis Macrocephalae volatile oil and be selected from one or more fragrant volatile oil in Oleum menthae, Rhzoma Atractylodis Lanceae volatile oil, Herba Pogostemonis Volatile oil, the Folium eucalypti globueli (Eucalyptus globulus Labill.) volatile oil.Vapor distillation extracts can adopt any disclosed process in this area, and the present invention proposes a kind of feasible process for extracting at this, and is specific as follows:
Get the Rhizoma Atractylodis Macrocephalae respectively, and the vegetable material that is selected from Herba Menthae, Rhizoma Atractylodis, Herba Pogostemonis, the Folium eucalypti globueli (Eucalyptus globulus Labill.) one or more, pulverize the back and add distilled water immersion, distill Aromatic water, separate Aromatic water and through the dehydrant processed.Obtain the phytovolatilization oil component.
Wherein:
1) above-mentioned vegetable material grinding particle size can be the 10-100 order;
2) amount soaked of above-mentioned vegetable material can be that the 5-10 of vegetable material doubly measures (g/mL);
3) above-mentioned vegetable material time of soaking can be 8-24 hour;
4) time of above-mentioned vapor distillation extraction can be 2-6 hour;
5) above-mentioned vapor distillation extracts and can use the dehydrant anhydrous sodium sulfate dehydration after the Aromatic water that obtains separates;
3. in balm of the present invention and preparation method thereof, employed adjuvant is selected from any one or a few in ethanol, tween 80, beta-schardinger dextrin-, Buddhist nun uncle tortoise beetle ester, Ethyl Hydroxybenzoate, propylene glycol, polypropylene ketopyrrolidine, vitamin E, vitamin C, Borneolum Syntheticum, cysteine, citric acid and the sodium sulfite, make plant component stable uniform in preparation, meet the physicochemical property requirement of preparation.
4. balm of the present invention comprises various suctions or external preparation, can be spray, aerosol, nasal drop, be coated with nose agent, ointment, ointment, liniment or oil preparation.
5. balm of the present invention has the effect of relieving emotional stress, anxiety, depression, picked at random 120 routine job hunting and application personnel, be divided into 3 groups at random by identical M-F, every group 40 people, as test group, matched group and blank group, test group was given before interview and by the balm of the mixed volatilization oil preparation of adopting embodiment 3 in the embodiment of the invention 7 in 10-20 minute, matched group was given and the placebo that does not contain above-mentioned plant component before interview with method in 10-20 minute, and blank group is not used any aromatic; Interview back questionnaire result adds up as follows:
Test group: feel nervous 1 example (2.5%), anxiety 0 example (0.0%), depressed 0 example (0.0%);
Matched group: feel nervous 13 examples (32.5%), anxiety 5 examples (12.5%), depressed 0 example (0.0%);
Blank group: feel nervous 27 examples (67.5%), anxiety 4 examples (10.0%), depressed 2 examples (5.0%);
The result shows that above balm is keeping tensions down, anxiety, depressive emotion effectively, and analysis is compared with blank group with matched group and had significant difference by statistics.Adopt as above identical method to give and the balm of other embodiment all effectively keeping tensions down, anxiety, depressive emotion, analysis is organized to compare with matched group and blank and is had significant difference by statistics.
The specific embodiment:
Embodiment 1: get Rhizoma Atractylodis Macrocephalae 1000g, be ground into coarse powder, add the 6000mL water boil, distilled 2 hours, Aromatic water is reclaimed in cooling, and Aromatic water left standstill 24 hours, separates upper strata volatile oil, gets Rhizoma Atractylodis Macrocephalae volatile oil.
Embodiment 2: get Rhizoma Atractylodis Macrocephalae 600g, fresh Herba Menthae 200g, Herba Pogostemonis 400g, add 9000mL water, in soaking at room temperature 8 hours, distilled 4 hours, Aromatic water is reclaimed in cooling, and Aromatic water left standstill 24 hours, separate upper strata volatile oil,, obtain mixed volatilization oil through anhydrous sodium sulfate dehydration.
