CN101087871B - 味道减轻的皂条组合物 - Google Patents
味道减轻的皂条组合物 Download PDFInfo
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- CN101087871B CN101087871B CN200580044445.9A CN200580044445A CN101087871B CN 101087871 B CN101087871 B CN 101087871B CN 200580044445 A CN200580044445 A CN 200580044445A CN 101087871 B CN101087871 B CN 101087871B
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- 230000002265 prevention Effects 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- XOJVVFBFDXDTEG-UHFFFAOYSA-N pristane Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical group 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 1
- DCBSHORRWZKAKO-UHFFFAOYSA-N rac-1-monomyristoylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OCC(O)CO DCBSHORRWZKAKO-UHFFFAOYSA-N 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 235000020945 retinal Nutrition 0.000 description 1
- 239000011604 retinal Substances 0.000 description 1
- 150000004492 retinoid derivatives Chemical class 0.000 description 1
- 235000019172 retinyl palmitate Nutrition 0.000 description 1
- 229940108325 retinyl palmitate Drugs 0.000 description 1
- 239000011769 retinyl palmitate Substances 0.000 description 1
- 239000010666 rose oil Substances 0.000 description 1
- 235000019719 rose oil Nutrition 0.000 description 1
- 239000010669 rosewood oil Substances 0.000 description 1
- 239000010670 sage oil Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229960001866 silicon dioxide Drugs 0.000 description 1
- 230000037075 skin appearance Effects 0.000 description 1
- 229910052938 sodium sulfate Chemical class 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 239000013042 solid detergent Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- 239000012177 spermaceti Substances 0.000 description 1
- 229940084106 spermaceti Drugs 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 229940012831 stearyl alcohol Drugs 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 235000020238 sunflower seed Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 239000010677 tea tree oil Substances 0.000 description 1
- 229940111630 tea tree oil Drugs 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 229920001897 terpolymer Polymers 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 150000003866 tertiary ammonium salts Chemical class 0.000 description 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical group [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000010678 thyme oil Substances 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-O triethanolammonium Chemical compound OCC[NH+](CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-O 0.000 description 1
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/22—Carbohydrates or derivatives thereof
- C11D3/221—Mono, di- or trisaccharides or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D10/00—Compositions of detergents, not provided for by one single preceding group
