CN101066374A - Chinese medicine prepn for treating sterility of varicocele - Google Patents

Abstract

The present invention provides Chinese medicine preparation for treating sterility of varicocele. The Chinese medicine preparation is prepared with over ten kinds of Chinese medicinal materials, including oyster shell, deglued antler powder, Chuanxiong rhizome, zedoary, prepared rhizome of rehmannia, etc. It has the functions of promoting blood circulation to disperse blood clots, and softening and resolving hard mass. The present invention is developed through combining syndrome analyzing treatment of Chinese medicine and modern research result. The Chinese medicine preparation has the features of determined curative effect, high safety, no toxic side effect and low cost.

Description

A kind of Chinese medicine preparation for the treatment of varicocele infertility

Technical field

The present invention relates to a kind of Chinese medicine preparation for the treatment of varicocele infertility, is that a kind of varicocele infertility for the treatment of is the Chinese medicine preparation of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

The constitutional varicocele is because the elongation of spermatic cord pampiniform plexus, expansion, tortuous appear in the spermatic vein backflow obstruction, causes the disease of a series of clinical symptoms then.Be more common in 20～30 years old male person between twenty and fifty, sickness rate is 6%～22.9% in the normal male, up to 21%～42%, surpasses other various causes of disease in the male infertility patient, is considered to cause one of modal reason of male sterility.The Secondary cases varicocele is secondary to diseases such as retroperitoneal neoplasms, hydronephrosis more, also is called symptomatic varicocele.The spermatic cord pampiniform plexus is divided into 3 groups: internal spermatic vein, deferent duct vein, carry the testis muscular veins.3 groups of veins respectively have side shoot to coincide mutually, can link up mutually with scrotum mediastinum and venae scrotales simultaneously.The closest with morbidity is internal spermatic vein, respectively organizes vein but also can involve.Chinese medicine thinks that the etiology and pathogenesis of primary disease is: 1, caused by liver and kidney deficiency; 2, cold and stagnate; 3, dampness and heat stasis; 4, blood stasis resistance network; 5, collapse of QI.Wherein QI-blood circulation is not smooth, and the stagnation of blood stasis venation is the key of primary disease pathogenesis.Old blood does not go, and fresh blood is not given birth to, asthenia of essence and blood, testis lose support then cause sterile.The traditional Chinese medical science is divided into caused by liver and kidney deficiency clinically, the yang deficiency folder stasis of blood, and the damp and hot folder stasis of blood, cold and stagnate, the resistance of blood stasis network, disease type Coryza Treated by Syndrome Differentiation such as collapse of QI obtain very good effect.Invent a kind of not only safety but also effective Chinese medicine preparation, be significant.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of varicocele infertility.Have determined curative effect, safe ready, have no side effect, cheap characteristics.

The present invention is made by the following weight proportion raw material:

1.0～4 parts of 1.5～6 parts of Rhizoma Chuanxiongs of 1.5～6 parts of Cornu Cervi Degelatinatums of Concha Ostreae

1.0～4 parts of 1.0～4 parts of Spica Prunellaes of 1.0～4 parts of Radix Rehmanniae Preparata of Rhizoma Curcumae

1.0～4 parts of 1.0～4 parts of Herba Leonuris of 1.0～4 portions of Radix Cyathulaes of rhizoma sparganic

0.1～2 part of 0.1～2 part of Semen Citri Reticulatae of 1.0～4 parts of Bulbus Fritillariae Thunbergiis of Rhizoma Cyperi

The weight proportion of each raw material of optimization formula of the present invention is:

1.5～2.5 parts of 2.5～3.5 parts of Rhizoma Chuanxiongs of 2.5～3.5 parts of Cornu Cervi Degelatinatums of Concha Ostreae

1.5～2.5 parts of 1.5～2.5 parts of Spica Prunellaes of 1.5～2.5 parts of Radix Rehmanniae Preparata of Rhizoma Curcumae

1.5～2.5 parts of 1.5～2.5 parts of Herba Leonuris of 1.5～2.5 portions of Radix Cyathulaes of rhizoma sparganic

0.5～1.5 part of 0.5～1.5 part of Semen Citri Reticulatae of 1.5～2.5 parts of Bulbus Fritillariae Thunbergiis of Rhizoma Cyperi

The weight proportion of each raw material of optimum formula of the present invention is:

2 parts of 3 parts of Rhizoma Chuanxiongs of 3 parts of Cornu Cervi Degelatinatums of Concha Ostreae

2 parts of 2 parts of Spica Prunellaes of 2 parts of Radix Rehmanniae Preparata of Rhizoma Curcumae

2 parts of 2 parts of Herba Leonuris of 2 portions of Radix Cyathulaes of rhizoma sparganic

1 part of 1 part of Semen Citri Reticulatae of 2 parts of Bulbus Fritillariae Thunbergiis of Rhizoma Cyperi

