CN101069769A - Needle-free pain-relieving instrument and its setting method - Google Patents

Needle-free pain-relieving instrument and its setting method Download PDF

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CN101069769A
CN101069769A CN 200710021061 CN200710021061A CN101069769A CN 101069769 A CN101069769 A CN 101069769A CN 200710021061 CN200710021061 CN 200710021061 CN 200710021061 A CN200710021061 A CN 200710021061A CN 101069769 A CN101069769 A CN 101069769A
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pulse
output
frequency
instrument
stimulation
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CN 200710021061
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韩济生
刘亦鸣
郝学元
刘希蒙
戴�峰
万绍瑾
陆显革
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南京济生医疗科技有限公司
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Abstract

The present invention relates to a needleless pain-alleviating apparatus. It is characterized by that said needleless pain-alleviating apparalus can output dilatational wave with 2H2 low-frequency and 100 plus or minus 10H2 high-frequency and uses said dilalational wave as electric pulse stimulation signal so as to attain the goal of alleviating pain. Said needleless pain-alleviating apparatus includes the following several portions: microcontroller, low-frequency signal generator, high-frequency signal generator, low-pass filter and mos switch. Said invention also provides the working principle of said meedleless pain-alleviating apparatus and its concrete operation method.

Description

一种无针镇痛仪器及其设置方法 A non Analgesia provided a method and apparatus

技术领域 FIELD

本发明涉及镇痛设备的设置方法和仪器,也包括人体植物神经刺激的方法和设备。 The present invention relates to a method and apparatus is provided analgesia equipment, also includes a method and apparatus for the human autonomic nervous stimulation.

背景技术 Background technique

针灸用于治疗多种急性和慢性疾病,在中国已有几千年历史。 Acupuncture is used to treat a variety of acute and chronic diseases, thousands of years of history in China. 特别是针灸的止痛作用,有时收到神奇的效果,但其作用原理鲜为人知。 In particular, the analgesic effect of acupuncture sometimes receive a magical effect, but its mechanism is known. 中医学认为,人体的功能由经络系统和运行于其中的气血来控制,针灸通过通经活血达到疗病保健的目的。 In medicine, the body's functions in the blood which is controlled by the meridian system and run through acupuncture pass through the blood to reach the purpose of curing diseases health care. 我国医学研究者在全力探索经络本质的同时,也试图用现代医学手段和理论来解释针灸作用原理。 Our medical researchers at the same time fully exploring the essence of meridian, also tried to explain the principles of acupuncture and moxibustion theory and modern medical means. 本世纪五十年代后期,有人用针刺穴位产生止痛效果的临床试验,并设计应用针刺方法来预防外科手术的疼痛,称之为“针刺麻醉”,在国内外引起极大兴趣。 This late fifties, was produce analgesic effects in clinical trials with acupuncture, and design applications of acupuncture methods to prevent surgical pain, called "acupuncture anesthesia", aroused great interest at home and abroad. 经研究发现,镇痛作用的产生需要20-30分钟的诱导期,而其消失则遵循一定的半衰期(约16分钟)。 The study found that the analgesic effect requires 20-30 minute induction period, and its disappearance follow certain half-life (about 16 minutes). 从这一规律他们提供假设,认为针刺穴位可以会引起脑内产生某种化学物质发挥镇痛作用。 From this rule them hypothesis that acupuncture can cause the brain to produce some chemical substances analgesic effect. 这一假设在兔子和大白鼠的实验中得到了证明。 This hypothesis was proved in experiments in rabbits and rats. 后来发现在穴位上施加低频和高频的电脉冲刺激可以在脑内生成和分泌出多种作用类似吗啡的化学物质,低频电针释放的脑啡肽(5个氨基酸组成)和内啡肽(31个氨基酸组成),高频释放的是强啡肽(17个氨基酸组成)。 Later found low and high frequency is applied to electrical stimulation can be morphine-like chemicals, low frequency needle release of enkephalin (5 amino acids) production and secretion in the brain and endorphins acts on a variety of points ( 31 amino acids), a high frequency is released dynorphin (17 amino acids). 如果使用低频和高频,则可使上述三种物质即脑啡肽、内啡肽、强啡肽同时释放出来,发挥最强的镇痛作用。 If low and high frequencies will enable the three materials i.e. enkephalins, endorphins, dynorphin released simultaneously play the strongest analgesic effect. 这一系列实验初步揭示了针刺镇痛的原理。 This series of preliminary experiments revealed the principle of acupuncture analgesia. 本发明人研制的“韩氏穴位刺激仪(HANS)”,简称韩氏仪,它发出的特定电脉冲既可以通过刺入穴位内的金属针进行刺激,也可以把电极贴在穴位皮肤的表面,使电流透过皮肤进入穴位。 The present invention is developed "Han points STIMULATOR (HANS)", referred to as HAN device, it sends a specific electrical pulse stimulation either by puncturing the metal needle in the acupuncture points, the electrode may be attached to the surface of the skin points so that the current through the skin into the points. 在后一情况下使用,可以免去扎针,而达到同样的治疗效果,被称为“无针的针灸仪。”1980年世界卫生组织曾提出43种病症可以用针灸疗法进行治疗,根据目前的资料,凡是针灸能治疗的,韩氏仪也都可治疗,从而大大简化了针灸疗法的应用,加速了针灸疗法在全世界的推广应用。 In the latter case it can be removed from an acupuncture treatment, and achieve the same therapeutic effect, known as "needle-free acupuncture instrument." In 1980 the World Health Organization has proposed 43 kinds of diseases can be treated with acupuncture, according to the current information, who can acupuncture treatment, Han also can treat instrument, which greatly simplifies the use of acupuncture to accelerate the popularization and application of acupuncture in the world. 针刺镇痛的效果如何定量地加以表达,是一个学术上的难题,其原因之一是针刺的手法各不相同,很难加以标准化,韩氏仪的应用使这一问题得到解决,因为该仪器输出脉冲的频率、电流波型、时间都以数字式精确显示。 How effective acupuncture analgesia be expressed quantitatively, is a problem academic, acupuncture is one of the reasons the tactics vary, it is difficult to be standardized, Han instrument application so that this problem is resolved, because the output pulse frequency of the instrument, a current waveform, the exact time in the digital display.

从中枢神经化学角度,系统研究针刺镇痛原理,发现针刺可动员体内的镇痛系统,释放出阿片肽、单胺类神经递质等,发挥镇痛作用;不同频率的电刺激可释放出不同种类阿片肽;针效的优劣取决于体内镇痛和抗镇痛两种力量的消长。 From the chemical point of the central nervous system the principle of acupuncture analgesia studies, found that acupuncture analgesia can be mobilized in vivo systems, release of opioid peptides, and other monoamine neurotransmitters, analgesic effect; Electrical stimulation frequencies releasable different types of opioid peptides; needle analgesic effect in vivo depends on the merits of the two forces and the anti-analgesia fluctuation. 这些世界领先的研究成果,得到了国际科学界的高度评价,取得了累累硕果,推进了神经科学的发展,推动了针灸疗法走向世界。 These world-leading research, has been highly praised the international scientific community, achieved fruitful results, and promote the development of neuroscience, promoting acupuncture to the world.

现有的国内外一般仪器输出的脉冲宽度都是恒定的,如脉冲幅度不变,频率增高到15Hz以后,因刺激脉冲过密,肌肉随脉冲刺激收缩,却无足够时间放松回到原位,相邻脉冲对肌肉刺激的叠加,最终成为疼痛难忍的强直(痉挛)。 The pulse width of a conventional domestic and general instrument output is constant as a constant amplitude pulse, increased frequency of 15Hz to later, too close due to the stimulation pulse, with the muscle stimulation pulse shrinkage, but no sufficient time to relax back into place, adjacent muscle stimulation pulse superposition, eventually became the pain of stiffness (spasticity). 脉冲频率增高,其刺激强度随之增大。 Pulse frequency increases, the intensity of which stimulates increases.

