CN101155923B - 用于产生源于益生菌的化合物的方法 - Google Patents

用于产生源于益生菌的化合物的方法 Download PDF

Info

Publication number
CN101155923B
CN101155923B CN2005800479299A CN200580047929A CN101155923B CN 101155923 B CN101155923 B CN 101155923B CN 2005800479299 A CN2005800479299 A CN 2005800479299A CN 200580047929 A CN200580047929 A CN 200580047929A CN 101155923 B CN101155923 B CN 101155923B
Authority
CN
China
Prior art keywords
microorganisms cultures
vitamin
combination
cultivate
vitamins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2005800479299A
Other languages
English (en)
Chinese (zh)
Other versions
CN101155923A (zh
Inventor
罗伯特·J·马歇尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Premier Research Labs LP
Original Assignee
Premier Research Labs LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Premier Research Labs LP filed Critical Premier Research Labs LP
Publication of CN101155923A publication Critical patent/CN101155923A/zh
Application granted granted Critical
Publication of CN101155923B publication Critical patent/CN101155923B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/185Heterocyclic compounds containing sulfur atoms as ring hetero atoms in the condensed system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/001Amines; Imines
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/06Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10Nitrogen as only ring hetero atom
    • C12P17/12Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/167Heterorings having sulfur atoms as ring heteroatoms, e.g. vitamin B1, thiamine nucleus and open chain analogs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)
CN2005800479299A 2005-01-03 2005-12-30 用于产生源于益生菌的化合物的方法 Expired - Fee Related CN101155923B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/028,272 2005-01-03
US11/028,272 US8530209B2 (en) 2003-11-26 2005-01-03 Method for producing probiotically derived compounds
PCT/US2005/047497 WO2006074094A2 (en) 2005-01-03 2005-12-30 Method for producing probiotically derived compounds

Publications (2)

Publication Number Publication Date
CN101155923A CN101155923A (zh) 2008-04-02
CN101155923B true CN101155923B (zh) 2013-06-05

Family

ID=36648071

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800479299A Expired - Fee Related CN101155923B (zh) 2005-01-03 2005-12-30 用于产生源于益生菌的化合物的方法

Country Status (7)

Country Link
US (2) US8530209B2 (https=)
EP (1) EP1836310A4 (https=)
JP (1) JP2008526767A (https=)
CN (1) CN101155923B (https=)
CA (2) CA2594187C (https=)
MX (1) MX2007008155A (https=)
WO (1) WO2006074094A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8530209B2 (en) * 2003-11-26 2013-09-10 Premier Research Labs, Lp Method for producing probiotically derived compounds
WO2007009187A1 (en) * 2005-07-22 2007-01-25 Tarac Technologies Pty Ltd Polyphenol and probiotic containing nutritional supplement
US9944960B2 (en) * 2015-11-17 2018-04-17 Premier Research Labs, Lp Process for microbial production of dihydrolipoic acid and extraction of dihydrolipoic acid with edible oils
US10403413B2 (en) * 2016-09-30 2019-09-03 Varian Medical Systems, Inc. Beam filter assembly and beam filter positioning device

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769329A (en) * 1981-07-02 1988-09-06 Basf Aktiengesellschaft Preparation of optically pure D- and L- lactic acid
CN1333335A (zh) * 2001-07-19 2002-01-30 上海交通大学 益生菌真菌共同发酵制备微生态制剂的方法
US6806069B2 (en) * 2001-01-09 2004-10-19 Pharmachem Laboratories, Inc. Ubiquinone composition and methods related thereto
CN1544356A (zh) * 2003-11-26 2004-11-10 雄 杨 一种益生菌复合菌剂的制造方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3037016A (en) * 1959-04-13 1962-05-29 Univ California B12 coenzymes and processes for preparing the same
JPS593197B2 (ja) * 1978-09-25 1984-01-23 十條製紙株式会社 補酵素q↓1↓0の製造法
JP4044975B2 (ja) * 1995-07-25 2008-02-06 株式会社叶匠壽庵 乳酸菌発酵物からなる糖尿病治療剤
US6080401A (en) * 1998-11-19 2000-06-27 Reddy; Malireddy S. Herbal and pharmaceutical drugs enhanced with probiotics
JP3478773B2 (ja) * 1999-12-21 2003-12-15 日東薬品工業株式会社 生菌組成物
WO2001075136A1 (en) 2000-03-31 2001-10-11 Idemitsu Petrochemical Co., Ltd. Process for producing lipids and lipid-secreting microorganisms
US6610530B2 (en) * 2000-07-05 2003-08-26 Danmarks Tekniske Universitet Method of improving biomass yield of lactic acid bacterial cultures
JP4183371B2 (ja) * 2000-08-31 2008-11-19 日本・バイオ株式会社 発酵ウコンの製造法
US20030095959A1 (en) * 2000-11-21 2003-05-22 Access Business Group International Llc. Topical skin composition
US20040235123A1 (en) * 2001-04-20 2004-11-25 Liao Hans H Production of alpha-lipoic acid
US6368617B1 (en) * 2001-05-15 2002-04-09 Reliv' International, Inc. Dietary supplement
US8530209B2 (en) * 2003-11-26 2013-09-10 Premier Research Labs, Lp Method for producing probiotically derived compounds
US8304217B2 (en) * 2003-11-26 2012-11-06 Premier Research Labs, Lp Stabilized dihydrolipoic acid and method of producing same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769329A (en) * 1981-07-02 1988-09-06 Basf Aktiengesellschaft Preparation of optically pure D- and L- lactic acid
US6806069B2 (en) * 2001-01-09 2004-10-19 Pharmachem Laboratories, Inc. Ubiquinone composition and methods related thereto
CN1333335A (zh) * 2001-07-19 2002-01-30 上海交通大学 益生菌真菌共同发酵制备微生态制剂的方法
CN1544356A (zh) * 2003-11-26 2004-11-10 雄 杨 一种益生菌复合菌剂的制造方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EM LANSFORD et al.Reversal by Ribonucleosides of Bacterial GrowthInhibitionCaused by Alcohol.THE JOUBNAL OF BIOLOGICALC HEMISTRY235 12.1960,235(12),3551-3554.
EM LANSFORD et al.Reversal by Ribonucleosides of Bacterial GrowthInhibitionCaused by Alcohol.THE JOUBNAL OF BIOLOGICALC HEMISTRY235 12.1960,235(12),3551-3554. *
GR Gibson et al.Colonic Microbiota,Nutrition and Health.Kluwer Rcademic Publishers,1999,44. *

