CN105944231A - Acupoint electrical stimulation method and device for auxiliary treatment of inflammatory pain - Google Patents

Acupoint electrical stimulation method and device for auxiliary treatment of inflammatory pain Download PDF

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Publication number
CN105944231A
CN105944231A CN201610516672.7A CN201610516672A CN105944231A CN 105944231 A CN105944231 A CN 105944231A CN 201610516672 A CN201610516672 A CN 201610516672A CN 105944231 A CN105944231 A CN 105944231A
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CN
China
Prior art keywords
frequency
pain
electrical stimulation
120hz
device
Prior art date
Application number
CN201610516672.7A
Other languages
Chinese (zh)
Inventor
周杰
方剑乔
梁宜
龚杰
庄晟坚
Original Assignee
浙江中医药大学
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Application filed by 浙江中医药大学 filed Critical 浙江中医药大学
Priority to CN201610516672.7A priority Critical patent/CN105944231A/en
Publication of CN105944231A publication Critical patent/CN105944231A/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H39/00Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
    • A61H39/002Using electric currents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014External stimulators, e.g. with patch electrodes
    • A61N1/36021External stimulators, e.g. with patch electrodes for treatment of pain
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/10Characteristics of apparatus not provided for in the preceding codes with further special therapeutic means, e.g. electrotherapy, magneto therapy or radiation therapy, chromo therapy, infra-red or ultraviolet therapy

Abstract

The invention discloses an acupoint electrical stimulation method and an acupoint electrical stimulation device for auxiliary treatment of inflammatory pain. The acupoint electrical stimulation method is characterized by outputting a bidirectional symmetric rectangular pulse current with output frequency of 2/120Hz, when the frequency is 2Hz, the wave width is 400mu s, when the frequency is 120Hz, the wave width is 100mu s, and sparse waves and dense waves each last 3 seconds, thereby achieving pain alleviation for inflammatory pain. The device for implementing the acupoint electrical stimulation method comprises a pulse generator and electrodes. The acupoint electrical stimulation method and the acupoint electrical stimulation device can obviously increase the secretion of central nerve endogenous enkephalin and beta-endorphin, inhibits generation of peripheral IL-1beta, has anti-inflammatory and pain alleviating effects, is conductive to alleviating the inflammatory pain, offers intelligent operation for a patient to relieve pain by using an instrument on his own, and can improve life quality of patients with pain.

Description

A kind of for assisting the electric acupoint stimulation method and device for the treatment of inflammatory pain

Technical field

The present invention relates to a kind of for analgesic apparatus and method, particularly relate to a kind of for assisting treatment inflammation The electric acupoint stimulation method and device of property pain.

Background technology

Pain is the subjective sensation of a kind of complexity caused by noxious stimulation, and it is as one " double-edged sword ", a side Face, it is provided that alarm signal when body is on the hazard, by promoting behavior and reflexive defence to make tissue Escape injury, be the indispensable a kind of defencive function of body;On the other hand, violent or long-term pain The dysfunction on organism physiology and psychological discomfort can be caused, be clinical a great problem.Inflammatory pain It is the most modal types of pain, belongs to such as various arthritis, gout, rheumatoid arthritis etc. Inflammatory pain, it may be said that as long as there being inflammation just to have " inflammatory pain ".Nonsteroidal antiinflammatory drug treats struvite pain The goldstandard of pain, such as conventional diclofenac, ibuprofen etc., but it inherently causes serious gastrointestinal to patient Road damages, and long-term taking analgesic brings huge economic pressures and serious actual bodily harm to patient, even The great side effect such as digestive tract hemorrhage occur, can threat to life.Therefore, for the nonsteroidal of single target spot Anti-inflammatory agent can not solve clinical problem.Transcutaneous electric nerve stimulation analgesia art has employed over half a century the most, Domestic scientist combines it with Chinese medicine meridian acupuncture point, has invented " Blood oxygen saturation " and has had very well Analgesic activity.It all has obvious therapeutic effect to local pain, overall pain, Encelialgia etc., and There is the advantages such as rapid-action, spectrum of disease is wide, good, the few side effects of integrally-regulated effect, can be used for treating various Acute or chronic pain, the therapy of these many targetings has become the main green analgesia means generally acknowledged both at home and abroad, has been The Typical Representative of " green analgesia ".The invention of this device exports specific impulse wave, solution that can be fabulous these Problem, it is theoretical that this device combines the acupuncture point in China's traditional medicine, transfers human endogenous by electric stimulate of point Property Opioid Mechanism produce analgesic effect, and suppress internal Inflammatory substances to secrete, be that a kind of safety non-toxic is secondary Reaction, can the analgesia health-care device device of life-time service.

