CN101072554A - 对于加速性骨再吸收的治疗 - Google Patents

对于加速性骨再吸收的治疗 Download PDF

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Publication number
CN101072554A
CN101072554A CNA2005800380014A CN200580038001A CN101072554A CN 101072554 A CN101072554 A CN 101072554A CN A2005800380014 A CNA2005800380014 A CN A2005800380014A CN 200580038001 A CN200580038001 A CN 200580038001A CN 101072554 A CN101072554 A CN 101072554A
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CN
China
Prior art keywords
alkyl
group
amino
agonist
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800380014A
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English (en)
Chinese (zh)
Inventor
P·菲什曼
S·巴尔耶胡达
L·麦迪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Can Fite Biopharma Ltd
Original Assignee
Can Fite Biopharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Can Fite Biopharma Ltd filed Critical Can Fite Biopharma Ltd
Publication of CN101072554A publication Critical patent/CN101072554A/zh
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA2005800380014A 2004-11-08 2005-11-08 对于加速性骨再吸收的治疗 Pending CN101072554A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62556404P 2004-11-08 2004-11-08
US60/625,564 2004-11-08

Publications (1)

Publication Number Publication Date
CN101072554A true CN101072554A (zh) 2007-11-14

Family

ID=36001028

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800380014A Pending CN101072554A (zh) 2004-11-08 2005-11-08 对于加速性骨再吸收的治疗

Country Status (9)

Country Link
EP (1) EP1811982A1 (ko)
JP (1) JP2008519029A (ko)
KR (1) KR20070085839A (ko)
CN (1) CN101072554A (ko)
AU (1) AU2005302090A1 (ko)
BR (1) BRPI0517639A (ko)
CA (1) CA2586845A1 (ko)
MX (1) MX2007005525A (ko)
WO (1) WO2006048884A1 (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102427819A (zh) * 2009-05-17 2012-04-25 坎-菲特生物药物有限公司 用于减小眼内压的a3腺苷受体激动剂

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006321165B2 (en) * 2005-11-30 2010-04-22 Can-Fite Biopharma Ltd. Use of A3 adenosine receptor agonist in osteoarthritis treatment
WO2008111082A1 (en) 2007-03-14 2008-09-18 Can-Fite Biopharma Ltd. Process for the synthesis of ib-meca
US8183225B2 (en) * 2007-11-08 2012-05-22 New York University Inhibition of bone resorption using medical implants containing adenosine receptor antagonists
MX356509B (es) 2011-12-22 2018-05-30 Alios Biopharma Inc Nucleósidos sustituidos, nucleótidos y análogos de los mismos.
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000072799A2 (en) * 1999-05-27 2000-12-07 The University Of Virginia Patent Foundation Method and compositions for treating the inflammatory response
IL133680A0 (en) * 1999-09-10 2001-04-30 Can Fite Technologies Ltd Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
US7141553B2 (en) * 2002-11-19 2006-11-28 Can-Fite Biopharma Ltd. Israel A3AR agonists for the treatment of inflammatory arthritis
GB0305150D0 (en) * 2003-03-07 2003-04-09 Cambridge Biotechnology Ltd Use of therapeutic compounds
EA011099B1 (ru) * 2004-03-05 2008-12-30 Кембридж Байотекнолоджи Лимитед Терапевтические соединения

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102427819A (zh) * 2009-05-17 2012-04-25 坎-菲特生物药物有限公司 用于减小眼内压的a3腺苷受体激动剂

Also Published As

Publication number Publication date
MX2007005525A (es) 2007-07-05
BRPI0517639A (pt) 2008-10-14
AU2005302090A1 (en) 2006-05-11
JP2008519029A (ja) 2008-06-05
KR20070085839A (ko) 2007-08-27
EP1811982A1 (en) 2007-08-01
CA2586845A1 (en) 2006-05-11
WO2006048884A1 (en) 2006-05-11

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Open date: 20071114