CN101066387A - Chinese medicine composition for treating sterility of teratospermia - Google Patents

Abstract

The present invention provides Chinese medicine composition for treating sterility of teratospermia. The Chinese medicine composition is prepared with over ten kinds of Chinese medicinal materials, including prepared rhizome of rehmannia, cistanche, sealwort, tree peony bark, prepared aconite root, etc. It has the functions of warming kidney, activating yang and producing sperm. The present invention is developed through combining syndrome analyzing treatment of Chinese medicine and modern research result. The Chinese medicine composition has the features of determined curative effect, high safety, no toxic side effect and low cost.

Description

A kind of Chinese medicine composition for the treatment of sterility of teratospermia

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of sterility of teratospermia, is that a kind of sterility of teratospermia for the treatment of is the Chinese medicine preparation of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

Teratozoospermia is meant that abnormal morphology sperm count in the seminal fluid surpasses a kind of disease of 20%, is male infertility or causes one of major reason of monster, in the male sterility patient about 2%～12%.Sperm deformity can be divided into sperm head deformity and sperm tail deformity, and they have different forms separately again, as the excessive person of sperm head, are referred to as the major part sperm.The too small person of sperm head is referred to as microcephaly's sperm, tip sperm.Also have double end sperm or unsetting sperm, body to be connected to such an extent that asymmetric sperm, two tail shape sperm, afterbody twisted shape sperm, afterbody curl shape sperm and tail meat contain endochylema droplet shape sperm or the like various forms with head in addition.Chinese medicine thinks that teratospermia too much is to lose void with kidney, and the stasis of wet Sheng is main etiology and pathogenesis.Excess of sexual intercourse, prolonged illness, or serious disease just heals, and causes kidney yin or deficiency of kidney yang, essence is become homeless and is supported and cause sperm deformity and increase; Or because of eating and drinking without temperance, give birth in damp and hot, or attack in the noxious dampness, pent up smart chamber and teratospermia occurs and increase; In addition, spirit depressing, disorder of QI movement, the smart chamber of stasis also can cause primary disease.In a word, the too much disease of teratospermia, etiology and pathogenesis its at the spleen kidney, wet contain stasis also and be marked on.The primary disease clinical manifestation is 1, sterile; 2, visible fatigue and weakness, poor appetite, abdominal distention is vexed, or soreness of the waist and knees, can have testis to weigh down the performance of expanding with varicocele; 3, the part patient has sexual dysfunction.The traditional Chinese medical science is divided into disease type Coryza Treated by Syndrome Differentiation such as insufficiency of the spleen leading to overabundance of dampness, damp invasion of lower energizer, insufficiency of kidney-YANG, hyperactivity of fire caused by deficiency of YIN clinically, obtains very good effect.Invent a kind of not only safety but also effective Chinese medicine preparation, be significant.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of sterility of teratospermia.Have determined curative effect, safe ready, have no side effect, cheap characteristics.

The present invention is made by the following weight proportion raw material:

1.0～4 parts of 1.0～4 parts of Rhizoma Anemarrhenaes of 1.5～6 parts of Fructus Mori of Radix Rehmanniae Preparata

1.0～4 parts of 1.0～4 portions of Cortex Phellodendris of 1.5～6 parts of Semen Cuscutae of Herba Cistanches

0.1～2 part of 1.0～4 parts of Herba Epimedii of 1.5～6 parts of Radix Morindae Officinaliss of Rhizoma Polygonati

0.1～1 part of 1.0～4 parts of Radix Aconiti Lateralis Preparata of 1.0～4 parts of Fructus Lycii of Cortex Moutan

The weight proportion of each raw material of optimization formula of the present invention is:

1.5～2.5 parts of 1.5～2.5 parts of Rhizoma Anemarrhenaes of 2.5～3.5 parts of Fructus Mori of Radix Rehmanniae Preparata

1.5～2.5 parts of 1.5～2.5 portions of Cortex Phellodendris of 2.5～3.5 parts of Semen Cuscutae of Herba Cistanches

0.5～1.5 part of 1.5～2.5 parts of Herba Epimedii of 2.5～3.5 parts of Radix Morindae Officinaliss of Rhizoma Polygonati

0.3～0.7 part of 1.5～2.5 parts of Radix Aconiti Lateralis Preparata of 1.5～2.5 parts of Fructus Lycii of Cortex Moutan

The weight proportion of each raw material of optimum formula of the present invention is:

2 parts of 2 parts of Rhizoma Anemarrhenaes of 3 parts of Fructus Mori of Radix Rehmanniae Preparata

2 parts of 2 portions of Cortex Phellodendris of 3 parts of Semen Cuscutae of Herba Cistanches

1 part of 2 parts of Herba Epimedii of 3 parts of Radix Morindae Officinaliss of Rhizoma Polygonati

0.5 part of 2 parts of Radix Aconiti Lateralis Preparata of 2 parts of Fructus Lycii of Cortex Moutan

Drug action mechanism among the present invention is as follows:

The Radix Rehmanniae Preparata sweet in the mouth, slightly warm in nature.Have nourishing YIN and supplementing blood, beneficial essence is filled out the effect of marrow.Can treat soreness of the waist and knees, osteopyrexia and fever, the night sweat seminal emission, interior-heat is quenched one's thirst, severe palpitation, menoxenia, metrostaxis, dizzy, tinnitus, early whitening of beard and hair, anemia etc.(the 197th page of chief editor such as the firm Xiao Ying of party " Chinese medicine and health food development and exploitation " People's Health Publisher).

