CN101112610A - Chinese traditional medicine gelling agent and method for preparing the same - Google Patents
Chinese traditional medicine gelling agent and method for preparing the same Download PDFInfo
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- CN101112610A CN101112610A CNA2007101199243A CN200710119924A CN101112610A CN 101112610 A CN101112610 A CN 101112610A CN A2007101199243 A CNA2007101199243 A CN A2007101199243A CN 200710119924 A CN200710119924 A CN 200710119924A CN 101112610 A CN101112610 A CN 101112610A
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Abstract
The present invention relates to a medicine gel and the preparation method, the traditional Chinese medicine gel is composed of the raw materials with the following weight percentages: traditional Chinese medicine clear paste with a density of 1.05 to 1.15 or 7 percent to 20 percent traditional Chinese medicine thick paste with a density of 1.35 to 1.50, 1.0 percent sodium alginate, 0.2 percent potassium sorbate, 10 percent to 20 percent sucrose, and the rest is the water. The preparation method of the traditional Chinese medicine gel is that: 7 to 20 parts by weight of the traditional Chinese medicine clear paste or thick paste is extracted from a single traditional Chinese medicine or a traditional Chinese medicine compound according to the conventional method, appropriate amount of water is added for dilution, then the even agitating and the filtration are carried out, other raw materials are taken additionally, appropriate amount of water is added for heating and dissolution, then the raw materials are filtered and added to the medicine liquid for agitating, water is added to 100 parts by weight for agitating and boiling, thermal insulation is carried out at 80 DEG C to 90 DEG C, and finally the traditional Chinese medicine gel is prepared by even agitating and filling.
Description
Technical field
The present invention relates to a kind of medicament gelling agent and preparation method thereof, particularly the Chinese medicine gel for preparing by Chinese medicine extract.
Background technology:
Gel is started to walk early abroad, and development is fast." British Pharmacopoeia " version in 1993 has been recorded 5 kinds of gels such as choline salicylate tooth gel, lidocaine gel, lignocaine hibitane compound gel." American Pharmacopeia " XXIII version (nineteen ninety-five) has been recorded the benzene azoles because of kind of gel surplus gel, the gel aluminum hydroxide etc. 30.The A Dabailin gel of France has also entered China's medical market with 2.5% ketone ibuprofen gel (Fastum) of Germany.Canada is used for the treatment of/bJL and adult's acute repeatability epilepsy the rectal gel agent---(Diazepam's diazepam Diastat) goes on the market.The U.S. is used for the treatment of the 1% testosterone gel (Testosterone, Ando Gel) of sexual disorder and also sells.Gel is to receive much attention in international the world of medicine in recent years, develops a kind of faster pharmaceutical dosage form.
Chinese medicine gel still is in the starting stage, but has demonstrated superiority.Normal pulse in summer being full is sweet " to select carbomer for use be substrate, has been processed into two yellow ice gels with Chinese medicine extraction such as Radix Scutellariae, Radix Et Rhizoma Rhei, the treatment herpes zoster has been obtained good efficacy.Dai Long proposes total alkaloids with medicines such as Radix Aconiti, Radixs Stephaniae Tetrandrae through acid alcohol, and adopting carbomer is that substrate is made the curing rheumatic disease gel, and Transdermal absorption is effective.The research and the application of Chinese medicine gel at present remains in many problems: the gel matrix material kind also seldom can't satisfy diversified day by day demand; The gel stickiness is big, and factors such as the adding of promoter and Chinese medicine ingredient complexity are brought difficulty to the pre-treatment of analytical test work; The Chinese medicine aboundresources combines gel with theory of Chinese medical science, adopt pharmacy new technique, new method to improve the quality of pharmaceutical preparation, and the Chinese medicine gel of development of new has very wide prospect.
Summary of the invention
The present invention discloses a kind of Chinese medicine gel and preparation method thereof.
Chinese medicine gel is made up of following raw materials by weight percent:
Density is that the Chinese medicine clear paste of 1.05-1.15 or density are 1.35～1.50 Chinese medicine thick paste 7%-20%, sodium alginate 1.0%, and potassium sorbate 0.2%, sucrose 10%-20%, all the other are water.
Can also add citric acid 0.1%-0.3% (preferred 0.2%) in the above-mentioned raw materials, aspartame 0.05%-2% (preferred 0.07%, 0.1%, 0.2%, 0.7%, 1.5%).
Above-mentioned Chinese medicine clear paste of the present invention or thick paste are meant that the density that single medicinal material or Chinese medicine compound are extracted gained as raw material according to conventional method is that the Chinese medicine clear paste of 1.05-1.15 or density are 1.35～1.50 Chinese medicine thick paste.
The preparation method of the above-mentioned Chinese medicine gel of the present invention is as follows:
Single medicinal material or Chinese medicine compound add the suitable quantity of water dilution according to the Chinese medicine clear paste or the thick paste 7-20 weight portion of conventional method extraction gained, stir evenly, filter, other gets other raw materials and adds the suitable quantity of water heating for dissolving, filters, join in the above-mentioned medicinal liquid, stir, add water to 100 weight portions, stir and boil, in 80～90 ℃ of insulations, stir evenly, Chinese medicine gel is made in fill.
Following experimental example is used to further specify but is not limited to the present invention.