Drug action mechanism among the present invention is as follows:

The Concha Ostreae property of medicine is salty, is slightly cold.Return liver, kidney channel.Have suppressing the hyperactive liver and subsiding YANG, tranquillization with heavy prescription, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating effect.Can treat vertigo and tinnitus, palpitation with fear insomnia, scrofula goiter ， mass in the abdomen mass in the abdomen, spontaneous sweating, seminal emission, metrorrhagia, leukorrhagia etc.(the 1574th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Cornu Cervi Degelatinatum property of medicine is salty, puckery, temperature.Return kidney, Liver Channel.Has reinforcing the kidney and supporting YANG, anastaltic effect.Can treat emission due to deficiency of the kidney, night sweat, anorexia and loose stool, chronic diarrhea chronic dysentery, metrorrhagia, leukorrhagia, frequent micturition, the enuresis, dribble of urine, skin infection disunion of a specified duration, wound hemorrhage etc.(the 3118th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Rhizoma Chuanxiong property of medicine suffering, temperature.Return liver, gallbladder, pericardium channel.Has blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, the effect of wind-expelling pain-stopping.Can treat menoxenia, the amenorrhea dysmenorrhea, the stagnant stomachache of the stasis of blood in puerperal ， mass in the abdomen lump, pain in chest and hypochondrium, it is dizzy to have a headache, anemofrigid-damp arthralgia, traumatic injury, ulcer sores etc.(the 292nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Rhizoma Curcumae nature and flavor hardship, suffering, temperature.Return liver, spleen channel.Have the circulation of qi promoting removing blood stasis with potent drugs, the removing food stagnancy pain relieving is changed poly-eliminating mass, the effect of antiearly pregnancy.Can treat that trusted subordinate's distending pain, lump in the abdomen, dyspepsia do not disappear, hepatosplenomegaly, abdominal pain due to blood stasis, amenorrhea due to stagnation of blood, cervical erosion, traumatic injury have a pain etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 995th page).

The Radix Rehmanniae Preparata sweet in the mouth, slightly warm in nature.Have nourishing YIN and supplementing blood, beneficial essence is filled out the effect of marrow.Can treat soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair, anemia etc.(the 197th page of chief editor such as the firm Xiao Ying of party " Chinese medicine and health food development and exploitation " People's Health Publisher).

Spica Prunellae property of medicine hardship, suffering, cold.Return liver, gallbladder meridian.Has liver heat removing and eyesight improving, the effect of powder detoxifcation.Can treat the conjunctival congestion photophobia, ophthalmalgia, it is dizzy to have a headache, tinnitus, scrofula goiter, acute mastitis mumps, carbuncle furuncle and phyma poison, acute and chronic hepatitis, hypertension etc.(the 2562nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Rhizoma sparganic nature and flavor suffering, hardship, flat.Return liver, spleen channel.Has removing blood stasis, circulation of qi promoting, removing food stagnancy analgesic effect.Can treat lump in the abdomen, coagulation of QI-blood, trusted subordinate's pain, the food stagnation distending pain, the side of body expands down painful, amenorrhea, dysmenorrhea, puerperal abdominalgia with blood stasis, traumatic injury, skin ulcer is swollen hard, hepatosplenomegaly etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 69th page).

Sweet, the little hardship of the Radix Cyathulae property of medicine, flat.Return liver, kidney channel.Has blood circulation promoting and blood stasis dispelling, the effect of expelling wind and removing dampness.Can treat the blood stasis amenorrhea, difficult labour, retention of placenta, postnatal blood stasis stomachache, pyretic stranguria, stranguria caused by urinary stone, dysmenorrhea, rheumatism lumbocrural pain, traumatic injury etc.(the 301st page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Herba Leonuri property of medicine suffering, hardship are slightly cold.Return liver, kidney, pericardium channel.Has promoting blood flow to regulate menstruation, inducing diuresis to remove edema, the effect of heat-clearing and toxic substances removing.Can treat menoxenia, amenorrhea, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, traumatic injury, dysuria, edema, carbuncle skin infection etc.(the 2697th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Rhizoma Cyperi property of medicine suffering, sweet, little hardship, flat.Return liver, tri-jiao channel.Has the resolving depression of regulating the flow of vital energy, regulating menstruation, antiabortive effect.Can treat distending pain over the hypochondrium, distending pain of the breast, hernia pain, menoxenia, gastral cavity abdomen feeling of fullness pain, belch acid regurgitation, vomiting and nausea, abdominal pain during menstruation, bleeding not during menses, frequent fetal movement etc.(the 2341st page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Bulbus Fritillariae Thunbergii property of medicine hardship, cold.Return lung, heart channel.Has removing heat-phlegm, sending down the abnormal ascending QI cough-relieving, the effect of mass dissipating and swelling eliminating.Can treat wind heat or phlegm-heat cough, lung abscess vomiting pus, scrofula goiter, sore and toxic etc.(the 2711st page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Semen Citri Reticulatae property of medicine hardship, flat.Return liver, kidney channel.Have and regulate the flow of vital energy, eliminating stagnation, analgesic effect.Can treat hernia, painful and swollen testis, acute mastitis, lumbago etc.(the 3745th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine)

