TWI724835B - Low frequency electro stimulation therapy with primo waveform - Google Patents

Abstract

During the preset pulse on time, the low-frequency electrical stimulation treatment instrument of the present invention gradually decreases the amplitude of the pulse from the peak value to zero, and the rate of decrease of the amplitude is gradually reduced. Limo waveform is output, so that the treatment effect can be maximized more effectively. In addition, there is no short circuit between the anode and the cathode, and it is directly transmitted to the human body, so that the imbalance of ions in the diseased part of the human body can be corrected, and the cell tissue can be regenerated normally without side effects.

Description

Low-frequency electrical stimulation treatment instrument with primo waveform

The present invention relates to a low-frequency electrical stimulation treatment instrument with a Primo waveform. More specifically, it relates to a low-frequency electrical stimulation treatment instrument that outputs pulses as a Primo waveform to maximize the therapeutic effect.

Conventional medical electrical therapy devices used direct current (DC), alternating current (AC), pulsating current (PC), etc., and physical therapy devices (high frequency, intermediate frequency, low frequency), etc. were used.

However, the anode (+) and cathode (-) flowing out of the conventional electrotherapy device itself flow out in the same circuit, and they are in an affinity-type relative relationship. Therefore, the human body is used as a conductor, which causes a short-circuit effect. Therefore, it does not have a relationship with the diseased parts of the human body. It only functions as an electrical conductor and cannot remove the causative substances of the disease. Therefore, as a conventional treatment device, in addition to the temporary physical effects based on heat, vibration and stimulation, no other effects can be obtained, and instead it is dangerous to the human body.

In order to eliminate the above-mentioned problems, a unipolar therapeutic device has recently been proposed, but this only uses the unipolar of the electrical two poles, which induces unidirectional changes in the human body, which has the disadvantage of causing an imbalance in the potential of human tissues and cells. .

In order to eliminate this shortcoming, Korean Patent No. 10-0483970 applied for a non-short-circuit anode electrotherapy device, but a small amount of short-circuit effect was found in actual use, so there is an increasing need for an electrotherapy device that can be used more safely. high.

The purpose of the present invention is to provide a low-frequency electrical stimulation therapeutic instrument with Primo waveform that can simultaneously improve safety and therapeutic effect.

The low-frequency electrical stimulation treatment instrument of the present invention is used as a low-frequency electrical stimulation treatment instrument that contacts the human body and applies low-frequency electrical stimulation to the contact part, wherein the waveform of the pulse output for applying the electrical stimulation is in the pulse period and is set in advance. During the ON time, the amplitude is gradually reduced from the pulse peak value (Peak value) to reach 0, and the amplitude of the reduction speed is gradually reduced, and output is a primordial waveform.

The pulse period is 2 to 3.5 ms, and the pulse on-time is 5 to 100 μs.

The peak value of the pulse is 400 to 1500V.

The pulse includes an anode pulse output by an anode transformer and an anode rectifier circuit, and a cathode pulse output by a cathode transformer and a cathode rectifier circuit.

Another aspect of the present invention is low-frequency electrical stimulation therapy as a low-frequency electrical stimulation therapy device that contacts the human body and applies low-frequency electrical stimulation to the contact site, wherein the waveform of the pulse output for applying the electrical stimulation is set in advance in the pulse period During the ON time of the pulse, the amplitude is gradually reduced from the peak value (Peak value) to reach 0, and the amplitude of the reduction speed is gradually reduced, and the pulse period is 2 to 3.5 ms, the pulse on time is 5 to 100 μs, so The pulse peak value is 400 to 1500V, and the pulse includes an anode pulse output by an anode transformer and an anode rectifier circuit, and a cathode pulse output by a cathode transformer and a cathode rectifier circuit.

During the preset pulse on time, the low-frequency electrical stimulation therapeutic apparatus of the present invention gradually decreases the amplitude of the pulse from the peak value of the pulse to reach 0, and the rate of decrease of the amplitude is gradually reduced. It is output in a waveform, which can more effectively maximize the treatment effect.

In addition, there is no short circuit between the anode and the cathode, and it is directly transmitted to the human body, so that the imbalance of ions in the diseased part of the human body can be corrected, and the cell tissue can be regenerated normally without side effects.

10: Primo Waveform Output Section

11: Anode Primo Waveform Exporter

12: Cathode Primo Waveform Exporter

70: Pulse generator

OUT1: anode output terminal

OUT2: cathode output terminal

P1: first pulse

P2: second pulse

R1: anode rectifier

R2: Cathode rectifier

T: pulse period

T1: Anode transformer

T2: Cathode transformer

t: time

t1: the first point in time

t2: second time point

t _on : pulse on time

V: amplitude

V _P : Pulse peak value

θ 1: the first inclination

θ 2: second inclination

Fig. 1 is a diagram showing a circuit diagram of a low-frequency electrical stimulation treatment instrument with a primordial waveform according to an embodiment of the present invention.