The addition test of adjuvant in the awake gel of experimental example 1 youngster's spleen
Prescription and method for making:
Fructus Crataegi 80g Fructus Hordei Germinatus 80g chicken Endothelium corneum 60g
Rhizoma Dioscoreae 60g Semen Coicis 40g Semen Lablab Album 60g
Pericarpium Citri Reticulatae 24g Poria 24g sodium alginate 10g
Sucrose 150g potassium sorbate 1g
More than eight the flavor medical materials, Fructus Crataegi, Pericarpium Citri Reticulatae are ground into coarse powder, according to the percolation under fluid extract and the extractum item (appendix IO of Chinese Pharmacopoeia version in 2000), ethanol with 65% is made solvent, flood after 24 hours, carry out percolation, collect percolate 625ml, percolate is condensed into the thick paste that relative density is 1.35～1.40 (60 ℃), and is standby; Six-element medical materials such as all the other Fructus Hordei Germinatus decoct with water three times, and each 1 hour, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is about 1.10 (60 ℃), adds equivalent ethanol and makes precipitation, get supernatant, reclaim ethanol, being concentrated into relative density is the thick paste of 1.35～1.40 (60 ℃), with above-mentioned Fructus Crataegi, the Pericarpium Citri Reticulatae thick paste merges, and adds the suitable quantity of water dilution, stirs evenly, filter, other gets sucrose and potassium sorbate, adds the suitable quantity of water heating for dissolving, filter, join in the above-mentioned medicinal liquid, add sodium alginate, stir, add water to ormal weight 1000g, stir and boil, in 80～90 ℃ of insulations, stir evenly, fill is made the 1000g gel, promptly.
The addition screening of sodium alginate and citric acid
Do the preliminary preparation of gel, to determine the amount of sodium alginate, above-mentioned experiment Chinese medicine clear paste or thick paste 7.14g are got in each test, add the suitable quantity of water dilution, stir evenly, filter, add citric acid respectively, mouth is tasted its flavor, adds Icing Sugar, sodium alginate and potassium sorbate again, adds water to 105g, 80～90 ℃ of insulations are also stirred 40～50min, take out, cool off under the room temperature, observe the gel forming situation and taste its mouthfeel.
The addition test of table 1 citric acid and sodium alginate
| The prescription number | 1 | 2 | 3 | 4 |
| Awake extractum (g) citric acid (g) Icing Sugar (g) sodium alginate (g) potassium sorbate (g) that extracts of youngster's spleen adds water to (g) 80～90 ℃ of temperature retention time (min) phenomenons and taste | 7.16 0.2 10 0.8 0.1 105 45 gels are soft excessively, acid | 7.14 0 10 0.9 0.1 105 45 gels are soft slightly, little acid | 7.13 0 10 1.0 0.1 105 45 gel hardness are moderate, little acid | 7.14 0 10 1.1 0.1 105 45 gels are hard slightly, little acid |
When medicinal liquid does not add citric acid, the little acid of medicinal liquid mouthfeel, if add citric acid medicinal liquid peracid, the patient is difficult for accepting; During medicinal liquid+adding 1.0% sodium alginate, therefore the gel that makes neither too hard, nor too soft determined not add citric acid, and the addition of sodium alginate is 1.0%.
The screening of sweeting agent and consumption thereof
Chinese medicine clear paste or thick paste 7.14g, add the suitable quantity of water dilution, stir evenly, filter, add Icing Sugar, steviosin, aspartame according to following table, mouth gustation road is chosen the good person of taste and is added sodium alginate and potassium sorbate, adds water to 105g, 80～90 ℃ of insulations are also stirred 40～50min, take out, cool off under the room temperature, observe the character and the taste of gel.
Table 2 prescription screening table
| The experiment number | 1 | 2 | 3 | 4 |
| Awake extractum (g) Icing Sugar (g) steviosin (g) aspartame (g) sodium alginate (g) potassium sorbate (g) that extracts of youngster's spleen adds water to heavy (g) mouthfeel of (g) 80～90 ℃ of temperature retention times (min) gel | 7.15 30--1.0 0.1 105 45 99.2 is sweet | 7.14 15 0.15------sweet excessively | 7.16 15-0.1-----sweet excessively | 7.13 15--1.0 0.1 105 45 99.5 sugarinesses are moderate |
Conclusion: do not add before sodium alginate and the potassium sorbate, 2, No. 3 sweet excessively, selects 1, No. 4 test specimen to add sodium alginate and potassium sorbate is made gel, and No. 1 sweet, and No. 4 sugariness is moderate, and mouthfeel is better, so finally select No. 4 prescriptions to be preparation prescription.
Consider in the production that sucrose needn't be ground into fine powder, but impurity is arranged, need to add the suitable quantity of water heating for dissolving, filter the back and use.Gel is in order to reach the effect of sterilization in addition, and gel boils 80～90 ℃ of insulations in back and fill, and the preparing gel process summary is as follows:
Get thick paste, add the suitable quantity of water dilution, stir evenly, filter, other gets 15% sucrose and 0.1% potassium sorbate, adds the suitable quantity of water heating for dissolving, filter, join in the above-mentioned medicinal liquid, add 1.0% sodium alginate, stir, add water to ormal weight, stir and boil, in 80～90 ℃ of insulations, stir evenly fill, every packed 10g, promptly.
The addition of adjuvant test in the experimental example 2 compound dandelion gels
1. write out a prescription and preparation technology
Herba Taraxaci 128g Radix Isatidis 128g sucrose 100g
Aspartame 1.0g citric acid 3g sodium alginate 10g
Potassium sorbate 1.0g
Make 1000g
More than two flavors, get Radix Isatidis 64g and be ground into fine powder, residue Radix Isatidis and Herba Taraxaci decoct with water secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, filtrate is condensed into the clear paste that relative density is 1.20～1.25 (65 ℃ of surveys), adds the suitable quantity of water dilution, filters; With the Radix Isatidis fine powder, join in the above-mentioned medicinal liquid, stir evenly, other gets sucrose, aspartame, citric acid and potassium sorbate, adds the suitable quantity of water heating for dissolving, filters, join in the above-mentioned medicinal liquid, add sodium alginate, fully stir, supply water to ormal weight, stirring is also boiled, 80～90 ℃ of also fills of insulation, every packed 10g, promptly.
