CN106038247A - Electrical acupuncture point stimulation method and device based on continuous wave - Google Patents
Electrical acupuncture point stimulation method and device based on continuous wave Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
- A61H39/002—Using electric currents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
- A61N1/36021—External stimulators, e.g. with patch electrodes for treatment of pain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
- A61H2201/10—Characteristics of apparatus not provided for in the preceding codes with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infrared or ultraviolet therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2203/00—Additional characteristics concerning the patient
- A61H2203/03—Additional characteristics concerning the patient especially adapted for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H2205/00—Devices for specific parts of the body
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Rehabilitation Therapy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Finger-Pressure Massage (AREA)
- Electrotherapy Devices (AREA)
Abstract
The invention discloses an electrical acupuncture point stimulation method and a stimulation device based on a continuous wave. According to the method, a pulse current, which is 1-50Hz in frequency and 50 [mu]s in wave width, or 51-80Hz in frequency and 100 [mu]s in wave width, or 81-100Hz in frequency and 200 [mu]s in wave width, or 101-120Hz in frequency and 300 [mu]s in wave width, is outputted, so that adjuvant analgesia is achieved. The device implementing the method comprises a pulse generator and an electrode. The stimulation method and the stimulation device disclosed by the invention can significantly improve the secretion of endogenous [beta]-endorphin in central nervous system, inhibit the generation of such pro-inflammatory cytokines as peripheral TNF-[alpha] and bring about benefits for relieving various acute and chronic pains, inflammatory pains, neuropathic pains and various mixed pains in patients; therefore, an intelligent operation is provided for the patients to relieve the pains by virtue of the instrument (the stimulation device), and the life quality of the patients with the pains is improved.
Description
Technical field
The present invention relates to a kind of for analgesic apparatus and method, particularly relate to a kind of acupuncture point based on continuous wave electricity thorn
Swash method and device.
Background technology
Pain is the subjective sensation of a kind of complexity caused by noxious stimulation, and it is as one " double-edged sword ", on the one hand, it
It is provided that alarm signal when body is on the hazard, by promoting behavior and reflexive defence to make tissue escape injury, is body
Indispensable a kind of defencive function；On the other hand, violent or long-term pain can cause the dysfunction on organism physiology
With psychological discomfort, it it is clinical a great problem.Along with deepening continuously pain research, the medicine layer for the treatment of pain goes out
Thoroughly, but the mechanism of pain is not yet fully elucidated, and the medicine researched and developed for single pain pathogenesis is only capable of solving
Subproblem, also drug price is expensive, and there is serious side reaction, long-term taking analgesic brings huge warp to patient
Ji pressure and serious actual bodily harm.If nonsteroidal antiinflammatory drug is the goldstandard for the treatment of inflammatory pain, but it is inherently
Serious gastrointestinal lesions is caused to patient；The treatment neuropathic pain such as antidepressants, antuepileptic only has 30%-40%
Patient pain can alleviate more than 50%, and the serious side effects such as drug dependence, Liver and kidney toxicity can be produced.Clinically, one
The pain that kind of disease occurs together often by multiple bone aching because of combined reaction, the pain occurred together such as cancer is inflammatory pain, lacks
The courageous and upright Different types of etiopathogenises such as pain, neuropathic pain comprehensively forms, and the analgesic for single target spot can not solve clinical problem.
Transcutaneous electric nerve stimulation analgesia art has employed over half a century the most, and domestic scientist exists it with the combination of Chinese medicine meridian acupuncture point
Together, invented " Blood oxygen saturation " and there is good analgesic activity.It is to local pain, overall pain, Encelialgia etc.
