CN101066444A - Chinese medicine prepn for treating acute nephritis - Google Patents
Chinese medicine prepn for treating acute nephritis Download PDFInfo
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- CN101066444A CN101066444A CN 200710100049 CN200710100049A CN101066444A CN 101066444 A CN101066444 A CN 101066444A CN 200710100049 CN200710100049 CN 200710100049 CN 200710100049 A CN200710100049 A CN 200710100049A CN 101066444 A CN101066444 A CN 101066444A
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Abstract
The present invention provides Chinese medicine preparation for treating acute nephritis. The Chinese medicine preparation is prepared with over ten kinds of Chinese medicinal materials, including tuckahoe peel, white mulberry bark, motherwort, etc. It has the functions of invigorating spleen, eliminating dampness, warming yang and promoting diuresis. The present invention is developed through combining syndrome analyzing treatment of Chinese medicine and modern research result. The Chinese medicine preparation has the features of determined curative effect, high safety, no toxic side effect and low cost.
Description
Technical field
The present invention relates to treat the Chinese medicine preparation of acute nephritis, is that a kind of acute nephritis for the treatment of is the Chinese medicine of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.
Background technology
Acute glomerulonephritis is called for short acute nephritis, is clinical common kidney disease.Acute onset is common clinical manifestation with hematuria, albuminuria, hypertension, edema, oliguria and azotemia.This is one group of clinical syndrome, is referred to as acute nephritic syndrome again.Most clinically acute poststreptococcal glomerulonephritises that belong to.TCM Document does not have this title of acute nephritis, belongs to " edema due to wind pathogen ", " YANG edema " and categories such as " hematuria " in motherland's medical science " edema "." edema " speech sees " element is asked hydro-thermal cave opinion " " lung is a dyspnea with stridor, and kidney is an edema " the earliest.In addition, according to the disease of primary disease hematuria, " element is asked the opinion of losing consciousness " cloud: " the uterus transferring pathogenic heat to the urinary bladder, then infirmity, hematuria ".In " the sick piece of writing of Medical Treasures of the Golden Chamber accumulation of pathogenic wind cold in five ZANG-organs " " heat in lower-JIAO is hematuria then ", be the record of acute nephritis hematuria syndrome.
Primary disease is more common in the child, and sending out the age well is 5～14 years old.In less involving, the old people, only account for below 10% of total number of the infected more than 40 years old.Rare morbidity below 2 years old.M-F is 2 to 1.Incubation period: most patients has the forerunner to infect history, and the lighter can FFI clinical manifestation.The order of severity of nephritis does not depend on the order of severity that the forerunner infects.1～3 week began to occur the clinical symptoms of nephritis after the streptococcal infection, on average about 10 days of incubation period, and also may be shorter.General skin infection than person due to the upper respiratory tract infection for long.The former mostly is 14～21 days, the latter mostly is 6～12 days.Surpass 3 all persons rare incubation period.Part patient can have one to cross slight albuminuria of property and microscopic hematuria in course of infection, may be with heating, that streptococcic erythrogenic toxin acts on GBM is relevant.
The traditional Chinese medical science is thought " institute of heresy gathers, and its gas must be empty, and deficiency of YIN person's sun must gather it ".Not outer inside and outside two ends of the cause of disease of acute nephritis.With regard to interior thereby speech, mainly be to give birth to a day natural endowment deficiency, or the day after tomorrow intemperance of taking food, work and rest is improper, nurses one's health inappropriately, causes deficiency of spleen and stomach.How the exopathogenic factor aspect is then attacked outward because of six climate exopathogens, and sore caves in.
Positive QI-insufficiency exopathogen invasion in addition is the main cause that acute nephritis takes place, and sick position is mainly at kidney, but closely related with lung, spleen.Syndrome develop trend be from table and in, reach the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels by the part of the body cavity above the diaphragm housing the heart and lungs, middle Jiao, be mainly to develop to vital QI being weakened and pathogen being violent, simulataneous insufficiency and excessive gradually from marking real.The pathological process that the acute edema phase strives for the good and evil play, the edema extinction phase then enters the deficient vital QI leading to lingering of pathogen stage.If make vital QI recovered after pathogens eliminated by treatment, then can make the patient to more, control wrong treatment otherwise lose, the state of an illness also can develop intensification, so that the five internal organs are all sick, all cards are grown thickly, the delay refractory, severe patient can have the heart attacked by pathogenic water, on cover clear key, even kidney unit is depleted, and blood vessels are obstructed, noxious dampness retention, threat to life.Invent a kind of not only safety but also effective Chinese medicine preparation, be significant.