2, the test of the addition of citric acid and sodium alginate
For determining the amount of sodium alginate, do the preliminary preparation of gel, get the 15.6g clear paste for every part, medical material fine powder 6g, clear paste add suitable quantity of water and stir, and filter, and add the medical material fine powder again, stir.Add citric acid, mouth is tasted its flavor, adds Icing Sugar, sodium alginate and potassium sorbate again, adds water to 100g (every bag is equivalent to the 10g gel), and 40～60min is also stirred in 80～90 ℃ of insulations, takes out, and cools off under the room temperature, observes the gel forming situation and tastes taste.The results are shown in following table:
The result of the test of the addition of table 3 citric acid and sodium alginate
| The prescription number | 1 | 2 | 3 | 4 |
| Clear paste (g) medical material fine powder (g) citric acid (g) medicinal liquid pH value Icing Sugar (g) sodium alginate (g) potassium sorbate (g) adds water to (g) temperature retention time (min) phenomenon and taste | 15.6 6 0.3 3.62 15 0.8 0.1 100 48 gels are softer, little acid, hardship | 15.6 6 0.5 3.51 15 0.9 0.1 100 50 gels are soft slightly, and are sour, bitter | 15.6 6 0.3 3.61 15 1.0 0.1 100 50 gel hardness are moderate, little acid, hardship | 15.6 6 0.3 3.62 15 1.1 0.1 100 50 gels are hard slightly, little acid, hardship |
Conclusion: when medicinal liquid added 0.3% citric acid, mouth was tasted medicinal liquid, and little acid of distinguishing the flavor of continues to add citric acid again and is unfavorable for that the molding of gel and part crowd are difficult for accepting; When medicinal liquid added 1.0% sodium alginate, therefore the gel that makes neither too hard, nor too soft determined that the addition of citric acid is 0.3%, and the addition of sodium alginate is 1.0%, and every bag is equivalent to the 10g gel.
3, the screening of sweeting agent
All get the 15.6g clear paste for every part, add suitable quantity of water and stir, filter, add medical material fine powder 6g again, stir, add Icing Sugar, aspartame, citric acid successively, mouthful gustation road according to following table, the good person of selected part taste adds sodium alginate and potassium sorbate, add water to 100g, 80～90 ℃ of insulations are also stirred 40～60min, take out, cool off under the room temperature, observe the character of gel and taste taste.
Table 4 prescription screening table (10 bags every part, 100g)
| The experiment number | 1 | 2 | 3 | 4 | 5 |
| Icing Sugar (g) aspartame (g) citric acid (g) sodium alginate (g) potassium sorbate (g) adds water to heavy (g) mouthfeel of (g) gel | 10-0.3----short sweetness | 15-0.3----short sweetness | 15 0.15 0.3 1.0 0.1 100 99.6 is sweet excessively | 15 0.1 0.3 1.0 0.1 100 100.1 is sweet | 10 0.1 0.3 1.0 0.1 100 99.9 is better |
Conclusion: 1, do not add sodium alginate and potassium sorbate No. 2, tentatively investigate mouthfeel, 3,4, No. 5 test specimens all add sodium alginate and potassium sorbate is made gel, No. 5 mouthfeel is better, and mildly bitter flavor, sweet is little puckery, take all factors into consideration, finally select No. 5 prescriptions to be this product preparation prescription.
The addition of adjuvant test in the experimental example 3 ageratum gels
1, prescription and preparation method
Herba Pogostemonis 39g Folium Perillae 13g Radix Angelicae Dahuricae 13g
The Rhizoma Atractylodis Macrocephalae (stir-fry) 26g Pericarpium Citri Reticulatae 26g Rhizoma Pinelliae Preparatum 26g
Cortex Magnoliae Officinalis (processed with Rhizoma Zingiberis Recens) 26g Poria 13g Radix Platycodonis 26g
Radix Glycyrrhizae 26g Pericarpium Arecae 13g Fructus Jujubae 6.5g
Rhizoma Zingiberis Recens 3.9g sucrose 200g citric acid 2g
Sodium alginate 10g potassium sorbate 1g
More than 13 the flavor, Rhizoma Pinelliae Preparatum is ground into fine powder, sieves; Herba Pogostemonis, Folium Perillae, Pericarpium Citri Reticulatae, Rhizoma Zingiberis Recens behind the extraction volatile oil, decoct with water secondary with Poria, Pericarpium Arecae, Radix Platycodonis, Radix Glycyrrhizae, Fructus Jujubae again, each 2 hours, filter merging filtrate; The Radix Angelicae Dahuricae, the Rhizoma Atractylodis Macrocephalae, Cortex Magnoliae Officinalis are made solvent according to the percolation under fluid extract and the extractum item with 70% ethanol, carry out percolation, collect the liquid of filtering, and reclaim ethanol.Merge above medicinal liquid, being evaporated to relative density is the clear paste of 1.20-1.25 (50 ℃), adds the suitable quantity of water dilution, filters, addition method Rhizoma Pinelliae fine powder, it is an amount of that other gets sucrose, citric acid and potassium sorbate, adds the suitable quantity of water heating for dissolving, filter, join in the above-mentioned medicinal liquid, the adding sodium alginate is an amount of, stir, add water to ormal weight 1000g, stir and boil, in 80～90 ℃ of insulations, add volatile oil such as Herba Pogostemonis, stir, fill, every packed 10g, promptly.
2, the test of the addition of citric acid and sodium alginate
Do the preliminary preparation of gel,, get the 11.22g clear paste for every part, add suitable quantity of water, stir, filter to 80ml to determine the amount of citric acid and sodium alginate, addition method Rhizoma Pinelliae fine powder 2.5g, recording the filtrate pH value is about 4.87.Add citric acid respectively, measure the pH value parallel port of medicinal liquid and taste its flavor, add Icing Sugar, sodium alginate and potassium sorbate again, add water to 105g, 80～90 ℃ of insulations are also stirred 30～50min, take out, and cool off under the room temperature, observe gel forming situation and mouthfeel.
