CN105771086A - Acupoint electrical stimulation method and device for assistant analgesia - Google Patents
Acupoint electrical stimulation method and device for assistant analgesia Download PDFInfo
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- CN105771086A CN105771086A CN201610162463.7A CN201610162463A CN105771086A CN 105771086 A CN105771086 A CN 105771086A CN 201610162463 A CN201610162463 A CN 201610162463A CN 105771086 A CN105771086 A CN 105771086A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36021—External stimulators, e.g. with patch electrodes for treatment of pain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
- A61H39/002—Using electric currents
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Abstract
The invention discloses an acupoint electrical stimulation method and device for assistant analgesia. The method realizes assistant analgesia by outputting pulse current, of which the frequency is 2 Hz and wave width is 50 mus, or the frequency is 10 Hz and wave width is 200 mus, or the frequency is 120 Hz and wave width is 300 mus. The device for realizing the method comprises a pulse generator and an electrode; and the pulse generator selects the output three different electric pulse signals above through a key group. The method and device can obviously improve secretion of peripheral and central endogenous enkephalin, beta-endorphin and dynorphin and suppress generation of peripheral and spinal cord IL-1beta, PGE2 and TNF-alpha, thereby helping patients to relieve various acute or chronic pain, inflammatory pain, neuropathic pain and various mixed pain, providing intelligent operation for allowing the patients to use instruments to relieve pain by themselves, and improving living quality of the pain-suffered patients.
Description
Technical field
The present invention relates to a kind of for analgesic apparatus and method, particularly relate to a kind of for assisting analgesic
Electric acupoint stimulation method and device.
Background technology
Pain is the subjective sensation of a kind of complexity caused by noxious stimulation, and it is as one " double-edged sword ", a side
Face, it is provided that alarm signal when body is on the hazard, by promoting behavior and reflectivity defence to make tissue
Escape injury, be the indispensable a kind of defencive function of body；On the other hand, violent or long-term pain
The dysfunction on organism physiology and psychological discomfort can be caused, be clinical a great problem.Along with to pain
Deepening continuously of pain research, the medicine layer for the treatment of pain goes out thoroughly, but the mechanism of pain is not yet by completely
Illustrating, the medicine researched and developed for single pain pathogenesis is only capable of solving subproblem, moreover drug price
Costliness, and there is serious side reaction, long-term taking anodyne brings huge economic pressures with tight to patient
The actual bodily harm of weight.If non-steroid anti-inflammatory drug is the goldstandard for the treatment of inflammatory pain, but it is inherently
Serious gastrointestinal lesions is caused to patient；The treatment neurogenic pain such as antidepressants, antiepileptic is only
The patient pain having 30%-40% can alleviate more than 50%, and it is tight to produce drug dependence, liver renal toxicity etc.
Heavily side effect.Clinically, the pain that a kind of disease occurs together often by multiple bone aching because of combined reaction,
The pain occurred together such as cancer is that the Different types of etiopathogenises such as inflammatory pain, avascular pain, neuropathic pain comprehensively form,
Anodyne for single target spot can not solve clinical problem.TCNS analgesia art makes the most
With over half a century, domestic scientist combines it with Chinese medicine meridian acupuncture point, has invented " percutaneous cave
Position electro photoluminescence " there is good analgesic activity.Local pain, overall pain, splanchnodynia etc. are all had substantially by it
Result for the treatment of, and there is the advantages such as rapid-action, spectrum of disease is wide, good, the few side effects of integrally-regulated effect,
Can be used for treating various Acute or chronic pain, the therapy of these many targetings has become generally acknowledge both at home and abroad the greenest
Look analgesia means, are the Typical Representatives of " green analgesia ".The invention of this device can be fabulous these problems of solution,
It is theoretical that this device combines the acupuncture point in China's traditional medicine, transfers human endogenous's property opium by electro photoluminescence acupuncture point
Peptide mechanism produces analgesic effect, be a kind of safety non-toxic side reaction, can the analgesia health-care device device of Long-Time Service.