Summary of the invention
The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide the Chinese medicine preparation for the treatment of acute nephritis.Have determined curative effect, safe ready, have no side effect, cheap characteristics.
The present invention is made by the following weight proportion raw material:
1.5～6 parts of 1.5～6 parts of Herba Leonuris of 1.5～6 parts of Cortex Mori of Cortex Sclerotii Poriae
1.0～4 parts of 1.0～4 portions of Polyporus of 1.0～4 portions of Rhizoma Alismatis of CORTEX ZINGIBERIS RHIZOMAE
1.0～4 parts of 1.0～4 portions of Rhizoma Dioscoreaes of 1.0～4 parts of stir-baked SEMEN ARMENIACAE AMARUMs of Rhizoma Atractylodis Macrocephalae (parched)
0.1～1 part in 0.1～2 portion of Herba Ephedrae of 0.1～2 part of Ramulus Cinnamomi of Pericarpium Arecae.
The weight proportion of each raw material of optimization formula of the present invention is:
2.5～3.5 parts of 2.5～3.5 parts of Herba Leonuris of 2.5～3.5 parts of Cortex Mori of Cortex Sclerotii Poriae
1.5～2.5 parts of 1.5～2.5 portions of Polyporus of 1.5～2.5 portions of Rhizoma Alismatis of CORTEX ZINGIBERIS RHIZOMAE
1.5～2.5 parts of 1.5～2.5 portions of Rhizoma Dioscoreaes of 1.5～2.5 parts of stir-baked SEMEN ARMENIACAE AMARUMs of Rhizoma Atractylodis Macrocephalae (parched)
0.3～0.7 part in 0.5～1.5 portion of Herba Ephedrae of 0.5～1.5 part of Ramulus Cinnamomi of Pericarpium Arecae.
The weight proportion of each raw material of optimum formula of the present invention is:
3 parts of 3 parts of Herba Leonuris of 3 parts of Cortex Mori of Cortex Sclerotii Poriae
2 parts of 2 portions of Polyporus of 2 portions of Rhizoma Alismatis of CORTEX ZINGIBERIS RHIZOMAE
2 parts of 2 portions of Rhizoma Dioscoreaes of 2 parts of stir-baked SEMEN ARMENIACAE AMARUMs of Rhizoma Atractylodis Macrocephalae (parched)
0.5 part in 1 portion of Herba Ephedrae of 1 part of Ramulus Cinnamomi of Pericarpium Arecae.