- C11D10/04—Compositions of detergents, not provided for by one single preceding group based on mixtures of surface-active non-soap compounds and soap
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/0047—Detergents in the form of bars or tablets
- C11D17/006—Detergents in the form of bars or tablets containing mainly surfactants, but no builders, e.g. syndet bar
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2072—Aldehydes-ketones
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2096—Heterocyclic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
- Fats And Perfumes (AREA)
Abstract
本发明涉及含有特定臭味遮蔽剂的皂条组合物。无须增加使用个人净化或暴露于组合物的个体不喜欢的遮蔽香料的量,所述臭味遮蔽剂降低了恶臭。
Description
本发明通常涉及皂条(toilet bar)组合物,更特别涉及使用少量外加香料或不使用外加香料的具有降低的恶臭或基本味道(baseodor)的特定皂条组合物。
恶臭是皂条中存在的普遍问题。产生恶臭的原因估计是由于配方组分。还可能是产品中使用组分的相互作用。恶臭对消费者具有非常负面的影响,并且当产品与皮肤直接接触时变得更差。恶臭通常通过向产品中加入香料来遮蔽。
出于各种原因,一些消费者选择避免含有香料或精油的产品。因此当香料不希望被以其有效作为臭味遮蔽剂的水平使用时,在产品中遮蔽基本味道或恶臭成为一项挑战。
为了解决这些问题,令人惊奇的发现了一种组合物及其制备方法。在该组合物中,以消除或基本上降低特定皂条组合物恶臭或基本味道的有效量使用麦芽酚、乙基麦芽酚或其类似物、衍生物或共混物。
麦芽酚、乙基麦芽酚和选定类似物、衍生物已经在各种净化组合物中用作香料组分。在题为“Automatic Dishwashing CompositionsComprising Diacyl Peroxide Bleach and Blooming Perfume”的美国专利US 6,723,687、题为“Transparent Solid Detergents”的美国专利US 5,518,665和题为“Composition to be Applied to Hair or Skin”的美国专利US 6,204,229中公开了在各种洗涤剂组合物中麦芽酚或乙基麦芽酚用作遮蔽组分或香料的用途。
本发明一方面提供了一种皂条,其包括但不限于:(a)总浓度范围为约5-75重量%的脂肪酸皂;(b)总浓度范围为约4-40重量%的游离C6-C22羧酸;(c)总浓度范围为约2-60重量%的非皂合成洗涤剂;(d)最多约20重量%的水;和(e)有效浓度的具有结构I、II的吡喃型臭味掩蔽剂或其共混物:
以降低皂条组合物中可察觉的恶臭,其中R1和R2可相同或不同并且为氢、烷基、烷氧基、烯基、烷芳基、芳基或炔基,任选取代,并且R3为烷基酯或烯基酯。
本发明另一方面提供了制备味道减轻的皂条的方法,所述方法包括但不限于以下步骤,其中步骤a)-c)没有特定顺序:
a)将一种或多种非皂阴离子表面活性剂任选与肥皂共混以形成洗涤剂共混物;
b)将具有结构I、II的吡喃型臭味掩蔽剂或其共混物溶解或分散在足够量的一种或多种多元醇中以形成臭味遮蔽预混物,以降低皂条中可察觉的恶臭:
其中R1和R2可相同或不同并且为氢、烷基、烷氧基、烯基、烷芳基、芳基或炔基,任选取代,并且R3为烷基酯或烯基酯;
c)将臭味遮蔽预混物加入到洗涤剂共混物中并混合直到均匀以形成最终共混物;并且最后
d)将最终共混物挤出,然后切割并压印以形成味道减轻的皂条。
本发明的一个方面提供了一种皂条,包括但不限于以下:
(a)总浓度范围为约5-75重量%的脂肪酸皂;(b)总浓度范围为约4-40重量%的游离C6-C22羧酸(优选其中羧酸为C6-C18或C12-C18羧酸);(c)总浓度范围为约2-60重量%的非皂合成洗涤剂;(d)最多约20重量%的水(优选最多约15、12、10、8、6、4或3重量%水);和(e)有效浓度的具有结构I、II的吡喃型臭味掩蔽剂或其共混物:
以降低皂条组合物中可察觉的恶臭,其中R1和R2可相同或不同并且为氢、烷基、烷氧基、烯基、烷芳基、芳基或炔基,任选取代(优选R1和R2分别为氢、C1-C6烷基、C1-C6烯基、C1-C6烷氧基、苄基或苯基,并且更优选R1为甲基或乙基,R2为氢),并且R3为烷基酯或烯基酯(优选C1-C5烷基或烯基酯)。
有利地,本发明皂条在25℃和50%RH在如下所述测量时具有约20kPa-400kPa的屈服应力。
臭味遮蔽剂优选为约0.0005重量%-0.25重量%的总浓度,优选具有约0.0025或0.004%的最小值,以及约0.025、0.01、0.005或0.025%的最大值。本发明皂条更优选另外包括总浓度为约0.01重量%-30重量%的一种或多种多元醇(优选具有约0.4或0.7%的最小值,以及约2、3、7或10重量%的最大值)。最优选这些多元醇选自二丙二醇、丙二醇、甘油或MW约200-1500的聚乙二醇,或其共混物。多元醇在30℃时有利地具有约1000cps以下的粘度。
非皂阴离子表面活性剂有利地选自C8-C14酰基羟乙基磺酸盐;C8-C14烷基硫酸盐;C8-C14烷基磺基琥珀酸盐;C8-C14烷基磺酸盐;C8-C14脂肪酸酯磺酸盐、衍生物或其共混物。在一个优选实施方案中,臭味遮蔽剂为麦芽酚(图A)、乙基麦芽酚(图B)或其共混物。
本发明另一方面提供了制备味道减轻的皂条组合物的方法,所述方法包括但不限于以下步骤,其中步骤a)-c)没有特定顺序:
a)将一种或多种非皂阴离子表面活性剂任选与肥皂混合以形成洗涤剂共混物;
b)将具有结构I、II的吡喃型臭味掩蔽剂或其共混物溶解或分散在足够量的一种或多种多元醇中以形成臭味遮蔽预混物,以降低皂条中可察觉的恶臭:
其中R1和R2可相同或不同并且为氢、烷基、烷氧基、烯基、烷芳基、芳基或炔基,任选取代,并且R3为烷基酯或烯基酯。
c)将臭味遮蔽预混物加入到洗涤剂共混物中并混合直到均匀以形成最终共混物;并且最后
d)将最终共混物挤出,然后切割并压印以形成味道减轻的皂条。
表面活性剂,还称为洗涤剂,为本发明皂条组合物中的主要成分。其为具有疏水和亲水部分的化合物,降低其所溶解的水溶液的表面张力。有用的表面活性剂包括皂类和非皂阴离子、非离子、两性和阳离子表面活性剂,以及其共混物。
本发明皂条组合物含有一种或多种非皂阴离子洗涤剂(合成洗涤剂)。合成洗涤剂优选具有50或更低的玉米蛋白值。玉米蛋白值可使用如下所述试验方法测量。
这种非皂阴离子洗涤剂或表面活性剂有利地在一个实施方案中以约35-40重量%的总浓度范围使用,或在另一优选实施方案中以约45-55重量%的总浓度范围使用,或在另一优选实施方案中以约2-20重量%的总浓度范围使用。阴离子表面活性剂可有利地构成这些量的约50、60、70、80、90或95重量%,或更多。
可以使用的阴离子洗涤活性剂可为脂肪族磺酸盐,例如伯烷(例如C8-C22)磺酸盐、伯烷(例如C8-C22)二磺酸盐、C8-C22烯烃磺酸盐、C8-C22羟基烷烃磺酸盐或烷基甘油基醚磺酸盐(AGS);或例如烷基苯磺酸盐的芳香族磺酸酯。
阴离子还可为烷基硫酸盐(例如C12-C18烷基硫酸盐)或烷基醚硫酸盐(包括烷基甘油基醚硫酸盐)。烷基醚硫酸盐具有以下通式:
RO(CH2CH2O)nSO3M
其中,R为具有8-18个碳原子,优选12-18个碳原子的烷基或烯基,n具有大于1.0优选大于3的平均值;并且M为增溶阳离子,例如钠、钾、铵或取代铵。优选月桂基醚硫酸钠和月桂基醚硫酸铵。
阴离子还可为烷基磺基琥珀酸盐(包括单烷基和二烷基,例如C6-C22磺基琥珀酸盐);烷基和酰基牛磺酸盐、烷基和酰基肌氨酸盐、磺基乙酸盐、C8-C22烷基磷酸盐和磷酸盐、烷基磷酸酯和烷氧基烷基磷酸酯、酰基乳酸盐、C8-C22单烷基琥珀酸盐和马来酸盐、磺基乙酸盐和烷基葡糖苷等等。
磺基琥珀酸盐可为下式的单烷基磺基琥珀酸盐:
R4O2CCH2CH(SO3M)CO2M;和
下式的酰胺-MEA磺基琥珀酸盐:
R4CONHCH2CH2O2CCH2CH(SO3M)CO2M
其中R4为C8-C22烷基,并且M为增溶阳离子。
肌氨酸盐通常由下式表示:
R1CON(CH3)CH2CO2M
其中R1为C8-C20烷基,并且M为增溶阳离子。
牛磺酸盐通常由下式表示:
R2CONR3CH2CH2SO3M
其中R2为C8-C20烷基,R3可为H或C1-C4烷基,并且M为增溶阳离子。
单酰基和/或二酰基C8-C18羟乙基磺酸盐表面活性剂具有通式:
RC-O(O)-CH2-CH2-SO3M+
或
(RC-O(O)-CH2-CH2-SO3)2M++
其中R为具有8-18个碳原子的烷基,并且M为一价或二价阳离子,例如钠、钾、铵、钙和镁,或其它可以使用的单或二价阳离子。羟乙基磺酸盐优选具有小于20的平均碘值。
本发明皂条组合物可含有皂,例如脂肪酸皂。此处使用的“皂”以其普遍意义使用,亦即优选具有约6-22个碳原子,更优选约6至约18或约12-18个碳原子的脂肪族烷烃或烯烃单羧酸的碱金属盐或醇铵盐。它们还可为脂肪族烃的碱金属羧酸盐。钠、钾、单乙醇铵、二乙醇铵、三乙醇铵阳离子或其组合适用于本发明目的。
钠皂通常用于本发明组合物中,然而约1-约25%的皂可为钾皂。皂可含有与商业标准一致的不饱和。通常避免过量不饱和以最小化颜色和臭味问题。这些皂有利地在一个实施方案中以约15-25重量%的总浓度范围使用,或在另一优选实施方案中以约7-10重量%的总浓度范围使用,或在另一优选实施方案中以约60-70重量%的总浓度范围使用。
本发明皂可通过传统罐煮法或现代连续制皂法制备,其中例如牛油或椰子油或其等价物的天然油脂使用本领域熟练技术人员已知的方法使用碱金属氢氧化物皂化。或者,皂可通过使用碱金属氢氧化物或碳酸盐中和脂肪酸制备,脂肪酸例如月桂酸(C12)、肉豆蔻酸(C14)、棕榈酸(C16)或硬脂酸(C18)。
本发明皂条中使用的有用的吡喃型遮蔽剂的具体实例包括如上所述结构,以及具有以下结构的具体化合物等等:
一种或多种两性表面活性剂可用于本发明。必要时,两性表面活性剂可以约1、2或3重量%至约5、6或7重量%的量使用。
这些表面活性剂包括至少一个酸基。其可为羧酸或磺酸基。其包括季氮并且因此为季酰胺酸。其通常包括7-18个碳原子的烷基或烯基。其通常符合以下结构式:
R1-[-C(O)-NH(CH2)n-]m-N+-(R2)(R3)X-Y
其中R1为7-18个碳原子的烷基或烯基;R2和R3分别独立地为1-3个碳原子的烷基、羟基烷基或羧基烷基;n为2-4;X为任选被羟基取代的具有1-3个碳原子的亚烷基,并且Y为-CO2-或-SO3-。
上述通式内合适的两性表面活性剂包括下式的简单甜菜碱:
R1-N+-(R2)(R3)CH2CO2 -
和下式的酰胺基甜菜碱:
R1-CONH(CH2)n-N+-(R2)(R3)CH2CO2 -
其中n为2或3。
两个式子中R1、R2和R3定义如上。R1特别可为来源于椰子油的C12和C14烷基的混合物,以使得至少一半,优选四分之三的R1具有10-14个碳原子。R2和R3优选甲基。
另外可能的是,两性洗涤剂为下式磺基甜菜碱:
R1-N+-(R2)(R3)(CH2)3SO3 -
或
R1-CONH(CH2)m-N+-(R2)(R3)(CH2)3SO3 -,
其中m为2或3,或者这些中的变量-(CH2)3SO3 -被以下基团取代:
-CH2C(OH)(H)CH2SO3 -
在这些式子中,R1、R2和R3如上所述。
两性乙酸盐和二两性乙酸盐还用来表示两性离子和/或两性化合物,例如使用月桂酰两性基乙酸钠、椰油酰两性基乙酸钠,以及其共混物等等。
一种或多种非离子型表面活性剂可用于本发明皂条组合物。当存在于本发明皂条中时,非离子表面活性剂可以以低至约1、2或3重量%并且高至约10、15或20重量%的量使用。
可以使用的非离子特别包括具有疏水基和活泼氢原子的化合物(例如脂族醇、酸、酰胺或烷基酚)与环氧烷(特别是单独的环氧乙烷,或者环氧乙烷与环氧丙烷)的反应产物。具体的非离子型洗涤剂化合物为烷基(C6-C22)苯酚环氧乙烷缩合物、脂肪族(C8-C18)伯或仲直链或支链醇与环氧乙烷的缩合产物,以及环氧乙烷与环氧丙烷和乙二胺的反应产物缩合得到的产物。其它所谓的非离子型洗涤剂化合物包括长链叔胺氧化物、长链叔膦氧化物和二烷基亚砜等。
