CN102225167B - Traditional Chinese medicine composition for treating pediatric acute nephritis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating pediatric acute nephritis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating pediatric acute nephritis and a preparation method thereof. The prescription of the traditional Chinese medicine composition comprises the following components in parts by mass: 20-30 parts of tangerine peel, 20-30 parts of fuling peel, 20-30 parts of pericarpium arecae, 20-30 parts of white mulberry rootbark, 10-20 parts of honeysuckle, 10-20 parts of fructus forsythiae, 10-20 parts of platycodon, 10-20 parts of figwort root, 10-20 parts of cogograss rhizome, 10-20 parts of rehmannia root and 10-20 parts of licorice root. The medicament has detoxifying, fever-reducing and diuretic functions, is capable of rapidly eliminating hyposarca, killing pathogenic bacteria of a kidney system and effectively treating pediatric acute nephritis, and has rapid and stable action and no obvious toxic or side effect. An obvious clinic effect is obtained by clinical application of the medicament.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition of treating infantile acute nephritis, belong to pure Chinese herbal medicine.The invention still further relates to its preparation method.
Background technology
Infantile acute nephritis is often referred to acute poststreptococcal glomerulonephritis, is by behind the A group β hemolytic streptococcal infection, exudative, proliferative inflammation pathological changes in the diffusivity glomerular capillary that caused immune complex deposit causes at glomerule.The clinical manifestation weight differs, and the typical case shows as edema, oliguria, hypertension.In treatment, adopt antibiotic at present, present antibiotic resistant is strong, and bigger toxic and side effects is all arranged more, and cost is high, can not be satisfactory aspect therapeutic effect.
Summary of the invention
Technical problem to be solved by this invention is a kind of Chinese medicine composition of treating infantile acute nephritis to be provided, through eliminating fire and detoxication; Sharp clearing away damp-heat; Anti-inflammation and sterilization, inducing diuresis to remove edema are fundamentally treated infantile acute nephritis, to overcome the defective of existing such disease medicine of treatment.
It is following that the present invention solves the problems of the technologies described above the technical scheme that is adopted:
A kind of Chinese medicine composition of treating infantile acute nephritis is characterized in that its set of dispense ratio is: Pericarpium Citri Reticulatae 20-30 part, Cortex Sclerotii Poriae 20-30 part, Pericarpium Arecae 20-30 part; Cortex Mori 20-30 part, Flos Lonicerae 10-20 part, Fructus Forsythiae 10-20 part; Radix Platycodonis 10-20 part, Radix Scrophulariae 10-20 part, Rhizoma Imperatae 10-20 part; Radix Rehmanniae 10-20 part, Radix Glycyrrhizae 10-20 part, described part refers to mass parts.
The preferred ingredients proportioning is: 25 parts of Pericarpium Citri Reticulataes, 25 parts of Cortex Sclerotii Poriae, 25 parts of Pericarpium Arecae, 25 parts of Cortex Mori, 15 parts of Flos Lonicerae, 15 parts of Fructus Forsythiaes, 15 parts of Radix Platycodoniss, 15 parts of Radix Scrophulariaes, 15 parts of Rhizoma Imperataes, 15 parts in the Radix Rehmanniae, 15 parts in Radix Glycyrrhizae.
A kind of method for preparing of treating the Chinese medicine composition of infantile acute nephritis is characterized in that:
(1), with the Pericarpium Citri Reticulatae of said ratio, Cortex Sclerotii Poriae, Pericarpium Arecae, Cortex Mori, Flos Lonicerae, Fructus Forsythiae, Radix Platycodonis, Radix Scrophulariae, Rhizoma Imperatae, the Radix Rehmanniae, the Radix Glycyrrhizae mix homogeneously is ground into 80 purpose granules.
(2) with above-mentioned granule in 130-135 ℃ the baking 6-10 minute, be cooled to room temperature.
(3) be ball with water with made mixture of (2) step, every ball weighs 3 grams.
The main Chinese herbal medicine of prescription of the present invention is according to traditional medicine and modern medicine analysis, and the property of medicine and pharmacological action are following:
Pericarpium Citri Reticulatae: meridian distribution of property and flavor: temperature; Hot, bitter; Return spleen, lung meridian.Function cures mainly: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.Be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Cortex Sclerotii Poriae: meridian distribution of property and flavor: flat; Sweet, light; GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.Be used for the edema oliguria, the phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in the loose stool, irritability, palpitation with fear insomnia.