Drug action mechanism among the present invention is as follows:
Herba Leonuri property of medicine suffering, hardship are slightly cold.Return liver, kidney, pericardium channel.Has promoting blood flow to regulate menstruation, inducing diuresis to remove edema, the effect of heat-clearing and toxic substances removing.Can treat menoxenia, amenorrhea, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, traumatic injury, dysuria, edema, carbuncle skin infection etc.(the 2697th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Cortex Mori nature and flavor are sweet, hot, and are cold.Return lung, spleen channel.Has eliminating pathogen from the lung for relieving asthma, the effect of inducing diuresis to remove edema.Cure mainly the fullness in the chest that lung-heat or diseases caused by retention of fluid stop lung and breath with cough hemoptysis, edema, beriberi, dysuria etc.(the 2787th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Cortex Sclerotii Poriae property of medicine is flat, and sweet in the mouth, light is nontoxic.Effect with inducing diuresis to remove edema.It is full to treat the water damp-edema, dysuria etc.(the 2156th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
CORTEX ZINGIBERIS RHIZOMAE property of medicine suffering, cold.Return spleen, lung meridian.Effect with line water detumescence.Can treat edema from the beginning of, dysuria etc.(the 927th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Polyporus property of medicine is sweet, light, and is flat.Return spleen, kidney, urinary bladder channel.Effect with promoting diuresis to eliminate damp pathogen.Can treat dysuria, the edema distension is had loose bowels, stranguria with turbid discharge, leukorrhagia, beriberi edema etc.(the 3060th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Rhizoma Atractylodis Macrocephalae (parched) hardship, sweet, temperature.Return spleen, stomach warp.Has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.Can treat the weak of deficiency-weakness of spleen-QI, lack of appetite abdominal distention is had loose bowels, constipation, the dysuria of fluid-retention stagnating in the interior, edema, dizziness due to fluid-retention, cold-damp numbness, general pain, spontaneous sweating due to deficiency of QI, frequent fetal movement etc.(the 945th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Rhizoma Alismatis property of medicine is sweet, light, and is cold.Return kidney, urinary bladder channel.Have promoting diuresis to eliminate damp pathogen, treating stranguria effect expels the heat-evil.Can treat dysuria, the puckery pain of pyretic stranguria, the edema distension is had loose bowels, dizziness due to fluid-retention, seminal emission etc.(the 2067th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Stir-baked SEMEN ARMENIACAE AMARUM property of medicine hardship, tepor, mild toxicity.Return lung, large intestine channel.Has lowering the adverse-rising QI to resolve phlegm, relieving cough and asthma, the effect of loosening bowel to relieve constipation.Can treat exogenous cough's dyspnea with fullness of the chest, dryness of the intestine constipation etc.The 1526th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
The Rhizoma Dioscoreae property of medicine is sweet, flat.Return spleen, lung, kidney channel.Have spleen reinforcing, support lung, reinforce the kidney, the effect that benefit is smart.Can treat diarrhea due to hypofunction of the spleen, the lack of appetite edema, cough and asthma due to lung deficiency is quenched one's thirst, seminal emission, leukorrhagia, the frequent micturition of suffering from a deficiency of the kidney.Carbuncle is controlled in external, scrofula etc.(the 218th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Pericarpium Arecae property of medicine suffering, tepor.Return spleen, stomach, large intestine, small intestine meridian.Has therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, the effect of line water detumescence.It is vexed to treat breast abdominal distention, edema, beriberi, dysuria etc.(the 177th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine)
Ramulus Cinnamomi property of medicine suffering, sweet, temperature.Return bladder, the heart, lung meridian.Has expelling cold and relieving exterior syndrome, warming the meridian, the effect of activating yang.Can treat exterior syndrome due to wind-cold, arthralgia due to cold-dampnes, extreme cold of the limbs, amenorrhea dysmenorrhea ， mass in the abdomen caking, the thoracic obstruction, cardiopalmus, phlegm retention, dysuria etc.(the 2522nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).
Herba Ephedrae property of medicine suffering, little hardship, temperature.Return lung, urinary bladder channel.Has relieving the exterior syndrome by diaphoresis, depressed lung-energy dispersing, the effect of inducing diuresis to remove edema.Can treat chill exterior syndrome, cough and asthma, edema due to wind pathogen, dysuria, rheumatic arthralgia, numbness of the skin, rubella pruritus, carbuncle of yin nature sucutaneous nodule etc.(the 3094th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine)
The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Cortex Sclerotii Poriae, Cortex Mori and Herba Leonuri; With CORTEX ZINGIBERIS RHIZOMAE, Rhizoma Alismatis, Polyporus, Rhizoma Atractylodis Macrocephalae (parched), Semen Armeniacae Amarum and Rhizoma Dioscoreae is ministerial drug; With Pericarpium Arecae, Ramulus Cinnamomi and Herba Ephedrae is adjuvant.All medicines are harmonious, the effect of tool invigorating the spleen for eliminating dampness altogether, warming YANG to promote diuresis.The treatment acute nephritis has determined curative effect, has no side effect taking convenience, cheap characteristics.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment acute nephritis of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.
2, rich in proteins in the medicine of the present invention, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.
3, the present invention not only can effectively treat acute nephritis, and the prevention of acute nephritis is also had good effect, and the treatment acute nephritis has determined curative effect, has no side effect taking convenience, cheap characteristics.