但无针的无针镇痛仪器的设置和仪器还未有公开。 However, needle-free analgesia instrument and instrument settings have not been disclosed. 包括人体植物神经刺激的方法和设备亦无公开。 Including human autonomic stimulation nor disclosed method and apparatus.

发明内容 SUMMARY

本发明目的是:提出一种无针的无针镇痛仪器的设置和仪器,尤其是结合东方医学与西方医学治疗疼痛的方法,提出一种无针的无针镇痛仪器产品,本仪器采用微控制器操作所有治疗参数并控制治疗的全过程,并通过液晶屏等显示给用户,使用户对该产品的操作能做到精准和实时。 Object of the present invention is: to provide a needle-free analgesia instrument and instrument settings, especially in combination Oriental Medicine and Western Medicine method of treating pain, to provide a needle-free products acupuncture analgesia instrument, the instrument used the microcontroller controls the operation of all treatment parameters and the whole course of treatment, and the like via the LCD display to the user, so the user can do the operation of the product in real time and accurately. 同时为顽痛病人解除痛苦。 At the same time relieve the pain as stubborn pain patients. 尤其是还应用于对人体植物神经产生有益刺激的方法和设备。 In particular, also have a beneficial stimulus applied to the method and apparatus of the human autonomic nervous.

本发明目的是这样实现的:无针镇痛仪器的设置方法,无针镇痛仪器采用输出为2Hz低频和高频100Hz±10Hz的疏密波为电脉冲刺激信号,电脉冲刺激信号且以恒流源方式输出,实现方式是:低频和高频的信号分别通过(两路)脉宽调制PWM信号产生,且从0-5V的连续可调输出,也可以是单路输出交替变换的低频和高频信号。 Object of the present invention is achieved: no analgesia is provided a method of instrument, the instrument uses no analgesia output 2Hz 100Hz ± 10Hz low and high frequency compressional wave electrical pulse stimulation signals, electrical stimulation pulse signal and a constant current source output mode, implementations are: low and high frequency signals, respectively by (two) pulse-width modulation (PWM) signal is generated and outputted continuously adjustable from 0-5V may be a low-frequency alternating single output and a high frequency signal.

实现发明的具体实施方式是另外控制开关管的打开与关断产生脉冲信号,利用运算放大器放大,根据工作电源与电流互感器,产生正负交替的恒定电流,两路信号互相独立。 DETAILED DESCRIPTION invention to achieve further embodiment the control switch is opened and off tube generates a pulse signal, using the operational amplifier, according to the operating power supply and a current transformer to produce alternating positive and negative constant current, independent of each other two signals.

本发明的输出是:每种频率的持续时间为3s±0.5s的设计具有良好的效果。 Output of the present invention are: the duration of each frequency is 3s ± 0.5s design with good results.

本发明以恒流源方式输出,确保治疗效果不因皮肤电阻差异而不同;优选的波形能使神经中具有镇痛作用的三种吗啡态物质同时释放出来,发挥最强的止痛效果。 In the present invention, the output of the constant current source manner, to ensure that treatment is not due to differences in skin resistance varies; preferably Three waveforms can neural state substance having analgesic effect of morphine is released simultaneously play the strongest analgesic effect. 另外当频率升高时,脉宽自动变窄,成为典型的“TENS”波形,所以本产品可以兼具“TENS”与针灸之优势,除了以上主要特色本机器还有定时关机、零输出自动关机、电池电量显示、锁定按键、背光照明等多项创新之处,是用户能够随心所欲的操作机器,从而使治疗效果达到最佳。 In addition, when the frequency is increased, the pulse width is narrowed automatically, a typical "TENS" waveform, so that this product can be both "TENS" acupuncture and advantages, in addition to the above main features of the machine as well as regular shutdown, automatic shutdown zero output , battery display, key lock, backlighting and many other novelties that the user can arbitrary operation of the machine, so that the optimal therapeutic effect.

本发明无针镇痛仪器的构成,包括微控制器,混合信号,并用于控制输出波形、频率幅度以及脉宽的控制,响应按键,驱动LCD显示、运算放大器等构成;Q3,Q4,Q5(三极管),D4(线性调整管),S6(开关管)组成电源电路,控制开关管以及电压转换,另外控制开关管的打开与关断产生脉冲信号,并利用运算放大器放大,根据工作电源与电流互感器,产生正负交替的恒定电流,两路信号互相独立。 No analgesia apparatus constituting the present invention, including a microcontroller, mixed signal, and for controlling the output waveform, amplitude and frequency of the control pulse width in response to the button, LCD display driver, an operational amplifier and the like; Q3, Q4, Q5 ( transistor), D4 (linear regulator), S6 (switch) composed of a power supply circuit, a control switch and a voltage conversion, while the control switch is turned on and off to generate a pulse signal tube, and using the operational amplifier, according to the power supply and the current transformer, generating alternating positive and negative constant current, independent of each other two signals. 微控制器产生两路独立的PWM信号(PWM_A、PWM_B),经阻容低通滤波(R16、R17、R18、R19、C1、C2)形成0-5V的电压信号。 The microcontroller generates two independent PWM signal (PWM_A, PWM_B), formed by the voltage signal 0-5V RC low-pass filter (R16, R17, R18, R19, C1, C2). 经过低通滤波再连接mos开关,同时微控制器精确定时信号(CP1、CP2)作为4066的开关信号也被送入,4066输出治疗波形(PWM_A_L/R、PWM_B_L/R)信号,并连接运算放大器D22输出放大,再经两组推挽三极管Q1、Q2或Q6、Q7轮流导通,两组推挽三极管输出至电流互感器D3、D5,电流互感器的输出产生正负间隔的脉冲波。 The low pass filtered reconnection mos switches, while the microcontroller accurate timing signals (CP1, CP2) is also fed as a switching signal 4066, 4066 treatment output waveform (PWM_A_L / R, PWM_B_L / R) signal, and is connected to an operational amplifier D22 of the output amplifier, and then the two push-pull transistors Q1, Q2 or Q6, Q7 turns oN, D5 D3 output current transformer,, two push-pull transistor current transformer to produce the output positive and negative pulse interval.

本发明的特点是:多项研究表明,在外科手术中应用本发明输出的疏密波,可使麻醉药品用量减少40-50%,在手术后疼痛的控制中;对植物神经具有良好的刺激作用。 Feature of the present invention are: a number of studies have shown that application of compressional wave output of the present invention in surgery, narcotic drugs can decrease the amount of 40-50%, in the control of post-operative pain; good stimulation of the autonomic effect. 本发明方法的应用也可使镇痛药用量减少40%以上。 Application of the method of the present invention also allows reduction of analgesia more than 40%. 这是一种定量的表示方法,可以在科学上进行验证。 This is a quantitative representation may be verified in science. 本发明凝聚了发明人40多年的理论和学术研究。 The present invention embodies 40 years of theoretical and academic inventor.