Summary of the invention

It is an object of the invention to: overcome the deficiencies such as existing nonsteroidal antiinflammatory drug unsatisfactory curative effect, side reaction are big, Existing electrostimulator uncertain therapeutic efficacy is cut, mostly without defects such as strict scientific research demonstrations;Thus provide one Kind of non-treatment purpose, modern electronic technology is combined with the acupuncture theory of China traditional Chinese medical science, for inflammatory Pain carries out assisting analgesic electric acupoint stimulation device and electric acupoint stimulation method.

It is an object of the invention to be achieved through the following technical solutions: a kind of for assisting treatment inflammatory pain Electric acupoint stimulation method, the method the method uses dilatational wave to carry out electricity irritation, and the size of current of dilatational wave is 0.1~50mA, voltage swing is 0.1~4V;The frequency of current impulse is 2/120Hz, when frequency is 2Hz, The a width of 400 μ s of ripple, when frequency is 120Hz, a width of 100 μ s of ripple, rarefaction wave and condensation wave each continue 3 seconds.

A kind of for assisting the electric acupoint stimulation device for the treatment of inflammatory pain, including pulse generator and electrode, Pulse generator carries out electricity irritation by electrode to acupuncture point;The pulse signal that described pulse generator sends includes Dilatational wave, the size of current of dilatational wave is 0.1~50mA, and voltage swing is 0.1~4V;The frequency of current impulse For 2/120Hz, when frequency is 2Hz, a width of 400 μ s of ripple, when frequency is 120Hz, a width of 100 μ s of ripple, rarefaction wave Each with condensation wave lasting 3 seconds.

Further, described electric acupoint stimulation device also includes liquid crystal display, and liquid crystal display is sent out with pulse Raw device is connected, the display frequency of work at present, ripple width and residue working time.

Further, described device also includes button group and single-chip microcomputer, and described button group passes through single-chip microcomputer and arteries and veins Rushing generator to be connected, described button group includes that intensifying current button and electric current reduce button, regulates stimulating current Size, regulation step-length is 1mA.

Further, described device also includes button group and single-chip microcomputer, and described button group passes through single-chip microcomputer and arteries and veins Rushing generator to be connected, described button group includes timing button, is used for setting electric stimulating time.

The beneficial effects of the present invention is: the present invention is machine-processed based on gate-control theory and endogenous opiatepeptide, And be verified by experiments and truly have anti-inflammatory and antalgic effect, maincenter endogenous opioids analgesic matter can be significantly improved, press down The peripheral inflammation factor processed.Research confirms that the present invention can promote that hypothalamus beta-endorphin, spinal cord enkephalin are secreted, and presses down The pro-inflammatory cytokines such as periphery IL-1 β processed produce, and are conducive to alleviating patient's inflammatory pain, reduce patient's analgesic drug product Application, uses for patient instrument to solve pain voluntarily and provides intellectualized operation, can improve pain-suffered patient life Quality.

Accompanying drawing explanation

Fig. 1 is the structural representation of electric acupoint stimulation device;

Fig. 2 is the assembly connection diagram of electric acupoint stimulation device;

Fig. 3 is the assembly connection diagram of electric acupoint stimulation device;

Fig. 4 is that CFA Pain Regulation In The Rat is compared by different frequency electricity irritation;

Fig. 5 is the different frequency electric-impulse stimulation comparison to CFA rat hypothalamus Content of B-ep;

Fig. 6 is the different frequency electric-impulse stimulation comparison to CFA rat hypothalamus enkephalin content;

Fig. 7 is the different frequency electric-impulse stimulation comparison to CFA rat paw IL-1 β content.

Detailed description of the invention

The invention will be further described below in conjunction with the accompanying drawings.

