CN101065131B - 新的抗微生物剂 - Google Patents

新的抗微生物剂 Download PDF

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Publication number
CN101065131B
CN101065131B CN2005800401862A CN200580040186A CN101065131B CN 101065131 B CN101065131 B CN 101065131B CN 2005800401862 A CN2005800401862 A CN 2005800401862A CN 200580040186 A CN200580040186 A CN 200580040186A CN 101065131 B CN101065131 B CN 101065131B
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China
Prior art keywords
polymer
polymers
residues
antimicrobial
amino acid
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Expired - Fee Related
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CN2005800401862A
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English (en)
Chinese (zh)
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CN101065131A (zh
Inventor
A·莫尔
I·拉德兹舍夫斯基
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Technion Research and Development Foundation Ltd
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Technion Research and Development Foundation Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
    • A23B2/729—Organic compounds; Microorganisms; Enzymes
    • A23B2/742—Organic compounds containing oxygen
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23B—PRESERVATION OF FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; CHEMICAL RIPENING OF FRUIT OR VEGETABLES
    • A23B2/00—Preservation of foods or foodstuffs, in general
    • A23B2/70—Preservation of foods or foodstuffs, in general by treatment with chemicals
    • A23B2/725—Preservation of foods or foodstuffs, in general by treatment with chemicals in the form of liquids or solids
    • A23B2/729—Organic compounds; Microorganisms; Enzymes
    • A23B2/762—Organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Peptides Or Proteins (AREA)
CN2005800401862A 2004-09-27 2005-09-26 新的抗微生物剂 Expired - Fee Related CN101065131B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61277804P 2004-09-27 2004-09-27
US60/612,778 2004-09-27
PCT/IL2005/001030 WO2006035431A2 (en) 2004-09-27 2005-09-26 Fatty acid modified polylysines as antimicrobial agents

Publications (2)

Publication Number Publication Date
CN101065131A CN101065131A (zh) 2007-10-31
CN101065131B true CN101065131B (zh) 2012-10-24

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CN2005800401862A Expired - Fee Related CN101065131B (zh) 2004-09-27 2005-09-26 新的抗微生物剂

Country Status (8)

Country Link
US (3) US7504381B2 (enExample)
EP (1) EP1793837A2 (enExample)
JP (1) JP2008514586A (enExample)
CN (1) CN101065131B (enExample)
AU (1) AU2005288519A1 (enExample)
CA (1) CA2581883A1 (enExample)
MX (1) MX2007003608A (enExample)
WO (1) WO2006035431A2 (enExample)

Families Citing this family (27)

