CN101085084A - Oral liquid containing sophora flavescens, scutellaria and other medicine with diarrhea-stopping function - Google Patents
Oral liquid containing sophora flavescens, scutellaria and other medicine with diarrhea-stopping function Download PDFInfo
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- CN101085084A CN101085084A CN 200710057759 CN200710057759A CN101085084A CN 101085084 A CN101085084 A CN 101085084A CN 200710057759 CN200710057759 CN 200710057759 CN 200710057759 A CN200710057759 A CN 200710057759A CN 101085084 A CN101085084 A CN 101085084A
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Abstract
The invention discloses an oral liquid for the effective treatment of livestock enteritis loose bowel movement, wherein the medicament comprises the following raw materials (by weight portion): creeping euphorbia 25-30%, Chinese mosla herb 10-15%, flavescent sophora root 20-30%, baikal skullcap root 15-20%, atractylodes rhizome 10-15% and dried orange peel 5-10%.
Description
Technical field
The present invention relates to the Chinese medicine composition field, more particularly, relate to be applicable to the dysentery relieving Chinese medicine composition of domestic animal.
Background technology
At present, the domestic animal of China is raised scattered based on peasant household mostly, and it is uneven that the raiser cultures level, lack relevant feeding and management and epidemic prevention and control knowledge, cause the sickness rate and the relapse rate of some diseases to significantly improve, some conditionality pathogenic bacterium such as colibacillosiss, salmonellosis etc., and these diseases antibacterial in therapeutic process is easy to generate drug resistance especially, adding spreading unchecked of Western medicine uses and makes and produced drug resistance with a lot of bacterial strains, therefore have a lot of veterinary drug producer to be devoted to the research and the production of Chinese medicine, it is little to give full play to herbal toxic effect, be difficult for producing drug resistance, drug residue free, do not influence advantages such as outlet.
Summary of the invention
Technical problem to be solved by this invention is: providing a kind of is main component, the oral liquid containing sophora flavescens, scutellaria and other medicine with diarrhea-stopping function that can effectively treat the domestic animal enteritis, diarrhea with the Radix Sophorae Flavescentis Radix Scutellariae.
Oral liquid containing sophora flavescens, scutellaria and other medicine with diarrhea-stopping function of the present invention is made up of according to described percentage by weight following component: Herba Euphorbiae Humifusae 25-30%, Herba Moslae 10-15%, Radix Sophorae Flavescentis 20-30%, Radix Scutellariae 15-20%, Rhizoma Atractylodis 10-15%, Pericarpium Citri Reticulatae 5-10%.
Radix Scutellariae, Radix Sophorae Flavescentis heat clearing and damp drying dysentery relieving among the present invention; During Herba Moslae diaphoresis expelling summer-heat, row water wet dissipation, stomach warming are transferred; The Herba Euphorbiae Humifusae heat-clearing and toxic substances removing is controlled dysentery; Rhizoma Atractylodis are drying damp and strengthening spleen; Pericarpium Citri Reticulatae is good for the stomach and regulates the flow of vital energy.Simultaneously, with the warm property restriction Radix Sophorae Flavescentis of Rhizoma Atractylodis, Herba Moslae, the cold and cool property of Radix Scutellariae, injure taste with the product of avoiding bitter cold.
Radix Scutellariae is usually used in treating the damp-heat type dysentery, and is main relevant with its antibacterial action.Radix Scutellariae decocting liquid has inhibitory action to dysentery bacterium, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus pyocyaneus, staphylococcus, Hemolytic streptococcus, Diplococcus pneumoniae, diphtheria corynebacterium etc.The immersion of Radix Scutellariae alcohol has inhibitory action to escherichia coli, bacillus subtilis, staphylococcus aureus.Each place of production Radix Scutellariae is antibiotic, antiinflammatory, analgesic and calm aspect all show good pharmacologically active.The R plasmid that escherichia coli is carried with baikal skullcap root and dysentery relieving spirit (main component is the Radix Pulsatillae, Cortex Phellodendri and Radix Sophorae Flavescentis) use in conjunction has the elimination effect, and antibacterial shows as losing of multi-drug resistant.
