CN101062415A - Il－18抑制剂的应用 - Google Patents

Il－18抑制剂的应用 Download PDF

Info

Publication number
CN101062415A
CN101062415A CNA2007101040701A CN200710104070A CN101062415A CN 101062415 A CN101062415 A CN 101062415A CN A2007101040701 A CNA2007101040701 A CN A2007101040701A CN 200710104070 A CN200710104070 A CN 200710104070A CN 101062415 A CN101062415 A CN 101062415A
Authority
CN
China
Prior art keywords
purposes
inhibitor
cell
mice
disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007101040701A
Other languages
English (en)
Chinese (zh)
Inventor
Y·奇韦提克
C·迪纳埃罗
C·普拉特尔－齐贝克
S·冯德文特
M·鲁宾斯坦
D·诺维克
S·H·金
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Serono laboratory Co.,Ltd.
Merck Serono SA
Yeda Research and Development Co Ltd
Original Assignee
Yeda Research and Development Co Ltd
Applied Research Systems ARS Holding NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd, Applied Research Systems ARS Holding NV filed Critical Yeda Research and Development Co Ltd
Publication of CN101062415A publication Critical patent/CN101062415A/zh
Pending legal-status Critical Current

Links

Images

CNA2007101040701A 2000-02-21 2001-02-20 Il－18抑制剂的应用 Pending CN101062415A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP00103597.1 2000-02-21
EP00103590.6 2000-02-21
EP00103590 2000-02-21
EP00121651.4 2000-10-04
EP00125633.8 2000-11-23

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB018052932A Division CN1322897C (zh) 2000-02-21 2001-02-20 Il－18抑制剂的应用

Publications (1)

Publication Number Publication Date
CN101062415A true CN101062415A (zh) 2007-10-31

Family

ID=30129156

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2007101040701A Pending CN101062415A (zh) 2000-02-21 2001-02-20 Il－18抑制剂的应用

Country Status (5)

Country Link
CN (1) CN101062415A (xx)
ES (1) ES2365600T3 (xx)
TR (1) TR200502061T2 (xx)
UA (1) UA94022C2 (xx)
ZA (1) ZA200205471B (xx)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103154032A (zh) * 2010-08-13 2013-06-12 弗·哈夫曼-拉罗切有限公司 用于疾病治疗的针对IL-1β和IL-18的抗体
CN104640879A (zh) * 2012-09-07 2015-05-20 诺华股份有限公司 Il-18结合分子
CN107660150A (zh) * 2015-03-05 2018-02-02 Ab2生物股份有限公司 Il‑18结合蛋白(il‑18bp)和抗体在炎性疾病中

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103154032A (zh) * 2010-08-13 2013-06-12 弗·哈夫曼-拉罗切有限公司 用于疾病治疗的针对IL-1β和IL-18的抗体
CN104474546A (zh) * 2010-08-13 2015-04-01 弗·哈夫曼-拉罗切有限公司 用于疾病治疗的针对IL-1β和IL-18的抗体
CN104640879A (zh) * 2012-09-07 2015-05-20 诺华股份有限公司 Il-18结合分子
CN109517065A (zh) * 2012-09-07 2019-03-26 诺华股份有限公司 Il-18结合分子
CN109517065B (zh) * 2012-09-07 2022-11-04 诺华股份有限公司 Il-18结合分子
CN107660150A (zh) * 2015-03-05 2018-02-02 Ab2生物股份有限公司 Il‑18结合蛋白(il‑18bp)和抗体在炎性疾病中
CN107660150B (zh) * 2015-03-05 2023-10-24 Ab2生物股份有限公司 Il-18结合蛋白(il-18bp)和抗体在炎性疾病中

Also Published As

Publication number Publication date
TR200502061T2 (tr) 2005-08-22
ZA200205471B (en) 2003-10-29
ES2365600T3 (es) 2011-10-07
UA94022C2 (ru) 2011-04-11

Similar Documents

Publication Publication Date Title
CN1404400A (zh) Il－18抑制剂的应用
CN1146441C (zh) 含有淋巴毒素-β受体的组合物
CN1317301C (zh) Il－2－和il－15－介导的t细胞应答的调节
EP0617126B1 (en) Polypeptide capable of inhibiting the binding between human IL-6 and its receptor
CN1529611A (zh) Il-18抑制剂在治疗或预防脓毒症中的应用
CN1636067A (zh) TACls和BR3多肽及其用途
CN1539970A (zh) 嗜中性白细胞因子α
CN1599754A (zh) 抗trail－r抗体
CN1612750A (zh) Taci－免疫球蛋白融合蛋白质
CN1507354A (zh) 通过给予整合蛋白αvβ3拮抗剂并与其它预防或治疗药剂配合来预防或者治疗炎性疾病或自身免疫疾病的方法
CN1839157A (zh) 抗白介素－22抗体及其应用
CN1342202A (zh) 可溶性受体br43×2和应用方法
CN1335884A (zh) 类白介素17受体蛋白
CN101028519A (zh) 治疗免疫性疾病的药用组合物
CN1399556A (zh) April受体(bcma)及其用途
CN1295482A (zh) 炎性介质拮抗剂
JPH08504817A (ja) ＩＦＮ−γインヒビターによる炎症性腸疾患の処置
CN1278736A (zh) 抗人gp39的人源化抗体、包含所述人源化抗体的组合物及其治疗用途
EA009074B1 (ru) АНТАГОНИСТИЧЕСКИЕ АНТИТЕЛА ПРОТИВ hTNFSF13b ЧЕЛОВЕКА
CN1891714A (zh) 单纯疱疹病毒进入介体的配体和使用方法
CN1360596A (zh) 与b7分子发生反应的人源化免疫球蛋白及应用该免疫球蛋白的治疗方法
CN1900116A (zh) 抗－LT－β－R抗体、含有该抗体的药用组合物及其制药应用
CN1272345C (zh) 沉默型抗cd－28抗体及其应用
US20230340054A1 (en) Interleukin-2 muteins and uses thereof
CN1909926A (zh) 能够结合il－18bp和抑制第二细胞因子活性的细胞因子的用途

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1117033

Country of ref document: HK

ASS Succession or assignment of patent right

Owner name: SERONO LABORATORY CO., LTD.

Free format text: FORMER OWNER: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Owner name: YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Free format text: FORMER OWNER: APPLIED RESEARCH SYSTEMS ARS HOLDING N. V.

Effective date: 20110131

Owner name: MERCK SERONO S. A.

Free format text: FORMER OWNER: SERONO LABORATORY CO., LTD.

C41 Transfer of patent application or patent right or utility model
COR Change of bibliographic data

Free format text: CORRECT: ADDRESS; FROM: CURACAO CITY, NETHERLANDS ANTILLES TO: REHOVOT CITY, ISRAEL

TA01 Transfer of patent application right

Effective date of registration: 20110131

Address after: Voight, Israel

Applicant after: YEDA RESEARCH AND DEVELOPMENT CO.,LTD.

Co-applicant after: Merck Serono S.A.

Address before: Voight, Israel

Applicant before: YEDA RESEARCH AND DEVELOPMENT CO.,LTD.

Co-applicant before: Serono laboratory Co.,Ltd.

Effective date of registration: 20110131

Address after: Voight, Israel

Applicant after: YEDA RESEARCH AND DEVELOPMENT CO.,LTD.

Co-applicant after: Serono laboratory Co.,Ltd.

Address before: Curacao, Netherlands Antilles

Applicant before: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.

Co-applicant before: YEDA RESEARCH AND DEVELOPMENT CO.,LTD.

C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication

Open date: 20071031

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1117033

Country of ref document: HK