The result of the test of the addition of table 5 citric acid and sodium alginate
| The prescription number | 1 | 2 | 3 | 4 |
| Ageratum extracts clear paste (g) Rhizoma Pinelliae Preparatum fine powder (g) citric acid (g) medicinal liquid pH value Icing Sugar (g) sodium alginate (g) potassium sorbate (g) and adds water to (g) 80～90 ℃ of temperature retention time (min) phenomenons and taste | 11.22 2.5 0.2 3.95 10 0.8 0.1 105 35 gels are soft excessively, little acid, little toil | 11.22 2.5 0.4 3.61 10 0.9 0.1 105 40 gels are soft slightly, sour, little toil | 11.22 2.5 0.2 3.92 10 1.0 0.1 105 40 gel hardness are moderate, little acid, little toil | 11.22 2.5 0.2 3.94 10 1.1 0.1 105 42 gels are hard slightly, little acid, little toil |
Conclusion: when medicinal liquid added 0.2% citric acid, the little acid of medicinal liquid mouthfeel continued to add citric acid mouthfeel peracid again; When medicinal liquid added 1.0% sodium alginate, therefore the gel that makes neither too hard, nor too soft determined that the addition of citric acid is 0.2%, and the addition of sodium alginate is 1.0%.
3, the screening of sweeting agent
Every part of equal qinghuo reagent 11.22g (10 bags of amounts), add suitable quantity of water to 70ml, stir, filter, add Icing Sugar, steviosin, aspartame, citric acid according to following table, mouth gustation road, the good person of selected part taste adds sodium alginate and potassium sorbate, adds water to 105g, 80～90 ℃ of insulations are also stirred 40～60min, take out, cool off under the room temperature, observe the character and the taste of gel.
Table 6 prescription screening table (10 bags every part, 100g)
| The experiment number | 1 | 2 | 3 | 4 | 5 |
| Icing Sugar (g) steviosin (g) aspartame (g) citric acid (g) sodium alginate (g) potassium sorbate (g) adds water to heavy (g) mouthfeel of (g) gel | 10--0.2----sweet taste is lighter, toil | 10 0.1-0.2----sweet taste is light | 10-0.1 0.2----sweet taste is light, little toil | 20-0.1 0.2 1.0 0.1 105 99.9 is sweet excessively, little toil | 20--0.2 1.0 0.1 105 99.5 sugarinesses are better, little toil |
Conclusion: do not add before sodium alginate and the potassium sorbate, No. 1, No. 2, No. 3 sweet taste is light excessively, selects 4, No. 5 test specimens to add sodium alginate and potassium sorbate is made gel, and No. 5 good slightly, and sugariness is moderate, and little toil finally selects No. 5 prescriptions to be this product preparation prescription.
Consider in the production that sucrose needn't be ground into fine powder, but impurity is arranged, need to add the suitable quantity of water heating for dissolving, filter the back and use.Gel is in order to reach the effect of sterilization in addition, and gel boils 80～90 ℃ of also fills of insulation more earlier.
The addition of adjuvant test in the experimental example 4 antivirus gel agent
1, prescription and preparation method
Radix Isatidis 72g Gypsum Fibrosum 32g Radix Rehmanniae 18g
Herba Pogostemonis 16g Fructus Forsythiae 26g Rhizoma Phragmitis 34g
Radix Curcumae 14g Rhizoma Acori Graminei 14g Rhizoma Anemarrhenae 14g
Sucrose 100g aspartame 1.0g citric acid 2g
Sodium alginate 11g potassium sorbate 1.0g
Make 1000g
More than nine flavors, the Fructus Forsythiae of Radix Curcumae, Rhizoma Acori Graminei and 1/2nd recipe quantities is placed in the extractor, carry most volatile oil, medicinal liquid filters, filtrate and volatile oil are standby; The five tastes such as above residue and Radix Isatidis, Gypsum Fibrosum, Radix Rehmanniae, Rhizoma Phragmitis, the Rhizoma Anemarrhenae are decocted with water three times, each 2 hours for the second time for the first time,, 1 hour for the third time, collecting decoction, filter, filtrate and above-mentioned standby medicinal liquid merge, and being condensed into relative density is the clear paste of 1.20～1.25 (50 ℃ of surveys), add the suitable quantity of water dilution, filter; The Fructus Forsythiae powder of Herba Pogostemonis and 1/2nd recipe quantities is broken into fine powder, joins in the above-mentioned medicinal liquid, stir evenly, other gets sucrose, aspartame, citric acid and potassium sorbate, adds the suitable quantity of water heating for dissolving, filters, join in the above-mentioned medicinal liquid, add sodium alginate, stir, supply water to ormal weight, stirring is also boiled, and 80～90 ℃ of insulations add volatile oil and fill in good time, every packed 10g, promptly.
2, the test of the addition of citric acid and sodium alginate
For determining the amount of sodium alginate, do the preliminary preparation of gel, get the 18g clear paste for every part, 2.72g medical material fine powder, clear paste add suitable quantity of water and stir, and filter, and add the medical material fine powder again, stir.Add citric acid, mouth is tasted its flavor, adds Icing Sugar, sodium alginate and potassium sorbate again, adds water to 100g (every bag is equivalent to the 10g gel), and 40-60min is also stirred in 80-90 ℃ of insulation, takes out, and cools off under the room temperature, observes gel forming situation and trial test taste.The results are shown in following table:
The result of the test of the addition of table 7 citric acid and sodium alginate
| The prescription number | 1 | 2 | 3 | 4 |
| Clear paste (g) medical material fine powder (g) citric acid (g) medicinal liquid pH value Icing Sugar (g) sodium alginate (g) potassium sorbate (g) adds water to (g) temperature retention time (min) phenomenon and taste | 18 2.72 0.2 3.80 15 0.9 0.1 100 50 gels are softer, little acid, hardship | 18 2.72 0.3 3.68 15 1.0 0.1 100 50 gels are soft slightly, and are sour, bitter | 18 2.72 0.2 3.78 15 1.1 0.1 100 50 gel hardness are moderate, little acid, hardship | 18 2.72 0.2 3.81 15 1.2 0.1 100 50 gels are hard slightly, little acid, hardship |
Conclusion: when medicinal liquid added 0.2% citric acid, mouth was tasted medicinal liquid, and little acid of distinguishing the flavor of continues to add citric acid again and is unfavorable for that the molding of gel and part crowd are difficult for accepting; When medicinal liquid added 1.1% sodium alginate, therefore the gel that makes neither too hard, nor too soft determined that the addition of citric acid is 0.2%, and the addition of sodium alginate is 1.1%, and every bag is equivalent to the 10g gel.