All there is obvious therapeutic effect, and there is the advantages such as rapid-action, spectrum of disease is wide, good, the few side effects of integrally-regulated effect, available
In treating various Acute or chronic pain, the therapy of these many targetings has become the main green analgesia means generally acknowledged both at home and abroad, is
The Typical Representative of " green analgesia ".The invention of this device can be fabulous these problems of solution, this device combines China tradition doctor
Acupuncture point in is theoretical, transfers human endogenous's property Opioid Mechanism by electric stimulate of point and produces analgesic effect, is a kind of peace
Atoxic side reaction, can the analgesia health-care device device of life-time service.
Summary of the invention
It is an object of the invention to: overcome the deficiencies such as existing analgesic drug product unsatisfactory curative effect, side reaction are big, existing electrostimulator
Uncertain therapeutic efficacy is cut, mostly without defects such as strict scientific research demonstrations；Thus provide a kind of non-treatment purpose, by modern times electricity
Sub-technology combines with the acupuncture theory of China traditional Chinese medical science, auxiliary analgesic electric acupoint stimulation device and electric acupoint stimulation method.
It is an object of the invention to be achieved through the following technical solutions: a kind of electric acupoint stimulation method based on continuous wave,
The method uses continuous wave to carry out electricity irritation, and the size of current of continuous wave is 0.1～50mA, and voltage swing is 0.1～4V；Frequency
It is 1～50Hz, a width of 50 μ s of ripple；Or frequency is 51～80Hz, a width of 100 μ s of ripple；Or frequency is 81～100Hz, ripple a width of 200
μs；Or frequency is 101～120Hz, a width of 300 μ s of ripple.
A kind of electric acupoint stimulation device, including pulse generator and electrode, pulse generator is carried out to acupuncture point by electrode
Electricity irritation；The pulse signal that described pulse generator sends include continuous wave, the size of current of described continuous wave be 0.1～
50mA, voltage swing is 0.1～4V；Frequency is 1～50Hz, a width of 50 μ s of ripple；Or frequency is 51～80Hz, a width of 100 μ s of ripple；
Or frequency is 81～100Hz, a width of 200 μ s of ripple；Or frequency is 101～120Hz, a width of 300 μ s of ripple.
Further, described electric acupoint stimulation device also includes liquid crystal display, liquid crystal display and pulse generator phase
Even, the display frequency of work at present, ripple width and the residue working time.
Further, described device also includes button group and single-chip microcomputer, and described button group passes through single-chip microcomputer and pulse generation
Device is connected, and described button group includes that frequency strengthens button and frequency reduces button, and by button regulating frequency size, frequency is from 1
～120Hz is adjustable, regulation step-length is 1Hz.
Further, described device also includes button group and single-chip microcomputer, and described button group passes through single-chip microcomputer and pulse generation
Device is connected, and described button group includes that intensifying current button and electric current reduce button, the size of regulation stimulating current, and regulation step-length is
0.1mA。
Further, described device also includes button group and single-chip microcomputer, and described button group passes through single-chip microcomputer and pulse generation
Device is connected, and described button group includes timing button, is used for setting electric stimulating time.
The beneficial effects of the present invention is: the present invention is machine-processed based on gate-control theory and endogenous opiatepeptide, and through reality
Checking is real truly has anti-inflammatory and antalgic effect, can significantly improve maincenter endogenous opioids analgesic matter, suppress the peripheral inflammation factor.Grind
Study carefully the confirmation present invention and can promote that maincenter endogenous beta-endorphin is secreted, suppress the pro-inflammatory cytokine secretions such as peripheral t NF-α, be conducive to subtracting
The light various Acute or chronic pain of patient, inflammatory pain, neuropathic pain and various Combination pain, reduce patient's analgesic
The application of thing, uses for patient instrument to solve pain voluntarily and provides intellectualized operation, can improve pain-suffered patient quality of life.
