CN101098873A - 作为激酶抑制剂的1,4-取代的吡唑并嘧啶 - Google Patents

作为激酶抑制剂的1,4-取代的吡唑并嘧啶 Download PDF

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Publication number
CN101098873A
CN101098873A CNA2005800464109A CN200580046410A CN101098873A CN 101098873 A CN101098873 A CN 101098873A CN A2005800464109 A CNA2005800464109 A CN A2005800464109A CN 200580046410 A CN200580046410 A CN 200580046410A CN 101098873 A CN101098873 A CN 101098873A
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China
Prior art keywords
phenyl
pyrazolo
amine
pyrimidine
methyl
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Pending
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CNA2005800464109A
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Chinese (zh)
Inventor
N·施密德伯格
P·菲雷
P·因巴赫
P·霍尔策
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P9/08—Vasodilators for multiple indications
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
CNA2005800464109A 2004-11-12 2005-11-10 作为激酶抑制剂的1,4-取代的吡唑并嘧啶 Pending CN101098873A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0425035.3 2004-11-12
GB0425035A GB0425035D0 (en) 2004-11-12 2004-11-12 Organic compounds

Publications (1)

Publication Number Publication Date
CN101098873A true CN101098873A (zh) 2008-01-02

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CNA2005800464109A Pending CN101098873A (zh) 2004-11-12 2005-11-10 作为激酶抑制剂的1,4-取代的吡唑并嘧啶

Country Status (15)

Country Link
US (1) US20080096868A1 (enExample)
EP (1) EP1812441A1 (enExample)
JP (1) JP2008519790A (enExample)
KR (1) KR20070084191A (enExample)
CN (1) CN101098873A (enExample)
AR (1) AR051485A1 (enExample)
AU (1) AU2005303965A1 (enExample)
BR (1) BRPI0517803A (enExample)
CA (1) CA2585660A1 (enExample)
GB (1) GB0425035D0 (enExample)
GT (1) GT200500325A (enExample)
MX (1) MX2007005644A (enExample)
RU (1) RU2007121846A (enExample)
TW (1) TW200621783A (enExample)
WO (1) WO2006050946A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102471335A (zh) * 2009-07-10 2012-05-23 大鹏药品工业株式会社 氮杂二环式化合物或其盐
CN109912599A (zh) * 2009-07-15 2019-06-21 英特利凯恩有限责任公司 化学实体、组合物和方法
CN110734437A (zh) * 2018-07-19 2020-01-31 金秋 吡唑并嘧啶化合物和药物组合物及其应用

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