Summary of the invention
It is an object of the invention to: overcome the deficiencies such as existing analgesic drug product unsatisfactory curative effect, side reaction are big, existing
Egersimeter uncertain therapeutic efficacy is cut, mostly without defects such as strict scientific research demonstrations；Thus provide a kind of non-
Therapeutic purposes, modern electronic technology is combined with the acupuncture theory of China traditional Chinese medical science, assists cave, analgesic
Position electrical stimulation device and electric acupoint stimulation method.
It is an object of the invention to be achieved through the following technical solutions: one is used for assisting acupuncture point, analgesic electricity thorn
The method of swashing, the size of current of the current impulse used by electro photoluminescence is 0.1～50mA, and voltage swing is 0.1～4V；
The frequency of current impulse is 2Hz, a width of 50 μ s of ripple；Or frequency is 10Hz, a width of 200 μ s of ripple；Or frequency is
120Hz, a width of 300 μ s of ripple.
A kind of electric acupoint stimulation device, including impulse generator and electrode, impulse generator passes through electrode to cave
Position carries out electro photoluminescence；Described impulse generator includes button group, and the electric pulse exported by button group selection is believed
Number, the size of current of described electric impulse signal is 0.1～50mA, and voltage swing is 0.1～4V；Current impulse
Frequency is 2Hz, a width of 50 μ s of ripple；Or frequency is 10Hz, a width of 200 μ s of ripple；Or frequency is 120Hz, ripple width
It is 300 μ s.
Further, described electric acupoint stimulation device also includes liquid crystal display, and liquid crystal display is sent out with pulse
Raw device is connected, the display frequency of work at present, ripple width and residue working time.
Further, described button group includes the first button, the second button and the 3rd button；Described first presses
Key is connected with impulse generator, and controlling impulse generator output frequency is 2Hz, the impulse wave of a width of 50 μ s of ripple；
Described second button is connected with impulse generator, and controlling impulse generator output frequency is 100Hz, and ripple is a width of
The impulse wave of 200 μ s；Described 3rd button is connected with impulse generator, controls impulse generator output frequency and is
120Hz, the impulse wave of a width of 300 μ s of ripple.
Further, described button group includes that intensifying current button and electric current reduce button, regulates stimulating current
Size, regulation step-length is 1mA.
Further, described button group includes that frequency strengthens button and frequency reduces button, regulates frequency of stimulation
Size, regulation step-length is 1Hz.
Further, described button group includes timing button, is used for setting electric stimulating time.
The beneficial effects of the present invention is: the present invention is machine-processed based on gate control theory and endogenous opiatepeptide,
And be verified by experiments and truly have anti-inflammatory and antalgic effect, maincenter endogenous opioids analgesic matter can be significantly improved, press down
The peripheral inflammation factor processed.Research confirms that the present invention can promote that hypothalamus beta-endorphin is secreted, and suppresses peripheral t NF-α
Pro-inflammatory cytokine produces, and is conducive to alleviating the various Acute or chronic pain of patient, inflammatory pain, neurogenic pain
And various Combination pain, reduce the application of patient's analgesic drug product, use for patient instrument to solve pain voluntarily
Pain provides intellectualized operation, can improve pain-suffered patient quality of life.
Accompanying drawing explanation
Fig. 1 is the structural representation of electric acupoint stimulation device；
Fig. 2 is the assembly connection diagram of electric acupoint stimulation device；
Fig. 3 is the assembly connection diagram of electric acupoint stimulation device；
Fig. 4 is that the analgesic effect of different frequency electro photoluminescence compares；
Fig. 5 is 2Hz electro photoluminescence and the comparison to Pain Regulation In The Rat of the different ripple wide array impulse waves；
Fig. 6 is 100Hz electro photoluminescence and the comparison to Pain Regulation In The Rat of the different ripple wide array impulse waves；
Fig. 7 is 120Hz electro photoluminescence and the comparison to Pain Regulation In The Rat of the different ripple wide array impulse waves；
Fig. 8 is 3 kinds of electric-impulse stimulations comparisons to CFA rat hypothalamus Content of B-ep；
Fig. 9 is 3 kinds of electric-impulse stimulations comparisons to CFA rat paw TNF-α content.