本发明仪器还具有下述特点:1)电脑精确控制和显示所有刺激参数:由电脑软硬件及外围基准准确控制所有刺激参数,全按键操作,使用者可以方便和准确地调节,数据以数码定量显示,符合国际通用标准,科研结果能无障碍地进行国际交流。 Apparatus of the present invention also has the following characteristics: 1) accurate control of the computer and display all stimulation parameters: accurate control of all the stimulation parameters by the computer hardware and software and peripheral reference, all the key operation, the user can easily and accurately adjusted, quantitative data in digital display, in line with internationally accepted standards, research results can be accessible to international exchanges. 克服了当前所有同类仪器无法提供合理和准确定量的缺陷。 Overcome all current similar instruments can not provide a reasonable and accurate quantification of defects.

2)输出脉冲采用峰值电流计量,采用恒流电路输出:不论在用皮肤或毫针电极治疗时,其刺激强度均用脉冲峰值电流计量,符合国际电生理学的计量要求。 2) using the output pulse peak current meter, the constant current circuit output: when whether or needle electrodes for skin treatment, which stimulates both a pulse peak current intensity measurement, the measurement in line with the requirements of international electrophysiology. 为确保刺激过程中脉冲峰值电流值不因机体极化等因素引起的电阻变化而改变,采用特殊的恒定电流输出电路,确保输出电流恒定不变。 To ensure the resistance change during stimulation pulse-peak-current value is not due to the body caused by factors such as the polarization changes, using a special constant current output circuit, ensure that the output current is constant. 克服了当前所有同类仪器无定量、或错以电压为计量单位,同时不能保障输出电流恒定的缺陷。 Overcome all currently no quantitatively similar equipment, or to the wrong voltage unit of measurement, can not guarantee a constant output current defect.

恒流输出电路不但使得被刺激穴位的胀、重得气感强,还避免了通常仪器非恒流输出电路的尖峰脉冲引起的表皮刺痛。 Constant current output circuit such that not only stimulate the acupuncture points of inflation, too heavy and strong sense of gas, but also to avoid skin irritation instrument generally non-spike caused by the constant current output circuit.

3)采用完全对称的双向矩形脉冲波:保证成对电极下刺激量完全相同。 3) a fully symmetric bi-rectangular wave pulse: the same as the amount of stimulation to ensure that the lower pair of electrodes. 彻底消除了通常仪器采用双向不对称脉冲,在成对电极下,刺激强度不对称的通病。 Complete elimination of the usual two-way asymmetrical pulse instrument, at the pair of electrodes, a common problem asymmetric stimulus intensity. 并确保电刺激的直流成分为零,杜绝了有些仪器造成毫针在体内断针的事故。 And to ensure that electrical stimulation of the DC component is zero, resulting in some instruments to eliminate the needle in the needle body accident.

4)将针刺镇痛40余年研究的精华——优选的2/100Hz疏密波,用于临床:采用了具有特定时间间隔的2/100Hz(赫兹)疏密波,能使神经系统中具有镇痛功能的三种吗啡类物质(内啡肽、脑啡肽、强啡肽)同时释放出来。 4) The acupuncture analgesia study the essence of 40 years - preferably 2 / 100Hz compressional wave, clinical: using 2 / 100Hz (Hz) compressional wave having a particular time interval, the nervous system can have three kinds of morphine-like substances (endorphins, enkephalins, dynorphin) while the analgesic release function. 通过三者的协同作用,发挥出最强烈的止痛效果。 By synergy of the three, played the strongest analgesic effect. 此波形的功效得到国外研究的重复证明,已被欧洲采用,且命名为HANS波。 Efficacy of this waveform is repeated by foreign research proves, has been used in Europe, and is named HANS wave.

5)波宽随频率而自动变化,确保本发明特色的2/100Hz疏密波得以实现:一定强度电脉冲列的刺激量,既取决于单个脉冲的宽度,也决于相邻脉冲刺激作用的迭加——频率。 5) automatic pulse width change with frequency, ensuring 2 / 100Hz compressional wave characteristics of the present invention is achieved: the amount of electrical stimulation pulse train of constant intensity, both depend on the width of a single pulse, also depends on the stimulation of adjacent pulses superposition - frequency. 当频率升高时,脉宽应自动变窄,当频率降低时,波宽应自动变宽,才能使低(2Hz)和高(100Hz)的频段都有相近的刺激量。 When the amount of the stimulation frequency is increased, the pulse width should be automatically narrowed, when the frequency decreases, pulse width should be broadened automatically to a low (2Hz), and high (100Hz) of the frequency band are similar. 同时较窄的脉宽是典型的”TENS”(经皮神经电刺激)波形;较宽的又是典型的“针灸样”波形。 While the pulse width is narrower typical "TENS" (transcutaneous electrical nerve stimulation) waveform; wide and is a typical "acupuncture-like" waveform. 因此当采用2/100Hz疏密交替波时,本发明无针镇痛仪器(治疗仪,亦称韩氏仪)可兼具TENS与针灸之优势。 Therefore, when using the 2 / 100Hz compressional waves alternately, the present invention is no analgesia instrument (treatment instrument, also called HAN meter) can be the advantages of both the TENS and acupuncture. 波宽随频率而自动变化技术的应用克服了通常仪器采用固定脉宽带来的高频端过强或低频端过弱而感到的不适,是世界首创。 Pulse width with the frequency changes automatically applied technology overcomes instrument generally fixed frequency pulse width to bring the low-frequency end of too strong or too weak end feel discomfort, is the world's first.

附图说明 BRIEF DESCRIPTION

图1无针镇痛仪器系统结构示意图图2无针镇痛仪器控制部分电路结构图图3无针镇痛仪器模拟部分电路结构图图4无针镇痛仪器软件流程图图5三种不同矩形脉冲作用的对象或结果示意图图6:不对称双向脉冲信号示意图图7:两种对称双向电脉冲信号示意图图8矩形脉冲信号示意图图9等效为电阻和电容组成的网络,由神经纤维去极化的条件等效图10恒压供电时,瞬态电阻增大使刺激电流下降示意图图11在体表皮肤上加以恒压和恒流的电脉冲的示意图具体实施方式参见电原理图(图2、图3)图2上电路板主要负责波形的产生、波形频率幅度以及脉宽的控制,LCD显示和按键处理等,图3为下电路板主要负责电压电流的变换、电流放大、正负波形产生、开关机控制等。 Three different non-rectangular 5 3 Analgesia Instrument configuration diagram of the analog part of the circuit in FIG. 4 without analgesia instrument software configuration diagram of a flowchart of part of the circuit of FIG. 1 FIG no analgesia system configuration diagram of the instrument without Analgesia Instrument Control 2 pulsed graph showing the results of an object or 6: a schematic view of an asymmetric bidirectional pulse signals 7: 9 network consisting of resistors and capacitors is equivalent to two symmetrical bidirectional pulse signals of FIG. 8 a schematic diagram of a rectangular pulse signal, a nerve fiber depolarization when the constant voltage power supply 10 of FIG equivalent conditions, a transient increase of stimulation current drop resistor 11 a schematic diagram of a constant current and constant voltage electrical pulse to be on the skin surface DETAILED DESCRIPTION Referring to FIG electrical schematic diagram (FIG. 2 embodiment, FIG. 3) FIG. 2 is mainly responsible for controlling the generation of the circuit board, and pulse amplitude waveform frequency waveform, LCD display and key processing, the circuit board 3 is primarily responsible for converting the voltage and current, current amplification, waveform generating positive and negative , switch control.

图2中微控制器D1采用台湾Elan的EM78P468N,8位混合信号单片机用于控制输出波形、频率幅度以及脉宽的控制,响应按键,驱动LCD显示等。 FIG 2 microcontroller D1 of Taiwan Elan EM78P468N, 8-bit hybrid signal SCM for controlling the output waveform, amplitude and frequency of the control pulse width in response to the key, to drive the LCD display.

