CN101099791A - Medicine composition for treating protrusion of lumber vertebral disc and its preparation method - Google Patents
Medicine composition for treating protrusion of lumber vertebral disc and its preparation method Download PDFInfo
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- CN101099791A CN101099791A CNA2007101452063A CN200710145206A CN101099791A CN 101099791 A CN101099791 A CN 101099791A CN A2007101452063 A CNA2007101452063 A CN A2007101452063A CN 200710145206 A CN200710145206 A CN 200710145206A CN 101099791 A CN101099791 A CN 101099791A
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Abstract
The invention is concerned with the medicine combination and the preparation method for treating lumbar intervertebral disc protrusion, the active constituent is with the following weight compound: notoginseng is 2 to 6 shares, barrenwort is 2 to 6 shares, prepared rhizome of rehmannia is 2 to 6 shares, paeonia lactiflora pallas is 2 to 6 shares, raw liquorice is 2 to 6 shares, angelica is 1 to 3 shares, hemlock parsley is 1 to 3 shares, eupolyphaga is 1 to 3 shares, scorpion is 1 to 3 shares, myrrh is 1 to 3 shares, aconitum chinese Paxton is 1 share, curare is 1 share.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of prolapse of lumbar intervertebral disc and preparation method thereof.
Background technology
Prolapse of lumbar intervertebral disc be a kind of be the common disease of principal character with the lumbago.Mostly occur 20～40 years old person between twenty and fifty.Diseased region with between the 4th, 5 lumbar vertebras or the 5th lumbar vertebra and the 1st sacrum intervertebral for seeing more.
Intervertebral disc is made of vertebral pulp, cartilaginous lamina and fibrous ring three parts.Vertebral pulp is the whippy colloid substance of canescence, in the middle of being enclosed in by the fibrous ring of periphery and the cartilaginous lamina of upper and lower partially after.Cartilaginous lamina is the hyaline cartilage of skim, with the spongy bone binding of neighbouring vertebral body.Fibrous ring is strong and be rich in flexible fibrocartilaginous ring, round the edge of cartilaginous lamina up and down, and closely is connected with last hypocentrum edge, and the restriction vertebral pulp is deviate from towards periphery.Intervertebral disc not only connects hypocentrum, and can absorb concussion, slows down external impacts.
The fundamental cause of prolapse of lumbar intervertebral disc is the disc tissue degeneration.Disc tissue is easily frayed at the bigger lumbar spine of mobility.Itself lacks blood circulation, a little less than the repair ability.When fibrous ring generation degeneration, add the effect that waist is subjected to excessive pressure and twisting resistance, fibrous ring can be broken, and vertebral pulp will be deviate from from rent.The weakness of fibrous ring is in the both sides of spinal column posterior longitudinal ligament, so prolapse of lumbar intervertebral disc mostly occurs in the one or both sides of posterior longitudinal ligament.
The vertebral pulp pressuring neural root of deviating from causes neuralgia and other dysfunctions, presents following clinical manifestation:
1. lumbago and skelalgia: vertebral pulp compressing lumbar nerve roots causes lumbago; Sciatic nerve is made up of lumbar nerves, thus cause sciatica again, and diffuse the shank outside and instep downwards.Patient bends over, walking, cough, sneeze or when firmly defecating, and pain is increased the weight of.
2. the waist posture changes: when standing because skoliosis appears in side musculus sacrospinalis anxiety.What have is protruding in strong side, and what have is protruding in sick side, depends primarily on the vertebral pulp deviate from which side in the pressurized nerve root.Above outside nerve root, in order to alleviate root compression, the upper body tendency is good for side, and then waist is to sick side male bend; If the vertebral pulp of deviating from nerve root below, upper body is inclined to the disease side, then the strong side male bend of waist body.The physiology lordosis of lumbar vertebra reduces, disappearance or back on the contrary protruding.The activity of waist all directions is all limited to some extent.
3. pressure pain point: spinous process of lumbar vertebra is other to be equivalent to the root compression position, and the local tenderness point is arranged.When with defeating or kowtow when hitting herein, pain is also diffused to the shank outside and instep.