非离子还可为糖酰胺,例如多糖酰胺。特别是,这种表面活性剂可为1995年2月14日授予Au等人的题为“Compositions ComprisingNonionic Glycolipid Surfactants”的美国专利US 5,389,279中所述的乳二糖酰胺中的一种,并入此处作为参考,或为1991年4月23日授予Kelkenberg的题为“Use of N-PoIy Hydroxyalkyl Fatty Acid Amidesas Thickening Agents for Liquid Aqueous Surfactant Systems”的美国专利US 5,009,814中所述的糖酰胺中的一种,并入此处作为参考。
本发明组合物中的任选组分为阳离子皮肤调节剂,其可为阳离子肤感剂或聚合物,例如阳离子纤维素或polyquarterium化合物。
阳离子肤感剂或聚合物有利地从约0.01、0.1或0.2重量%到约1、1.5或2.0重量%的量用于本发明皂条中。
阳离子纤维素得自Amerchol公司(Edison,NJ,USA)聚合物系列聚合物JR(商标)和LR(商标),作为羟乙基纤维素与三甲基铵取代的环氧化物反应得到的盐,在工业上(CTFA)相应于Polyquarterium 10。另一类阳离子纤维素包括羟乙基纤维素与月桂基二甲基铵取代的环氧化物反应得到的聚合季铵盐,在工业上(CTFA)相应于Polyquarterium 24。这些材料以商品名聚合物LM-200得自Amerchol公司(Edison,NJ,USA),并且季铵化合物例如烷基二甲基卤化铵。
可以使用的特别合适的阳离子多糖聚合物为阳离子瓜耳胶衍生物,例如瓜耳羟丙基三铵氯化物(其可从Phone-Poulenc公司以其商标系列JAGUAR买到)。实例为JAGUAR C13S,其具有低的阳离子基团取代度和高粘度;JAGUAR C15,其具有中等程度的取代程度和低粘度;JAGUAR C17(高取代程度和高粘度);JAGUAR C16,其为含有低水平取代基以及阳离子季铵基团的羟丙基化的阳离子瓜耳胶衍射物;还有JAGUAR 162,其为具有低取代程度的高度透明、中等粘度的瓜耳胶。
特别优选的阳离子聚合物有JAGUAR C13S、JAGUAR C15、JAGUAR C17、JAGUAR C16和JAGUAR 162,尤其是JAGUARC13S。也可使用本领域已知的其它阳离子肤感剂,只要它们与本发明的配方相容。
其它优选的可用于本发明的阳离子化合物包括酰胺基季铵化合物,例如季铵丙酸盐和乳酸盐,和丝绸或小麦蛋白的季铵水解产物等。许多这些化合物可从McIntyre集团有限公司(University Park,IL)以MackineTM酰胺基官能胺、MackaleneTM酰氨基官能叔胺盐和Mackpro阳离子蛋白水解产物得到。
在本发明具有水解蛋白调节剂的优选皮肤清洁剂方案中,水解蛋白的平均分子量优选为约2500。优选90%的水解蛋白具有约1500-约3500的分子量。在优选实施方案中,MackproTM WWP(亦即小麦胚芽酰胺基二甲基胺水解的小麦蛋白)以0.1%(按原状)的浓度加入到皂条中。在此实施方案中,这导致在最终皂条配方中0.035%的MackproTM WWP“固体”。
一种或多种阳离子表面活性剂还可用于本发明皂条组合物。需要时,阳离子表面活性剂可以以约0.1、0.5或1.0重量%至约1.5、2.0或2.5重量%的量使用。
阳离子洗涤剂的实例为季铵化合物,例如卤化烷基二甲铵。
可以使用的其它合适的表面活性剂详见1973年3月27日授予Parran Jr.的、题为“Detergent Compositions Containing ParticleDeposition Enhancing Agents”的美国专利US 3,723,325,和Schwartz,perry & Berch著“Surface Active Agents and Detergents”(卷I和II),其也在此引入作为参考。
此外,本发明皂条组合物可包括0至约15重量%的如下任选组分:螯合剂例如乙二胺四乙酸四钠(EDTA)、EHDP或混合物,其量为约0.01-1%,优选为约0.01-0.05%;和着色剂,防晒剂和珠光剂,例如硬脂酸锌、硬脂酸镁、TiO2、EGMS(乙二醇单硬脂酸酯)或Lytron621(苯乙烯/丙烯酸酯共聚物)等,这些可全部用于增强该产品的外观或化妆性能。
香料可以以小于约2、1、0.5或优选小于约0.3、0.2或0.1重量%的量包括在内。在某些实施方案中,组合物可不含有香料。
该组合物中还可含有防腐剂,例如二羟甲基二甲基乙内酰脲(Glydant XL1000)、对羟基苯甲酸酯、山梨酸等。组合物中还可包括椰油酰单或二乙醇酰胺作为增泡剂,而且还可使用例如氯化钠和硫酸钠的强离子化盐来有利于产物。
抗氧化剂例如丁基化羟基甲苯(BHT)等,适当时可以以约0.01%或更高的数量有利地使用。
例如润肤剂的皮肤调节剂可有利地用于本发明的个人皂条组合物。亲水润肤剂包括湿润剂例如多元醇,例如甘油和丙二醇;聚醇,例如以下聚乙二醇;等等,并且可使用亲水植物提取物。湿润剂可有利地以约0.01、0.2或1.0重量%至约3、5或10重量%的量用于皂条中。湿润剂还可赋予皂条保持水分的能力。
Polyox WSR-205 PEG 14M
Polyox WSR-N-60K PEG 45M,或
Polyox WSR-N-750 PEG 7M
疏水性润肤剂可用于本发明皂条。疏水性润肤剂可有利地以约5、10或15重量%至约20、25、30、35、40、45重量%的量用于本发明皂条。
术语“润肤剂”定义为通过增加其含水量能够软化或改善皮肤的弹性、外观和年轻度(角质层),并通过延缓其含水量减少来保持其柔软性的物质。
有用的润肤剂包括如下:
(a)硅油及其改性物,例如直链和环状的聚二甲基硅氧烷;氨基、烷基、烷芳基和芳基硅油;
(b)脂肪和油类,包括天然脂肪和油脂,例如霍霍巴油、大豆油、葵花籽油、米糠油、鳄梨油、杏仁油、橄榄油、芝麻油、桃仁油、蓖麻油、椰子油、貂油;可可脂、牛油、猪油;通过氢化上述油类得到的硬化油;以及合成的甘油单酯、二酯和三酯,例如肉豆蔻酸甘油酯和2-乙基己酸甘油酯;
(c)蜡类,例如巴西棕榈蜡、鲸蜡、蜂蜡、羊毛脂,以及它们的衍生物;
(d)疏水性植物提取物;
(e)烃类,例如液体石蜡、凡士林、微晶蜡、纯地蜡、角鲨烯、pristan和矿物油;
(f)高级脂肪酸,例如月桂酸、肉豆蔻酸、棕榈酸、硬脂酸、山嵛酸、油酸、亚油酸、亚麻酸、羊毛脂酸、异硬脂酸、花生四烯酸和多不饱和脂肪酸(PUFA);
(g)高级醇,例如月桂醇、鲸蜡醇、硬脂醇、油醇、山嵛醇、胆固醇和2-己基癸醇;
(h)酯,例如辛酸鲸蜡酯、乳酸肉豆蔻酯、乳酸鲸蜡酯、肉豆蔻酸异丙酯、肉豆蔻酸肉豆蔻酯、棕榈酸异丙酯、己二酸异丙酯、硬脂酸丁酯、油酸癸酯、异硬脂酸胆固醇酯、单硬脂酸甘油酯、二硬脂酸甘油酯、三硬脂酸甘油酯、乳酸烷基酯、柠檬酸烷基酯和酒石酸烷基酯;