Pericarpium Arecae: meridian distribution of property and flavor: tepor; Hot; Return spleen, stomach, large intestine, small intestine meridian.Function cures mainly: therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO, line water detumescence.Be used for retention of damp leading to blockage of QI, gastral cavity abdominal distention is vexed, and it is not well to defecate, edema distension, beriberi edema, dysuria.
Cortex Mori: meridian distribution of property and flavor: cold; Sweet; Return lung meridian.Function cures mainly: eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.Be used for dyspnea and cough due to lung-heat, edema distension oliguria, appearance skin edema.
Flos Lonicerae: meridian distribution of property and flavor: cold; Sweet; Return lung, the heart, stomach warp.Function cures mainly: heat-clearing and toxic substances removing, wind-heat dissipating.Be used for carbuncle and treat skin ulcer, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease heating.
Fructus Forsythiae: meridian distribution of property and flavor: be slightly cold; Bitter; Return lung, the heart, small intestine meridian.Function cures mainly: heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Be used for carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, the hyperpyrexia excessive thirst, coma is sent out speckle, the pyretic stranguria urine retention.
Radix Platycodonis: meridian distribution of property and flavor: flat; Bitter, hot; Return lung meridian.Function cures mainly: lung qi dispersing, sore-throat relieving eliminates the phlegm, evacuation of pus.Be used for cough with copious phlegm, uncomfortable in chest not smooth, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Radix Scrophulariae: meridian distribution of property and flavor: be slightly cold; Sweet, bitter, salty; Return lung, stomach, kidney channel.Function cures mainly: removing heat from blood YIN nourishing, eliminating fire and detoxication.Be used for consumption of YIN caused by febrile disease, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus.
Rhizoma Imperatae: meridian distribution of property and flavor: cold; Sweet; Return lung, stomach, urinary bladder channel.Function cures mainly: cooling blood for hemostasis, clearing away heat and promoting diuresis.Be used for heat in blood and spit blood epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria, acute nephritis edema.
The Radix Rehmanniae: meridian distribution of property and flavor: cold; Sweet, bitter; GUIXIN, liver, kidney channel.Function cures mainly: Radix Rehmanniae: be used for calentura crimson tongue excessive thirst, and interior-heat caused by deficiency of YIN, the hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis is sent out the speckle dermexanthesis.
Radix Glycyrrhizae: meridian distribution of property and flavor: flat; Sweet; GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
The Fang Xieyu good effect:
The traditional Chinese medical science is thought: suffer from a deficiency of the kidney and wet, stagnation of QI water retention can cause infantile acute nephritis.Treatment should inducing diuresis to remove edema be main.Pericarpium Citri Reticulatae among the present invention, Cortex Sclerotii Poriae, Pericarpium Arecae; The all medicines of Cortex Mori are all had a promoting the circulation of QI to induce diuresis effect, cooperate surplus each medical instrument detoxifcation, heat clearing away, diuretic comprehensive function, can eliminate hydrosarca rapidly; Kill kidney system pathogenic bacteria, treat infantile acute nephritis effectively, and effect is fast; Surely, no obvious toxic and side effects.Obtained tangible clinical effectiveness through clinical practice,
The specific embodiment
Further specify the present invention below in conjunction with concrete preparation instance.
Prescription instance one:
The set of dispense ratio is: 20 parts of Pericarpium Citri Reticulataes, 20 parts of Cortex Sclerotii Poriae, 20 parts of Pericarpium Arecae, 20 parts of Cortex Mori, 10 parts of Flos Lonicerae, 10 parts of Fructus Forsythiaes, 10 parts of Radix Platycodoniss, 10 parts of Radix Scrophulariaes, 10 parts of Rhizoma Imperataes, 10 parts in the Radix Rehmanniae, 10 parts in Radix Glycyrrhizae.
Method for preparing:
(1) get 20 parts of Pericarpium Citri Reticulataes, 20 parts of Cortex Sclerotii Poriae, 20 parts of Pericarpium Arecae, 20 parts of Cortex Mori, 10 parts of Flos Lonicerae, 10 parts of Fructus Forsythiaes, 10 parts of Radix Platycodoniss, 10 parts of Radix Scrophulariaes, 10 parts of Rhizoma Imperataes, 10 parts in the Radix Rehmanniae, 10 parts of mix homogeneously of Radix Glycyrrhizae are ground into 80 purpose granules.
(2) with above-mentioned granule in 130-135 ℃ the baking 6-10 minute, be cooled to room temperature.
(3) be ball with water with (2) made mixture, every ball weighs 3 grams.
Instructions about how to take medicine and usage: oral, every clothes 1 ball, every day 2 times.