Embodiment 3: get fresh Rhizoma Atractylodis Macrocephalae 600g, Herba Menthae 200g, Rhizoma Atractylodis 600g, Herba Pogostemonis 400g, Folium eucalypti globueli (Eucalyptus globulus Labill.) 400g adds 18000mL water, in soaking at room temperature 12 hours, distilled 4 hours, Aromatic water is reclaimed in cooling, and Aromatic water left standstill 24 hours, separates upper strata volatile oil, through anhydrous sodium sulfate dehydration, obtain mixed volatilization oil.
Embodiment 4: get fresh Rhizoma Atractylodis Macrocephalae 600g, Herba Menthae 200g, Rhizoma Atractylodis 600g, Herba Pogostemonis 400g, Folium eucalypti globueli (Eucalyptus globulus Labill.) 400g, add 8 times of amounts (g/mL) water respectively,, distilled respectively 6 hours in soaking at room temperature 24 hours, Aromatic water is reclaimed in cooling, merge Aromatic water, left standstill 12 hours, separate upper strata volatile oil, through anhydrous sodium sulfate dehydration, obtain mixed volatilization oil.
Embodiment 5: get fresh Rhizoma Atractylodis Macrocephalae 600g, Herba Menthae 200g, Rhizoma Atractylodis 600g, Herba Pogostemonis 400g, Folium eucalypti globueli (Eucalyptus globulus Labill.) 400g, add 8 times of amounts (g/mL) water respectively,, distilled respectively 6 hours in soaking at room temperature 24 hours, Aromatic water is reclaimed in cooling respectively, left standstill 12 hours, and separated upper strata volatile oil, through anhydrous sodium sulfate dehydration, obtain Rhizoma Atractylodis Macrocephalae volatile oil, Oleum menthae, Rhzoma Atractylodis Lanceae volatile oil, Herba Pogostemonis Volatile oil, Folium eucalypti globueli (Eucalyptus globulus Labill.) volatile oil respectively, in the preparation process, mix.
Embodiment 6: get fresh Rhizoma Atractylodis Macrocephalae 600g, Herba Menthae 200g, Folium eucalypti globueli (Eucalyptus globulus Labill.) 400g, add 8 times of amounts (g/mL) water respectively, in soaking at room temperature 24 hours, distilled respectively 6 hours, Aromatic water is reclaimed in cooling, merges Aromatic water, left standstill 12 hours, separate upper strata volatile oil,, obtain mixed volatilization oil through anhydrous sodium sulfate dehydration.
Embodiment 7: get the mixed volatilization oil of embodiment 2-6, add an amount of ethanol and make dissolving, add 0.1% ethyl hydroxybenzoate, add water and stir, promptly.
Embodiment 8: Borneolum Syntheticum is ground, gets in right amount, add dissolve with ethanol; The weight equivalent of pressing vegetable material calculates, and gets the volatile oil of Herba Menthae 200g preparation, the volatile oil of Rhizoma Atractylodis Macrocephalae 800g preparation, and the volatile oil preparation method is with embodiment 2-6, add an amount of ethanol respectively, add 0.02% Tween 80, stir and make dissolving, the methyl hydroxybenzoate of adding 0.05% stirs.Said mixture is poured in the water, stirred, canned in the nasal spray device.
Embodiment 9: the weight equivalent of pressing vegetable material calculates; get the volatile oil of Herba Menthae 500g preparation, the volatile oil of Rhizoma Atractylodis 500g preparation, the volatile oil of Folium eucalypti globueli (Eucalyptus globulus Labill.) 500g preparation; the volatile oil preparation method is with embodiment 2-6; add Tween 80 and mix; and in mortar, grind, make volatile oil be dispersed into spherolite preferably.Add an amount of Aromatic water and continue to grind, to forming metastable oil/water type Emulsion.
Embodiment 10: the weight equivalent of pressing vegetable material calculates; get the volatile oil of Herba Menthae 300g preparation, the volatile oil of Herba Pogostemonis 400g preparation, the volatile oil of Rhizoma Atractylodis Macrocephalae 800g preparation, the volatile oil of Folium eucalypti globueli (Eucalyptus globulus Labill.) 400g preparation; the volatile oil preparation method is with embodiment 2-6; add 95% an amount of ethanol and make dissolving; add sodium benzoate, vitamin C again, stir.Adding water is to contain the alcohol amount to 30%, transfers pH to 7 with sodium hydroxide, divides in the device liniment bottle every bottle of 5mL.