3, the screening of sweeting agent
All get the 18g clear paste for every part, add suitable quantity of water and stir, filter, add 2.72g medical material fine powder again, stir, add Icing Sugar, aspartame, citric acid successively, mouthful gustation road according to following table, the good person of selected part taste adds sodium alginate and potassium sorbate, add water to 100g, 80-90 ℃ of insulation also stirred 40-60min, takes out, cool off under the room temperature, observe the character of gel and taste taste.
Table 8 prescription screening table (10 bags every part, 100g)
| The experiment number | 1 | 2 | 3 | 4 | 5 |
| Icing Sugar (g) aspartame (g) citric acid (g) sodium alginate (g) potassium sorbate (g) adds water to heavy (g) mouthfeel of (g) gel | 10-0.2----short sweetness | 15-0.2----short sweetness | 15 0.15 0.2 1.1 0.1 100 100.1 is sweet excessively | 15 0.1 0.2 1.1 0.1 100 99.9 is sweet | 10 0.1 0.2 1.1 0.1 100 99.7 is better |
Conclusion: 1, do not add sodium alginate and potassium sorbate No. 2, tentatively investigate mouthfeel, 3,4, No. 5 test specimens all add sodium alginate and potassium sorbate is made gel, No. 5 mouthfeel is better, and mildly bitter flavor, sweet is little puckery, take all factors into consideration, finally select No. 5 prescriptions to be this product preparation prescription.
The addition of adjuvant test in the experimental example 5 shake bile-fritillary gels
1, prescription and preparation method
Fel Serpentis 20g Bulbus Fritillariae Ussuriensis 150g
Sucrose 100g aspartame 1g citric acid 1g
Sodium alginate 10g potassium sorbate 1g
Make 1000g
More than two flavors, the Bulbus Fritillariae Uninbracteatae of making even adds 80% alcohol heating reflux and extracts, extracting solution filters, filtrate is condensed into fluid extract, adds the suitable quantity of water dilution, filters, and other gets sucrose, aspartame, citric acid and potassium sorbate, add the suitable quantity of water heating for dissolving, filter, join in the above-mentioned medicinal liquid, add sodium alginate and Fel Serpentis, aqua armeniacae, stir, add water to ormal weight, stirring is also boiled, and in 80～90 ℃ of insulations, adds a small amount of Mentholum and stirs evenly, fill, every packed 5g, promptly.
2, definite experiment of sodium alginate amount and citric acid amount
Do the preliminary preparation of gel, with the amount of definite sodium alginate and the amount of citric acid, Bulbus Fritillariae Uninbracteatae fluid extract 7.5ml, Fel Serpentis 1g, aqua armeniacae 3ml make even at every turn, add 40ml water, stir, filter, add 10g Icing Sugar, 0.1g potassium sorbate, after the stirring, add the citric acid and the sodium alginate of different proportion at last, add water to 55g, 80-90 ℃ of insulation also stirred 40-60min, take out, cool off under the room temperature, promptly.Observe the character and the taste of gel.
The addition test of table 9 sodium alginate
| The prescription number | 1 | 2 | 3 | 4 |
| Fluid extract (ml) Icing Sugar (g) sodium alginate (g) Fel Serpentis (g) aqua armeniacae (ml) Mentholum potassium sorbate (g) citric acid (g) adds water to (g) 80～90 ℃ of temperature retention time (min) phenomenons and taste | 7.5 10 0.4 13 an amount of 0.05--55 45 gels are soft excessively, hardship | 7.5 10 0.45 13 an amount of 0.05 0.05 55 45 gels are soft slightly, hardship | 7.5 10 0.5 13 an amount of 0.05 0.05 55 45 gel hardness are moderate, hardship | 7.5 10 0.55 13 an amount of 0.05 0.1 55 45 gels are hard slightly, acid, hardship |
Conclusion: prescription 1 does not add citric acid, and the gel color is dark as a result, gel is soft slightly, taste is poor than other prescription.Prescription 2, prescription 3 and write out a prescription 4 relatively, 3 gels of writing out a prescription are neither too hard, nor too soft, and mouthfeel is better, determines that therefore the addition of citric acid is 0.1%, and the addition of sodium alginate is 1.0%.
3, the screening experiment of sweeting agent and consumption thereof
It is Bulbus Fritillariae Ussuriensis fluid extract 7.5ml, Fel Serpentis 1g, aqua armeniacae 3ml that 10 bags of amounts are got in each test, add the suitable quantity of water dilution, filter, add Icing Sugar, aspartame according to following table, mouth gustation road, choose the good person of taste and add sodium alginate and potassium sorbate, add water to 55g, 80-90 ℃ of insulation also adds a small amount of Mentholum, stir 40-50min simultaneously, take out, cool off under the room temperature, observe the character and the taste of gel.
Table 10 prescription screening table
| The experiment number | 1 | 2 | 3 | 4 | 5 |
| Fluid extract amount (ml) Fel Serpentis (g) aqua armeniacae (ml) Icing Sugar (g) aspartame (g) sodium alginate (g) citric acid (g) potassium sorbate (g) adds water to (g) 80～90 ℃ of temperature retention times (min) mouthfeel | 7.5 13 2.5-0.5 0.05 0.05 55 45 short sweetness are bitter slightly | 7.5 13 5-0.5 0.05 0.05 55 45 short sweetness are bitter slightly | 7.5 13 10-0.5 0.05 0.05 55 45 short sweetness are bitter slightly | 7.5 135 0.05 0.5 0.05 0.05 55 45 sugarinesses are moderate | 7.5 13 10 0.05 0.5 0.05 0.05 55 45 is sweet excessively |
Conclusion: 1,2, No. 3 short sweetness are bitter slightly.No. 5 sweet excessively, and No. 4 mouthfeel is better, and sugariness is moderate, and little hardship is so finally select No. 4 prescriptions to be this product preparation prescription.Mentholum is volatile, so should add Mentholum after 80-90 ℃ of insulation, stirs evenly.