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Concha Ostreae and Cornu Cervi Degelatinatum, is ministerial drug with Rhizoma Chuanxiong, Rhizoma Curcumae, Radix Rehmanniae Preparata, Spica Prunellae, rhizoma sparganic, Radix Cyathulae, Herba Leonuri and Rhizoma Cyperi; With Bulbus Fritillariae Thunbergii and Semen Citri Reticulatae is adjuvant.All medicines are harmonious, and are total to the tool blood circulation promoting and blood stasis dispelling, the effect of hard masses softening and resolving.The treatment varicocele infertility has determined curative effect, has no side effect taking convenience, cheap characteristics.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment varicocele infertility of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.

2, rich in proteins in the medicine of the present invention, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.

3, the present invention not only can effectively treat varicocele infertility, prevention to varicocele infertility also has good effect, and the treatment varicocele infertility has determined curative effect, has no side effect, taking convenience, cheap characteristics.

For showing the therapeutic effect of medicine of the present invention, as follows through clinical test results to the treatment varicocele infertility; Treatment varicocele infertility patient 20 examples.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.Three months is a course of treatment, take continuously three the course of treatment observe the curative effect.10 examples of fully recovering account for 50%, and 9 examples that take a turn for the better account for 45%, and more 1 example does not account for 5%, and total effective rate reaches 95%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

The embodiment decoction takes by weighing raw material by following weight:

2 parts of 3 parts of Rhizoma Chuanxiongs of 3 parts of Cornu Cervi Degelatinatums of Concha Ostreae

2 parts of 2 parts of Spica Prunellaes of 2 parts of Radix Rehmanniae Preparata of Rhizoma Curcumae

2 parts of 2 parts of Herba Leonuris of 2 portions of Radix Cyathulaes of rhizoma sparganic

1 part of 1 part of Semen Citri Reticulatae of 2 parts of Bulbus Fritillariae Thunbergiis of Rhizoma Cyperi

Preparation method is to get above-mentioned raw materials to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1～1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The decoction of the treatment varicocele infertility that the present invention makes is that plastic packaging is packed, and every bag of 210ml is oral, one time one bag, every day two to three times.Three months is a course of treatment.

Claims (3)

1, a kind of Chinese medicine preparation for the treatment of varicocele infertility is characterized in that it is made by the following weight proportion raw material:

1.0～4 parts of 1.5～6 parts of Rhizoma Chuanxiongs of 1.5～6 parts of Cornu Cervi Degelatinatums of Concha Ostreae

1.0～4 parts of 1.0～4 parts of Spica Prunellaes of 1.0～4 parts of Radix Rehmanniae Preparata of Rhizoma Curcumae

1.0～4 parts of 1.0～4 parts of Herba Leonuris of 1.0～4 portions of Radix Cyathulaes of rhizoma sparganic

0.1～2 part of 0.1～2 part of Semen Citri Reticulatae of 1.0～4 parts of Bulbus Fritillariae Thunbergiis of Rhizoma Cyperi.

2, a kind of Chinese medicine preparation for the treatment of varicocele infertility according to claim 1, wherein the weight proportion of each raw material is:

1.5～2.5 parts of 2.5～3.5 parts of Rhizoma Chuanxiongs of 2.5～3.5 parts of Cornu Cervi Degelatinatums of Concha Ostreae

1.5～2.5 parts of 1.5～2.5 parts of Spica Prunellaes of 1.5～2.5 parts of Radix Rehmanniae Preparata of Rhizoma Curcumae

1.5～2.5 parts of 1.5～2.5 parts of Herba Leonuris of 1.5～2.5 portions of Radix Cyathulaes of rhizoma sparganic

0.5～1.5 part of 0.5～1.5 part of Semen Citri Reticulatae of 1.5～2.5 parts of Bulbus Fritillariae Thunbergiis of Rhizoma Cyperi.

3, a kind of Chinese medicine preparation for the treatment of varicocele infertility according to claim 1, wherein the weight proportion of each raw material is:

2 parts of 3 parts of Rhizoma Chuanxiongs of 3 parts of Cornu Cervi Degelatinatums of Concha Ostreae

2 parts of 2 parts of Spica Prunellaes of 2 parts of Radix Rehmanniae Preparata of Rhizoma Curcumae

2 parts of 2 parts of Herba Leonuris of 2 portions of Radix Cyathulaes of rhizoma sparganic

1 part of 1 part of Semen Citri Reticulatae of 2 parts of Bulbus Fritillariae Thunbergiis of Rhizoma Cyperi.