其中Q3,Q4,Q5(三极管),D4(78L05线性调整管),S6(开关)组成电源电路负责控制开关机以及电压转换电路,当S6被按下Q3导通,D4转换出5V电压,微控制器被上电并开始工作,并维持Q3导通,当需要关机时微控制器检测S6被按下的时间达到一定的时长以后通过HOLD_t关断Q4,Q5以及Q6使整个机器的电源关断。 Wherein Q3, Q4, Q5 (triode), D4 (78L05 linear regulator), S6 (switch) responsible for controlling the composition of the power switch circuit and a voltage conversion circuit S6 is pressed when Q3 is turned on, D4 converts the voltage of 5V, micro after the controller is powered on and start working, and Q3 is turned on is maintained, when the need to shut down the microcontroller detects S6 is pressed up to a certain time duration by HOLD_t off Q4, Q5 and Q6 of the entire power-off machine . 开机后通过调节图1中S1-S4,微控制器产生两路独立的PWM信号(PWM_A、PWM_B),经过低通滤波(R16、R17、R18、R19、C1、C2)形成0-5V的电压信号,整机的电流调节有40档,所以每增加一档输出微控制器脉宽调制信号输出经滤波后增加0.125V,然后信号送入mos开关(4066,图2中D11),同时微控制器经过内部精确定时计算输出的信号(CP1、CP2)作为4066的开关信号也被送入,在时序上调整过的脉宽调制信号变成了最初的治疗波形(PWM_A_L/R、PWM_B_L/R),之后信号经过运算放大器D22输出放大,最后经过三极管Q1、Q2或Q6、Q7轮流导通并通过特制的电流互感器D3、D5就产生了正负间隔的脉冲波,并形成不同的频率(2Hz,15Hz,50Hz,100Hz等),最后通过CON1、CON2连接的导线与电极片形成最终的治疗波形。 By adjusting the boot S1-S4 in FIG. 1, the microcontroller generating two independent PWM signal (PWM_A, PWM_B), after low-pass filtering (R16, R17, R18, R19, C1, C2) forming the voltage 0-5V current signal, is adjusted the whole file 40, so that each additional output of the microcontroller after a file outputting the filtered pulse width modulated signal increases 0.125V, and then fed to the signal mos switches (4066, D11 in FIG. 2), while the control micro after an internal accurate timing signals (CP1, CP2) is calculated as the output of the switching signal 4066 is also fed, at the timing adjusted pulse width modulated signal becomes a waveform initial treatment (PWM_A_L / R, PWM_B_L / R) after the output signal is amplified through the operational amplifier D22, and finally through the transistor Q1, Q2 or Q6, Q7 and alternately conducting current through a special transformer D3, D5 generates a negative pulse interval, and (2Hz form different frequencies , 15Hz, 50Hz, 100Hz, etc.), and finally to form the final treatment by CONl waveform, and a wire connected to the electrode sheet CON2.

另外精密电压比较器im393负责监视电压,当电源电压低于标准电压时,微控制器会做出相应的处理,用户可以及时更换电池。 Further im393 precision voltage comparator monitors the voltage when the supply voltage is lower than the standard voltage, the microcontroller will make corresponding processing, the user can change the batteries.

1、定时的控制技术的研究、开发:本发明利用特定输出波形,采用当代计算软件技术,设计了具有自主知识产权的专有软件,控制微控制器内部的两个定时器,一个作为全局的实时时钟,一个作为频率改变的间隔定时器。 1, the timing control Research, Development: The present invention takes advantage of a particular output waveform, contemporary technology calculation software, a proprietary software design proprietary, controlled by two timers internal microcontroller, a global as real-time clock, a frequency change as an interval timer.

实时时钟作为全局时钟用于整个机器的定时包括键盘锁定计时,背光延时定时,自动关机定时、按键扫描等;间隔定时器作为频率改变定时,控制频率间隔相互交替的时间,这个时间根据韩式波形而特别指定。 Real-time clock is used as a global clock timing of the entire machine, including a keyboard locking timer, the backlight delay timing of automatic shutdown timing of the key scanning and the like; the frequency change timing interval timer, the control frequency alternating intervals of time, this time according to the Korean waveform specified.

2、波宽随频率而自动变化和优选的疏密波:当频率升高时,波宽自动变窄,成为典型的”TENS”(经皮神经电刺激)波形;当频率降低时,波宽自动变宽,成为典型的“针灸样”刺激。 2, pulse width and frequency changes automatically with the preferred density wave: When the frequency increases, the pulse width is narrowed automatically, a typical "TENS" (transcutaneous electrical nerve stimulation) waveform; when the frequency decreases, pulse width automatic widened, becoming a typical "acupuncture-like" stimulus.

尤其是具有特定时间间隔的2/100Hz(赫兹)疏密波,能使神经系统中具有镇痛功能的三种吗啡类物质(内啡肽、脑啡肽、强啡肽)同时释放出来。 Especially 2 / 100Hz (Hz) compressional wave having a particular time interval, the nervous system can Three substances morphine (endorphins, enkephalins, dynorphin) with analgesic function simultaneously released. 通过三者的协同作用,发挥出最强烈的止痛效果。 By synergy of the three, played the strongest analgesic effect.

经本发明人在针刺镇痛研究反复试验验证,最有效的刺激参数,就是2Hz、100Hz和2/100Hz;2Hz可激发脑和脊髓中产生内吗啡肽、脑啡肽、和内啡肽三种内源性吗啡;100Hz产生强啡肽这一种内源性吗啡。 By the present invention in Acupuncture verification trial study, the most effective stimulation parameters is 2Hz, 100Hz, and 2 / 100Hz; 2Hz excitable generated in the brain and spinal cord of morphine, enkephalins, and endorphins three the species endogenous morphine; 100Hz dynorphin generating this kind of endogenous morphine. 尤其是2/100Hz两种频率相互交替的疏密波(DD波),可以同时产生4种内源性吗啡。 Especially 2 / 100Hz alternating two frequencies compressional wave (DD wave) can be generated simultaneously four kinds of endogenous morphine. 人体和动物实验表明,每3s±0.5s秒钟交替的设计,最符合内源性吗啡(神经介质)半衰期的要求,可获最佳效果。 Human and animal experiments show that every 3s ± 0.5s seconds alternate design, the most in line with the requirements of endogenous morphine (neurotransmitters) half-life, will receive the best results.

为了有效利用多种波形在针刺和理疗中的使用,2、4导仪分别提供了以下的波形: To effectively use a variety of waveforms used in the therapy and acupuncture, 2,4 conductivity meter are provided the following waveforms:

■不同频率下,自动调节脉冲宽度一般仪器如果输出2和100Hz交替的疏密波,频率相差50倍,很难正常工作。 ■ at different frequencies, automatically adjust the pulse width and general instrument 2 if the output compressional wave alternating 100Hz, a frequency difference of 50 times, is difficult to work. 为使优选的每3秒钟自动交换的2/100Hz能正常工作,本发明(韩氏)仪产品采用了在不同频率下,脉冲宽度自动调节的技术,频率升高时,脉宽自动变窄,频率降低时,脉宽自动变宽,实现了在频率相差50倍的情况下,对人体肌肉等刺激强度的自动调节,确保2Hz和100Hz都能有效刺激,实现同时释放4种内啡肽,这是一种创新的设计。 For every 3 seconds, preferably automatic exchange of 2 / 100Hz to work properly, the present invention (HAN) instrument using the products at a different frequency, the pulse width of automatic adjustment in the art, when the frequency increases, the pulse width is narrowed automatically when the frequency decreases, the pulse width is widened automatically achieved in the case where a frequency difference of 50 times, human muscle stimulation intensity adjusted automatically, to ensure effective stimulation can 2Hz and 100Hz, achieved while the release of four kinds of endorphins, this is an innovative design.