Consider in the production that sucrose needn't be ground into fine powder, but impurity is arranged, need to add the suitable quantity of water heating for dissolving, filter the back and use.Gel is in order to reach the effect of sterilization in addition, and gel boils 80-90 ℃ of insulation in back and fill.
The addition of adjuvant test in the experimental example 6 jade screen wind gels
1, prescription and preparation method
The Radix Astragali 300g Radix Saposhnikoviae 100g Rhizoma Atractylodis Macrocephalae (stir-fry) 100g
Sodium alginate 10g sucrose 100g citric acid 2g
Potassium sorbate 1g
More than three flavors, Radix Saposhnikoviae is given as one thinks fit cataclasm, extract volatile oil, the aqueous solution after distillation device is in addition collected; Two flavors such as medicinal residues and all the other Radixs Astragali decoct with water twice, and 1.5 hours for the first time, 1 hour for the second time, collecting decoction filters, and filtrate is concentrated in right amount, add an amount of ethanol and make precipitation, get supernatant, decompression recycling ethanol, add the aqueous solution after Radix Saposhnikoviae is distilled, being concentrated into relative density is 1.20-1.25 (85 ℃ of surveys), adds the suitable quantity of water dilution, filter, other gets sucrose, citric acid and potassium sorbate are an amount of, add the suitable quantity of water heating for dissolving, filter, join in the above-mentioned medicinal liquid, add an amount of sodium alginate, stir, add water to ormal weight, stir and boil, in 80～90 ℃ of insulations, add volatile oil, stir evenly fill, make the 1000g gel, promptly.
2, the addition of sodium alginate and citric acid test
Do the preliminary preparation of oral gel, to determine the amount of sodium alginate and citric acid.The 19.65g clear paste is got in each test, adds the suitable quantity of water dilution, filters, and adds citric acid respectively, mouth is tasted its flavor, adds Icing Sugar, sodium alginate and potassium sorbate again, adds water to 105g, and 40～50min is also stirred in 80～90 ℃ of insulations, take out, cool off under the room temperature, observe the gel forming situation and taste its mouthfeel.The results are shown in following table:
The addition test of table 11 citric acid and sodium alginate
| The prescription number | 1 | 2 | 3 | 4 |
| Extract extractum (g) citric acid (g) Icing Sugar (g) sodium alginate (g) potassium sorbate (g) and add water to (g) 80～90 ℃ of temperature retention time (min) phenomenons and taste | 19.65 0.1 10 0.8 0.1 105 45 gels are soft excessively, tart flavour is light, bitter slightly | 19.65 0.2 10 0.9 0.1 105 45 gels are soft slightly, little acid, bitter slightly | 19.65 0.2 10 1.0 0.1 105 45 gel hardness are moderate, little acid, bitter slightly | 19.65 0.2 10 1.1 0.1 105 45 gels are hard slightly, little acid, bitter slightly |
Conclusion: when medicinal liquid adds 0.2% citric acid, the little acid of medicinal liquid mouthfeel, mouthfeel is better; When medicinal liquid added 1.0% sodium alginate, therefore the gel that makes neither too hard, nor too soft determined that the addition of citric acid is 0.2%, and the addition of sodium alginate is 1.0%.
3, the screening of sweeting agent and consumption thereof
It is 19.65g that 10 bags of amount extraction clear paste are got in each test, add the suitable quantity of water dilution, filter, add Icing Sugar, steviosin, aspartame, citric acid, mouthful gustation road according to following table, choose the good person of taste and add sodium alginate and potassium sorbate, add water to 105g, 80～90 ℃ of insulations are also stirred 40～50min, take out, cool off under the room temperature, observe the character and the taste of gel.
Table 12 prescription screening table
| The experiment number | 1 | 2 | 3 | 4 | 5 |
| Extract extractum (g) Icing Sugar (g) steviosin (g) aspartame (g) citric acid (g) sodium alginate (g) potassium sorbate (g) and add water to heavy (g) mouthfeel of (g) 80～90 ℃ of temperature retention times (min) gel | 19.65 5--0.2------sweet taste is light excessively | 19.65-0.15 0.15 0.2------sweet excessively | 19.65-0.15 0.1 0.2------sweet excessively | 19.65 5 0.1 0.1 0.2 1.0 0.1 105 45 99.5 is sweeter | 19.65 10--0.2 1.0 0.1 105 45 99.4 sugarinesses are moderate |
Conclusion: do not add before sodium alginate and the potassium sorbate, No. 1 short sweetness, 2, No. 3 are sweet excessively, select 4, No. 5 test specimens to add sodium alginate and potassium sorbate is made gel, No. 4 sweeter, and No. 5 taste good are so finally select No. 5 prescriptions to be this product preparation prescription.Volatile oil is volatile, so should add volatile oil after 80～90 ℃ of insulations, stirs evenly.
The following embodiment of the present invention all can realize above-mentioned experimental example effect.
The specific embodiment
Embodiment 1: the gel of treatment anemopyretic cold
Radix Puerariae 150g Radix Angelicae Dahuricae 100g Flos Lonicerae 150g
Flos Chrysanthemi 150g Fructus Forsythiae 100g Radix Scutellariae 150g
Fructus Gardeniae 100g Radix Isatidis 150g Folium Isatidis 150g
Herba Artemisiae Scopariae 150g Rhizoma Osmundae 150g sodium alginate 10g
Sucrose 100g aspartame 2g citric acid 3g
Potassium sorbate 1g
More than ten simply, Flos Lonicerae, Flos Chrysanthemi, the Radix Angelicae Dahuricae, Fructus Forsythiae were soaked 1 hour, extracted volatile oil, medicinal residues and extracting solution are standby; Herba Artemisiae Scopariae adds 60% ethanol 900ml, soaks 1 hour, and reflux 1 hour filters filtrate for later use; Radix Puerariae, Radix Scutellariae, Radix Isatidis, Folium Isatidis, Fructus Gardeniae, Rhizoma Osmundae adds medicinal residues and extracting solution, soak 1 hour again after, decoct with water three times, 1 hour for the first time, second, three times each 45 minutes, collecting decoction, filter, filtrate is concentrated into about 300ml, adds ethanol 300ml, stir evenly, left standstill 12 hours, filter, get filtrate and Herba Artemisiae Scopariae extracting solution and merge, reclaim ethanol and be concentrated into about 200ml, add the suitable quantity of water dilution, filter, other gets sucrose, aspartame, citric acid and potassium sorbate add the suitable quantity of water heating for dissolving, filter, join in the above-mentioned medicinal liquid, add sodium alginate, stir, add water to ormal weight, stirring is also boiled, and in 80～90 ℃ of insulations, adds volatile oil, stir evenly, fill is made the 1000g gel, promptly.