4. the change of sensation and muscular strength: the sick side shank outside and instep are insensitive.The sick side big toe back of the body power of stretching weakens; Achilles tendon reflex also weakens.
5. the sick side lower limb straight-leg raising test positive.
The X line is taken the photograph the sheet inspection, as seen changes institute's scoliosis that causes and physiology lordosis by posture and reduces or disappear; As seen what have has indirect signs such as narrowing of intervertebral space or vertebral rim hypertrophy.Can consider spinal canal myelography etc. when needing, with auxiliary definite diagnosis and differential diagnosis.CT and MRI can provide pathological changes imageology foundation more clearly.
The method of existing treatment prolapse of lumbar intervertebral disc mainly contains: machine reset adds comprehensive expectant treatment, the percutaneous puncture nucleus pulposus is absorbed art, collagenase the dissolving skill, MED minimally-invasive treatment, artificial nucleus pulposus implantation and the treatment of conventional open operation
Summary of the invention
The object of the present invention is to provide a kind of pharmaceutical composition for the treatment of prolapse of lumbar intervertebral disc and preparation method thereof.
The present invention adopts following technical scheme:
A kind of pharmaceutical composition for the treatment of prolapse of lumbar intervertebral disc of the present invention, described active ingredient in pharmaceutical extract from following Chinese medicinal raw materials in portion by weight medicine: Radix Notoginseng 2-6 part, Herba Epimedii 2-6 part, Radix Rehmanniae Preparata 2-6 part, Radix Paeoniae Alba 2-6 part, Radix Glycyrrhizae 2-6 part, Radix Angelicae Sinensis 1-3 part, Rhizoma Chuanxiong 1-3 part, eupolyphaga 1-3 part, Scorpio 1-3 part, Myrrha (processed) 1-3 part, 1 part of Radix Aconiti Preparata, 1 part of Semen Strychni (processed).
Preferably, active ingredient in pharmaceutical of the present invention is extracted from following Chinese medicinal raw materials in portion by weight medicine: 4 parts of Radix Notoginseng, 4 parts of Herba Epimedii, 4 parts in Radix Rehmanniae Preparata, 4 parts of the Radix Paeoniae Albas, 4 parts of Radix Glycyrrhizae, 2 parts of Radix Angelicae Sinensis, 2 parts of Rhizoma Chuanxiongs, 2 parts of eupolyphaga, 2 parts of Scorpio, 2 parts of Myrrha (processed)s, 1 part of Radix Aconiti Preparata, 1 part of Semen Strychni (processed).
The present invention provides a kind of method for preparing the pharmaceutical composition of described treatment prolapse of lumbar intervertebral disc simultaneously, and described method follows these steps to carry out:
1), Semen Strychni is put into the oil cauldron that burns heat, and fried the surface is little yellow to fluffy, Semen Strychni (processed);
2), with 4 parts of Radix Notoginseng, 4 parts of Herba Epimedii, 4 parts in Radix Rehmanniae Preparata, 4 parts of the Radix Paeoniae Albas, 4 parts of Radix Glycyrrhizae, 2 parts of Radix Angelicae Sinensis, 2 parts of Rhizoma Chuanxiongs, 2 parts of eupolyphaga, 2 parts of Scorpio, 1 part of 2 parts of Myrrha (processed)s and Radix Aconiti Preparata are removed impurity, dry or dry back and Semen Strychni (processed) and be ground into fine powder in the lump for 1 part.
The present invention can put into fine powder in the pellet processing machine, adds Mel mediation post-treatment with hot boiled water and becomes water-honeyed pill.
Perhaps, fine powder is prepared into capsule, every capsules contains the 0.5g fine powder.