Fig. 2 is a diagram showing the primo waveform of the pulse of the low-frequency electrical stimulation treatment instrument with primo waveform according to the embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described with reference to the drawings.

The low-frequency electrical stimulation therapeutic apparatus of the embodiment of the present invention is a device that contacts the shoulder, back, waist, etc. of the human body, and applies low-frequency electrical stimulation to the contact part to treat the contact part.

Fig. 1 is a diagram showing a circuit diagram of a low-frequency electrical stimulation treatment instrument with a primordial waveform according to an embodiment of the present invention.

If referring to FIG. 1, the low-frequency electrical stimulation treatment apparatus with a primordial waveform according to an embodiment of the present invention includes a pulse generator 70, and a primordial pulse generator that outputs the pulses generated by the pulse generator 70 as pulses with a primordial waveform. Wave output unit 10.

The pulses include anode pulses and cathode pulses respectively output from circuits independent of each other.

The pulse generator 70 includes: an amplifying circuit (not shown in the figure) that amplifies the frequency generating signal received by the CPU (not shown in the figure) to a predetermined level; a transistor circuit (not shown in the figure) (Not shown), the transistor circuit is connected to the amplifying circuit (not shown in the figure) and pulses are generated.

The primordial waveform output unit 10 includes: an anode primordial waveform outputter 11, which receives the first pulse P1 generated by the pulse generator 70 and outputs it as primordial The anode pulse of the waveform; the cathode primordial waveform output device 12, the cathode primordial waveform output device 12 receives and inputs the second pulse P2 generated by the pulse generator 70, and outputs the cathode pulse of the primordial waveform.

The anode primordial waveform output device 11 includes: an anode transformer T1, the anode transformer T1 receives and inputs the first pulse P1 generated by the pulse generator 70 and converts it into alternating current; an anode rectifier circuit R1 The anode rectifier circuit R1 transforms the + and-AC signals from the anode transformer T1 into a + signal with one polarity.

If referring to FIG. 2, the waveform of the anode pulse output by the anode primordial waveform output device 11 is in the pulse period T. During the preset pulse ON time t _on , the amplitude V changes from the peak value) _{A waveform in which V p} gradually decreases to reach 0, and the decreasing speed of the amplitude V gradually decreases.

The slope of the tangent to the waveform is less than 0 and gradually increases with time t. For example, it can be seen that the second inclination tan (θ 2) of the tangent at the second time point t2 is greater than the first inclination tan (θ 1) of the tangent at the first time point t1.

This waveform is different from the original square wave or sine wave, and is defined as a primo waveform. The primordial waveform is a downwardly convex curved shape.

The pulse period T of the anode pulse is 2 to 3.5 ms, the pulse on time t _on of the anode pulse is 5 to 100 μs, and the pulse peak value V _p of the anode pulse is 400 to 1500V.

When the anode pulse is output, the initial amplitude corresponds to the peak value, and during the pulse on time during which the anode pulse lasts, the amplitude of the pulse gradually decreases from the peak value to zero. The rate of decrease when the amplitude of the pulse decreases gradually decreases. After the pulse on time has elapsed, the amplitude is zero.

The anode primordial waveform output device 11 is connected to an anode output terminal OUT1 that outputs the anode pulse.

The cathode primordial waveform output device 12 includes: a cathode transformer T2, which receives and inputs the second pulse P2 generated by the pulse generator 70 and converts it into alternating current; a cathode rectifier circuit R2 The cathode rectifier circuit R2 transforms the + and-AC signals from the cathode transformer T2 into a-signal with one polarity.

The waveform of the cathode pulse output by the cathode primordial waveform output device 12 is the same as the waveform of the anode pulse.

If referring to Figure 2, the waveform of the cathode pulse is in the pulse period. During the pre-set pulse ON time, the amplitude gradually decreases from the peak value of the pulse to 0, and the amplitude is The decreasing speed is a gradually decreasing primo waveform.

The slope of the tangent to the waveform is less than 0 and gradually increases with time t. For example, it can be seen that the second inclination tan(θ 2) of the tangent at the second time point t2 is greater than the first inclination tan(θ 1) of the tangent at the first time point t1.

The pulse period T of the cathode pulse is 2 to 3.5 ms, the pulse on time t _on of the cathode pulse is 5 to 100 μs, and the pulse peak value V _p of the cathode pulse is 400 to 1500V.