Detailed description of the invention
The invention will be further described below in conjunction with the accompanying drawings.
The present invention provides a kind of non-treatment purpose, by the acupuncture theory phase of modern electronic technology with China's traditional Chinese medical science
In conjunction with, auxiliary analgesic electric acupoint stimulation device and electric acupoint stimulation method.Proved by lot of experiments,
Three kinds of electrical stimulation methods have better effects to analgesia below, and the frequency of (1) current impulse is 2Hz, and ripple is a width of
50μs；(2) frequency is 10Hz, a width of 200 μ s of ripple；(3) frequency is 120Hz, a width of 300 μ s of ripple.Electricity
Stream size is 0.1～50mA, and voltage swing is 0.1～4V；Electric acupoint stimulation is improved analgesia by said method
Effect is own to be proven in rat experiment, is better than other same quasi-instruments the most on the market.Specific as follows:
Use SD rat, select classical ridge god ligation (SNL) model as pain model, by 48 rats with
Machine is divided into 6 groups: normal group, model group, 2Hz electro photoluminescence group, 15Hz electro photoluminescence group, 50Hz electro photoluminescence group,
100Hz electro photoluminescence group, 120Hz electro photoluminescence group, pulse radio is wide is fixed as 250 μ s, electric current 1mA.Select foot
In three, Kunlun point, treat 30min every time, through 9 days electronic stimulations, detect the rat machinery threshold of pain, warp
Results of statistical analysis display 2Hz, 100Hz and 120Hz group analgesic effect is best, is better than 15Hz and 50Hz
(P<0.05).Shown result is with reference to Fig. 4, table 1.
Table 1: the analgesic effect of different frequency electro photoluminescence compares
Relatively 42 rats are randomly divided into 7 groups: 50 μ s by 2Hz impulse wave and the analgesic effect of different ripple wide arrays
Group, 100 μ s groups, 200 μ s groups, 300 μ s groups, 400 μ s groups, 500 μ s groups, 600 μ s groups, electro photoluminescence frequency is equal
For 2Hz, current strength is 1mA, and electric stimulating time is 30min, compares Pain Regulation In The Rat change before and after electro photoluminescence,
Through statistical analysis, result shows, the 50 μ s group threshold of pains are improved the most substantially (P < 0.05).Shown result reference Fig. 5,
Table 2.
The impact on Pain Regulation In The Rat of table 2 2Hz electro photoluminescence and different ripple wide array impulse waves
42 rats are randomly divided into 7 groups by relatively 100Hz impulse wave and the analgesic effect of different ripple wide arrays:
50 μ s groups, 100 μ s groups, 200 μ s groups, 300 μ s groups, 400 μ s groups, 500 μ s groups, 600 μ s groups, electro photoluminescence frequency
Rate is 100Hz, and current strength is 1mA, and electric stimulating time is 30min, compares rat pain before and after electro photoluminescence
Threshold changes, and result shows, the 200 μ s group threshold of pains are improved the most substantially (P < 0.05).Shown result is with reference to Fig. 6, table 3.
The impact on Pain Regulation In The Rat of table 3 100Hz electro photoluminescence and different ripple wide array impulse waves
42 rats are randomly divided into 7 groups by relatively 120Hz impulse wave and the analgesic effect of different ripple wide arrays:
50 μ s groups, 100 μ s groups, 200 μ s groups, 300 μ s groups, 400 μ s groups, 500 μ s groups, 600 μ s groups, electro photoluminescence frequency
Rate is 120Hz, and current strength is 1mA, and electric stimulating time is 30min, compares rat pain before and after electro photoluminescence
Threshold changes, and result shows, the 300 μ s group threshold of pains are improved the most substantially (P < 0.05).Shown result is with reference to Fig. 7, table 4.
