CN101056879B - 作为a3和a1腺苷受体激动剂的嘌呤衍生物 - Google Patents

作为a3和a1腺苷受体激动剂的嘌呤衍生物 Download PDF

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CN101056879B
CN101056879B CN2005800363201A CN200580036320A CN101056879B CN 101056879 B CN101056879 B CN 101056879B CN 2005800363201 A CN2005800363201 A CN 2005800363201A CN 200580036320 A CN200580036320 A CN 200580036320A CN 101056879 B CN101056879 B CN 101056879B
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compound
salt
group
medicine
disease
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CN101056879A (zh
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肯尼思·A·雅各布森
巴尔钱德拉·V·乔希
苏珊娜·奇利邦
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
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    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P25/08—Antiepileptics; Anticonvulsants
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Neurosurgery (AREA)
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  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
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  • Pain & Pain Management (AREA)
  • Hematology (AREA)
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  • Gynecology & Obstetrics (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
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  • Rheumatology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
CN2005800363201A 2004-09-09 2005-09-02 作为a3和a1腺苷受体激动剂的嘌呤衍生物 Expired - Fee Related CN101056879B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60882304P 2004-09-09 2004-09-09
US60/608,823 2004-09-09
PCT/US2005/031678 WO2006031505A1 (en) 2004-09-09 2005-09-02 Purine derivatives as a3 and a1 adenosine receptor agonists

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CN101056879A CN101056879A (zh) 2007-10-17
CN101056879B true CN101056879B (zh) 2011-10-05

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US (1) US7825126B2 (https=)
EP (1) EP1794162A1 (https=)
JP (2) JP2008512457A (https=)
KR (1) KR20070050484A (https=)
CN (1) CN101056879B (https=)
AU (1) AU2005285284B2 (https=)
BR (1) BRPI0515030A (https=)
CA (1) CA2601996A1 (https=)
IL (1) IL181716A0 (https=)
WO (1) WO2006031505A1 (https=)

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GB0607950D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
GB0607944D0 (en) * 2006-04-21 2006-05-31 Novartis Ag Organic compounds
EP2322525B1 (en) * 2006-04-21 2013-09-18 Novartis AG Purine derivatives for use as adenosin A2A receptor agonists
WO2007139775A2 (en) * 2006-05-23 2007-12-06 University Of Connecticut N-methanocarba derivatives to treat cardiac diseases
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EP1889846A1 (en) 2006-07-13 2008-02-20 Novartis AG Purine derivatives as A2a agonists
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EP1903044A1 (en) * 2006-09-14 2008-03-26 Novartis AG Adenosine Derivatives as A2A Receptor Agonists
CA2669108A1 (en) * 2006-11-10 2008-05-15 Novartis Ag Cyclopentene diol monoacetate derivatives
NZ601866A (en) 2007-06-29 2013-12-20 Acucela Inc Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders
EP2170401A1 (en) 2007-06-29 2010-04-07 Government of the United States of America, Represented by the Secretary, Department of Health and Human Services Dendrimer conjugates of agonists and antagonists of the gpcr superfamily
JP5592262B2 (ja) 2007-10-15 2014-09-17 キャン−ファイト・バイオファーマ・リミテッド 肝細胞の増殖を誘導する方法及びその使用
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WO2010014921A2 (en) * 2008-08-01 2010-02-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services A3 adenosine receptor antagonists and partial agonists
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WO2011123518A1 (en) 2010-03-31 2011-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders
WO2012100654A1 (zh) * 2011-01-26 2012-08-02 北京化工大学 呋喃核糖基嘌呤类化合物及其制备方法和应用
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KR102445887B1 (ko) * 2016-04-21 2022-09-21 아스트로사이트 파마슈티컬스, 인코포레이티드 신경계 및 심혈관계 병태 치료를 위한 화합물 및 방법
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AU2005285284A1 (en) 2006-03-23
BRPI0515030A (pt) 2008-07-01
JP2012229215A (ja) 2012-11-22
IL181716A0 (en) 2007-07-04
JP2008512457A (ja) 2008-04-24
CN101056879A (zh) 2007-10-17
KR20070050484A (ko) 2007-05-15
CA2601996A1 (en) 2006-03-23
AU2005285284B2 (en) 2011-06-02
WO2006031505A1 (en) 2006-03-23
US20070232626A1 (en) 2007-10-04
EP1794162A1 (en) 2007-06-13
US7825126B2 (en) 2010-11-02

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