Radix Sophorae Flavescentis is external to have antibacterial action.Its effective ingredient Radix Sophorae Flavescentis total alkaloids has antibacterial action to staphylococcus aureus, escherichia coli, dysentery bacterium, bacillus pyocyaneus and Candida albicans.The time of energy significant prolongation melena discharge first after matrine is oral, the muck efflux time that is caused by Oleum Ricini there is tangible retarding action, reduce discharging faecal pellet digital display work in the certain hour after the mice administration, show that matrine can play anti-diarrhea effect by suppressing enterokinesia.
Herba Moslae has pharmacological actions such as resisting pathogenic microbes, antiinflammatory, analgesic, analgesia, spasmolytic, enhance immunity.Mosla chinensis Maxim. volatile oil has stronger broad-spectrum antibacterial action, its volatile oil or water decoction all have remarkable antibacterial action to escherichia coli, staphylococcus epidermidis, group B streptococcus, Bacillus paratyphosus B, bacillus typhi murium, dysentery bacterium, diphtheria corynebacterium, pneumobacillus, Bacillus proteus, anthrax bacillus bacillus pyocyaneus and meningococcus etc., the isolated rat ileum contraction that acetylcholine is caused has obvious antagonism, can alleviate the stripped intestinal smooth muscle spasm of animal, thereby the stomachache and the diarrhoea of bacillary dysentery is had certain effect.
The bright juice of Herba Euphorbiae Humifusae, water decoction, ethanol extract, decocting ethanol extract tool broad-spectrum antibacterial action, external have the inhibition killing action to multiple dysentery bacterium, escherichia coli, Bacillus typhi, Salmonella paratyphi, bacillus pyocyaneus, bacillus enteritidis, Salmonella choleraesuls, diphtheria corynebacterium, Bacillus proteus, staphylococcus aureus, Staphylococcus albus, Streptococcus hemolyticus, micrococcus catarrhalis, leptospira etc.
Rhzoma Atractylodis Lanceae volatile oil all has bacteriostasis to staphylococcus epidermidis, golden Portugal bacterium, alpha streptococcus, group B streptococcus, streptococcus pneumoniae, bacillus pyocyaneus, escherichia coli.Rhizoma Atractylodis 70% ethanol extraction has obvious inhibitory action to mice gastric emptying, intestinal propulsion.
Pericarpium Citri Reticulatae can suppress intestinal and shrink, suppresses the intestinal propulsion motion, has the antidiarrheal effect.Pericarpium Citri Reticulatae volatile oil can promote the secretion of the normal gastric juice of rat, helps digestion.Pericarpium Citri Reticulatae decocting liquid experiment showed, outward people's ptyalin enzymatic activity is increased.
Among the present invention, the extracting solution of Herba Euphorbiae Humifusae, Herba Moslae compatibility is to escherichia coli type strain, yellow scour of piglet clinical strain B
5, C
3, 9d all has inhibitory action.The extracting solution of Radix Sophorae Flavescentis Radix Scutellariae compatibility is 0.78% to the minimal inhibitory concentration of escherichia coli type strain, and minimal bactericidal concentration is 1.56%.
Preparation of the present invention is discharged the melena time first to the mice that irritate to feed the Radix Et Rhizoma Rhei diarrhea inducing certain delay action, and can reduce mice row's melena grain number and passage of loose stools grain number, therefore diarrhea of mouse is had good inhibitory effect.Mouse small intestine carbon powder propulsion trial shows that this preparation can suppress the enterokinesia of mice, intestinal propulsion speed is slowed down, thereby play anti-diarrhea effect.
The invention belongs to pure Chinese medicinal preparation, toxic and side effects is little, and does not produce drug resistance, drug residue free.