The present invention provides a kind of non-treatment purpose, by the acupuncture theory phase of modern electronic technology with China's traditional Chinese medical science In conjunction with, auxiliary analgesic electric acupoint stimulation device and electric acupoint stimulation method.Proved by lot of experiments, This certain pulses electrical stimulation method has better effects to inflammatory pain, is mainly characterized by bi-directional symmetrical rectangle electricity The frequency of stream pulse is 2/120Hz, when frequency is 2Hz, and a width of 400 μ s of ripple, when frequency is 120Hz, ripple width Being that 100 μ s, rarefaction wave and condensation wave are each continues 3 seconds.Above-mentioned electric acupoint stimulation method is to improving inflammatory pain analgesia effect Fruit is own to be proven in rat experiment, is better than other same quasi-instruments the most on the market.Specific as follows:

Use SD rat, select metapedes plantar subcutaneous injection (Complete freund ' s adjuvant, CFA), induction classics Chronic inflam-matory pain model, 42 rats are randomly divided into 7 groups: normal group, model group, 2Hz electricity irritation Group, 100Hz electricity irritation group, 120Hz electricity irritation group, 2/100Hz electricity irritation group, 2/120Hz electricity irritation group, Pulse radio width is provided that when frequency is 2Hz, a width of 400 μ s of ripple;When frequency is 100Hz, ripple is a width of 200μs;When frequency is 120Hz, a width of 100 μ s of ripple;Dilatational wave is each continues 3s, electric current 1mA.Select foot three In, Kunlun point, treat 30min every time, through 9 days electronic stimulations, detect the rat machinery threshold of pain, through system Meter learns analysis result display 2/120Hz group the 7th, 9 days analgesic effect preferably (equal P < 0.05).Shown result ginseng According to Fig. 4, table 1.

Table 1: CFA Pain Regulation In The Rat is compared by different frequency electricity irritation

Further, through 9 days electronic stimulations, put to death rat, detect rat hypothalamus beta-endorphin, brain coffee Peptide, foot sole of the foot IL-1 β content, result shows that above 5 kinds of electric-impulse stimulations treatment can significantly improve inflammatory pain rat Hypothalamus beta-endorphin, enkephalin content, and suppress foot sole of the foot IL-1 β content, there is statistics to anticipate with model group ratio Justice (P < 0.05).Shown result is with reference to Fig. 5-7, table 5.

The impact on CFA rat index of correlation of the table 5 different frequency electronic stimulation

Based on above electrical stimulation method, present invention also offers a kind of electric acupoint stimulation device, send out including pulse Raw device and electrode, pulse generator carries out electricity irritation by electrode to acupuncture point;Described pulse generator include by Key group, the electric impulse signal exported by button group selection, the size of current of described electric impulse signal is 0.1~50mA, voltage swing is 0.1~4V;The frequency of bi-directional symmetrical rectangular current pulses is 2/120Hz, frequency During for 2Hz, a width of 400 μ s of ripple, when frequency is 120Hz, a width of 100 μ s of ripple, rarefaction wave and condensation wave each lasting 3 Second.

As the common knowledge of this area, pulse generator generally comprises Single Chip Microcomputer (SCM) system and constant current output electricity Road.Single Chip Microcomputer (SCM) system is the control core of whole system, can use STC industry microcontroller, control system Working according to normal requirement, control to export different pulse signals, pulse signal can be entered by button group Row regulation, constant current output circuit is as shown in Figure 3.This high-precision constant flow source circuit can realize 0-4V Control of Voltage 0-50mA electric current exports, and uses the output of high reliability operational amplifier OPA211 constant-current source the most to drive.MOS The low impedance characteristic of pipe, is particularly suitable in constant-current source output circuit, and whole system activated amplifier as Driving, the temperature that works long hours is waftd little, and output is stable.The circuit stability exported is made of audion than traditional Height, precision is high.

Said apparatus can also include liquid crystal display, and liquid crystal display is connected with pulse generator, with display The frequency of work at present, ripple width and residue working time.