Also Published As

Publication number Publication date
CN101155923A (zh) 2008-04-02
WO2006074094A3 (en) 2006-10-19
EP1836310A4 (en) 2011-10-19
CA2830842A1 (en) 2006-07-13
WO2006074094A2 (en) 2006-07-13
MX2007008155A (es) 2008-02-20
CA2594187A1 (en) 2006-07-13
US20050118694A1 (en) 2005-06-02
US8530209B2 (en) 2013-09-10
US20140011244A1 (en) 2014-01-09
EP1836310A2 (en) 2007-09-26
CA2594187C (en) 2014-01-07
JP2008526767A (ja) 2008-07-24

Similar Documents

Publication Publication Date Title
ES2672871T3 (es) Producto de fermentación del eje embrionario de soja que contiene equol y método de obtención del mismo
Bedani et al. B-group vitamins as potential prebiotic candidates: their effects on the human gut microbiome
US9895400B2 (en) Composition and use of Lactobacillus reuteri GMNL-263 in decreasing blood lipid levels
KR101425466B1 (ko) 발효 청미래덩굴 잎, 이의 제조방법 및 이의 용도
JP2004505625A (ja) 腸内共生生物の共発酵培養による天然薬の転換および修飾
CN105853467B (zh) 罗伊氏乳杆菌gmnl-263用于制备降血脂组合物的用途
WO2002032441A1 (en) Bone metabolism improving agent
CN115462478A (zh) 一种增强免疫力和改善肠道菌群的鲍配合饲料及其应用
US20140011244A1 (en) Method for Producing Probiotically Derived Compounds
CN102246956A (zh) 一种含有松花粉的保健食品及其制备方法
Kwon et al. Biotransformation of Pueraria lobata extract with lactobacillus rhamnosus vitaP1 enhances anti-melanogenic activity
KR101252249B1 (ko) 선옥균을 이용한 식품첨가용 발효 조성물과 그 제조방법
KR102651337B1 (ko) 남성 호르몬 불균형 개선 및 혈행 이완 효과를 갖는 추출물을 유효성분으로 포함하여 여성형 유방 예방 또는 완화 가능한 식품 조성물
EP1222919A2 (en) Compositions comprising glycoprotein matrix and active compound and methods for manufacture thereof
EP4356757A1 (en) Microbial method for reproducing the human urolithin metabotypes in vitro and in vivo
CN100556414C (zh) 一种具免疫调节功能的多菌组合物及其制备方法与用途
Sengupta et al. Spirulina as a Dietary Supplement: Moving Toward Food Security
US20050112111A1 (en) Stabilized dihydrolipoic acid and method of producing same
CN120137892B (zh) 一种用于抗衰老的干细胞外泌体的培养方法及其应用
Alslibi et al. Effect of Dunaliella salina on enhancing viability of probiotic and the nutritional value
Chakravarti et al. Therapeutic and preventive role of nutraceuticals and production of vitamins & low-calorie sugars from food-grade microorganisms as nutraceuticals.
JP2011105656A (ja) 脱共役タンパク質発現誘導剤及び冷え改善剤
CN121775021A (zh) 植物乳杆菌后生元的应用、麦角硫因植物乳杆菌后生元组合物及其应用
CN120899770A (zh) 一种有助于控制体内脂肪的组合物及其应用
Ranmeechai et al. Innovative production of microencapsulated multistrain probiotic product mixed with turmeric, galingale, gotu kola, and black sesame with spray drying

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20130605

Termination date: 20161230

CF01 Termination of patent right due to non-payment of annual fee