Accompanying drawing explanation
Fig. 1 is the structural representation of electric acupoint stimulation device；
Fig. 2 is the assembly connection diagram of electric acupoint stimulation device；
Fig. 3 is the assembly connection diagram of electric acupoint stimulation device；
Fig. 4 is 50 μ s electricity irritation and the comparison to rat pain of the different frequency assembled pulse ripple；
Fig. 5 is 100 μ s electricity irritation and the comparison to rat pain of the different frequency assembled pulse ripple；
Fig. 6 is 200 μ s electricity irritation and the comparison to rat pain of the different frequency assembled pulse ripple；
Fig. 7 is 300 μ s electricity irritation and the comparison to rat pain of the different frequency assembled pulse ripple；
Fig. 8 is the different frequency continuous wave electric-impulse stimulation comparison to inflammatory pain Pain Regulation In The Rat；
Fig. 9 is the different frequency continuous wave electric-impulse stimulation comparison to neuropathic pain Pain Regulation In The Rat
Figure 10 is the different frequency continuous wave electric-impulse stimulation comparison to chronic pain rat hypothalamus Content of B-ep；
Figure 11 is the different frequency continuous wave electric-impulse stimulation comparison to chronic pain rat paw TNF-α content.
Detailed description of the invention
The invention will be further described below in conjunction with the accompanying drawings.
The present invention provides a kind of non-treatment purpose, is combined with the acupuncture theory of China traditional Chinese medical science by modern electronic technology
, auxiliary analgesic electric acupoint stimulation device and electric acupoint stimulation method.Proved by lot of experiments, following electricity irritation frequency and
Ripple wide array method has better effects to analgesia, and (1) frequency is 1～50Hz, a width of 50 μ s of ripple；(2) frequency is 51～80Hz,
The a width of 100 μ s of ripple；(3) frequency is 81～100Hz, a width of 200 μ s of ripple；(4) frequency is 101～120Hz, a width of 300 μ s of ripple.Electricity
Stream size is 0.1～50mA, and voltage swing is 0.1～4V；Said method to electric acupoint stimulation improve analgesic effect oneself
Rat experiment is proven, is better than other same quasi-instruments the most on the market.Specific as follows:
Use SD rat, compare the analgesic effect of 50 μ s electricity irritation and the combination of different frequency assembled pulse ripple, big by 60
Mus is randomly divided into 10 groups: 1Hz group, 15Hz group, 50Hz group, 60Hz group, 70Hz group, 80Hz group, 90Hz group, 100Hz group, 110Hz
Group, 120Hz group, pulse radio is wide is 50 μ s, and current intensity is 1mA, and electric stimulating time is 30min, before and after comparing electricity irritation
Pain Regulation In The Rat changes, and through statistical analysis, result show, 1Hz group, 15Hz group, the 50Hz group threshold of pain improve relatively other organize obvious (P <
0.05), zero difference between three groups.Shown result is with reference to Fig. 4, table 1.
The comparison to rat pain of table 1 50 μ s electricity irritation and different frequency assembled pulse ripple
60 rats are randomly divided into by relatively 100 μ s electricity irritation and the analgesic effect of different frequency assembled pulse ripple combination
10 groups: 1Hz group, 15Hz group, 50Hz group, 60Hz group, 70Hz group, 80Hz group, 90Hz group, 100Hz group, 110Hz group, 120Hz
Group, pulse radio is wide is 100 μ s, and current intensity is 1mA, and electric stimulating time is 30min, compares rat pain before and after electricity irritation
Threshold changes, and through statistical analysis, result show, 60Hz group, 70Hz group, the 80Hz group threshold of pain improve relatively other organize obvious (P <
0.05), zero difference between three groups.Shown result is with reference to Fig. 5, table 2.