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Publication number Priority date Publication date Assignee Title
US20060013862A1 (en) * 2004-07-19 2006-01-19 Held Jerry M Onychomycosis: a new process for cure
US7915223B2 (en) 2004-09-27 2011-03-29 Technion Research & Development Foundation Ltd. Antimicrobial agents
EP2390255B1 (en) * 2006-04-03 2016-07-13 Technion Research & Development Foundation Ltd. Novel aminoglycosides and uses thereof in the treatment of genetic disorders
KR101487719B1 (ko) 2006-05-16 2015-01-29 페르가뭄 아베 개선된 항미생물성 펩타이드
EP2092071B1 (en) * 2006-12-14 2014-11-12 Technion Research & Development Foundation Ltd. Compositions and methods for concentrating and depleting microorganisms
CN101622271B (zh) * 2007-01-16 2014-08-27 加利福尼亚大学董事会 抗微生物肽
US20080214417A1 (en) * 2007-02-07 2008-09-04 University Of Waterloo Lubricant for wear testing of joint replacements and associated materials
FR2913335B1 (fr) * 2007-03-06 2009-06-05 Michel Geffard Utilisation de conjugues d'acides gras et de poly-l-lysine pour lutter contre des microorganismes pathogenes.
WO2008132737A1 (en) * 2007-04-30 2008-11-06 Technion Research & Development Foundation Ltd. Novel antimicrobial agents
WO2008132738A2 (en) * 2007-04-30 2008-11-06 Technion Research & Development Foundation Ltd. Anticancerous polymeric agents
AU2009269702B2 (en) 2008-07-11 2016-07-21 Universal Biosensors Pty Ltd Enhanced immunoassay sensor
JP2010154765A (ja) * 2008-12-26 2010-07-15 Hiroshi Kaino 健康食材
CZ301719B6 (cs) * 2009-02-12 2010-06-02 Ústav organické chemie a biochemie Akademie ved Ceské republiky, v. v. i. Antimikrobiální peptidy
JP2010279329A (ja) * 2009-06-08 2010-12-16 Hiroshi Kaino 健康食材
RU2400069C1 (ru) * 2009-06-11 2010-09-27 Галина Ивановна Эль-Регистан Способ защиты материалов от микробного разрушения
WO2011016043A2 (en) 2009-08-06 2011-02-10 Technion Research & Development Foundation Ltd. Antibiotic drug delivery and potentiation
US9264184B2 (en) * 2009-10-30 2016-02-16 Sony Corporation Coordinated signaling of scheduling information for uplink and downlink communications
US20120305482A1 (en) * 2010-02-09 2012-12-06 Exthera Medical, Llc Removal of virulence factors through extracorporeal therapy
WO2012081944A2 (en) * 2010-12-16 2012-06-21 Republic Of Korea(Management : Rural Development Administration) Dental membrane and method of manufacturing the same
US20120219682A1 (en) * 2011-02-28 2012-08-30 Frank Monteleone Antimicrobial compositions within antioxidant solutions used to protect whole protein foods
BR112014011868A2 (pt) * 2011-11-16 2017-05-16 3M Innovative Properties Co composições corantes poliméricas e métodos de uso
RU2666605C2 (ru) * 2013-05-01 2018-09-11 Неокули Пти Лтд Способы лечения бактериальных инфекций
BR112018076309A8 (pt) * 2016-06-17 2022-06-28 Univ Erasmus Med Ct Rotterdam Compostos de geminóide e seus usos
CN112386563A (zh) * 2019-08-12 2021-02-23 湖南早晨纳米机器人有限公司 微纳米载药机器人及其制备方法
CN113563261B (zh) * 2021-07-28 2023-09-01 西北大学 一种水溶性多脲抗菌分子及其制备方法和应用
CN114533679B (zh) * 2022-01-28 2023-03-14 马超锋 一种磺胺氯哒嗪缓释纳米胶粒及其制备方法
CN119837867B (zh) * 2025-01-13 2025-10-03 中国水产科学研究院长江水产研究所 防耐药复方氟苯尼考与盐酸小檗碱粉剂的制备方法

Citations (1)

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WO2003035677A2 (en) * 2001-08-17 2003-05-01 University Of Bern Antimicrobial peptides from the venom of the spider cupiennius salei

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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2003035677A2 (en) * 2001-08-17 2003-05-01 University Of Bern Antimicrobial peptides from the venom of the spider cupiennius salei

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EFRON L. ET AL..Direct interaction of Dermaseptin S4 AminoheptanoylDerivative with Intraerythrocytic Malaria Parasite Leading toIncreased Spacific Antiparasitic activity in Colture.THE JOURNAL OF BI0LOGICAL CHEMISTRY277 27.2002,277(27),P24867-24872,.
EFRON L. ET AL..Direct interaction of Dermaseptin S4 AminoheptanoylDerivative with Intraerythrocytic Malaria Parasite Leading toIncreased Spacific Antiparasitic activity in Colture.THE JOURNAL OF BI0LOGICAL CHEMISTRY277 27.2002,277(27),P24867-24872,. *

Also Published As

Publication number Publication date
AU2005288519A1 (en) 2006-04-06
WO2006035431A2 (en) 2006-04-06
US20120295837A1 (en) 2012-11-22
CA2581883A1 (en) 2006-04-06
US7504381B2 (en) 2009-03-17
US20060074021A1 (en) 2006-04-06
CN101065131A (zh) 2007-10-31
EP1793837A2 (en) 2007-06-13
US20100278807A1 (en) 2010-11-04
WO2006035431A3 (en) 2007-05-24
JP2008514586A (ja) 2008-05-08
MX2007003608A (es) 2007-08-14

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