For showing the therapeutic effect of medicine of the present invention, as follows through clinical test results to the treatment acute nephritis; Treatment acute nephritis patient 18 examples, male's 10 examples, women's 8 examples.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.One month is a course of treatment, take continuously three the course of treatment observe the curative effect.8 examples of fully recovering account for 44.44%, and 8 examples that take a turn for the better account for 44.44%, and more 2 examples do not account for 11.11%, and total effective rate reaches 88.89%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.
The specific embodiment
The embodiment decoction takes by weighing raw material by following weight:
3 parts of 3 parts of Herba Leonuris of 3 parts of Cortex Mori of Cortex Sclerotii Poriae
2 parts of 2 portions of Polyporus of 2 portions of Rhizoma Alismatis of CORTEX ZINGIBERIS RHIZOMAE
2 parts of 2 portions of Rhizoma Dioscoreaes of 2 parts of Semen Armeniacae Amarums of Rhizoma Atractylodis Macrocephalae (parched)
0.5 part in 1 portion of Herba Ephedrae of 1 part of Ramulus Cinnamomi of Pericarpium Arecae
Preparation method is to get above-mentioned raw materials to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1～1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The decoction of the treatment acute nephritis that the present invention makes is that plastic packaging is packed, and every bag of 210ml is oral, one time one bag, every day two to three times.One month is a course of treatment.
Claims (3)
1, the Chinese medicine preparation of treatment acute nephritis is characterized in that it is made by the following weight proportion raw material:
1.5～6 parts of 1.5～6 parts of Herba Leonuris of 1.5～6 parts of Cortex Mori of Cortex Sclerotii Poriae
1.0～4 parts of 1.0～4 portions of Polyporus of 1.0～4 portions of Rhizoma Alismatis of CORTEX ZINGIBERIS RHIZOMAE
1.0～4 parts of 1.0～4 portions of Rhizoma Dioscoreaes of 1.0～4 parts of stir-baked SEMEN ARMENIACAE AMARUMs of Rhizoma Atractylodis Macrocephalae (parched)
0.1～1 part in 0.1～2 portion of Herba Ephedrae of 0.1～2 part of Ramulus Cinnamomi of Pericarpium Arecae.
2, the Chinese medicine preparation of treatment acute nephritis according to claim 1, wherein the weight proportion of each raw material is:
2.5～3.5 parts of 2.5～3.5 parts of Herba Leonuris of 2.5～3.5 parts of Cortex Mori of Cortex Sclerotii Poriae
1.5～2.5 parts of 1.5～2.5 portions of Polyporus of 1.5～2.5 portions of Rhizoma Alismatis of CORTEX ZINGIBERIS RHIZOMAE
1.5～2.5 parts of 1.5～2.5 portions of Rhizoma Dioscoreaes of 1.5～2.5 parts of stir-baked SEMEN ARMENIACAE AMARUMs of Rhizoma Atractylodis Macrocephalae (parched)
0.3～0.7 part in 0.5～1.5 portion of Herba Ephedrae of 0.5～1.5 part of Ramulus Cinnamomi of Pericarpium Arecae.
3, the Chinese medicine preparation of treatment acute nephritis according to claim 1, wherein the weight proportion of each raw material is:
3 parts of 3 parts of Herba Leonuris of 3 parts of Cortex Mori of Cortex Sclerotii Poriae
2 parts of 2 portions of Polyporus of 2 portions of Rhizoma Alismatis of CORTEX ZINGIBERIS RHIZOMAE
2 parts of 2 portions of Rhizoma Dioscoreaes of 2 parts of stir-baked SEMEN ARMENIACAE AMARUMs of Rhizoma Atractylodis Macrocephalae (parched)
0.5 part in 1 portion of Herba Ephedrae of 1 part of Ramulus Cinnamomi of Pericarpium Arecae.