Among the present invention, Radix Notoginseng has the function of dissipating blood stasis hemostasis, subduing swelling and relieving pain.Herba Epimedii has kidney invigorating and YANG supporting, the merit of sleeve wind dehumidifying.Radix Rehmanniae Preparata sweet in the mouth tepor matter profit is gone into Liver and kidney two warps, and the both kind YIN nourishing of enriching blood again can vital essence replenishing and marrow benifiting, cures mainly the cloudy disease of losing oligospermia of all blood deficiency.Major function nourishing the blood and yin, vital essence replenishing and marrow benifiting.The Radix Paeoniae Alba has the function of suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.The Radix Glycyrrhizae heat-clearing and toxic substances removing.The sweet Wen Zhirun of Radix Angelicae Sinensis is the key medicine of enriching blood.Rhizoma Chuanxiong has effects such as blood-activating and qi-promoting, wind-expelling pain-stopping, dissipating depression of QI dampness.Eupolyphaga has the effect of blood circulation promoting and blood stasis dispelling, the smart network of mediation.The Scorpio relieving spasm by calming endogenous wind, wind-expelling pain-stopping, detoxicating and resolving stagnation of pathogens.Myrrha (processed) drug for invigorating blood circulation and eliminating stasis, blood-activating analgesic, Radix Aconiti Preparata expelling wind and removing dampness, antalgic.Be used for anemofrigid-damp arthralgia, arthralgia.Semen Strychni (processed) is opened meridians, and the merit that reaches the joint thoroughly outclass its medicine.
The present invention selects invigorating kidney, promoting blood circulation, the comprehensive compatibility of silt releasing and analgesia medicine, and effect is remarkable.
Prolapse of lumbar intervertebral disc is the result that degenerative change appears in intervertebral disc, and fibrous ring break degeneration and vertebral pulp pressurized will make the patient produce lumbosacral region and pain of buttock.When annuler bulge, disc height descends simultaneously, and interbody space narrows down, and can cause the disorderly displacement of the little dislocation of corresponding intervertebral, causes the vertebral body loss of stability, and these factors all can cause low back pain or skelalgia.
The traditional Chinese medical science thinks that prolapse of lumbar intervertebral disc belongs to categories such as Chinese medicine arthromyodynia, congestion lumbago, rheumatism involving the bone disease.How because of deficiency of the liver and kindey, deficiency of the kidney or chronic strain are experienced the rheumatism cold-evil and are caused due to the resistance of congestion numbness.The marrow sky of suffering from a deficiency of the kidney plays an important role in the generation of prolapse of lumbar intervertebral disc, development, after more." between element. the big opinion of YIN YANG classification of natural phenomena " say " kidney producing bone marrow ", " kidney is not given birth to, and then marrow can not be expired ".Deficiency of kidney-essence, the resistance of congestion numbness is to cause the main diseases of prolapse of lumbar intervertebral disc because of the place.Thereby, invigorating kidney, promoting blood circulation of the present invention, silt releasing and analgesia has been obtained significant effect in this type of disease of treatment.
Instructions of taking of the present invention is: obey 12g every day, respectively obey 6g, warm boiled water sooner or later.The present invention is through 360 routine clinical statisticses, and the treatment prolapse of lumbar intervertebral disc has instant effect, and side effect is little, total effective rate 95%, cure rate 70﹠amp; More than.
The specific embodiment
Embodiment 1
1), Semen Strychni is put into the oil cauldron that burns heat, and fried the surface is little yellow to fluffy, Semen Strychni (processed);
2), with Radix Notoginseng 6g, Herba Epimedii 6g, Radix Rehmanniae Preparata 6g, Radix Paeoniae Alba 6g, Radix Glycyrrhizae 6g, Radix Angelicae Sinensis 3g, Rhizoma Chuanxiong 3g, eupolyphaga 3g, Scorpio 3g, Myrrha (processed) 3g and Radix Aconiti Preparata 1.5g remove impurity, dry or dry the back and Semen Strychni (processed) 1.5g be ground into fine powder in the lump.
3), fine powder is put in the pellet processing machine, adding Mel with hot boiled water is in harmonious proportion post-treatment and becomes water-honeyed pill.