The Herba Cistanches property of medicine is sweet, salty, temperature.Return kidney, large intestine channel.Has kidney-replenishing, benefiting essence-blood, the effect in intestine moistening road.Can treat the sexual impotence of kidney yang deficiency, asthenia of essence and blood, seminal emission, nebulousurine, the frequent micturition heeltap, the lumbago flaccidity of the lower limbs, tinnitus order flower, menstruation is spread out the phase, infertility, dryness of the intestine constipation etc.(the 1226th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Rhizoma Polygonati property of medicine is sweet, and is flat.Return spleen, lung, kidney channel.Has nourishing YIN and moistening the lung, invigorating the spleen and replenishing QI, the effect of nourishing kidney replenishing essence.Can treat deficiency of YIN chronic cough, the xeropulmonary cough; Insufficiency of the spleen weak, the lack of appetite xerostomia is quenched one's thirst; The deficiency of the kidney soreness of the waist and knees, impotence and seminal emission, the tinnitus order is dark, early whitening of beard and hair, the body weakness with emaciation is thin, wind favus disease etc.(the 2830th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Cortex Moutan property of medicine hardship, suffering are slightly cold.GUIXIN, liver, kidney channel.Has clearing away heat and cooling blood, the effect of promoting blood circulation to remove blood stasis.Can treat the epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, the calentura later stage, hot Fu Yin divided heating, osteopyrexia and fever, and amenorrhea due to stagnation of blood, dysmenorrhea, mass in the abdomen, carbuncle sore tumefacting virus falls and pounces on the pain of injury, rheumatic arthralgia etc.(the 1578th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Fructus Mori property of medicine is sweet, sour, and is cold.Return liver, kidney channel.Have nourishing YIN and benefiting blood, promote the production of body fluid, the effect of intestine moistening.Can treat having a dizzy spell of deficiency of the liver and kindey and blood deficiency damage of essence, tinnitus, early whitening of beard and hair, the soreness of waist, dryness of the intestine constipation, tinea alba etc. are quenched one's thirst in insomnia.(the 2791st page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Semen Cuscutae property of medicine suffering, sweet, flat.Return the liver,kidney,spleen warp.Have the kidney invigorating and essence nourishing, Gu nourishing the liver to improve visual acuity is the effect of tire stopping leak.Can treat soreness of waist and knee joint, seminal emission, sexual impotence, premature ejaculation, sterile, quench one's thirst, stranguria with turbid discharge, the enuresis, blurred vision tinnitus, frequent fetal movement, miscarriage is had loose bowels etc.(the 2896th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Radix Morindae Officinalis property of medicine suffering, sweet, tepor.Return liver, kidney channel.Has reinforcing the kidney and supporting YANG, bone and muscle strengthening, the effect of expelling wind and removing dampness.Can treat impotence due to deficiency of the kidney, the seminal emission premature ejaculation, few abdomen cold type of pain, incontinence of urine, cold womb is infertile, anemofrigid-damp arthralgia, soreness of the waist and knees, rheumatism beriberi etc.(the 709th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Fructus Lycii property of medicine is sweet, flat.Return liver, kidney, lung meridian.Has nourishing the liver, nourishing kidney, the effect of lung moistening.Can treat caused by liver and kidney deficiency, have a dizzy spell, visual unclear, soreness of the waist and knees, impotence and seminal emission, cough due to consumptive disease, the taking fluids profusely etc. of quenching one's thirst.(the 2248th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Rhizoma Anemarrhenae property of medicine hardship, cold.Return lung, stomach, kidney channel.Has clearing away heat-fire, nourishing yin and moistening dryness.Can treat epidemic febrile disease hyperpyrexia excessive thirst, the cough due to lung-heat, osteopyrexia and fever, seminal emission, night sweat, restlessness of asrhenia type and insomnia is quenched one's thirst etc.(the 1924th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Cortex Phellodendri property of medicine hardship, cold.Return kidney, bladder, large intestine channel.Has heat clearing and damp drying, the effect of eliminating fire and detoxication.Can treat hygropyretic dysentery, have loose bowels, jaundice, nocturnal emission, stranguria with turbid discharge, leukorrhagia, hectic fever due to YIN-deficiency consumptive fever ， Wei Bi, and aphtha of the mouth and tongue, conjunctival congestion and swelling pain, skin sore, skin eczema etc.(the 2823rd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Herba Epimedii property of medicine suffering, sweet, temperature.Return kidney, Liver Channel.Has kidney invigorating and YANG supporting, strengthening the tendons and bones, the effect of expelling wind and removing dampness.Can treat impotence and seminal emission, cold caused by deficiency is sterile, the frequent micturition incontinence, and dyspnea and cough due to deficiency of the kidney, soreness of the waist and knees, rheumatic arthralgia, hemiplegia, extremity are meciless etc.(the 3152nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Radix Aconiti Lateralis Preparata property of medicine suffering, sweet, heat, poisonous.GUIXIN, kidney, spleen channel.Has recuperating depleted YANG and rescuing the patient from collapse, the effect of dispelling cold and removing dampness.Can treat excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhoea is fainted contrary, trusted subordinate's cold type of pain, cold-dysentery, beriberi edema, anemofrigid-damp arthralgia, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses etc.(the 1672nd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Radix Rehmanniae Preparata, Herba Cistanches and Rhizoma Polygonati, is ministerial drug with Fructus Mori, Semen Cuscutae, Radix Morindae Officinalis, Cortex Moutan, the Rhizoma Anemarrhenae, Cortex Phellodendri and Fructus Lycii; With Herba Epimedii and Radix Aconiti Lateralis Preparata is adjuvant.All medicines are harmonious, and are total to the tool warming the kidney to activate YANG, and spermatogenesis helps the effect of educating.The treatment sterility of teratospermia has determined curative effect, has no side effect taking convenience, cheap characteristics.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of The Drug Administration Law of People's Republic of China, utilizes the comprehensive function treatment sterility of teratospermia of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.