(i)精油及其萃取物,例如薄荷属(menta)油、茉莉花油、樟脑油、白雪松(white cedar)油、苦橙皮油、黑麦粒(ryu)油、松节油、肉桂油、香柠檬油、温州蜜柑油、白菖蒲油、松油、熏衣草油、月桂叶油、丁香油、丝柏(hiba)油、桉树油、柠檬油、琉璃苣(starflower)油、百里香油、薄荷油、玫瑰油、鼠尾草油、芝麻油、姜油、罗勒油、刺柏油、柠檬草油、迭迭香油、蔷薇木油、鳄梨油、葡萄油、葡萄籽油、没药油、黄瓜油、水芹油、金盏花油、接骨木花油、老鹳草油、椴树花油、苋菜红油、海藻油、银杏油、人参油、胡萝卜油、瓜拉那油、茶树油、霍霍巴油、雏菊油、燕麦粉油、可可油、橙花油、香子兰油、绿茶油、除蚤薄荷油、真芦荟油、薄荷醇、桉叶油素、丁香酚、柠檬醛、香茅、冰片、里哪醇、香茅醇、月见草油、樟脑油、百里酚、绶草醇、蒎烯、柠烯、类萜油;和
(j)由上述任何组分组成的混合物,等。
优选的疏水润肤保湿剂选自脂肪酸、甘油二酯和甘油三酯油、矿物油、凡士林、硅油,以及其混合物;并且对于皂条最优选脂肪酸。脂肪酸有利地在一个实施方案中以约25-30重量%的总浓度范围使用,或在另一优选实施方案中以约20-25重量%的总浓度范围使用,或在另一优选实施方案中以约2-10重量%的总浓度范围使用。
表面活性剂的克拉夫特点定义为表面活性剂溶解度急剧上升的温度(或更精确的说,狭窄的温度范围)。在此温度,表面活性剂的溶解度等于临界胶束浓度。还可通过在溶解度/温度或1/T的对数表的斜率上找出突变确定,或者可使用以下所述快速评价方法快速估算。
本发明皂条可含有脱皮剂(exfoliants),例如平均直径大于50微米能够帮助除去干燥皮肤的颗粒。不受理论限制,脱落程度取决于颗粒的大小和形态。较大和粗糙的颗粒通常非常粗糙和刺激。非常小的颗粒可能起不到有效脱落的作用。本领域使用的脱皮剂包括天然物质,例如二氧化硅、滑石、方解石、浮石、磷酸三钙;种子,例如稻、杏核等;压碎外壳,例如杏核和胡桃壳;燕麦片;聚合物例如聚乙烯和聚丙烯珠粒、花瓣和叶子;微晶蜡珠粒;霍霍巴酯珠粒等;这些脱皮剂可为多种颗粒大小,并且形态可为微米规模到几个毫米。其还具有一定硬度。某些实施例在下表A中给出。
表A
材料 | 硬度(Mohs) |
滑石 | 1 |
方解石 | 3 |
浮石 | 4-6 |
胡桃壳 | 3-4 |
白云石 | 4 |
聚乙烯 | ~1 |
除了上述皮肤调节剂外,任选的活化剂有利地加入到本发明皂条中。这些活性组分有利地选自杀菌剂、维生素、抗粉刺活性物;抗皱、抗皮肤萎缩和皮肤修复活性物;皮肤屏障修理活性剂;非甾体化妆用平滑活性剂;人工晒黑剂和促进剂;亮肤活性剂;防晒活性剂;皮脂激活剂;皮脂抑制剂;抗氧化剂;蛋白酶抑制剂;皮肤绷紧剂;抗痒组分;毛发生长抑制剂;5-α还原酶抑制剂;表皮脱落酶增强剂;抗糖基化剂或其组合物等。
这些活化剂可选自水溶性活性剂、油溶性活性剂、药物可接受的盐及其混合物。此处使用的术语“活性剂”指的是个人护理活性剂,其能够为皮肤和/或毛发带来好处并且通常不用来产生前述润肤剂所产生的调理益处。此处使用的术语“安全和有效量”指的是活性剂的量足够高,能够改变处理条件或产生所需皮肤护理作用,但又足够低以避免严重的副作用。
此处使用的术语“好处”指的是使用一种或多种此处所述活性剂的与处理具体条件相关的治疗性、预防性和/或长期好处。活性组分的安全和有效量将随着特定活性剂、活性剂穿过皮肤的能力、年龄、卫生条件、使用者的皮肤状况等因素而变化。本发明个人皂条组合物优选含有约0.0001-50重量%,更优选约0.05-25重量%,更优选约0.1-10重量%,并且最优选约0.1-5重量%的活性剂组分。
各种活性剂组分可用于本发明个人皂条组合物,并且选自抗粉刺活性剂、抗皱和抗皮肤萎缩活性剂、皮肤屏障修理助剂、化妆用平滑助剂、局部麻醉剂、人工晒黑剂和促进剂、亮肤活性剂、抗菌和抗真菌活性剂、防晒活性剂、皮脂激活剂、皮脂抑制剂、抗糖化活性剂及其混合物。
抗粉刺活性剂可有效用于治疗散播性痤疮、皮脂毛囊的慢性疾病。有用的抗粉刺活性剂的非限制性实例包括角质层分离剂,例如水杨酸(邻羟基苯甲酸)、如5-辛酰基水杨酸和4-甲氧基水杨酸的水杨酸衍生物;间苯二酚;例如视黄酸及其衍生物的类视黄醇(例如顺式和反式);含硫D和L氨基酸以及其衍生物和盐,特别是N-乙酰基衍生物,及其混合物等。
抗细菌和抗真菌活性剂可有效预防细菌和真菌的繁殖和生长。抗微生物和抗真菌活性剂的非限制性实例包括b-内酰胺药物、喹诺酮药物、环丙沙星、诺氟沙星、四环素、红霉素、氨丁卡霉素、2,4,4′-三氯-2′-羟基二苯醚、3,4,4′-三氯碳酰替苯胺(三氯二苯脲)、苯氧乙醇、2,4,4′-三氯-2′-羟基二苯醚(三氯生);以及其混合物等等。
抗皱纹、抗皮肤萎缩和皮肤修复活性剂可用于表皮层的补充或复原。通过促进和保持表皮脱落的自然过程,这些活性剂通常能够提供所需的皮肤护理作用。抗皱纹、抗皮肤萎缩活性剂非限制性的实例包括维生素、矿物质和皮肤营养物,例如牛奶、维生素A、E和K;维生素烷基酯,包括维生素C烷基酯;镁、钙、铜、锌和其它金属组分;视黄酸及其衍生物(例如顺式或反式);视黄醛、视黄醇、视黄酯,例如乙酸视黄酯、棕榈酸视黄酯和丙酸视黄酯的视黄酯;维生素B3化合物(例如烟酰胺和烟酸)、α醇酸、β醇酸,例如水杨酸及其衍生物(例如5-辛酰基水杨酸和庚氧基4水杨酸和4-甲氧基水杨酸),以及其混合物等。
皮肤屏障修理活性剂为能够修理和补充表皮天然防水功能的皮肤护理活性剂。皮肤屏障修理活性剂的非限制性实例包括脂类,例如欧洲专利说明书No.556,957中所述的胆固醇、神经酰胺、蔗糖酯和拟神经酰胺;抗坏血酸;生物素;生物素酯;磷脂,以及其混合物等。
非甾体化妆用平滑活性剂可有效用于预防或治疗皮肤炎症。平滑活性增强了本发明皮肤外观益处,例如这种活性剂有助于更加均匀和可接受的肤质和颜色。非甾体化妆用平滑剂的非限制性例子包括以下种类:丙酸衍生物;乙酸衍生物;芬那酸衍生物;以及其混合物等。许多这些化妆用平滑剂已经公开在1991年1月15日授予Sunshine等人的美国专利No.4,985,459中,将其全文引用于此作为参考。
通过增加皮肤中的黑色素或通过产生皮肤中黑色素增加的外观,人工晒黑剂可有助于模拟自然晒黑。人工晒黑剂和促进剂的非限制性例子包括二羟基acetaone、酪氨酸、酪氨酸酯,例如酪氨酸乙酯和酪氨酸葡萄糖酯,以及其混合物等。
亮肤活性剂可实际上减少皮肤中黑色素的量,或通过其它机制提供这种效果。可用于此处的亮肤活性剂的非限制性例子包括芦荟提取物、α-甘油基-L-抗坏血酸、氨基酪氨酸、乳酸铵、乙醇酸、对苯二酚、4-羟基苯甲醚,以及其混合物等。