Embodiment 2: the wind-repellent itching-relieving gel
Radix Saposhnikoviae 50g Periostracum Cicadae 50g Cortex Lycii 90g
Rhizoma Atractylodis (stir-fry) 60g pockmarks 90g Radix Angelicae Sinensis 90g
Radix Rehmanniae 150g Caulis Akebiae 30g Herba Schizonepetae 50g
Gypsum Fibrosum 30g Radix Glycyrrhizae 30g sucrose 100g
Aspartame 0.5g citric acid 3g sodium alginate 10g
Potassium sorbate 1.0g
Make 1000g
More than ten simply, get Gypsum Fibrosum and smash and added water boil 2 hours, add ten flavors such as all the other Radix Saposhnikoviaes and continue to decoct secondaries, 3 hours for the first time, 2 hours for the second time, merging filtrate filtered, filtrate is concentrated in right amount (every 1ml contains the 0.5g medical material).Add ethanol and make and contain alcohol amount and reach 70%, stir evenly, leave standstill, filter, filtrate is concentrated into the clear paste of 1.20～1.25 (65 ℃ of surveys), adds the suitable quantity of water dilution; Other gets sucrose, aspartame, citric acid and potassium sorbate, adds the suitable quantity of water heating for dissolving, filters, and joins in the above-mentioned medicinal liquid, stir evenly, add sodium alginate, fully stir, supply water to ormal weight, stirring is also boiled, 80～90 ℃ of also fills of insulation, and every packed 10g, promptly.
Embodiment 3: the infantile diarrhea gel
Radix Codonopsis 150g Rhizoma Atractylodis Macrocephalae 200g Poria 200g
Radix Puerariae 250g Radix Glycyrrhizae 50g Herba Pogostemonis 50g
Radix Aucklandiae 50g sodium alginate 10g sucrose 100g
Aspartame 1g citric acid 2g potassium sorbate 1g
More than seven flavors, the Rhizoma Atractylodis Macrocephalae, Herba Pogostemonis, the Radix Aucklandiae add water distillation, it is an amount of to collect distillate, medicinal residues and all the other Radix Codonopsis four flavors decoct with water twice at every turn, and each 2 hours, collecting decoction, filter, filtrate is concentrated in right amount, puts cold, adding ethanol makes and contains the alcohol amount and reach 50%, leave standstill, filter, filtrate recycling ethanol also is concentrated into the clear paste that relative density is about 1.20 (60～65 ℃), add the suitable quantity of water dilution, filter; Other gets sucrose, aspartame, citric acid and potassium sorbate, adds the suitable quantity of water heating for dissolving, filters, and joins in the above-mentioned medicinal liquid, add sodium alginate, stir, add distillate and suitable quantity of water, stir and boil to ormal weight, in 80～90 ℃ of insulations, fill is made the 1000g gel, promptly.
Embodiment 4: the Herba Leonuri gel
Herba Leonuri 500g sucrose 100g aspartame 1.5g citric acid 4g sodium alginate 10g potassium sorbate 1.0g
Get Herba Leonuri 500g, decoct with water three times, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, filter, merging filtrate is concentrated into about 250ml, cool off, add the ethanol of equivalent, stir evenly, left standstill 24 hours, and filtered, decompression filtrate recycling ethanol also is concentrated into the thick paste shape, thin up is to 500ml, and cold preservation 24 hours filters, filtrate is concentrated into the clear paste that relative density is 1.10～1.15 (60 ℃), adds the suitable quantity of water dilution, filters; Other gets sucrose, aspartame, citric acid and potassium sorbate, adds the suitable quantity of water heating for dissolving, filters, and joins in the above-mentioned medicinal liquid, stir evenly, add sodium alginate, fully stir, supply water to ormal weight, stirring is also boiled, 80～90 ℃ of also fills of insulation, and every packed 10g, promptly.
The test of the addition of citric acid and sodium alginate
For determining the amount of sodium alginate, do the preliminary preparation of oral gel, get the 20.8g clear paste for every part, add the suitable quantity of water dilution, filter, add citric acid, mouth is tasted its flavor, add Icing Sugar, sodium alginate and potassium sorbate again, add water to 106g, 80～90 ℃ of insulations are also stirred 40～60min, take out, cool off under the room temperature, observe the gel forming situation and taste taste.The results are shown in following table:
The result of the test of the addition of table 13 citric acid and sodium alginate
| The prescription number | 1 | 2 | 3 | 4 |
| Clear paste amount (g) citric acid (g) medicinal liquid pH value Icing Sugar (g) sodium alginate (g) potassium sorbate (g) adds water to (g) temperature retention time (min) phenomenon and taste | 20.8 0.4 3.68 20 0.8 0.1 106 45 gels are softer, little acid, hardship | 20.8 0.6 3.53 20 0.9 0.1 106 50 gels are soft slightly, and are sour, bitter | 20.8 0.4 3.67 20 1.0 0.1 106 50 gel hardness are moderate, little acid, hardship | 20.8 0.4 3.69 20 1.1 0.1 106 52 gels are hard slightly, little acid, hardship |
Conclusion: when medicinal liquid added 0.4% citric acid, mouth was tasted its flavor, and little acid of distinguishing the flavor of continues to add the part crowd again and is difficult for accepting, and is unfavorable for the molding of gel; When medicinal liquid adds 1.0% sodium alginate, the gel that makes neither too hard, nor too soft, amount is many or amount is few, and molding is all not so good; Therefore the addition of determining citric acid is 0.4%, and the addition of sodium alginate is 1.0%, and every bag is equivalent to the 10g gel.