Prescription instance two:
The set of dispense ratio is: 25 parts of Pericarpium Citri Reticulataes, 25 parts of Cortex Sclerotii Poriae, 25 parts of Pericarpium Arecae, 25 parts of Cortex Mori, 15 parts of Flos Lonicerae, 15 parts of Fructus Forsythiaes, 15 parts of Radix Platycodoniss, 15 parts of Radix Scrophulariaes, 15 parts of Rhizoma Imperataes, 15 parts in the Radix Rehmanniae, 15 parts in Radix Glycyrrhizae.
Method for preparing:
(1) get 25 parts of Pericarpium Citri Reticulataes, 25 parts of Cortex Sclerotii Poriae, 25 parts of Pericarpium Arecae, 25 parts of Cortex Mori, 15 parts of Flos Lonicerae, 15 parts of Fructus Forsythiaes, 15 parts of Radix Platycodoniss, 15 parts of Radix Scrophulariaes, 15 parts of Rhizoma Imperataes, 15 parts in the Radix Rehmanniae, 15 parts of mix homogeneously of Radix Glycyrrhizae are ground into 80 purpose granules.
(2) with above-mentioned granule in 130-135 ℃ the baking 6-10 minute, be cooled to room temperature.
(3) be ball with water with made mixture of (2) step, every ball weighs 3 grams.
Instructions about how to take medicine and usage are with embodiment one.
Prescription instance three:
The set of dispense ratio is: 30 parts of Pericarpium Citri Reticulataes, 30 parts of Cortex Sclerotii Poriae, 30 parts of Pericarpium Arecae, 30 parts of Cortex Mori, 20 parts of Flos Lonicerae, 20 parts of Fructus Forsythiaes, 20 parts of Radix Platycodoniss, 20 parts of Radix Scrophulariaes, 20 parts of Rhizoma Imperataes, 20 parts in the Radix Rehmanniae, 20 parts in Radix Glycyrrhizae.
Method for preparing:
(1) get 30 parts of Pericarpium Citri Reticulataes, 30 parts of Cortex Sclerotii Poriae, 30 parts of Pericarpium Arecae, 30 parts of Cortex Mori, 20 parts of Flos Lonicerae, 20 parts of Fructus Forsythiaes, 20 parts of Radix Platycodoniss, 20 parts of Radix Scrophulariaes, 20 parts of Rhizoma Imperataes, 20 parts in the Radix Rehmanniae, 20 parts of mix homogeneously of Radix Glycyrrhizae are ground into 80 purpose granules.
(2) with above-mentioned granule in 130-135 ℃ the baking 6-10 minute, be cooled to room temperature.
(3) be ball with water with (2) made mixture, every ball weighs 3 grams.
Instructions about how to take medicine and usage are with embodiment one.
It below is clinical report
From year February in January, 2008 to 2011; The Fushan District the People's Hospital uses the present invention's instance two treatment infantile acute nephritis 75 examples of writing out a prescription to the inventor in Yantai; And treat 30 examples and carry out controlled observation with using erythromycin 30mg/ (kgd) intravenous drip the same period, receive better effects, existing report is as follows.
1, clinical data
Physical data is observed case totally 105 examples, is divided into 2 groups at random.Women 30 examples are organized in treatment, male 45 examples, totally 75 examples; (4 ± 2 years old age; The course of disease (16 ± 2) sky; Matched group woman 13 examples, male 17 examples, totally 30 examples; Year at age (4 ± 2); The course of disease (16 ± 2) sky.2 groups of physical data are through statistical procedures, and there are no significant that meaning (P＞0.05) has comparability for difference.
2, diagnosis
2.1. the diagnosis of clinical characters typical case acute glomerulonephritis is not difficult, after the streptococcal infection, edema, hypertension, hematuria (can with albuminuria) in various degree occur through 1～3 all asymptomatic intermissions, in addition the dynamic change of blood C3 can be clarified a diagnosis again.
2.2 lab testing but make a definite diagnosis APSGN and then need comprise 2 points in following 3:
(1) detects pathogenic bacterium:, detect nephritogenic β Hemolytic streptococcus at pharyngeal or skin lesion place.
(2) detect antibody: the antibody to the streptococcus composition has one or multinomial being positive, like ASO, anti-DNAaseB antibody, anti-Hase antibody, anti-ADPNase antibody etc.In order to make accurate rate of diagnosis reach 90%, must carry out multiple antibody test.It should be noted that early stage use antibiotic therapy can stop above-mentioned production of antibodies, and make pharyngeal antibacterial culturing negative but can not stop the generation of APSGN.
(3) complement reduces: serum complement C3 reduces.