其设计如下:每个电脉冲的刺激强度取决于脉冲的宽度和幅度,宽度或幅度的增大,都使刺激增强。 Which is designed as follows: the width and amplitude of each stimulus intensity electrical pulse depends on the pulse width or amplitude is increased, so that both stimulate enhanced. 电脉冲也对电极下的肌肉产生刺激,2Hz刺激时,可见肌肉收缩和返回的跳动,脉冲强度越大,跳动越大。 Also produce electrical pulses in the muscle stimulation electrodes, when 2Hz stimulation, muscle contraction and return of the visible jitter, the greater the pulse intensity, the greater the jitter.

本发明的2/100Hz疏密波的频率突变50倍,如果脉宽保持不变,刺激强度将相差悬殊。 Frequency 2 / 100Hz compressional wave mutant of the present invention 50 times, if the pulse width remains the same, the differences between the stimulus intensity. 换言之,若脉冲幅度恰到好处地满足2Hz的刺激强度,转为100Hz时,必痛苦难忍。 In other words, if the pulse amplitude just right to meet the stimulus intensity of 2Hz, into 100Hz, the pain will be unbearable. 反之,如果在100Hz时强度合适,转到2Hz时,强度就会很低得没用。 On the contrary, if the intensity when appropriate 100Hz, time to 2Hz, will be very low intensity was useless. 只有在不同频率下,自动调节脉冲宽度,才使2/100Hz疏密波正常工作。 Only at different frequencies, automatically adjust the pulse width, so that only 2 / 100Hz compressional wave work.

■同时具有电针(EA)与经皮神经电刺激(TENS)之优势电针(EA)与经皮神经电刺激(TENS)之特点如下表: ■ having both EA (EA) and transcutaneous electrical nerve stimulation (TENS) Advantage of EA (EA) and transcutaneous electrical nerve stimulation (TENS) of the characteristics as follows:

本发明治疗仪系列产品兼具两者的特点。 Therapy device of the present invention combines features of both series. 当频率升高时,脉冲宽度自动变窄,成为典型的”TENS”;当频率降低时,脉冲宽度自动变宽,成为典型的“EA”。 When the frequency increases, the pulse width is narrowed automatically, a typical "TENS"; when the frequency decreases, the pulse width is widened automatically, a typical "EA". 因此同时具有TENS与EA之优势。 So also has the advantage of TENS and EA.

应用EA时,毫针刺入机体,所需刺激电流远低于TENS。 Application EA, mm needle into the body, the required stimulation current is far lower than TENS. 因此我们为实际使用设计的台式4导仪器,输出强度分为“针”、“皮”两档,前者最高强度是10mA,后者是50mA,不论用何种电极均可获得细致、舒适的调节。 Therefore, we guide instrument 4, the output intensity is divided into "needle", "skin" two tranches of actual use for the desktop design, the former highest intensity is 10mA, which is 50mA, no matter what kind of electrode can be used to obtain detailed, comfortable adjustment .

3、对称双向电脉冲技术的研究、开发:单向矩形脉冲,其电流经一对电极(毫针、皮肤电极)流入和流出机体,构成完整的回路。 3, symmetrical bi-directional pulse technology research, development: unidirectional rectangular pulse, which current through a pair of electrodes (needle, skin electrodes) into and out of the body to form a complete circuit. 脉冲电流流入处为正电极,流出处为负电极,负电极下的神经纤维才被刺激产生兴奋,正电极下不产生兴奋。 A pulse current flows into the positive electrode, a negative electrode flow source, stimulation of nerve fibers was only excited to produce a negative electrode, a positive electrode does not generate excitement lower. 单极性的脉冲电流总是单向流动,故只在负电极处引起刺激,另一个正电极只起导电充当无关电极,没有治疗作用,电极的利用率是50%(图5中A所示)参见图5三种不同矩形脉冲作用的结果。 Unipolar pulse current is always unidirectional flow, so the only cause irritation at the negative electrode, the other serving as a positive electrode conductive only as the indifferent electrode, no therapeutic effect, the utilization of the electrode is 50% (A shown in FIG. 5 ) 5 the results of three different rectangular pulsed see FIG.

一般仪器为降低成本,简化电路,发出正、负不对称的双向脉冲(图6所示),即由单方向的不规则的矩形脉冲波和反方向的尖脉冲组成,两个脉冲的形状和幅度都不对称,经常造成两个电极的刺激:一有一无,或一强一弱,使用不便,影响效果。 General instrument to reduce costs, simplify the circuit, emitted positive and negative asymmetrical biphasic pulse (FIG. 6), i.e. a single direction, the rectangular irregular pulse spikes in the opposite direction and the composition, shape, and two pulses amplitude are asymmetric, often cause irritation of the two electrodes: one has a free, or a strong and weak, inconvenient to use, affect the results.

“对称双向电脉冲”有大小相同、方向相反的两个矩形电脉冲交替工作,电路的两个电极轮流充当正和负极,交替得到相同强度的刺激,没有“一有一无,一强一弱”的问题,电极的利用率是100%。 "Symmetrical bidirectional pulses" have the same magnitude and direction of the two rectangular electric pulses are alternately work contrary, two electrode circuit turns to act as the positive and negative electrodes alternately to obtain the same intensity stimulation, there is no "one has a free, a strong and weak" problem, the utilization of the electrode is 100%. 可使治疗效果加倍。 The therapeutic effect can be doubled.

本发明采用了两种不同的对称双向电脉冲如图5和图7中的B和C所示。 The present invention uses two different symmetrical bidirectional pulses shown in FIGS. 5 and 7 B and C.

其中“B”波形用于2导(电极)和4导(电极)两种(韩氏)仪器,工作时,两个电极轮流充当负极,产生刺激。 Wherein "B" the waveform for the second guide (electrode) 4 and a conductive (electrode) while both (Han) instrument, in operation, both electrodes serving as the negative electrode in turn, cause irritation. 若2Hz工作时,可感到,两个电极不是同时有刺激,而是交替刺激(如图5中B所示)。 If 2Hz work, it can be felt, while two electrodes are not stimulate, but alternate stimulation (as shown in FIG. 5 B). 一个周期是:每个脉冲正脉冲之后经过波形的频率间隔时间产生一个负脉冲,以此产生周期连续的刺激波形;以2Hz为例:即每个电极得到的刺激是1Hz,而传到中枢的刺激是两个电极的共同结果。 Is a period of: generating a negative pulse frequency interval elapsed time after each pulse waveform is a positive pulse, thereby generating a continuous cycle of stimulation waveforms; 2Hz In Example: i.e. each electrode is obtained 1Hz stimulation, and reached the hub stimulation is a common result of two electrodes. 仍是2Hz。 Still 2Hz.

其中“C”为新设计的矩形脉冲,用于4导韩氏仪,每个脉冲的“前置正“脉冲在一个电极产生刺激,“前置”脉冲的后沿紧随“后续负“脉冲,“前置正“脉冲和“后续负“脉冲成一个刺激波形,经波形的频率间隔时间产生周期连续的刺激波形;它在另一个电极产生刺激(如图7中C所示),其刺激效率比“B”波形提高一倍。 Wherein "C" is the rectangular pulse of the new design, the guide 4 for instrument Han, "pre-positive" pulse of each pulse in generating a stimulation electrode, followed by the trailing edge of the "front" pulses "subsequent negative" pulse "pre-positive" pulse and a "negative follow-up" into a stimulation pulse waveform generated by the waveform of a periodic frequency interval of continuous stimulation waveform; which causes irritation (C shown in FIG. 7) on the other electrode, which stimulates double the efficiency ratio "B" wave. 是最有效的矩形脉冲。 It is the most effective rectangular pulse. 由于两个电极同时向中枢传递信息,有叠加增强作用,临床实践表明,可以提高疗效。 Since the two electrodes are simultaneously transmitting information to the center, there is superimposed reinforcing effect, clinical practice has shown that efficacy can be improved. 波形最好是方波。 Preferably the waveform is a square wave.