Button group can arrange output bi-directional symmetrical rectangular current pulses, and frequency is 2/120Hz, and frequency is 2Hz Time, a width of 400 μ s of ripple, when frequency is 120Hz, a width of 100 μ s of ripple, rarefaction wave and condensation wave each continue 3 seconds.Also Can include that intensifying current button and electric current reduce button, to regulate the size of stimulating current, regulation step-length is 1mA.Also include timing button, be used for setting electric stimulating time.

Claims (5)

1. the electric acupoint stimulation method being used for assisting treatment inflammatory pain, it is characterised in that the method the party Method uses dilatational wave to carry out electricity irritation, and the size of current of dilatational wave is 0.1~50mA, and voltage swing is 0.1~4V; The frequency of current impulse is 2/120Hz, when frequency is 2Hz, and a width of 400 μ s of ripple, when frequency is 120Hz, The a width of 100 μ s of ripple, rarefaction wave and condensation wave are each continues 3 seconds.
2. the electric acupoint stimulation device being used for assisting treatment inflammatory pain, it is characterised in that include that pulse is sent out Raw device and electrode, pulse generator carries out electricity irritation by electrode to acupuncture point;Described pulse generator sends Pulse signal includes dilatational wave, and the size of current of dilatational wave is 0.1~50mA, and voltage swing is 0.1~4V;Electricity The frequency of stream pulse is 2/120Hz, when frequency is 2Hz, and a width of 400 μ s of ripple, when frequency is 120Hz, ripple width Being that 100 μ s, rarefaction wave and condensation wave are each continues 3 seconds.
Electric acupoint stimulation device the most according to claim 2, it is characterised in that described device can also wrap Including liquid crystal display, liquid crystal display is connected with pulse generator, display the frequency of work at present, ripple width with And the residue working time.
Electric acupoint stimulation device the most according to claim 2, it is characterised in that described device can also wrap Including button group and single-chip microcomputer, described button group is connected with pulse generator by single-chip microcomputer, described button group bag Including intensifying current button and electric current reduces button, the size of regulation stimulating current, regulation step-length is 1mA.
Electric acupoint stimulation device the most according to claim 2, it is characterised in that described device can also wrap Including button group and single-chip microcomputer, described button group is connected with pulse generator by single-chip microcomputer, described button group bag Include timing button, be used for setting electric stimulating time.
CN201610516672.7A 2016-06-28 2016-06-28 Acupoint electrical stimulation method and device for auxiliary treatment of inflammatory pain CN105944231A (en)

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PCT/CN2016/101462 WO2018000650A1 (en) 2016-06-28 2016-10-08 Acupoint electrical stimulation method and device for adjuvant treatment of inflammatory pain

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Cited By (1)

* Cited by examiner, † Cited by third party
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WO2018000650A1 (en) * 2016-06-28 2018-01-04 浙江中医药大学 Acupoint electrical stimulation method and device for adjuvant treatment of inflammatory pain

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CN102743816A (en) * 2012-07-06 2012-10-24 符竞之 Handheld portable transcuataneous electrical nerve stimulation analgesic method, analgesic device and application

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CN1762509B (en) * 2004-10-20 2010-05-26 合肥奥力智能系统有限公司 Acupoint electrostimulation device and method for improving cerebral function
EP2606931B1 (en) * 2011-12-23 2015-12-16 Mitsunori Minami Brain state support apparatus and program
CN202909298U (en) * 2012-10-25 2013-05-01 韩济生 Nerve regulation instrument
CN203355132U (en) * 2013-07-01 2013-12-25 安徽桑乐金股份有限公司 Electrical acupoint stimulation apparatus having vola physiotherapy function
CN105944231A (en) * 2016-06-28 2016-09-21 浙江中医药大学 Acupoint electrical stimulation method and device for auxiliary treatment of inflammatory pain

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1745857A (en) * 2005-10-28 2006-03-15 清华大学 Implant nervous electric pulse stimulus system
CN101069769A (en) * 2007-03-23 2007-11-14 南京济生医疗科技有限公司 Needle-free pain-relieving instrument and its setting method
CN102743816A (en) * 2012-07-06 2012-10-24 符竞之 Handheld portable transcuataneous electrical nerve stimulation analgesic method, analgesic device and application

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018000650A1 (en) * 2016-06-28 2018-01-04 浙江中医药大学 Acupoint electrical stimulation method and device for adjuvant treatment of inflammatory pain

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