CN101156899A - New medicament usage of paeonol unction - Google Patents

Abstract

The invention relates to new medical use of paeonol ointment, namely, the application of the paeonol ointment for preparing a medicine for treating common acne. Acne is a chronic and phlogistic skin disease of hair follicles and sebaceous glands. In Western medicines, antibiotics and antiandrogen for incretion regulation, and retinoic acid medicines are commonly used, although the medicines have curative effect, side effects are in a large amount, and misuse of the medicines by female can cause congenital malformation to infants. In Chinese medicines, loquat lung clearing decoction and antiphlogistic decoction of five drugs are commonly used for peroral treatment, but have suboptimal taste, thereby being uneasily accepted by patients. The paeonol ointment is an antiallergic medicine for external use, and applicants use the paeonol ointment for treating acne, with the total effectiveness ratio of 100 percent.

Description

The medical usage that paeonol unguentum is new

One, technical field

The present invention relates to a kind of new purposes of known substance, specifically the new medical usage of paeonol unguentum.

Two, background technology

The tenth of paeonol unguentum system " the Sanitation Ministry medicine standard " Chinese patent medicine prescribed preparation records kind, is made up of paeonol, Flos Caryophylli wet goods supplementary material.The clinical antiallergic that is used for has the anti-inflammatory anti-itch effect.Be mainly used in the various dermatopathies such as various eczemas, dermatitis, urticaria, skin pruritus and mosquito bedbug bite redness that cause by allergy, determined curative effect.Dermatitis, eczema, urticaria pathogenic factor comprise intrinsic factor and extrinsic factor: so-called intrinsic factor are exactly the allergic constitution that patient itself has, spirit such as the perhaps instability of interior environment such as chronic digestive system disease, psychentonia, insomnia, overtired, emotion changes change and infection focus, dysbolism and endocrine function imbalance etc., all can bring out or add the state of an illness such as celsus' papules, dermatitis.Extrinsic factor is also a lot, comprises diet, inhalation (inhalatio), weather, contact allergy thing factor etc.Wherein seafood, spicy food, wine, pollen, dust, cold snap, chemical substance, soap, detergent etc. are the modal inducements of eczema, dermatitis.

Acne vulgaris claims acne of youth again, is called for short acne, is the chronic inflammatory disease dermatoses of a kind of hair follicle and sebaceous gland.In the pubarche morbidity, good sending out enriched part in sebaceous gland such as face, thoracic dorsals, is symmetrically distributed.The traditional Chinese medical science claims that primary disease is " Cuo ", " acne ", " rosacea caused by lung-wind ", and paddy claims " skin sore ", " wine rice ", " comedo ", " strong pimple " etc.Acne is a kind of pilosebaceous chronic inflammatory disease, and just sending out is acne, and two kinds of hoary hair's acne and blackhead are arranged.When the acne inflammation continues development expansion and deep, show as acne papulosa (inflammatory pimple and blackhead person) or pustular acne (is main person with pustule and inflammatory pimple) or acne cystica (for the sebaceous cyst that differs in size contains the thickness pus of being with blood, sinus tract that forms behind the ulceration and cicatrix); And pustular acne can develop into acne nodosum and (is wall thickness, the tuberosity that differs in size, be positioned at subcutaneous or exceed surface, present pale red or kermesinus, quality is harder) or acne atrophica (infringement of pimple or pustular destroy body of gland and form pit shape atrophic scar person); Several acne nodule are assembled fusion in the deep, color is livid purple, is called amalgamation or acne conglobata.According to statistics, have 80% adult to suffer from acne approximately, but the light and heavy degree of morbidity differ in adolescence.It is relevant with microorganism in sebum secretion, follicular canal keratinization and the hair follicle that majority think, the generation of acne is also closely related with cryptorrhea.Studies confirm that the parasitic vermiform mite of human body skin is one of cause of disease of bringing out symptom such as acne.Have the scholar to think, this makes individual exdermoptosis and supersecretion relevant with inherited genetic factors.Adolescence,, androgen secretion increased, and sebum synthesizes and drainage increases, and can make infundibulum of hair follicle portion keratinization propagation, caused pore to stop up, and forming the fat bolt is acne.Exist corynebacterium acnes and vermiform mite etc. to decompose the sebum that is retarded by silt in the hair follicle, produce free fatty proinflammatory effect is arranged, make the follicular wall infringement, the acne content enters corium, struvite pimple or infringements such as pustule, tuberosity appear, even form depression or hypertrophy type spot, have a strong impact on appearance, and adolescent psychology is had certain harmful effect.

Treat acne great majority at present clinically and use treatments such as antibiotic antiinflammatory, antiandrogen endocrine regulation, tretinoin medicines (have anti-keratinization, suppress sebaceous gland differentiation and sebum generation, effects such as the collagenase in the antiinflammatory, inhibition skin histology is synthetic, immunomodulating), though certain clinical efficacy is arranged, but side effect is more, as the untoward reaction to the influence of liver function, pachylosis, central nervous system, the women uses even causes baby's congenital malformation.The product of heat-clearing and toxic substances removing, hard masses softening and resolving are used in Chinese traditional treatment more, oral medications such as PIPA QINGFEI YIN commonly used, wuwei xiaodu drink, because its flavour of a drug mouthfeel is not good enough, the patient is not easy to accept.