前后沿陡峭的,具有一定时间间隔和电流幅度的矩形脉冲,易于准确定量和控制,使被刺激神经纤维产生兴奋和传导。 Steep front-rear direction, a rectangular pulse having a predetermined time interval and current amplitude, quantitative and easy to control accurately, so that the nerve fibers are stimulated and generate excitement conduction. 神经科学研究用的电生理刺激器首选是矩形脉冲,自然成为本的首选。 Neuroscience electrophysiological stimulation with rectangular pulse is preferred, this is a natural choice.

矩形电脉冲工作时,只在输出脉冲的瞬间耗电,其余时间基本不耗电,特别省电,适合电池供电和便携家用,也有利安全。 Rectangular electrical impulses, only the instantaneous output power pulse, the time remaining substantially no power, especially power, and for battery-powered portable household, safety is also advantageous.

4、恒流输出:利用PWM方式,量化输出电压使按键能够做到均匀调节,通过滤波器以及精密放大器使电压信号转换成电流信号。 4, constant current output: a PWM mode, the output voltage of the quantized key can do so uniformly adjusted, by the filter and amplifier enable accurate voltage signal into a current signal.

针刺和皮肤电极下人体的电特性:经针和经皮两种不同条件下,机体的电学特性相差很大,对仪器的要求不同。 The electrical characteristics of the human body and skin electrodes needling: under two different conditions by percutaneous needle and, very different electrical properties of the body, the different requirements of the instrument. 扎针的部位、深浅。 Acupuncture treatment site, depth. 皮肤电极的部位、大小、干湿、气候环境、温度等等,都影响刺激对象的电特性。 Parts of the skin electrodes, size, wet and dry, climate, temperature, etc., all affect the electrical characteristics of the stimulus object. 经实验测定,经针或经皮的人体组织,可等效为电阻和电容组成的网络(图10所示),其结构相同,但参数有很大差异,如下表所示,其中T为时间常数(R1×C),经皮的时间常数(T)比经针的小10-20倍,表明在同样电压作用下,经皮电极下机体极化电容的充电速度,比经针要快10-20倍,即机体组织的瞬态电阻会急速增大,而经针较慢。 Determined experimentally, by percutaneous needle or human tissue, may be equivalent network consisting of a resistor and a capacitor (FIG. 10), the same structure, but the parameters are very different, as shown in the following table, where T is the time constant (R1 × C), percutaneous time constant (T) by 10-20 times smaller than the needle, indicating that the same voltage is applied, the speed of the charged body subcutaneous electrode polarization capacitance, through the needle faster than 10 -20 times, i.e., transient resistance will rapidly increase in body tissue, and the needle slowly through. 恒压供电时,瞬态电阻增大使刺激电流下降(图11),为维持有效刺激电流,经皮刺激仪器输的出电路应具有恒流特性,使设计和制造难度加大。 When the constant voltage power supply, the transient current drop resistance increases of stimulation (FIG. 11), to maintain effective stimulation current, the output circuit transcutaneous stimulation instrument should have constant characteristics, make more difficult to design and manufacture.

R1(KΩ) R2(KΩ) C(MF) T(ms)针 0.25 2.5 4 1皮 1 1.1-10 0.1 0.05-0.1恒压与恒流脉冲输出:目前市场上,电针和经皮电刺激仪器的输特性有两类仪器输出脉冲的电压幅度为可调,一旦电压幅度确定后,不再随负载而变,称为“恒压输出”(简称恒压)。 R1 (KΩ) R2 (KΩ) C (MF) T (ms) 0.25 2.5 41 needle sheath 1.1-10 0.1 1 0.05-0.1 constant voltage of the constant current pulse output: on the market today, EA, and transcutaneous electrical stimulation instrument there are two types of output voltage amplitude characteristics of instrument output pulse is adjustable, the voltage amplitude is determined once, with no load change, it referred to as "constant output" (referred to as constant voltage). 但其输出电流将随电极间机体电阻的变化而变化。 But its output current will vary with the resistance of the body between the electrodes. 应用皮肤电极时,电流经皮肤流入机体,皮肤角质层的通透性差,阻碍离子流动,正负离子在阻挡层两侧堆积,造成极化,皮肤电阻在通电后0.05mS(十万分之五秒)内增大2-10倍,脉冲电流下降为为原来的1/2-1/10,形成尖而窄的脉冲电流,极易引起表皮刺痛,难以接受。 Applying skin electrodes, a current flows into the body through the skin, the stratum corneum permeability difference hinder the flow of ions, both positive and negative ions in the barrier layer is deposited, resulting in the polarization, the skin resistance of 0.05 mS after energization (five hundred thousandths seconds ) is increased 2 to 10 times the pulse current is decreased to the original 1 / 2-1 / 10, is formed sharp and narrow pulse current can easily cause skin irritation, it is difficult to accept. 仪器常用脉冲的宽度,虽为0.2-1ms(万分之二到千分之一秒),在恒压方式下,真正有效作用的时间不到0.05mS。 Instrument used pulse width, although the 0.2-1ms (ten thousandths to a thousandth of a second), at a constant pressure mode, the real time is less than the effective role 0.05mS. 故恒压输出的仪器不适于经皮肤电极的刺激。 Therefore, the constant voltage output of the instrument is not suitable for stimulation of the skin by electrodes. 在经毫针进行刺激时,极化作用发生较慢,机体电阻增大稍慢,虽对脉冲电流仍有影响,可用脉宽0.5-1ms以内的恒压脉冲,因此,恒压仪器只宜用于要求不高的电针治疗,不得用于要求准确定量的科学实验研究。 When stimulated by the needle, polarization occurs slowly, the body resistance increases slower, although still impact on the pulse current, constant-voltage pulse width can be used within 0.5-1ms, therefore, suitable only for constant-voltage instrument less demanding electro-acupuncture may not be used for experimental research scientifically accurate quantitative requirements.

在体表皮肤上加以恒压和恒流的电脉冲的试验结果如图11所示:恒压输出时,形成明显的尖脉冲电流。 Test results to be constant current and constant voltage electrical pulses on the skin surface 11: constant voltage output to form a clear spike current. 图11所示,仪器输出脉冲的电流幅度为可调,一旦电流幅度确定后,不再随负载而变,称为“恒流输出”(简称恒流)。 As shown in FIG. 11, the instrument output pulse current amplitude is adjustable current amplitude is determined once, with no load change, known as the "current output" (referred to as CC). 实验曲线显示,虽皮肤极化造成电阻增大,但是脉冲电流值不变,确保稳定工作,韩氏仪是恒流输出,电流可以准确定量控制。 Experimental curve display, although the skin caused by the polarization resistance increases, but the pulse current value unchanged, to ensure stable operation, Han instrument is constant output current control can be accurately quantified. 脉冲电流的前沿圆滑过度,作用深度大,范围广,穴位的胀、重、得气感强,由于无刺痛感,感觉舒适,患者易于接受更大的刺激强度,特别有利于激发内源性吗啡的治疗。 Excessive leading edge pulse current sleek, large depth of interaction, a wide range of points of swelling, heavy, have a strong sense of gas, because no tingling, feeling comfortable, easily accepted by patients greater stimulus intensity, particularly conducive to stimulate endogenous treatment of morphine. 恒流仪器能充分满足经皮刺激,自然更能够满足电针的需要。 Constant-current equipment can fully meet the transcutaneous stimulation, naturally better able to meet the needs of electric needle. 恒流仪器性能优越、电路结构复杂,价格较贵。 Constant current instrument superior performance, the circuit configuration complicated, expensive. 电生理刺激器均采用恒流输出,在穴位神经电刺激的科研和临床应用时,国际上都以脉冲电流峰值为计量单位,要求仪器有准确的数字显示,确保科研和使用的客观准确,可重复、可比较。 Electrophysiological stimulation constant current output are used in research and clinical applications when the electrical nerve stimulation points, the international community has a pulse peak current measurement units, requires accurate digital display instruments, ensuring accurate and objective research use, can repeat, may be compared. 上述要求唯有在恒流工作方式下才能实现。 These requirements can be achieved only under the constant current operation.