3, Therapeutic Method
3.1 matched group adopts erythromycin 30mg/ (kgd) intravenous drip treatment.The 7-14 days course of treatment.
3.2 the treatment group adopts every clothes 1 ball of oral medicine of the present invention, every day 2 times, the 7-14 days course of treatment.
3.3 edema, hypertension, urine amount, hematuria situation before and after the observation item treatment,
34 statistical methods adopt the SPSS statistical software to analyze.
4, criterion of therapeutical effect and therapeutic outcome
4.1 criterion of therapeutical effect is with reference to relevant criterion of therapeutical effect in " disease of tcm judgement criterion of therapeutical effect ".Recovery from illness: clinical symptoms all disappears, and the test chamber inspection is normal.Take a turn for the better: clinical symptom relief, lab testing improve or are normal.Invalid: clinical symptoms does not have being clearly better or increases the weight of.
4.2 therapeutic outcome
2 groups of clinical efficacies are relatively seen table 1.Total effective rate treatment group is 87.9%, and matched group is 76.6%, 2 group and compares that difference has significance meaning (P＜0.05).With preceding relatively ※ P＜0.01 of treatment; With comparison after the treatment of control group, △ P＜0.01.
This shows that medicine of the present invention is superior to other medicines for treatment infantile acute nephritis effect, cures the effective percentage height, is the medicine of ideal treatment infantile acute nephritis.
Table 1 liang group clinical efficacy relatively
Group n improvement recovery from illness invalid total effective rate (%)
Treatment organizes 75 13 (17.3%) 53 (70.6%) 9 (12%) 87.9%
Matched group 30 2 (6.6%) 21 (70%) 7 (23.3%) 76.6%
Claims (3)
1. a Chinese medicine composition of treating infantile acute nephritis is characterized in that its set of dispense ratio is: Pericarpium Citri Reticulatae 20-30 part, Cortex Sclerotii Poriae 20-30 part, Pericarpium Arecae 20-30 part; Cortex Mori 20-30 part, Flos Lonicerae 10-20 part, Fructus Forsythiae 10-20 part; Radix Platycodonis 10-20 part, Radix Scrophulariae 10-20 part, Rhizoma Imperatae 10-20 part; Radix Rehmanniae 10-20 part, Radix Glycyrrhizae 10-20 part, described part refers to mass parts.
2. the Chinese medicine composition of treatment infantile acute nephritis as claimed in claim 1 is characterized in that its set of dispense ratio is: 25 parts of Pericarpium Citri Reticulataes, 25 parts of Cortex Sclerotii Poriae; 25 parts of Pericarpium Arecae, 25 parts of Cortex Mori, 15 parts of Flos Lonicerae; 15 parts of Fructus Forsythiaes, 15 parts of Radix Platycodoniss, 15 parts of Radix Scrophulariaes; 15 parts of Rhizoma Imperataes, 15 parts in the Radix Rehmanniae, 15 parts in Radix Glycyrrhizae.
3. according to claim 1 or claim 2 a kind of method for preparing of treating the Chinese medicine composition of infantile acute nephritis is characterized in that:
(1), with the Pericarpium Citri Reticulatae of said ratio, Cortex Sclerotii Poriae, Pericarpium Arecae, Cortex Mori, Flos Lonicerae, Fructus Forsythiae, Radix Platycodonis, Radix Scrophulariae, Rhizoma Imperatae, the Radix Rehmanniae, the Radix Glycyrrhizae mix homogeneously is ground into 80 purpose granules;
(2) with above-mentioned granule in 130-135 ℃ the baking 6-10 minute, be cooled to room temperature;
(3) be ball with water with made mixture of (2) step, every ball weighs 3 grams.
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| CN104740618B (en) * | 2015-03-28 | 2017-06-30 | 孙华堂 | A kind of sugar-pill of acute glomerulonephritis of baby and preparation method thereof |
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| CN1175447A (en) * | 1997-07-10 | 1998-03-11 | 迟经惠 | Restoration injection for nephropathy |
| CN101066444A (en) * | 2007-06-05 | 2007-11-07 | 北京艺信堂医药研究所 | Chinese medicine prepn for treating acute nephritis |
| CN101095928A (en) * | 2007-07-19 | 2008-01-02 | 关岩华 | Chinese traditional medicine composition for treating nephritis |
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| CN101066444A (en) * | 2007-06-05 | 2007-11-07 | 北京艺信堂医药研究所 | Chinese medicine prepn for treating acute nephritis |
| CN101095928A (en) * | 2007-07-19 | 2008-01-02 | 关岩华 | Chinese traditional medicine composition for treating nephritis |
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