The comparison to rat pain of table 2 100 μ s electricity irritation and different frequency assembled pulse ripple
60 rats are randomly divided into by relatively 200 μ s electricity irritation and the analgesic effect of different frequency assembled pulse ripple combination
10 groups: 1Hz group, 15Hz group, 50Hz group, 60Hz group, 70Hz group, 80Hz group, 90Hz group, 100Hz group, 110Hz group, 120Hz
Group, pulse radio is wide is 200 μ s, and current intensity is 1mA, and electric stimulating time is 30min, compares rat pain before and after electricity irritation
Threshold changes, and through statistical analysis, result shows, 90Hz group, the 100Hz group threshold of pain improve relatively other groups substantially (P < 0.05), between group
Zero difference.Shown result is with reference to Fig. 6, table 3.
The comparison to rat pain of table 3 200 μ s electricity irritation and different frequency assembled pulse ripple
60 rats are randomly divided into by relatively 300 μ s electricity irritation and the analgesic effect of different frequency assembled pulse ripple combination
10 groups: 1Hz group, 15Hz group, 50Hz group, 60Hz group, 70Hz group, 80Hz group, 90Hz group, 100Hz group, 110Hz group, 120Hz
Group, pulse radio is wide is 300 μ s, and current intensity is 1mA, and electric stimulating time is 30min, compares rat pain before and after electricity irritation
Threshold changes, and through statistical analysis, result shows, 110Hz group, the 120Hz group threshold of pain improve relatively other groups substantially (P < 0.05), between group
Zero difference.Shown result is with reference to Fig. 7, table 4.
The comparison to rat pain of table 4 300 μ s electricity irritation and different frequency assembled pulse ripple
Further, we use SD rat, select metapedes plantar subcutaneous injection (Complete freund ' s adjuvant,
CFA), the chronic inflam-matory pain model that induction is classical, test representative 4 continuous impulse electricity irritation big to inflammatory pain
The Mus threshold of pain affects.36 rats are randomly divided into 6 groups: normal group, model group, 2Hz/50 μ s electricity irritation group, 70Hz/100 μ s control
Treatment group, 100Hz/200 μ s electricity irritation group, 120Hz/300 μ s electricity irritation group, electric current 1mA.Select tsu san li, Kunlun point, control every time
Treating 30min, through 10 days electronic stimulations, detect the rat machinery threshold of pain every day, result shows that 4 kinds of continuous impulse electricity irritation can be bright
Aobvious raising chronic inflam-matory pain Pain Regulation In The Rat.Shown result is with reference to Fig. 8, table 5.
Inflammatory pain Pain Regulation In The Rat is compared (unit: g) by table 5 different frequency electricity irritation
Further, we pass through Banded Rats sciatic nerve, make SNL europathology pain model, test and have representative
4 continuous waves of property.36 rats are randomly divided into 6 groups: normal group, model group, 2Hz/50 μ s electricity irritation group, 70Hz/100 μ s
Treatment group, 100Hz/200 μ s electricity irritation group, 120Hz/300 μ s electricity irritation group, electric current 1mA.Select tsu san li, Kunlun point, every time
Treatment 30min, through 10 days electronic stimulations, detects the rat machinery threshold of pain every day, and result shows that 4 kinds of continuous waves can significantly improve
The europathology pain rat threshold of pain.Shown result is with reference to Fig. 9, table 6.
Neuropathic pain Pain Regulation In The Rat is compared (unit: g) by table 6 different frequency electricity irritation
Detection rat hypothalamus beta-endorphin, foot sole of the foot TNF-α content further, result shows above 4 kinds of electric-impulse stimulations
Treatment can significantly improve pain rat hypothalamus Content of B-ep, and suppresses foot sole of the foot TNF-α content, has statistics with model group ratio
Learn meaning (P < 0.05).Shown result is with reference to Figure 10-11, table 7.
Table 7 electronic stimulation is on CFA rat hypothalamus beta-endorphin, the impact of TNF-α content
Based on above electrical stimulation method, present invention also offers a kind of electric acupoint stimulation device, including pulse generator and
Electrode, pulse generator carries out electricity irritation by electrode to acupuncture point；Described pulse generator includes button group, is selected by button group
Selecting the electric impulse signal of output, the size of current of described electric impulse signal is 0.1～50mA, and voltage swing is 0.1～4V；Output
Frequency is 1～50Hz, a width of 50 μ s of ripple；Or frequency is 51～80Hz, a width of 100 μ s of ripple；Or frequency is 81～100Hz, ripple width
It is 200 μ s；Frequency is 101～120Hz, a width of 300 μ s of ripple.