4、本仪器采用了现代计算机技术、液晶显示、手机外观设计、人机友好界面的软件技术,给人外观流畅、美观、实用的外形、使用方便的特点,便于普通人群使用。 4. The instrument uses modern computer technology, LCD, mobile phone design, friendly man-machine interface software technology, giving the appearance of smooth, beautiful and practical shape, easy to use features, ease of use of the general population. 仪器符合国际通用标准化的技术参数,以数码准确定量、控制、显示。 The instrument complies with internationally accepted standardized technical parameters to digital quantitative accuracy, control, display. 用准确定量的参数治疗各种不同的症状。 Treatment with precise quantitative parameters of various symptoms.

经过了中日友好医院、北京妇产医院、北京医院、天坛医院等多家医院的临床应用,上海针灸经络研究所、武汉协和医院、珠海瑞桦戒毒康复中心等临床应用取得了显著的效果。 After the clinical application of the Sino-Japanese Friendship Hospital, Beijing Maternity Hospital, Beijing Hospital, Tiantan Hospital and a number of hospitals, clinical application of Shanghai Institute of Acupuncture and Meridian, Wuhan Union Hospital, beads Hai Hua drug rehabilitation centers achieved remarkable results.

5、工艺1)仪器采用当今手机外观设计技术,简捷、饱满、圆润的形态;亮银上下盖与深色金属质感的中间包圈;精致、个性化的操作按键设计;独立的LOGO标牌,与镜片统一的型号放置;凹入的插口平面丰富形体;背部凸出的方行支撑机体呈现放置倾角。 5, process 1) Instruments used in today's mobile phone design techniques, simple, full, rounded shape; Silver metallic upper and lower covers and the tundish dark circles; exquisite personalized operation key design; LOGO separate signs, and unified lens placement type; rich concave socket body plane; back side projecting support body presenting rows inclination angle. 2)仪器内部采用当今流行的SMT表面贴装技术,在集成度、可靠性上比传统工艺有极大的提高。 Internal 2) instrument using today's popular SMT Surface Mount Technology, degree of integration, has greatly improved reliability than the traditional process. 3)严格按照YYT0287-2003 idt ISO13485:2003标准的要求,从产品企划、产品开发、采购、生产、检验、储存等制定了严格的流程。 3) strictly in accordance with ISO13485 YYT0287-2003 idt: 2003 standard requirements, from product planning, product development, procurement, production, testing, storage and other developed a rigorous process.

总之:本发明无针镇痛仪器能缓减疼痛甚至彻底治愈疼痛疾病。 In summary: The present invention is a needleless analgesic pain relief device can even be completely cured pain disorders.

疼痛不仅给患者带来极大的痛苦,而且还对中枢神经、循环、呼吸、内分泌、消化和自主神经等系统造成不良影响,因此解除疼痛是治疗疼痛性疾病的重要工作,也是病人的基本权利。 Pain not only brought great suffering to the patient, but also on the central nervous, circulatory, respiratory, endocrine, digestive and autonomic nervous systems adversely affected, so pain relief is an important work in treating pain disorders, but also the fundamental rights of patients . 医学界已经将疼痛认定为继呼吸、脉搏、体温和血压之后的人类的“第五大生命指征”加以重视,把慢性疼痛作为一种疾病来认真对待。 The medical profession has to be respect for human pain finds "fifth vital sign big" as the following after breathing, pulse, temperature and blood pressure, chronic pain as a disease to be treated seriously. 自古以来,人们就一直在寻找疼痛的原因及治疗方法,随着社会经济和文化的发展,人类生存质量的改善和提高,人们对疼痛治疗的需要日益增加。 Since ancient times, people have been looking for the cause and treatment of pain, with the development of socio-economic and cultural quality of human life to improve and enhance people need pain treatment is increasing. 韩氏无针镇痛仪器的研制成功并进入家庭,对缓解疼痛和治疗疼痛开创了先河,是疼痛历史上的里程碑。 Han no analgesia instrument of successful development and into the family, for pain relief and treatment of pain breaking new ground, is a milestone in the history of pain.

本发明无针镇痛仪器产品将推动了针灸疗法走向世界针灸在中国应用了数千年,在西方只有几十年历史,且多在民间进行,并未进入主流医学,也未正式纳入社会医疗保险支付的项目之内。 The present invention will no analgesia instrument to promote the product to the world of acupuncture acupuncture applied in China for thousands of years, only a few decades of history in the West, and mostly in private, did not enter mainstream medicine, has not formally incorporated into the medical community within the project insurance payment. 但由于近20-30年来针刺治疗疼痛等疗效确切,原理逐渐阐明,消除了某种神秘感,增加了科学上的可信度,因此逐渐得到国际医学界的重视。 But in recent 20--30 years to treat pain, acupuncture is effective, the principle of gradually clarified, eliminating certain mystique, increase the credibility of the science, and therefore an increased emphasis on the international medical community. 韩氏仪作为无针的针灸仪,由于其刺激参数明确,可重复性强,使用标准化,易于掌握,在简单的指导下可自行操作等优点,为针灸疗法走向世界作出了巨大的贡献。 Han instrument as a needle-free acupuncture instrument, due to its stimulation parameters clear, repeatable, standardized, easy to learn, under the guidance of a simple self-operation, etc., made a great contribution to acupuncture to the world.

本发明依照YY 0016-1993(低频电子脉冲治疗仪)的要求,进行开发、验证等,主要试验项目有:1)试验环境环境温度5℃-40℃。 In accordance with the present invention YY 0016-1993 (low frequency electronic pulse therapeutic apparatus) requirements, development, verification, the main test items: 1) the test environment temperature 5 ℃ -40 ℃. 相对湿度≤80%。 Relative humidity ≤80%. 2)外观检查:以目力进行观察3)电器性能检验:电器试验项目。 2) visual inspection: The eyesight observation 3) Electrical performance test: electrical test items.