When the cathode pulse is output, the initial amplitude corresponds to the peak value, and during the pulse on time during which the cathode pulse lasts, the amplitude of the pulse gradually decreases from the peak value to zero. The rate of decrease when the amplitude of the pulse decreases gradually decreases. After the pulse on time has elapsed, the amplitude is zero.

The cathode primordial waveform output device 12 is connected to a cathode output terminal OUT2 that outputs the cathode pulse.

The anode pulse and the cathode pulse are output at the same time.

In the embodiment of the present invention constructed as described above, the anode pulse and the cathode pulse are output from independent circuits that do not affect each other. Therefore, there is no short circuit between the anode and the cathode, and it is directly transmitted to the human body, thereby correcting the imbalance of ions in the diseased parts of the human body and allowing the normal regeneration of cell tissues.

In addition, the anode pulse and the cathode pulse are respectively output as the primo waveform, so that the therapeutic effect can be improved.

In order to understand the effect of the low-frequency electrical stimulation treatment device with a primordial waveform of the present invention, experiments were conducted as follows.

<Experimental example>

-Age: 55 years old and above

-Personnel: 55

-Duration: 4 weeks

-Target: Patients whose insomnia lasts for more than 6 months and are under medication

-Method: More than 5 days a week, 30 minutes before the insomnia-related medicine is taken, use a low-frequency electrical stimulation treatment device for a predetermined time and apply it to the shoulder and neck.

The average use time per day (min) is 40.4±8.92, the total use days (day) is 23.5±3.81, the total use time (min) is 959.5±302.37, and the average current intensity is within 1.3mA.

The pulse period of each of the anode pulse and the cathode pulse is 2.5 ms, the on-time of each pulse of the anode pulse and the cathode pulse is within 100 μs, and the peak value of each pulse of the anode pulse and the cathode pulse is 900V, the experiment was carried out under the above conditions.

Of the 55 specimens in total, 6 agreed to withdraw (the use of equipment, there was skin-related inconvenience), 2 had worsening of insomnia, 1 had hypoglycemia, 1 had fatigue, and 1 died (accidents related to the use of equipment) , The above sample gave up halfway and measured the effectiveness analysis index for 44 people.

In the sleep diary and questionnaire survey, each subject completed the sleep diary on the morning of the next day after their nighttime electrical stimulation time. The checklist of the diary includes sleep latency, bed time, sleep delay, the intensity and duration of TENS use, and the amount of medication taken. The effectiveness of sleep quality (Pittsburgh Sleep Quality Index: PSQI), daytime narcolepsy (Epworth sleepiness scale: ESS), and insomnia severity (Insomnia Severity Index: ISI) was measured. It was also confirmed that blood pressure and heart rate were included. Because the individual’s mood or pain state will affect the symptoms of insomnia, the anxiety and depression assessment scale (HADS) and the numerical evaluation scale (NRS) were also measured. The measurement results are shown in Table 1.

As shown in Table 1, in the last 44 people analyzed, sleep quality (from PSQI=12.42±3.73 to 11.0±3.71, P=0.001) and insomnia severity (from ISI=13.88±7.23 to 12.10±6.08) , P=0.004) significantly decreased after the experiment.

After treatment, 6 patients in the specimens had reduced benzodiazepine dosages, and 23 patients showed treatment response (57.5% response rate). Comparing the changes in sleep variables in the sleep diaries of the treatment group and the non-treatment group, sleep waiting time decreased (from 44.46±26.9 minutes to 30.26±17.55, p<0.001, Cohen's d=0.625), and sleep time increased (from 308.7) ±82.2 becomes 347±77.66 points, p=0.001, Cohen's d=0.479). Treatment predicted a baseline increase in ESS scores and a baseline increase in HADS scores. Both scores are adjusted for age, gender, other mental illnesses, insomnia disease period, amount and intensity of treatment. Compared with the non-treatment group (from 13.7±9.1 to 14.5±11.9), the relative δ power of the hindbrain region of the treatment group decreased (from 16.5±9.7 to 10.9±8.9).

After low-frequency electric therapy, the sleep waiting time and wake-up time are reduced. In addition, polysomnography, which will help improve insomnia treatment-related improvement, has found a significant increase in slow wave sleep and total delta sleep. Different from the positive effect of δ during sleep, the increase of δ waves during wakefulness is recorded in various pathological conditions such as brain tissue damage and cognitive decline. The delta wave in the awake state is generally shown as the result of fatigue and mental fatigue due to insomnia. In the awake state, the relative delta power is significantly reduced. This is related to the subjective reduction of the degree of insomnia. In this experiment, the relative δ between the treatment group and the non-treatment group The difference in power reduction can be regarded as the reduced delta power in the arousal state due to the therapeutic effect produced by the use of low-frequency electrical stimulation.