2, rich in proteins in the medicine of the present invention, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.

3, the present invention not only can effectively treat sterility of teratospermia, and the prevention of sterility of teratospermia is also had good effect, and the treatment sterility of teratospermia has determined curative effect, has no side effect taking convenience, cheap characteristics.

For showing the therapeutic effect of medicine of the present invention, as follows through clinical test results to the treatment sterility of teratospermia; Treatment sterility of teratospermia patient 20 examples.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.Three months is a course of treatment, take continuously three the course of treatment observe the curative effect.10 examples of fully recovering account for 50%, and 9 examples that take a turn for the better account for 45%, and more 1 example does not account for 5%, and total effective rate reaches 95%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

The embodiment decoction takes by weighing raw material by following weight:

2 parts of 2 parts of Rhizoma Anemarrhenaes of 3 parts of Fructus Mori of Radix Rehmanniae Preparata

2 parts of 2 portions of Cortex Phellodendris of 3 parts of Semen Cuscutae of Herba Cistanches

1 part of 2 parts of Herba Epimedii of 3 parts of Radix Morindae Officinaliss of Rhizoma Polygonati

0.5 part of 2 parts of Radix Aconiti Lateralis Preparata of 2 parts of Fructus Lycii of Cortex Moutan

Preparation method is to get above-mentioned raw materials to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1～1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The decoction of the treatment sterility of teratospermia that the present invention makes is that plastic packaging is packed, and every bag of 210ml is oral, one time one bag, every day two to three times.Three months is a course of treatment.

Claims (3)

1, a kind of Chinese medicine composition for the treatment of sterility of teratospermia is characterized in that it is made by the following weight proportion raw material:

1.0～4 parts of 1.0～4 parts of Rhizoma Anemarrhenaes of 1.5～6 parts of Fructus Mori of Radix Rehmanniae Preparata

1.0～4 parts of 1.0～4 portions of Cortex Phellodendris of 1.5～6 parts of Semen Cuscutae of Herba Cistanches

0.1～2 part of 1.0～4 parts of Herba Epimedii of 1.5～6 parts of Radix Morindae Officinaliss of Rhizoma Polygonati

0.1～1 part of 1.0～4 parts of Radix Aconiti Lateralis Preparata of 1.0～4 parts of Fructus Lycii of Cortex Moutan.

2, a kind of Chinese medicine composition for the treatment of sterility of teratospermia according to claim 1, wherein the weight proportion of each raw material is:

1.5～2.5 parts of 1.5～2.5 parts of Rhizoma Anemarrhenaes of 2.5～3.5 parts of Fructus Mori of Radix Rehmanniae Preparata

1.5～2.5 parts of 1.5～2.5 portions of Cortex Phellodendris of 2.5～3.5 parts of Semen Cuscutae of Herba Cistanches

0.5～1.5 part of 1.5～2.5 parts of Herba Epimedii of 2.5～3.5 parts of Radix Morindae Officinaliss of Rhizoma Polygonati

0.3～0.7 part of 1.5～2.5 parts of Radix Aconiti Lateralis Preparata of 1.5～2.5 parts of Fructus Lycii of Cortex Moutan.

3, a kind of Chinese medicine composition for the treatment of sterility of teratospermia according to claim 1, wherein the weight proportion of each raw material is:

2 parts of 2 parts of Rhizoma Anemarrhenaes of 3 parts of Fructus Mori of Radix Rehmanniae Preparata

2 parts of 2 portions of Cortex Phellodendris of 3 parts of Semen Cuscutae of Herba Cistanches

1 part of 2 parts of Herba Epimedii of 3 parts of Radix Morindae Officinaliss of Rhizoma Polygonati

0.5 part of 2 parts of Radix Aconiti Lateralis Preparata of 2 parts of Fructus Lycii of Cortex Moutan.