The specific embodiment
Below in conjunction with embodiment the present invention is described further.
The present invention carries out proportioning (unit: g) according to each embodiment in the following table
| Herba Euphorbiae Humifusae | Herba Moslae | Radix Sophorae Flavescentis | Radix Scutellariae | Rhizoma Atractylodis | Pericarpium Citri Reticulatae | |
| Embodiment 1 | ?250 | ?150 | ?200 | ?150 | ?150 | ?100 |
| Embodiment 2 | ?250 | ?120 | ?300 | ?150 | ?100 | ?80 |
| Embodiment 3 | ?250 | ?150 | ?200 | ?200 | ?150 | ?50 |
| Embodiment 4 | ?300 | ?100 | ?200 | ?180 | ?120 | ?100 |
| Embodiment 5 | ?280 | ?100 | ?270 | ?200 | ?100 | ?50 |
| Embodiment 6 | ?300 | ?150 | ?200 | ?150 | ?150 | ?50 |
With embodiment 1 in detail preparation method is described in detail:
Herba Moslae 150g, Rhizoma Atractylodis 150g, Pericarpium Citri Reticulatae 100g are mixed, and distillate 2000ml is collected in the direct distillation distillation, and the medicinal liquid in the alembic of distillation back is stand-by;
With above-mentioned distillate redistillation, divide 2 sections to collect re-distilled liquid I (300ml) and II (200ml) respectively, in re-distilled liquid I, add propylene glycol 100ml; Re-distilled liquid II is stand-by;
With the medical filtration after the distillation, get filtrate I and medicinal residues;
Medicinal residues add Radix Sophorae Flavescentis 200g, Radix Scutellariae 150, Herba Euphorbiae Humifusae 250g, decoct with 10 times of water gagings and extract 2 times, and each 2h filters respectively at every turn;
Above-mentioned twice filtrate and filtrate I are merged, be concentrated into 1000ml, slowly add 3 times of amount 95% ethanol, the limit edged stirs, and leaves standstill the 48h after-filtration, gets filtrate II;
Reclaim the ethanol in the filtrate II, and filtrate II is concentrated into 500ml, add the mixed liquor 400ml of re-distilled liquid I and propylene glycol then, adjust capacity to 1000ml with re-distilled liquid II behind the mix homogeneously, packing, the oral liquid containing sophora flavescens, scutellaria and other medicine with diarrhea-stopping function that contains crude drug 1g/ml is made in sterilization.
Safety of the present invention: (be equivalent to 10g crude drug/kgw) and throw stomach and gavage, the test white mice is not had lethal effect, show that this pharmacy security is good by 10ml/kgw.The once oral maximum tolerated dose of mice is 34.97ml/kg.
Clinical efficacy of the present invention: through clinical treatment test, press 10ml/ time, every day 2 oral administrations, to the piglets of 23 trouble yellow scours, cure rate is 91.3%, average cure time is 1.5 days.To suffering from 35 piglets of Hakuri, cure rate is 94.3%, and average cure time is 2 days.
To calf bacterial diarrhea clinical efficacy, press dosage 40ml/ time, every day 2 times is oral, and 23 ill calves are treated in administration 2 days, cure rate 86.96%, improvement rate 16.70%, total effective rate are 95.66%.