Embodiment 2
1), Semen Strychni is put into the oil cauldron that burns heat, and fried the surface is little yellow to fluffy, Semen Strychni (processed);
2), with Radix Notoginseng 2g, Herba Epimedii 6g, Radix Rehmanniae Preparata 2g, Radix Paeoniae Alba 6g, Radix Glycyrrhizae 2g, Radix Angelicae Sinensis 3g, Rhizoma Chuanxiong 1g, eupolyphaga 3g, Scorpio 1g, Myrrha (processed) 3g and Radix Aconiti Preparata 1g remove impurity, dry or dry the back and Semen Strychni (processed) 1g be ground into fine powder in the lump.
3), fine powder is prepared into capsule, every capsules contains the 0.5g fine powder.
Embodiment 3
1), Semen Strychni is put into the oil cauldron that burns heat, and fried the surface is little yellow to fluffy, Semen Strychni (processed);
2), with Radix Notoginseng 6g, Herba Epimedii 2g, Radix Rehmanniae Preparata 6g, Radix Paeoniae Alba 2g, Radix Glycyrrhizae 6g, Radix Angelicae Sinensis 1g, Rhizoma Chuanxiong 3g, eupolyphaga 1g, Scorpio 3g, Myrrha (processed) 1g and Radix Aconiti Preparata 1g remove impurity, dry or dry the back and Semen Strychni (processed) 1g be ground into fine powder in the lump.
3), fine powder is put in the pellet processing machine, adding Mel with hot boiled water is in harmonious proportion post-treatment and becomes water-honeyed pill.
Embodiment 4 cases
1, Liu Dongfang, man, 28 years old, the Five Dragons, Shangcai County township Ma Zhuan people from village.The main suit: lumbago and skelalgia 1 year is surplus.Once took Western medicine and cooperate traction therapeutic two months, effect is not good enough.Take the pharmaceutical composition of the embodiment of the invention 1 preparation, sooner or later respectively obey 6g, recurrence is not seen in symptom complete obiteration after two months so far.
2, Yu Zhanxuan, man, 46 years old, people from Jinshan District, Zhengzhou City.Patient's lumbago companion sees that lower-left acroesthesia is surplus half a year, and sx during tired whenever and cold weather be can't take care of oneself.Take the pharmaceutical composition of the embodiment of the invention 1 preparation, sooner or later respectively obey 6g, obeyed the pain complete obiteration altogether 3 months.
3, Zhang Xinchang, man, 34 years old, the safe Kang County outskirts of a town village people in Henan.Patient's lumbago and skelalgia 5 years is surplus.Adopt the several different methods treatment in the locality, poor effect.Take the pharmaceutical composition of the embodiment of the invention 1 preparation, sooner or later respectively obey 6g, obey recovery from illness in 4 months altogether.
4, Hou Shuanyin, man, 28 years old, dragon's pool people from town, Tanghe County, Henan.Patient's lumbago companion leg pain 2 years is surplus, fails to respond to any medical treatment in the locality.Take the pharmaceutical composition of the embodiment of the invention 1 preparation, took altogether 2 months, every day is each 6g sooner or later, the above-mentioned symptom complete obiteration.
The present invention is not limited to above-mentioned preferred forms, and other any identical with the present invention or akin products that anyone draws under enlightenment of the present invention all drop within protection scope of the present invention.
Claims (5)
1, a kind of pharmaceutical composition for the treatment of prolapse of lumbar intervertebral disc is characterized in that described active ingredient in pharmaceutical extracts from following Chinese medicinal raw materials in portion by weight medicine: Radix Notoginseng 2-6 part, Herba Epimedii 2-6 part, Radix Rehmanniae Preparata 2-6 part, Radix Paeoniae Alba 2-6 part, Radix Glycyrrhizae 2-6 part, Radix Angelicae Sinensis 1-3 part, Rhizoma Chuanxiong 1-3 part, eupolyphaga 1-3 part, Scorpio 1-3 part, Myrrha (processed) 1-3 part, 1 part of Radix Aconiti Preparata, 1 part of Semen Strychni (processed).