Three, summary of the invention

The present invention aims to provide a kind of external used medicine for the treatment of acne vulgaris, and technical problem to be solved is to select effective kind in the Chinese traditional patent formulation preparation.

The applicant carries out careful selectively screening by clinical and in conjunction with the achievement in research of modern pharmacology to active ingredient of Chinese herbs in effective Chinese traditional patent formulation preparation, confirm the application of paeonol unguentum as preparation treatment acne vulgaris medicine.

Active component in the paeonol unguentum is mainly paeonol and Oleum Caryophylli.Modern pharmacological research shows, paeonol has the effect of anti-inflammation, concentration solution had obvious inhibitory action to escherichia coli, bacillus subtilis in external 1: 15000,1: 2000 pair of staphylococcus aureus, influenza virus and common pathogenic dermatophytes also have obvious inhibitory action, its antiinflammatory action does not also rely on hypophysis-adrenal system, does not have the effect of cortisone sample yet.Research shows that also paeonol can significantly strengthen the phagocytic function of blood neutrophilic leukocyte to external staphylococcus aureus.The thrombosis syndrome that the rat intravenous injection endotoxin is brought out has significant curative effect.

Oleum Caryophylli is the volatile oil that the dry flower of plant clove of myrtaceae Eugenia caryophyllata Thunb. obtains through vapor distillation.The volatile oil of armaticity has the anthelmintic effect more.Oleum Caryophylli has bacteriostasis, antifungic action.Contain β-caryophyllane, eugenol, aceteugenol in the Oleum Caryophylli, wherein eugenol content is higher.Eugenol has antiinflammatory, pain relieving and wind dispelling effect.Eugenol also has the scavenging action of oxygen-derived free radicals.

Four, the specific embodiment

Now paeonol unguentum being treated the clinical and result of adolescence acne vulgaris is described below:

Divide the treatment group 104 example and matched group 101 examples adolescence acne vulgaris patient 205 examples at random, the treatment of treatment group external paeonol unguentum, the flat acne in matched group external pool are treated only.

1 clinical data treatment is organized in 104 examples, male 56 examples, women 48 examples; Year mean age (19.97 ± 2.56); Average course of disease (4.05 ± 1.68) year.In matched group 101 examples, male 52 examples, women 49 examples; Year mean age (20.04 ± 1.98); Average course of disease (3.85 ± 0.93) year.Data such as two groups of sexes, age, clinical manifestation are learned by statistics and are handled difference and do not have significance (P＞0.05), have comparability.

1.1 diagnostic criteria is drafted with reference to the related standards in " Chinese medicine (new drug) clinical research guideline ".General clinically pubarche morbidity is sent out in face well, is gone up the flourishing position of sebaceous gland such as breast and back.Skin lesion is hair follicle pimple, blackhead, pustule, tuberosity, cyst and cicatrix, with seborrhea, is chronic process.

1.2 the standard of including in (1) age is 12～25 years old, male or female, and be the volunteer; (2) unsystematic disease; (3) do not take antibiotic or other system anti-acne medicine in preceding 4 weeks of treatment; (4) any antibiotic or other anti-acne medicines were not used in the part in preceding 2 weeks of test.

1.3 exclusion standard (1) merges anaphylaxis dermatosis such as eczema, contact dermatitis, urticaria or other may influence the skin disease patient of observed result; (2) intestinal tract disease persons such as enteritis, ulcerative colitis or chronic diarrhea were once arranged; (3) liver, kidney and blood patient are arranged; (4) affected part has open wound or severe acne that rotten to the corn person is arranged; (5) can not with the fine person of cooperation of test plan.

2 Therapeutic Method

2.1 the treatment group adopts an amount of outer coating of paeonol unguentum affected part treatment.Morning every day, noon, evening respectively 1 time, morning every day of serious symptom, noon, evening respectively 2 times, 4 weeks were 1 course of treatment.

2.2 matched group adopts the clean affected part of exterior coating of damp flat acne.Morning every day, noon, evening respectively 1 time, morning every day of serious symptom, noon, evening respectively 2 times, 4 weeks were 1 course of treatment.

3 observation of curative effect

3.1 observational technique is mainly observed and writes down before two groups of treatments and treatment back its face at the 1st, 2,4 weekend, the various skin lesion number of breast and back (acne, pimple, pustule) and all untoward reaction (as erythema, edema, burn feeling, pruritus, desquamation) etc.

3.2 criterion of therapeutical effect is drafted with reference to the related standards in " Chinese medicine (new drug) clinical research guideline ".Generally begin to estimate curative effect the 4th weekend in medication, mainly the percentage rate that reduces according to skin lesion sum before and after the treatment is estimated.Cure: skin lesion extinction rate 〉=95%; Produce effects: skin lesion extinction rate 〉=70%, but＜95%; Effectively: skin lesion extinction rate 〉=50%, but＜70%; Invalid: skin lesion extinction rate＜50%, or counter see increase.

3.3 therapeutic outcome (seeing the following form)

Group	n	Cure	Produce effects	Effectively	Invalid	Total effective rate %
							The treatment group	104	43	39	22	0	100
Matched group	101	39	32	24	6	94.06

Claims (1)

1. medical usage that paeonol unguentum is new is characterized in that: paeonol is as the application of preparation treatment acne vulgaris medicine.