本发明个人用皂条组合物中还有用的为防晒活性剂。各种防晒剂公开在1992年2月11日授予Haffey等人的美国专利No.5,087,445、1991年12月17日授予Turner等人的美国专利No.5,073,372、1991年12月17日授予Terner等人的美国专利No.5,073,371和Segarin等人的《化妆品科学技术》第三章第189页及以下,所有这些以其全文引用于此作为参考。可用于本发明组合物的防晒剂的非限制性例子为选自下组的那些:辛基甲氧基肉桂酸酯(Parsol MCX)和丁基甲氧基苯甲酰基甲烷(Parsol 1789)、2-乙基己基对甲氧基肉桂酸酯、2-乙基己基-N,N-二甲基对氨基苯甲酸酯、对氨基苯甲酸、2-苯基苯并咪唑-5-磺酸、氧苯酮,以及其混合物等。
皮脂激活剂可增加皮脂腺的皮脂产生。皮脂激活剂的非限制性例子包括泻根醇酸(bryonolic acid)、去氢表雄酮(DHEA)、阿魏酸酯,以及其混合物等。
皮脂抑制剂可减少皮脂腺的皮脂产生。有用的皮脂抑制活性剂的非限制性例子包括羟基铝氯化物、皮质类固醇、脱氢乙酸及其盐、二氯苯基咪唑二氧戊环(购自Elubiol),以及其混合物等。
在本发明个人用皂条组合物中还可用作活性剂的为蛋白酶抑制剂。蛋白酶抑制剂可分为两大类:蛋白酶和肽酶。蛋白酶作用于蛋白质的特定内部肽键,并且肽酶作用于与蛋白末端游离氨基或羧基相邻的肽键,并由此将蛋白由体表分离。适用于本发明个人用皂条组合物的蛋白酶抑制剂包括但不限于蛋白酶类,例如丝氨酸蛋白酶、金属蛋白酶、半胱氨酸蛋白酶和天冬氨酰基蛋白酶,以及肽酶,例如羧肽酶、二肽酶和氨肽酶,以及其混合物等。
其它可用于本发明个人用皂条组合物的有用活性成分为皮肤绷紧剂。用于本发明组合物的皮肤绷紧剂的非限制性例子包括可将聚合物连接至皮肤的单体,如乙烯吡咯烷酮的三元共聚物、(甲基)丙烯酸和由长烷基(甲基)丙烯酸酯组成的疏水单体,以及其混合物等。
本发明个人用皂条组合物的活性组分还包括抗痒组分。用于本发明组分的抗痒组分的合适的例子包括氢化可的松、methdilizine和异丁嗪(trimeprazine),以及其混合物等。
用于本发明个人用皂条组合物的毛发生长抑制剂的非限制性例子包括17p雌二醇、抗血管生成甾体、姜黄提取物、环氧酶抑制剂、月见草油、亚油酸等。合适的5a还原酶抑制剂例如为乙炔基雌二醇和genistine,以及其混合物等。
用于本发明个人用皂条组合物的表皮脱落酶增强剂的非限制性例子包括丙氨酸、天冬氨酸、N-甲基丝氨酸、丝氨酸、三甲基甘氨酸,以及其混合物等。
用于本发明组分的抗糖基化剂的非限制性例子将为Amadorin(购自Barnet Products Distributor)等。
实施例
除了在操作和对比实施例外或者另有说明,说明书中表示材料用量的所有数字均应理解为被“约”限制。
以下实施例将更加详细地说明本发明的实施方案。除非另有说明,所有的份数、百分比和比例在这里和所附的权利要求中都以重量表示。物理试验方法如下所述。以下本发明皂条组合物可根据下文所述的制造方法配制:
实施例1
根据表1可以制备本发明有用的合成洗涤剂皂条(本发明)和对比皂条(对比):
表1
组分 | A(对比) | B(本发明) | C(本发明) | D(本发明) |
椰油基羟乙基磺酸钠 | 50.00 | 50.00 | 50.00 | 50.00 |
羟乙基磺酸钠 | 10.00 | 10.00 | 10.00 | 10.00 |
硬脂酸 | 23.00 | 23.40 | 23.20 | 23.00 |
椰油基甜菜碱 | 3.00 | 3.00 | 3.00 | 3.00 |
82/18牛油/椰油皂 | 4.00 | 4.00 | 4.00 | 4.00 |
防腐剂/遮光剂 | 0.50 | 0.50 | 0.50 | 0.50 |
硬脂酸钠 | 1.50 | 1.50 | 1.50 | 1.50 |
椰油脂肪酸 | 2.00 | 2.00 | 2.00 | 2.00 |
乙基麦芽酚或麦芽酚 | 0.003 | 0.004 | 0.01 | |
聚醇(例如二丙二醇(DPG)) | 0.597 | 0.796 | 0.99 | |
香料 | 1.00 | |||
水 | 5.00 | 5.00 | 5.00 | 5.00 |
总计 | 100.00 | 100.00 | 100.00 | 100.00 |
实施例2
根据表2可以制备本发明有用的混合皂条(本发明)和对比皂条(对比):
表2
组分 | E(对比) | F(本发明) | G(本发明) | H(本发明) |
70/30牛油/椰油皂基 | 76.46 | 74.45 | 63.960 | 68.700 |
椰油基羟乙基磺酸钠 | 20.000 | 10.000 | ||
硬脂酸 | 5.00 | 5.00 | 4.000 | 5.000 |
αC10-14烯烃磺酸酯 | 3.00 | 3.00 | 2.000 | |
椰油酰胺丙基甜菜碱 | 3.00 | 3.00 | 2.000 | |
防腐剂/遮光剂 | 0.54 | 0.54 | 0.540 | 0.540 |
麦芽酚 | 0.01 | 0.003 | 0.004 | |
聚醇(DPG) | 2.00 | 0.497 | 0.756 | |
凡士林/矿物油 | 2 | 2 | 1 | 1 |
水 | 10.00 | 10.00 | 10.000 | 10.000 |
总计 | 100.00 | 100.00 | 100.000 | 100.000 |
实施例3
根据表3可以制备本发明有用的具有麦芽酚和/或乙基麦芽酚和降低香料水平的合成皂条(本发明)和对比皂条(对比):
表3
组分 | I(对比) | J(本发明) | K(本发明) | L(本发明) |
椰油基羟乙基磺酸钠 | 50 | 50 | 49.5 | 49.2 |
羟乙基磺酸钠 | 10 | 10 | 10 | 10 |
硬脂酸 | 23 | 23.4 | 23.4 | 23.4 |
椰油基甜菜碱 | 3 | 3 | 3 | 3 |
82/18皂(牛油/椰油) | 4 | 4 | 4 | 4 |
防腐剂/遮光剂 | 0.5 | 0.5 | 0.5 | 0.5 |
硬脂酸钠 | 1.5 | 1.5 | 1.5 | 1.5 |
椰油脂肪酸 | 2 | 2 | 2 | 2 |
水 | 5 | 5 | 5 | 5 |
乙基麦芽酚或麦芽酚 | 0.003 | 0.003 | 0.003 | |
二丙二醇 | 0.597 | 0.597 | 0.597 | |
香料 | 1 | 0.5 | 0.8 | |
总计 | 100 | 100 | 100 | 100 |
实施例4
根据表4可以制备本发明有用的使用麦芽酚和/或乙基麦芽酚代替部分或全部麦芽酚和降低香料水平的合成皂条(本发明)和对比皂条(对比):
加工方法
皂条可如下配制。