2, the pharmaceutical composition of treatment prolapse of lumbar intervertebral disc as claimed in claim 1 is characterized in that described active ingredient in pharmaceutical extracts from following Chinese medicinal raw materials in portion by weight medicine: 4 parts of Radix Notoginseng, 4 parts of Herba Epimedii, 4 parts in Radix Rehmanniae Preparata, 4 parts of the Radix Paeoniae Albas, 4 parts of Radix Glycyrrhizae, 2 parts of Radix Angelicae Sinensis, 2 parts of Rhizoma Chuanxiongs, 2 parts of eupolyphaga, 2 parts of Scorpio, 2 parts of Myrrha (processed)s, 1 part of Radix Aconiti Preparata, 1 part of Semen Strychni (processed).
3, a kind of method for preparing the pharmaceutical composition of treatment prolapse of lumbar intervertebral disc as claimed in claim 2 is characterized in that described method follows these steps to carry out:
1), Semen Strychni is put into the oil cauldron that burns heat, and fried the surface is little yellow to fluffy, Semen Strychni (processed);
2), with 4 parts of Radix Notoginseng, 4 parts of Herba Epimedii, 4 parts in Radix Rehmanniae Preparata, 4 parts of the Radix Paeoniae Albas, 4 parts of Radix Glycyrrhizae, 2 parts of Radix Angelicae Sinensis, 2 parts of Rhizoma Chuanxiongs, 2 parts of eupolyphaga, 2 parts of Scorpio, 1 part of 2 parts of Myrrha (processed)s and Radix Aconiti Preparata are removed impurity, dry or dry back and Semen Strychni (processed) and be ground into fine powder in the lump for 1 part.
4, the preparation of drug combination method of treatment prolapse of lumbar intervertebral disc as claimed in claim 3 is characterized in that fine powder is put in the pellet processing machine, adds Mel mediation post-treatment with hot boiled water and becomes water-honeyed pill.
5, the preparation of drug combination method of treatment prolapse of lumbar intervertebral disc as claimed in claim 3 is characterized in that fine powder is prepared into capsule, and every capsules contains the 0.5g fine powder.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007101452063A CN100531762C (en) | 2007-08-17 | 2007-08-17 | Medicine composition for treating protrusion of lumber vertebral disc and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2007101452063A CN100531762C (en) | 2007-08-17 | 2007-08-17 | Medicine composition for treating protrusion of lumber vertebral disc and its preparation method |
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| CN100531762C CN100531762C (en) | 2009-08-26 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102283942A (en) * | 2011-09-16 | 2011-12-21 | 耿彬 | Orally-administrated Chinese medicinal preparation for treating ankylosing spondlitis |
| CN101337002B (en) * | 2008-08-08 | 2012-06-20 | 韩敏 | Traditional Chinese medicine capsule for treating rheumatism and nervous system |
| CN105641248A (en) * | 2015-12-31 | 2016-06-08 | 丁伟杰 | Traditional Chinese medicine composition capable of treating lumbar disc herniation and preparation method thereof |
| CN110292613A (en) * | 2019-08-08 | 2019-10-01 | 杨博 | A kind of pharmaceutical composition and preparation method thereof for treating the protrasion of the lumbar intervertebral disci |
-
2007
- 2007-08-17 CN CNB2007101452063A patent/CN100531762C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101337002B (en) * | 2008-08-08 | 2012-06-20 | 韩敏 | Traditional Chinese medicine capsule for treating rheumatism and nervous system |
| CN102283942A (en) * | 2011-09-16 | 2011-12-21 | 耿彬 | Orally-administrated Chinese medicinal preparation for treating ankylosing spondlitis |
| CN105641248A (en) * | 2015-12-31 | 2016-06-08 | 丁伟杰 | Traditional Chinese medicine composition capable of treating lumbar disc herniation and preparation method thereof |
| CN110292613A (en) * | 2019-08-08 | 2019-10-01 | 杨博 | A kind of pharmaceutical composition and preparation method thereof for treating the protrasion of the lumbar intervertebral disci |
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| Publication number | Publication date |
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| CN100531762C (en) | 2009-08-26 |
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