The impact on Pain Regulation In The Rat of table 4 120Hz electro photoluminescence and different ripple wide array impulse waves
Further, we use SD rat, select metapedes plantar subcutaneous injection (Complete freund ' s adjuvant,
CFA), the chronic pain model that induction is classical, 30 rats are randomly divided into 5 groups: normal group, model group,
2Hz/50 μ s electro photoluminescence group, 100Hz/200 μ s electro photoluminescence group, 120Hz/300 μ s electro photoluminescence group, electric current 1mA.
Select Zusanli, Kunlun point, treat 30min every time, through 10 days electronic stimulations, detect rat hypothalamus
Beta-endorphin, foot sole of the foot TNF-α content, result shows that above 3 kinds of electric-impulse stimulations treatment can significantly improve pain
Rat hypothalamus Content of B-ep, and suppress foot sole of the foot TNF-α content, statistically significant with model group ratio
(P<0.05).Shown result is with reference to Fig. 8-9, table 5.
Table 5 electronic stimulation is on CFA rat hypothalamus beta-endorphin, the impact of content
Based on above electrical stimulation method, present invention also offers a kind of electric acupoint stimulation device, send out including pulse
Raw device and electrode, impulse generator carries out electro photoluminescence by electrode to acupuncture point；Described impulse generator include by
Key group, the electric impulse signal exported by button group selection, the size of current of described electric impulse signal is
0.1～50mA, voltage swing is 0.1～4V；The frequency of current impulse is 2Hz, a width of 50 μ s of ripple；Or frequency is
10Hz, a width of 200 μ s of ripple；Or frequency is 120Hz, a width of 300 μ s of ripple.
As the common knowledge of this area, impulse generator generally comprises SCM system and constant current output circuit.
SCM system is the control core of whole system, can use STC industry microcontroller, control system according to
Normal requirement works, and controls to export different pulse signals, and pulse signal can be adjusted by button group
Joint, constant current output circuit is as shown in Figure 3.This high-precision constant flow source circuit can realize 0-4V Control of Voltage 0-50mA
Electric current exports, and uses the output of high reliability operational amplifier OPA211 constant-current source the most to drive.Metal-oxide-semiconductor low
Impedance operator, is particularly suitable in constant-current source output circuit, and whole system activated amplifier is as driving,
The temperature that works long hours is waftd little, and output is stable.Make the circuit stability exported of triode high than traditional, essence
Degree height.
Said apparatus can also include liquid crystal display, and liquid crystal display is connected with impulse generator, with display
The frequency of work at present, ripple width and residue working time.
Button group can arrange the first button, the second button and the 3rd button；Output frequency is 2Hz respectively, ripple
The impulse wave of a width of 50 μ s；Frequency is 100Hz, the impulse wave of a width of 200 μ s of ripple；Frequency is 120Hz, ripple width
It it is the impulse wave of 300 μ s.Can also include that intensifying current button and electric current reduce button, to regulate stimulating current
Size, regulation step-length is 1mA.Or including that frequency strengthens button and frequency reduces button, regulation stimulates frequency
The size of rate, regulation step-length is 1Hz.Also include timing button, be used for setting electric stimulating time.
Claims (7)
1. one kind is used for assisting analgesic electric acupoint stimulation method, it is characterised in that the electric current arteries and veins used by electro photoluminescence
The size of current of punching is 0.1～50mA, and voltage swing is 0.1～4V；The frequency of current impulse is 2Hz, ripple width
It is 50 μ s；Or frequency is 10Hz, a width of 200 μ s of ripple；Or frequency is 120Hz, a width of 300 μ s of ripple.
2. the electric acupoint stimulation device realizing method described in claim 1, it is characterised in that include pulse
Generator and electrode, impulse generator carries out electro photoluminescence by electrode to acupuncture point；Described impulse generator includes
Button group, the electric impulse signal exported by button group selection, the size of current of described electric impulse signal is
0.1～50mA, voltage swing is 0.1～4V；The frequency of current impulse is 2Hz, a width of 50 μ s of ripple；Or frequency is
10Hz, a width of 200 μ s of ripple；Or frequency is 120Hz, a width of 300 μ s of ripple.