在合成皂条方法中,首先将润肤剂和结构剂在曲拐式搅拌机中在90℃以上加热熔融。然后在混合器中加入阴离子表面活性剂并搅拌均匀以形成皂基。此时可加入其它任选组分例如二氧化钛、抛光剂和粘土。游离水含量最佳调节至约5-6%。然后将所得松软或流动液体物质冷却辊压。辊压的物质加入到碎屑混合器,并将其余少量组分,例如颜料、任选的香料和特色组分加入并混合。
在此刻加入乙基麦芽酚,并与皂基混合。已经注意到预先在多元醇或香料中稀释的乙基麦芽酚(EM)在最终产物中提供良好的分散。不同聚醇可用于溶解EM。已经令人吃惊地发现,本发明皂条的颜色和气味在43℃老化4星期后在二丙二醇(DPG)中更加稳定。
在初始阶段另一个观察是,可以确定麦芽酚的特征气味,其被称为水果糖类气味,然而在约2-3星期老化期间这种特征气味慢慢消失,并且如果皂条中不含有其它香料,则皂条慢慢变得没有气味。在本发明一个优选实施方案中,分别使用EM和多元醇制备了预混物,例如EM在0.5重量%与DPG混合。该预混物以0.1-2.0%加入到皂基,或任选加入到碎屑混合器。混合的物料然后研磨/提纯并挤出。将挤出的皂条冲压并装箱/包装。
通过将麦芽酚与皂基和其它组分在碎屑混合器中共混,可产生combar皂条。然后混合的物料加工以通过上述方法得到最终皂条。
浇铸熔融皂条
流动和可浇铸本发明组合物使用本领域已知或其它等价方法产生。以10-30重量%的总浓度范围,优选大于10%、12%、14%和15重量%的总浓度范围,通过加入低克拉夫特点表面活性剂/构成剂/润肤剂/湿润剂/溶剂等(优选表面活性剂KP<30℃)和/或水,可以制备合适的组合物。为了最小化浇铸熔融皂条的噪声因素,优选避免使用非常高的浓度。
在优选实施方案中,通过在皮肤润肤剂例如甘油、丙二醇和/或脂肪醇的存在下使用有效量的硬脂酸钠或12羟基硬脂酸,构成了椰油羟乙基磺酸钠和椰油羟乙基磺酸镁的混合物。这些作为增溶剂的润肤剂在高温下需要以均匀液体得到,其在冷却时得到硬条,以确定其屈服应力。任选克拉夫特点小于30℃的一些共表面活性剂还可用于制剂中。
成条方法
除了本发明的臭味遮蔽剂外,任选的香料、向日葵籽油、SCI和MgCl2、其余组分加入到混合器中。将混合物加热到约90℃,缓慢混合以成为均匀液体。缓慢加入SCI和MgCl2并在约100℃溶解。一旦物料均匀,将温度转到约80℃并在连续混合下缓慢加入向日葵籽油。任选向均匀物料中加入香料,优选在约70℃加入以避免香料变质。将均匀的灰白色液体倒入模具中。通过合适的冷却工艺或在环境温度下冷却以得到固体皂条。
测试方法的描述
测试方法
A)估算皂条中麦芽酚、乙基麦芽酚或其衍生物或类似物含量的分析 方法
例如麦芽酚或乙基麦芽酚的吡喃类臭味遮蔽化合物可使用应用于皂条的下列固相微萃取(SPME)液上取液方法定量。
使用CTC Analytics Pal自动SPME取样系统在皂条样品的顶部空间取样。然后SPME纤维脱附到GC-MS中。使用以下参数。
样品制备
将2克样品放入20毫升液上取样瓶。
将瓶使用隔膜折边盖密封。
SPME液上取样参数
平衡时间:2分钟
取样时间:30分钟
取样温度:35℃
SPME纤维:DVB/CAR/PDMS(灰色)Supelco(Belleton,PA)
部分#57299-U
SPME纤维脱附参数
内部温度:250℃
脱附时间:5分钟
GC-MS参数
柱:SPB-1 30米×0.25毫米×0.25微米厚(得自Supelco(Belleton,PA)的100%甲基硅酮柱)。
载气:氦气
流速:1毫升/分钟
裂缝模式:无缝
烤箱:保持50℃3分钟
温升:6℃/分钟
最终温度:保持240℃10分钟
总时间:45分钟
检测器:Agilent Mass Selective检测器
结构:Scan 35-350
B)使用奶酪切力设备计算屈服应力的方法
通过奶酪切断方法可以确定屈服应力的近似值。测定原理为:当线上的力与重力平衡时,以恒定力深入材料的线将停止移动。力平衡为:
拉动线的重力=由于材料应力的线上的力
mg=K ys l D
其中
m=拉动线的质量(用于计算的实际质量为放在设备上的质量加上加到样品上的支架重量)
g=重力加速度,9.8m/sec2
ys=屈服应力
l=1分钟后线进入皂条的长度(毫米)
D=线的直径(米)
K=几何参数
最终方程式为:ys=(3/8)mg/(l D)
过程
切取正方形皂条并置于屈服应力设备上。在屈服应力设备上添加质量同时保持支架。400克为合适质量,不过对于非常软的材料可能需要更少的质量。逐渐降低支架以使得线刚刚接触皂条并使支架离开。1分钟后停止支架的垂直运动,并推动皂条水平通过线以将样品切开一角。将质量移开设备,然后测量切入样品的长度。线将以较低速率继续切割样品,然而线在1分钟内切开的长度作为最终值。在试验进行时测量皂条的温度。
样品计算
在屈服应力设备上使用400克重量,在线切割皂条1分钟后测得22毫米切口。假定线的直径为0.6毫米,预计的屈服应力为:
(3/8)(400+56)[g]9.8[m/sec2]10-3[kg/g]=1.3105Pa或130kPa 22[mm]0.6[mm]10-6[m2/mm2]
任选可以使用拉伸强度试验机测试装置(Instron公司提供,Boston,MA)代替砝码,以向与皂条接触的线加力。
C)克拉夫特点确定
制备表面活性剂或其它样品在水中10重量%的溶液。如果需要的话,将体系加热以彻底溶解样品。将透明溶液转移到玻璃试管中。将试管放置在具有搅拌器并装有足够水的烧杯中以将表面活性剂或样品溶液均匀冷却。溶液应当在连续搅拌下冷却并且应当连续记录温度。当开始结晶并溶液变得浑浊时注意温度。该温度作为克拉夫特点。如果结晶温度低于室温,向烧杯中加入冰以将试管冷却到室温之下以确定低于室温的克拉夫特点。
D)玉米蛋白测试方法
使用如下所述的玉米蛋白溶解度法,本发明皂条组合物(特别是个人皮毛的净化)优选具有低于约50、40、30,并最优选低于约25的玉米蛋白溶解度。玉米蛋白值越低,则可认为产品越柔和。该方法包括在清洗基溶液中根据如下所述测量玉米蛋白的溶解度。
0.3克清洗基和29.7克水在室温(25℃)下充分混合。向其中加入1.5克玉米蛋白并混合1小时。然后将混合物在3000rpm离心30分钟。离心后分离出颗粒,用水洗涤,在真空烘箱中干燥24小时直到已经蒸发了基本上所有的水分。测量干燥颗粒的重量并使用以下公式计算玉米蛋白溶解的百分率:
玉米蛋白溶解百分率=100(1-干燥颗粒的重量/1.5)
玉米蛋白溶解百分率另外公开在以下参考文献中:E.Gotte,Skincompatibility of tensides measured by their capacity for dissolving zeinprotein,Proc.IV International Congress of Surface ActiveSubstances,Brussels,1964,第83-90页。