The screening of sweeting agent
All get the 20.8g clear paste for every part, add the suitable quantity of water dilution, filter, add Icing Sugar, steviosin, aspartame, citric acid successively, mouthful gustation road according to following table, the good person of selected part taste adds sodium alginate and potassium sorbate, add water to 106g, 80～90 ℃ of insulations are also stirred 40～60min, take out, cool off under the room temperature, observe the character of gel and taste taste.
Table 14 prescription screening table (10 bags every part, 100g)
| The experiment number | 1 | 2 | 3 | 4 | 5 |
| Icing Sugar (g) steviosin (g) aspartame (g) citric acid (g) sodium alginate (g) potassium sorbate (g) adds water to heavy (g) mouthfeel of (g) gel | 15--0.4----short sweetness | 10 0.10-0.4 1.0 0.1 106 99.4 short sweetness | 15 0.10 0.15 0.4 1.0 0.1 106 99.5 is sweet excessively | 15 0.15-0.4 1.0 0.1 106 99.2 is sweet | 10-0.15 0.4 1.0 0.1 106 99.8 is better |
Conclusion: do not add sodium alginate and potassium sorbate No. 1, tentatively investigate mouthfeel, 2,3,4, No. 5 test specimens all add sodium alginate and potassium sorbate is made gel, No. 5 mouthfeel is better, mildly bitter flavor, sweet is taken all factors into consideration, and finally selects No. 5 prescriptions to be this product preparation prescription.
Consider in the production that sucrose needn't be ground into fine powder, but impurity is arranged, need to add the suitable quantity of water heating for dissolving, filter the back and use.Gel is in order to reach the effect of sterilization in addition, and gel boils 80～90 ℃ of also fills of insulation more earlier, and the preparing gel process summary is as follows:
Get quantitative clear paste, add the suitable quantity of water dilution, filter, other gets 10% sucrose, 0.15% aspartame, 0.4% citric acid and 0.1% potassium sorbate, adds the suitable quantity of water heating for dissolving, filters, join in the above-mentioned medicinal liquid, add 1.0% sodium alginate, fully stir, add water to ormal weight, stirring is also boiled, in 80～90 ℃ of insulations and fill, every packed 10g, promptly.
Claims (6)
1. Chinese medicine gel is characterized in that this Chinese medicine gel is made up of following raw materials by weight percent:
Density is Chinese medicine clear paste or 1.35～1.50 thick paste 7%-20% of 1.05-1.15, sodium alginate 1.0%, and potassium sorbate 0.2%, sucrose 10%-20%, all the other are water.
2. Chinese medicine gel as claimed in claim 1 is characterized in that also adding citric acid 0.1%-0.3% in this Chinese medicine gel raw material, aspartame 0.05%-2%.
3. Chinese medicine gel as claimed in claim 2 is characterized in that adding in this Chinese medicine gel raw material citric acid 0.2%, aspartame 0.07%, 0.1%, 0.2%, 0.7% or 1.5%.
4. as claim 1,2 or 3 described Chinese medicine gel, it is characterized in that Chinese medicine clear paste in this Chinese medicine gel raw material or thick paste are meant that the density that single medicinal material or Chinese medicine compound are extracted gained as raw material according to conventional method is that the Chinese medicine clear paste of 1.05-1.15 or density are 1.35～1.50 Chinese medicine thick paste.
5. as the preparation method of claim 1,2 or 3 described Chinese medicine gel, it is characterized in that this method is:
Single medicinal material or Chinese medicine compound add the suitable quantity of water dilution according to the Chinese medicine clear paste or the thick paste 7-20 weight portion of conventional method extraction gained, stir evenly, filter, other gets other raw materials and adds the suitable quantity of water heating for dissolving, filters, join in the above-mentioned medicinal liquid, stir, add water to 100 weight portions, stir and boil, in 80～90 ℃ of insulations, stir evenly, Chinese medicine gel is made in fill.
6. the preparation method of Chinese medicine gel as claimed in claim 4 is characterized in that this method is:
Single medicinal material or Chinese medicine compound add the suitable quantity of water dilution according to the Chinese medicine clear paste or the thick paste 7-20 weight portion of conventional method extraction gained, stir evenly, filter, other gets other raw materials and adds the suitable quantity of water heating for dissolving, filters, join in the above-mentioned medicinal liquid, stir, add water to 100 weight portions, stir and boil, in 80～90 ℃ of insulations, stir evenly, Chinese medicine gel is made in fill.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105125781A (en) * | 2015-10-12 | 2015-12-09 | 陈红 | Traditional Chinese medicine gel for treating stage-III pressure sore and preparing method of traditional Chinese medicine gel |
| CN108743465A (en) * | 2018-06-08 | 2018-11-06 | 苏州思源天然产物研发有限公司 | Traditional Chinese medicine gel composition and its preparation method and application |
| CN114027258A (en) * | 2021-11-29 | 2022-02-11 | 重庆市大足区瑞丰现代农业发展有限公司 | Organic breeding method of black goats |
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2007
- 2007-08-03 CN CNA2007101199243A patent/CN101112610A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105125781A (en) * | 2015-10-12 | 2015-12-09 | 陈红 | Traditional Chinese medicine gel for treating stage-III pressure sore and preparing method of traditional Chinese medicine gel |
| CN108743465A (en) * | 2018-06-08 | 2018-11-06 | 苏州思源天然产物研发有限公司 | Traditional Chinese medicine gel composition and its preparation method and application |
| CN114027258A (en) * | 2021-11-29 | 2022-02-11 | 重庆市大足区瑞丰现代农业发展有限公司 | Organic breeding method of black goats |
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