Electric acupoint stimulation device the most according to claim 2, it is characterised in that described electric acupoint stimulation fills
Put and also include that liquid crystal display, liquid crystal display are connected with impulse generator, display work at present frequency,
The information such as ripple width and residue working time.
Electric acupoint stimulation device the most according to claim 2, it is characterised in that described button group includes
First button, the second button and the 3rd button；Described first button is connected with impulse generator, controls pulse
Generator output frequency is 2Hz, the impulse wave of a width of 50 μ s of ripple；Described second button is connected with impulse generator,
Controlling impulse generator output frequency is 100Hz, the impulse wave of a width of 200 μ s of ripple；Described 3rd button and arteries and veins
Rushing generator to be connected, controlling impulse generator output frequency is 120Hz, the impulse wave of a width of 300 μ s of ripple.
Electric acupoint stimulation device the most according to claim 4, it is characterised in that described button group includes
Intensifying current button and electric current reduce button, and the size of regulation stimulating current, regulation step-length is 1mA.
Electric acupoint stimulation device the most according to claim 4, it is characterised in that described button group includes
Frequency strengthens button and frequency reduces button, and the size of regulation frequency of stimulation, regulation step-length is 1Hz.
Electric acupoint stimulation device the most according to claim 2, it is characterised in that described button group includes
Timing button, is used for setting electric stimulating time.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610162463.7A CN105771086A (en) | 2016-03-21 | 2016-03-21 | Acupoint electrical stimulation method and device for assistant analgesia |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610162463.7A CN105771086A (en) | 2016-03-21 | 2016-03-21 | Acupoint electrical stimulation method and device for assistant analgesia |
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| CN105771086A true CN105771086A (en) | 2016-07-20 |
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| CN201610162463.7A Pending CN105771086A (en) | 2016-03-21 | 2016-03-21 | Acupoint electrical stimulation method and device for assistant analgesia |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107088153A (en) * | 2017-04-24 | 2017-08-25 | 李晓刚 | Intelligent therapeutic instrument and its application method |
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| CN1745857A (en) * | 2005-10-28 | 2006-03-15 | 清华大学 | Implant nervous electric pulse stimulus system |
| CN101007198A (en) * | 2007-01-22 | 2007-08-01 | 周鹏 | Wrist apparatus for rapid postoperative analgesia |
| CN101069769A (en) * | 2007-03-23 | 2007-11-14 | 南京济生医疗科技有限公司 | Needle-free pain-relieving instrument and its setting method |
| CN102743816A (en) * | 2012-07-06 | 2012-10-24 | 符竞之 | Handheld portable transcuataneous electrical nerve stimulation analgesic method, analgesic device and application |
| CN202933390U (en) * | 2012-07-13 | 2013-05-15 | 北京品驰医疗设备有限公司 | External-use test stimulator |
| CN104548343A (en) * | 2015-01-14 | 2015-04-29 | 深圳市是源医学科技有限公司 | Intelligent analgesic apparatus |
-
2016
- 2016-03-21 CN CN201610162463.7A patent/CN105771086A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1745857A (en) * | 2005-10-28 | 2006-03-15 | 清华大学 | Implant nervous electric pulse stimulus system |
| CN101007198A (en) * | 2007-01-22 | 2007-08-01 | 周鹏 | Wrist apparatus for rapid postoperative analgesia |
| CN101069769A (en) * | 2007-03-23 | 2007-11-14 | 南京济生医疗科技有限公司 | Needle-free pain-relieving instrument and its setting method |
| CN102743816A (en) * | 2012-07-06 | 2012-10-24 | 符竞之 | Handheld portable transcuataneous electrical nerve stimulation analgesic method, analgesic device and application |
| CN202933390U (en) * | 2012-07-13 | 2013-05-15 | 北京品驰医疗设备有限公司 | External-use test stimulator |
| CN104548343A (en) * | 2015-01-14 | 2015-04-29 | 深圳市是源医学科技有限公司 | Intelligent analgesic apparatus |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107088153A (en) * | 2017-04-24 | 2017-08-25 | 李晓刚 | Intelligent therapeutic instrument and its application method |
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Application publication date: 20160720 |