Positive results appeared in low-frequency electrical stimulation performed at the trapezius muscle at less than 1 mA (average 137-138 μA) after use for more than 20 days, use time for 30 to 60 minutes, and less than 1 mA. Choosing the site for stimulation is as important as choosing the appropriate time and degree of electrical stimulation. In particular, the anatomy and functional nerve distribution of the cervical nerves in the trapezius muscle have been confirmed. Therefore, psychological anxiety for sleep disorders is a strong predictor of the increase in the upper trapezius muscle response. Therefore, patients with insomnia receive muscles during sleep therapy. During relaxation therapy, high tension of the trapezius muscle is generally observed. Therefore, it is preferable to perform low-frequency electrical stimulation on the neck or shoulders.

Using low-frequency electrical stimulation to alleviate the mechanism of insomnia, the first is the effect of electrical stimulation on neuromuscular.

When the surface electromyography is recorded in both the trapezius and deltoid regions, it shows that people with psychological problems such as sleep disorders have increased muscle contraction. Since the positive relationship between muscle relaxation and improvement of sleep quality is clear, the effect of low-frequency electrical stimulation in the muscles is manifested as increased muscle expansion and decreased stiffness in patients with cerebral palsy. In addition, it also has the effect of improving blood supply, skin temperature, muscle oxidation function, and inhibiting inflammatory cytokine. Second, low-frequency electrical stimulation can induce neurophysiological effects in the brain.

In the comparison after low-frequency electrical stimulation treatment, PSQI and ISI were observed to improve significantly, which shows the therapeutic effect of the low-frequency electrical stimulation treatment instrument on insomnia. The low-frequency electrical stimulation of the low-frequency electrical stimulation treatment instrument of the present invention is more than half of the In chronic insomnia, it is effective in reducing the severity of insomnia without obvious side effects. In addition, electrical stimulation not only helps some patients reduce the use of sleep drugs, but the higher the degree of daytime narcolepsy and depression-anxiety, the higher the effect.

The low-frequency electrical stimulation treatment instrument of the present invention as described above does not have a short circuit between the anode (+) and the cathode (-), so that it is directly transmitted to the human body. It is helpful and has no side effects, and can be easily attached to the appropriate position of the user, using two or more poles to expand the treatment range. Compared with the original low-frequency treatment instrument, it can be used in a larger range at the same time, shortening the treatment time, according to the affected area The amount of state adjustment bipolar or multipolar is used, so it has a very useful effect that can maximize the therapeutic effect.

The present invention has been described with reference to the embodiments illustrated in the drawings, but this is only an example, as long as it is understood by those with ordinary knowledge in the technical field, various modifications and equivalents can be changed from this. Other embodiments. Therefore, the true technical protection scope of the present invention should be determined by the technical ideas of the attached patent application scope.

T: pulse period

t: time

t1: the first point in time

t2: second time point

t _on : pulse on time

V: amplitude

V _P : Pulse peak value

θ 1: the first inclination

θ 2: second inclination

Claims (4)

A low-frequency electrical stimulation treatment instrument with a Primo waveform. The low-frequency electrical stimulation treatment instrument contacts the human body and applies a low-frequency electrical stimulation to the contact part, wherein the waveform of a pulse output for applying the electrical stimulation is In a pulse period, during a preset ON time of a pulse, the amplitude gradually decreases from a pulse peak value to zero, and the rate of decrease of the amplitude is gradually reduced. Limo waveform and output; among them, the pulse peak value is 400 to 1500V. The low-frequency electrical stimulation therapeutic apparatus with a primordial waveform according to claim 1, wherein the pulse period is 2 to 3.5 ms, and the pulse on-time is 5 to 100 μs. The low-frequency electrical stimulation therapy device with a primordial waveform according to claim 1, wherein the pulse includes an anode pulse output by an anode transformer and an anode rectifier circuit, and an anode pulse output by a cathode transformer and a cathode rectifier circuit. A cathode pulse output. A low-frequency electrical stimulation treatment instrument with a primordial waveform. The low-frequency electrical stimulation treatment instrument contacts the human body and applies a low-frequency electrical stimulation to the contact part, wherein the waveform of a pulse output for applying the electrical stimulation is a pulse In the cycle, during a preset ON time of a pulse, output as a waveform whose amplitude gradually decreases from the pulse peak value (Peak value) to reach 0 and the rate of decrease of the amplitude gradually decreases. The pulse period is 2 to 3.5 ms, the pulse on-time is 5 to 100 μs, and the pulse peak value is 400 to 1500V. The pulse includes an anode pulse output by an anode transformer and an anode rectifier circuit, and a cathode pulse output by a cathode transformer and a cathode rectifier circuit.

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