Claims (11)
2.根据权利要求1所述的皂条组合物,其在25℃和50%RH时为具有20kPa-400kPa屈服应力的皂条形式。
3.根据前述任意一项权利要求所述的皂条组合物,进一步包括一种或多种总浓度范围为0.01重量%-30重量%的多元醇。
4.根据权利要求3所述的皂条组合物,其中一种或多种多元醇选自二丙二醇、丙二醇、甘油,或MW为200-1500的聚乙二醇,或其共混物。
5.根据权利要求1-2任意一项所述的皂条组合物,其中非皂阴离子表面活性剂选自C8-C14酰基羟乙基磺酸盐;C8-C14烷基硫酸盐;C8-C14烷基磺基琥珀酸盐;C8-C14烷基磺酸盐;C8-C14脂肪酸酯磺酸盐、或其共混物。
6.根据权利要求3所述的皂条组合物,其中非皂阴离子表面活性剂选自C8-C14酰基羟乙基磺酸盐;C8-C14烷基硫酸盐;C8-C14烷基磺基琥珀酸盐;C8-C14烷基磺酸盐;C8-C14脂肪酸酯磺酸盐、或其共混物.
7.根据权利要求4所述的皂条组合物,其中非皂阴离子表面活性剂选自C8-C14酰基羟乙基磺酸盐;C8-C14烷基硫酸盐;C8-C14烷基磺基琥珀酸盐;C8-C14烷基磺酸盐;C8-C14脂肪酸酯磺酸盐、或其共混物.
8.根据权利要求1-2任意一项所述的皂条组合物,其中臭味遮蔽剂为麦芽酚、乙基麦芽酚或其共混物。
9.根据权利要求3所述的皂条组合物,其中臭味遮蔽剂为麦芽酚、乙基麦芽酚或其共混物。
10.根据权利要求5所述的皂条组合物,其中臭味遮蔽剂为麦芽酚、乙基麦芽酚或其共混物。
11.根据权利要求4、6和7任意一项所述的皂条组合物,其中臭味遮蔽剂为麦芽酚、乙基麦芽酚或其共混物。
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US11/019,794 US7015179B1 (en) | 2004-12-22 | 2004-12-22 | Reduced odor toilet bar composition |
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PCT/EP2005/012872 WO2006066705A1 (en) | 2004-12-22 | 2005-11-28 | Reduced odor toilet bar composition |
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US20080206351A1 (en) * | 2007-02-23 | 2008-08-28 | Conopco, Inc., D/B/A Unilever | Malodor Reduction of Cosmetic Products |
GB0717485D0 (en) | 2007-09-08 | 2007-10-17 | Unilever Plc | Improvements relating to fabric conditioners |
ES2398622T3 (es) | 2008-06-05 | 2013-03-20 | Unilever N.V. | Mejoras relacionadas con acondicionadores de tejidos |
US8133853B1 (en) | 2010-09-28 | 2012-03-13 | Conopco, Inc. | Fragranced soap compositions |
JP2013043861A (ja) * | 2011-08-24 | 2013-03-04 | Japan Enviro Chemicals Ltd | 尿臭抑制剤 |
WO2013144603A1 (en) * | 2012-03-30 | 2013-10-03 | Reckitt & Colman (Overseas) Limited | Bar soaps |
CN103289839A (zh) * | 2013-06-28 | 2013-09-11 | 广州丹奇日用化工厂有限公司 | 一种丰胸手工皂 |
CN103361200A (zh) * | 2013-08-02 | 2013-10-23 | 太仓市伟基生物科技有限公司 | 一种当归养肤沐浴皂的配置方法 |
CA3047424A1 (en) | 2016-12-22 | 2018-06-28 | Unilever Plc | Stabilization of cosmetic compositions comprising fish oils and hydroxylated fatty acids and/or its derivatives |
CN110099722B (zh) | 2016-12-22 | 2022-04-29 | 联合利华知识产权控股有限公司 | 化妆品组合物的臭味减少 |
US11104870B1 (en) * | 2020-04-01 | 2021-08-31 | Jonathan Diaz | Automatic flush activated toilet odor prevention tablet |
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- 2005-11-28 CN CN200580044445.9A patent/CN101087871B/zh not_active Expired - Fee Related
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CA2586715A1 (en) | 2006-06-29 |
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MY137802A (en) | 2009-03-31 |
CA2586715C (en) | 2013-02-19 |
AR052171A1 (es) | 2007-03-07 |
JP5242164B2 (ja) | 2013-07-24 |
DE602005017191D1 (de) | 2009-11-26 |
WO2006066705A1 (en) | 2006-06-29 |
US7015179B1 (en) | 2006-03-21 |
CN101087871A (zh) | 2007-12-12 |
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