As the common knowledge of this area, pulse generator generally comprises Single Chip Microcomputer (SCM) system and constant current output circuit.Monolithic
Machine system is the control core of whole system, can use STC industry microcontroller, and control system works according to normal requirement,
Controlling to export different pulse signals, pulse signal can be adjusted by button group, constant current output circuit such as Fig. 3 institute
Show.This high-precision constant flow source circuit can realize the output of 0-4V Control of Voltage 0-50mA electric current, uses high reliability operational amplifier
The output of OPA211 constant-current source the most drives.The low impedance characteristic of metal-oxide-semiconductor, is particularly suitable in constant-current source output circuit, and whole system
System activated amplifier is as driving, and the temperature that works long hours is waftd little, and output is stable.The circuit exported is made of audion than traditional
Stability is high, and precision is high.
Said apparatus can also include liquid crystal display, and liquid crystal display is connected with pulse generator, to show current work
Frequency, ripple width and the residue working time made.
Described button group includes that frequency strengthens button and frequency reduces button, the size of regulation stimulus frequency, regulates step-length
For 1Hz.Described button group includes that intensifying current button and electric current reduce button, the size of regulation stimulating current, and regulation step-length is
0.1mA.Also include timing button, be used for setting electric stimulating time.
Claims (6)
1. an electric acupoint stimulation method based on continuous wave, it is characterised in that the method uses continuous wave to carry out electricity irritation, even
The size of current of continuous ripple is 0.1～50mA, and voltage swing is 0.1～4V；Frequency is 1～50Hz, a width of 50 μ s of ripple；Or frequency is
51～80Hz, a width of 100 μ s of ripple；Or frequency is 81～100Hz, a width of 200 μ s of ripple；Or frequency is 101～120Hz, ripple is a width of
300 μ s etc..
2. an electric acupoint stimulation device based on continuous wave, it is characterised in that include pulse generator and electrode, pulse generation
Device carries out electricity irritation by electrode to acupuncture point；The pulse signal that described pulse generator sends includes continuous wave, and size of current is
0.1～50mA, voltage swing is 0.1～4V；The frequency of continuous wave is 1～50Hz, a width of 50 μ s of ripple；Or frequency be 51～
80Hz, a width of 100 μ s of ripple；Or frequency is 81～100Hz, a width of 200 μ s of ripple；Or frequency is 101～120Hz, a width of 300 μ of ripple
s。
Electric acupoint stimulation device the most according to claim 2, it is characterised in that described electric acupoint stimulation device also includes liquid
Crystal display, liquid crystal display is connected with pulse generator, the display frequency of work at present, ripple width and residue working time.
Electric acupoint stimulation device the most according to claim 2, it is characterised in that described device can also include button group
And single-chip microcomputer, described button group is connected with pulse generator by single-chip microcomputer, and described button group includes that frequency strengthens button and frequency
Rate reduces button, and the size of regulation stimulus frequency, regulation step-length is 1Hz.
Electric acupoint stimulation device the most according to claim 2, it is characterised in that described device can also include button group
And single-chip microcomputer, described button group is connected with pulse generator by single-chip microcomputer, and described button group includes intensifying current button and electricity
Stream reduces button, and the size of regulation stimulating current, regulation step-length is 1mA.
Electric acupoint stimulation device the most according to claim 2, it is characterised in that described device can also include button group
And single-chip microcomputer, described button group is connected with pulse generator by single-chip microcomputer, and described button group includes timing button, is used for setting
Electric stimulating time.
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