Claims (10)

1.无针镇痛仪的设置方法,其特征是无针镇痛仪采用输出为2Hz低频和高频100±10Hz的疏密波为电脉冲刺激信号,电脉冲刺激信号且以恒流源方式输出,实现方式是:低频和高频的信号分别通过两路PWM信号产生,且从0-5V的连续可调输出,也可以是单路输出交替变换的低频和高频信号。 Set 1. No analgesia instrument, wherein the instrument used no analgesia output 2Hz 100 ± 10Hz low and high frequency compressional wave electrical stimulation pulse signal, and electrical pulse stimulation signal constant current source manner output, implementations are: low and high frequency signals are generated by the two PWM signals, and outputted continuously adjustable from 0-5V, may be low and high frequency signal of alternating single output.
2.根据权利要求1所述的无针镇痛仪的设置方法,其特征是输出是:每3±0.5秒钟交替输出的2Hz低频和高频100±10Hz波形。 2. The method of claim 1 provided no analgesia meter claim, wherein the output is: 3 ± 2Hz ​​every 0.5 seconds alternating low and high frequency output waveform 100 ± 10Hz.
3.根据权利要求1所述的无针镇痛仪的设置方法,其特征是频率升高时,脉宽应自动变窄,当频率降低时,波宽应自动变宽,使低频2 Hz和高频100Hz的频段都有相近的刺激量。 3. The method of claim 1 provided no analgesia meter claim, characterized in that the frequency rises, the pulse width should be automatically narrowed, when the frequency decreases, the wave width should automatically widened, and the low-frequency 2 Hz the amount of stimulus frequency bands are close to 100Hz.
4.根据权利要求3所述的无针镇痛仪的设置方法,其特征是波宽的范围是:较宽是0.3-1.0ms和和较窄的0.1-0.2ms。 4. The method of claim 3 provided no analgesia meter according to claim, wherein a wide range of wave: 0.3-1.0ms and is wider and a narrower 0.1-0.2ms.
5.根据权利要求1所述的无针镇痛仪的设置方法,其特征是采用了两种不同的对称双向电脉冲交替刺激波形:1)一个周期是:每个脉冲正脉冲之后经过波形的频率间隔时间产生一个负脉冲,以此产生周期连续的刺激波形;2)每个脉冲的“前置正“脉冲在一个电极产生刺激,“前置”脉冲的后沿紧随“后续负“脉冲,“前置正“脉冲和“后续负“脉冲成一个刺激波形,经波形的频率间隔时间产生周期连续的刺激波形。 5. The method of claim 1 provided no analgesia instrument as claimed in claim, which is characterized by using two different two-way symmetrical alternating electrical stimulation pulse waveform: 1) is a period: after each pulse waveform after the positive pulse frequency generating a negative pulse interval, thereby generating a continuous cycle of stimulation waveforms; 2) "front positive" pulse of each pulse in generating a stimulation electrode, followed by the trailing edge of the "front" pulses "subsequent negative" pulse "pre-positive" pulse and a "negative follow-up" into a stimulation pulse waveform generated by the waveform of a periodic frequency interval of continuous stimulation waveforms.
6.无针镇痛仪,包括混合信号,并用于控制输出波形、频率幅度以及脉宽的控制,响应按键,驱动LCD显示的微控制器、运算放大器构成;控制电压转换,控制开关管的打开与关断产生脉冲信号的三极管(Q3,Q4,Q5)和线性调整管(D4)和开关(S6)组成电源电路;其特征是微控制器输出两路独立的PWM信号(PWM_A、PWM_B),经过阻容低通滤波(R16、R17、R18、R19、C1、C2)形成0-5V的电压信号;经过低通滤波再连接mos开关(4066),同时微控制器精确定时信号(CP1、CP2)作为mos开关的控制信号也被送入,mos开关(4066)输出治疗波形(PWM_A_L/R、PWM_B_L/R)信号,并连接运算放大器D22输出放大,再经两组推挽三极管Q1、Q2或Q6、Q7轮流导通,两组推挽三极管输出至电流互感器D3、D5,电流互感器的输出产生正负间隔的脉冲波。 6. No analgesia meter, including mixed-signal, and for controlling the output waveform, amplitude and frequency of the control pulse width in response to the key, to drive a microcontroller, LCD display of the operational amplifier; voltage conversion control, controls the opening of the switch generating and off the transistor (Q3, Q4, Q5) and a linear regulator (D4) and a switch (S6) a power supply circuit consisting of a pulse signal; characterized in that two independent microcontroller outputs a PWM signal (PWM_A, PWM_B), after RC low-pass filter (R16, R17, R18, R19, C1, C2) is formed 0-5V voltage signal; a low-pass filtered reconnection mos switches (4066), while the microcontroller accurate timing signals (CP1, CP2 ) is also fed as a control signal mos of the switch, the switch mos (4066) treatment of the output waveform (PWM_A_L / R, PWM_B_L / R) signal, and an output connected to the operational amplifier amplifies D22, and then the two push-pull transistors Q1, Q2, or Q6, Q7 turns oN, D5 output current transformer D3,, two push-pull transistor current transformer to produce the output positive and negative pulse interval.
7.根据权利要求6所述的的无针镇痛仪,其特征是微处理器的模拟输入调节端设有40档电流调节电阻器,每增加一档输出,微控制器PWM信号输出经滤波后增加0.125V。 7. No analgesia meter according to claim 6, wherein the adjusting the analog input of the microprocessor 40 is provided with a current adjusting resistor files, each additional file output, the microcontroller outputs a PWM signal filtered after the increase 0.125V.
8.根据权利要求6所述的的无针镇痛仪,其特征是设有监视电源电压比较器(393)。 No analgesia meter according to claim 6, characterized in that the power supply is provided to monitor the voltage comparator (393).
9.根据权利要求6所述的的无针镇痛仪,其特征是控制微控制器内部的两个定时器,一个作为全局的实时时钟,一个作为频率改变的间隔定时器。 No analgesia meter according to claim 6, characterized in that the microcontroller's internal control two timers, a real time clock as a global, a frequency change as an interval timer.
10.根据权利要求6所述的的无针镇痛仪,其特征是仪器输出强度分为“针”、“皮”两档,前者最高强度是10mA,后者是50mA。 10. The method of claim 6 needleless analgesic instrument, wherein the instrument into the output intensity "needle", "skin" two steps, the former highest intensity is 10mA, which is 50mA.
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CN102580238B (en) * 2012-03-06 2014-06-11 复旦大学 Multilevel high and constant voltage pulse generator circuit
CN102579042A (en) * 2012-03-06 2012-07-18 复旦大学 Multilevel constant-current pulse generating circuit
CN105395311B (en) * 2014-08-15 2017-12-01 土井瞳 The device and its application method to be stimulated circulation with heat and electric shock
CN105395311A (en) * 2014-08-15 2016-03-16 土井瞳 Device for promoting blood circulation through heat and electric shocks and use method thereof
CN104784821A (en) * 2015-04-24 2015-07-22 山东威高集团医用高分子制品股份有限公司 Electronic equilibrium auxiliary anesthesia instrument
CN105771086A (en) * 2016-03-21 2016-07-20 浙江中医药大学 Acupoint electrical stimulation method and device for assistant analgesia
CN106038247A (en) * 2016-06-28 2016-10-26 浙江中医药大学 Electrical acupuncture point stimulation method and device based on continuous wave
CN106178253A (en) * 2016-06-28 2016-12-07 浙江中医药大学 A kind of electric acupoint stimulation method and device based on dilatational wave
CN105944231A (en) * 2016-06-28 2016-09-21 浙江中医药大学 Acupoint electrical stimulation method and device for auxiliary treatment of inflammatory pain
WO2018000650A1 (en) * 2016-06-28 2018-01-04 浙江中医药大学 Acupoint electrical stimulation method and device for adjuvant treatment of inflammatory pain
CN106344392A (en) * 2016-09-05 2017-01-25 广东工业大学 Physical therapy apparatus
CN106511066A (en) * 2016-09-05 2017-03-22 广东工业大学 Stomach disease treatment apparatus
CN107376119A (en) * 2017-08-11 2017-11-24 南京安泰睿医疗科技有限公司 For the production method and therapeutic equipment of the micro-current for correcting brain wave

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