Embodiment 11: the weight equivalent of pressing vegetable material calculates; get the volatile oil of Herba Menthae 200g preparation, the volatile oil of Rhizoma Atractylodis 1000g preparation, the volatile oil of Folium eucalypti globueli (Eucalyptus globulus Labill.) 500g preparation; the volatile oil preparation method is with embodiment 2-6; add an amount of 95% ethanol and make dissolving; add film former polypropylene ketopyrrolidine, plasticizer propylene glycol, adds low amounts of water and grinds, and makes into membranaceous; packing, promptly.
Embodiment 12: the mixed volatilization oil 10g that gets embodiment 2-6.Volatile oil is gently poured in the 100mL glycerol, and stirred with adding with being stirred to.Borneolum Syntheticum 10g is ground the adding dissolve with ethanol, slowly pour in the glycerite of volatile oil, stir with adding with being stirred to.Glycerite is dissolved in the 500mL water, add sodium chloride furnishing isosmotic solution at last, packing, sterilization, promptly.
Embodiment 13: take by weighing in 50 ℃ of water of a certain amount of B-cyclodextrin adding and make saturated aqueous solution, water and beta-schardinger dextrin-are about 12: 1, and constant temperature stirs.The weight equivalent of pressing vegetable material calculates, with the volatile oil of the Herba Menthae of equal proportion and Rhizoma Atractylodis Macrocephalae preparation mix the back with dehydrated alcohol (1: 1) dilution after, slowly be added drop-wise in the beta-schardinger dextrin-solution with syringe in 1: 6 ratio, jump a queue, enclose 2h, place 24h in 4 ℃ of refrigerators, sucking filtration is used a small amount of distilled water wash, the reuse petroleum ether is a small amount of, the volatile oil that divides 3 flush awaies not comprise, 40 ℃ of dryings 2 hours, the clathrate of volatile oil.This clathrate is dissolved in the 500mL water, and refrigerator cold-storage 24 hours filters, and is sub-packed in the 10mL nasal drop bottle, promptly by the sterile working.
Claims (10)
1. a relieving emotional stress, anxiety, depressed plant component aromatic preparation, it is characterized in that described balm comprise the volatile oil produced by the vegetable material Rhizoma Atractylodis Macrocephalae and add in addition by one or more the fragrant volatile oil produced in vegetable material Herba Menthae, Rhizoma Atractylodis, Herba Pogostemonis, the Folium eucalypti globueli (Eucalyptus globulus Labill.).
2. balm according to claim 1, the consumption that it is characterized in that being used to producing the vegetable material of volatile oil is a Rhizoma Atractylodis Macrocephalae 5-10 weight portion; Except that the volatile oil that the Rhizoma Atractylodis Macrocephalae is produced, add in addition by one or more the fragrant volatile oil produced in vegetable material Herba Menthae, Rhizoma Atractylodis, Herba Pogostemonis, the Folium eucalypti globueli (Eucalyptus globulus Labill.), above-mentioned vegetable material consumption be respectively: Herba Menthae 2-5 weight portion, Rhizoma Atractylodis 5-10 weight portion, Herba Pogostemonis 1-5 weight portion, Folium eucalypti globueli (Eucalyptus globulus Labill.) 3-8 weight portion.
3. balm according to claim 2 is characterized in that the fragrant volatile oil of being produced by vegetable material Herba Menthae, Rhizoma Atractylodis, Herba Pogostemonis, Folium eucalypti globueli (Eucalyptus globulus Labill.) that described balm comprises the volatile oil produced by the Rhizoma Atractylodis Macrocephalae and adds in addition.
4. balm according to claim 3 is characterized in that described balm is used to produce the vegetable material Rhizoma Atractylodis Macrocephalae of volatile oil, Herba Menthae, Rhizoma Atractylodis, Herba Pogostemonis, Folium eucalypti globueli (Eucalyptus globulus Labill.) and equals 6: 2: 6 by vegetable material weight equivalent ratio: 4: 4.