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| CN 200710100049 CN101066444A (en) | 2007-06-05 | 2007-06-05 | Chinese medicine prepn for treating acute nephritis |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991799A (en) * | 2010-11-24 | 2011-03-30 | 杨春元 | Medicine for treating nephritis |
| CN102225167A (en) * | 2011-05-28 | 2011-10-26 | 宫兆荣 | Traditional Chinese medicine composition for treating pediatric acute nephritis and preparation method thereof |
| CN102772773A (en) * | 2012-07-30 | 2012-11-14 | 李承平 | Tablets for promoting circulation of Qi and inducing diuresis |
| CN102836403A (en) * | 2012-08-09 | 2012-12-26 | 王迪峰 | Chinese medicine for treating chronic nephritis by using root of low greenbrier |
| CN103006998A (en) * | 2012-12-31 | 2013-04-03 | 王建文 | Medicine for treating acute glomerulonephritis (AGN) hypertensive crisis |
| CN104258320A (en) * | 2014-09-11 | 2015-01-07 | 湖北省中医院 | Traditional Chinese medicine preparation for treating hypertensive renal injury edema and preparation method of traditional Chinese medicine preparation |
| CN104474501A (en) * | 2014-11-27 | 2015-04-01 | 孙月霞 | Traditional Chinese medicine preparation for treating edema and preparation method of traditional Chinese medicine preparation |
| CN104524504A (en) * | 2014-12-22 | 2015-04-22 | 吉林大学 | Traditional Chinese medicine for treating female idiopathic edema |
| CN115634252A (en) * | 2022-09-09 | 2023-01-24 | 辽宁上药好护士药业（集团）有限公司 | Diuretic and quality control method thereof |
-
2007
- 2007-06-05 CN CN 200710100049 patent/CN101066444A/en active Pending
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991799A (en) * | 2010-11-24 | 2011-03-30 | 杨春元 | Medicine for treating nephritis |
| CN102225167A (en) * | 2011-05-28 | 2011-10-26 | 宫兆荣 | Traditional Chinese medicine composition for treating pediatric acute nephritis and preparation method thereof |
| CN102225167B (en) * | 2011-05-28 | 2012-10-31 | 宫兆荣 | Traditional Chinese medicine composition for treating pediatric acute nephritis and preparation method thereof |
| CN102772773A (en) * | 2012-07-30 | 2012-11-14 | 李承平 | Tablets for promoting circulation of Qi and inducing diuresis |
| CN102836403A (en) * | 2012-08-09 | 2012-12-26 | 王迪峰 | Chinese medicine for treating chronic nephritis by using root of low greenbrier |
| CN102836403B (en) * | 2012-08-09 | 2014-07-02 | 王迪峰 | Chinese medicine for treating chronic nephritis by using root of low greenbrier |
| CN103006998B (en) * | 2012-12-31 | 2013-12-04 | 王建文 | Medicine for treating acute glomerulonephritis (AGN) hypertensive crisis |
| CN103006998A (en) * | 2012-12-31 | 2013-04-03 | 王建文 | Medicine for treating acute glomerulonephritis (AGN) hypertensive crisis |
| CN104258320A (en) * | 2014-09-11 | 2015-01-07 | 湖北省中医院 | Traditional Chinese medicine preparation for treating hypertensive renal injury edema and preparation method of traditional Chinese medicine preparation |
| CN104258320B (en) * | 2014-09-11 | 2016-01-20 | 湖北省中医院 | A kind ofly treat Chinese medicine preparation of hypertensive renal damage edema and preparation method thereof |
| CN104474501A (en) * | 2014-11-27 | 2015-04-01 | 孙月霞 | Traditional Chinese medicine preparation for treating edema and preparation method of traditional Chinese medicine preparation |
| CN104524504A (en) * | 2014-12-22 | 2015-04-22 | 吉林大学 | Traditional Chinese medicine for treating female idiopathic edema |
| CN104524504B (en) * | 2014-12-22 | 2017-12-08 | 吉林大学 | Treat the Chinese medicine of women idiopathic edema |
| CN115634252A (en) * | 2022-09-09 | 2023-01-24 | 辽宁上药好护士药业（集团）有限公司 | Diuretic and quality control method thereof |
| CN115634252B (en) * | 2022-09-09 | 2023-09-29 | 辽宁上药好护士药业（集团）有限公司 | Diuretic and quality control method thereof |
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Open date: 20071107 |