Claims (1)
1. an oral liquid containing sophora flavescens, scutellaria and other medicine with diarrhea-stopping function is characterized in that, forms Herba Euphorbiae Humifusae 25-30%, Herba Moslae 10-15%, Radix Sophorae Flavescentis 20-30%, Radix Scutellariae 15-20%, Rhizoma Atractylodis 10-15%, Pericarpium Citri Reticulatae 5-10% by following component according to described percentage by weight.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100577593A CN101085084B (en) | 2007-06-26 | 2007-06-26 | Oral liquid containing sophora flavescens, scutellaria and other medicine with diarrhea-stopping function |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100577593A CN101085084B (en) | 2007-06-26 | 2007-06-26 | Oral liquid containing sophora flavescens, scutellaria and other medicine with diarrhea-stopping function |
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| Publication Number | Publication Date |
|---|---|
| CN101085084A true CN101085084A (en) | 2007-12-12 |
| CN101085084B CN101085084B (en) | 2011-06-22 |
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| CN2007100577593A Expired - Fee Related CN101085084B (en) | 2007-06-26 | 2007-06-26 | Oral liquid containing sophora flavescens, scutellaria and other medicine with diarrhea-stopping function |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810718B (en) * | 2009-11-09 | 2011-08-10 | 天津瑞贝特科技发展有限公司 | Chinese medicinal composition for curing scours and preparation method and application thereof |
| CN102613413A (en) * | 2012-04-10 | 2012-08-01 | 胡海波 | Feed and traditional Chinese medicine for treating white scour of piglets and preparation method as well as applications |
| CN102961563A (en) * | 2012-12-11 | 2013-03-13 | 青岛农业大学 | Pharmaceutical composition for treating livestock and poultry dysentery and preparation method thereof |
| CN104688883A (en) * | 2015-03-27 | 2015-06-10 | 天津市畜牧兽医研究所 | Traditional Chinese medicine composition containing humifuse euphorbia herbs, radix sophorae flavescentis and scutellaria baicalensis and preparation method thereof |
| CN104784299A (en) * | 2015-03-27 | 2015-07-22 | 施瑞客（天津）生物技术有限公司 | Fermentation traditional Chinese medicine composition containing humifuse euphorbia herb, radix sophorae flavescentis and radix scutellariae and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1879730A (en) * | 2006-04-22 | 2006-12-20 | 天津生机集团有限公司 | Chinese medicinal composition for preventing and treating baby pig diarrhea, its preparation method and use |
-
2007
- 2007-06-26 CN CN2007100577593A patent/CN101085084B/en not_active Expired - Fee Related
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810718B (en) * | 2009-11-09 | 2011-08-10 | 天津瑞贝特科技发展有限公司 | Chinese medicinal composition for curing scours and preparation method and application thereof |
| CN102613413A (en) * | 2012-04-10 | 2012-08-01 | 胡海波 | Feed and traditional Chinese medicine for treating white scour of piglets and preparation method as well as applications |
| CN102613413B (en) * | 2012-04-10 | 2013-12-11 | 胡海波 | Feed and traditional Chinese medicine for treating white scour of piglets and preparation method as well as applications |
| CN102961563A (en) * | 2012-12-11 | 2013-03-13 | 青岛农业大学 | Pharmaceutical composition for treating livestock and poultry dysentery and preparation method thereof |
| CN102961563B (en) * | 2012-12-11 | 2015-02-18 | 青岛农业大学 | Pharmaceutical composition for treating livestock and poultry dysentery and preparation method thereof |
| CN104688883A (en) * | 2015-03-27 | 2015-06-10 | 天津市畜牧兽医研究所 | Traditional Chinese medicine composition containing humifuse euphorbia herbs, radix sophorae flavescentis and scutellaria baicalensis and preparation method thereof |
| CN104784299A (en) * | 2015-03-27 | 2015-07-22 | 施瑞客（天津）生物技术有限公司 | Fermentation traditional Chinese medicine composition containing humifuse euphorbia herb, radix sophorae flavescentis and radix scutellariae and preparation method thereof |
| CN104784299B (en) * | 2015-03-27 | 2017-11-21 | 施瑞客（天津）生物技术有限公司 | A kind of fermented tcm composition of kuh-seng containing wolf's milk and radix scutellariae and preparation method thereof |
| CN104688883B (en) * | 2015-03-27 | 2018-01-16 | 天津市畜牧兽医研究所 | A kind of Chinese medicine composition of kuh-seng containing wolf's milk and radix scutellariae and preparation method thereof |
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|---|---|
| CN101085084B (en) | 2011-06-22 |
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