5. according to the described balm of claim 1-4, it is characterized in that described balm comprises any one or a few the adjuvant that is selected from ethanol, tween 80, beta-schardinger dextrin-, Buddhist nun uncle tortoise beetle ester, Ethyl Hydroxybenzoate, propylene glycol, polypropylene ketopyrrolidine, vitamin E, vitamin C, Borneolum Syntheticum, cysteine, citric acid and the sodium sulfite.
6. according to the described balm of claim 1-5, it is characterized in that described balm is spray, aerosol, nasal drop, is coated with nose agent, ointment, ointment, liniment or oil preparation.
7. preparation method as the described relieving emotional stress of claim 1-5, anxiety, depressed plant component aromatic preparation, it is characterized in that the Rhizoma Atractylodis Macrocephalae, extract through mixing water steam distillation with one or more vegetable material of the Herba Menthae of other adding, Rhizoma Atractylodis, Herba Pogostemonis, Folium eucalypti globueli (Eucalyptus globulus Labill.), or extract back united extraction thing with vapor distillation respectively, dewater through acceptable dehydrant, thereby obtain comprising Rhizoma Atractylodis Macrocephalae volatile oil and be selected from one or more fragrant volatile oil in Oleum menthae, Rhzoma Atractylodis Lanceae volatile oil, Herba Pogostemonis Volatile oil, the Folium eucalypti globueli (Eucalyptus globulus Labill.) volatile oil.
8. according to the preparation method of the described balm of claim 7, it is characterized in that the volatile oil that to produce by the Rhizoma Atractylodis Macrocephalae, with preparing with the preparation acceptable auxiliary of other adding, make balm by one or more fragrant volatile oil of producing in vegetable material Herba Menthae, Rhizoma Atractylodis, Herba Pogostemonis, the Folium eucalypti globueli (Eucalyptus globulus Labill.).
9. the preparation method of described balm according to Claim 8 is characterized in that described adjuvant is selected from any one or a few in ethanol, tween 80, beta-schardinger dextrin-, Buddhist nun uncle tortoise beetle ester, Ethyl Hydroxybenzoate, propylene glycol, polypropylene ketopyrrolidine, vitamin E, vitamin C, Borneolum Syntheticum, cysteine, citric acid and the sodium sulfite.
10. according to the preparation method of the described balm of claim 6-9, it is characterized in that described balm is spray, aerosol, nasal drop, is coated with nose agent, ointment, ointment, liniment or oil preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006101405532A CN101164560A (en) | 2006-10-17 | 2006-10-17 | Plant component aromatic preparation for relieving emotional stress, anxiety and depression and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2006101405532A CN101164560A (en) | 2006-10-17 | 2006-10-17 | Plant component aromatic preparation for relieving emotional stress, anxiety and depression and preparation method thereof |
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| CN101164560A true CN101164560A (en) | 2008-04-23 |
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| CNA2006101405532A Pending CN101164560A (en) | 2006-10-17 | 2006-10-17 | Plant component aromatic preparation for relieving emotional stress, anxiety and depression and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040649A (en) * | 2012-12-20 | 2013-04-17 | 浦江欧妮雅化妆品有限公司 | Patchouli perfume |
| CN109315782A (en) * | 2017-08-01 | 2019-02-12 | 无限极（中国）有限公司 | It is a kind of to have effects that improve the composition of depressive anxiety and its application |
-
2006
- 2006-10-17 CN CNA2006101405532A patent/CN101164560A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103040649A (en) * | 2012-12-20 | 2013-04-17 | 浦江欧妮雅化妆品有限公司 | Patchouli perfume |
| CN103040649B (en) * | 2012-12-20 | 2014-04-23 | 浦江欧妮雅化妆品有限公司 | Patchouli perfume |
| CN109315782A (en) * | 2017-08-01 | 2019-02-12 | 无限极（中国）有限公司 | It is a kind of to have effects that improve the composition of depressive anxiety and its application |
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Open date: 20080423 |