CN101056608A - Base composition for anti-wrinkle of lips, lipstick containing the same and manufacturing method thereof - Google Patents
Base composition for anti-wrinkle of lips, lipstick containing the same and manufacturing method thereof Download PDFInfo
- Publication number
- CN101056608A CN101056608A CNA2004800443714A CN200480044371A CN101056608A CN 101056608 A CN101056608 A CN 101056608A CN A2004800443714 A CNA2004800443714 A CN A2004800443714A CN 200480044371 A CN200480044371 A CN 200480044371A CN 101056608 A CN101056608 A CN 101056608A
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- China
- Prior art keywords
- wrinkle
- lips
- base composition
- lip
- lip pomade
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- 239000000203 mixture Substances 0.000 title claims abstract description 85
- 230000001153 anti-wrinkle effect Effects 0.000 title claims abstract description 76
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- WYQVAPGDARQUBT-FGWHUCSPSA-N Madecassol Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O WYQVAPGDARQUBT-FGWHUCSPSA-N 0.000 claims abstract description 33
- WYQVAPGDARQUBT-XCWYDTOWSA-N asiaticoside Natural products O=C(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@H](O)[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](CO)O2)O1)[C@@]12[C@@H]([C@@H](C)[C@H](C)CC1)C=1[C@](C)([C@@]3(C)[C@@H]([C@@]4(C)[C@H]([C@@](CO)(C)[C@@H](O)[C@H](O)C4)CC3)CC=1)CC2 WYQVAPGDARQUBT-XCWYDTOWSA-N 0.000 claims abstract description 33
- 229940022757 asiaticoside Drugs 0.000 claims abstract description 32
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 claims abstract description 32
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 26
- 235000012000 cholesterol Nutrition 0.000 claims abstract description 13
- DDOVBCWVTOHGCU-QMXMISKISA-N n-[(e,2s,3r)-3-hydroxy-1-[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxynonadec-4-en-2-yl]octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCCC)CO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O DDOVBCWVTOHGCU-QMXMISKISA-N 0.000 claims abstract description 13
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 13
- 239000007788 liquid Substances 0.000 claims abstract description 12
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 238000002360 preparation method Methods 0.000 claims description 12
- 239000000049 pigment Substances 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 4
- 239000003921 oil Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 230000037307 sensitive skin Effects 0.000 abstract description 4
- 230000007794 irritation Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 29
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 230000000052 comparative effect Effects 0.000 description 12
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Natural products OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 11
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 229960003471 retinol Drugs 0.000 description 6
- 235000020944 retinol Nutrition 0.000 description 6
- 239000011607 retinol Substances 0.000 description 6
- 241001597008 Nomeidae Species 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 230000000638 stimulation Effects 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 4
- 206010015150 Erythema Diseases 0.000 description 3
- 206010022998 Irritability Diseases 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000007613 environmental effect Effects 0.000 description 3
- 231100000321 erythema Toxicity 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 229950004959 sorbitan oleate Drugs 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 150000003077 polyols Chemical class 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- -1 retinol ester Chemical class 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical class CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 1
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 244000146462 Centella asiatica Species 0.000 description 1
- 235000004032 Centella asiatica Nutrition 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- FGUZFFWTBWJBIL-XWVZOOPGSA-N [(1r)-1-[(2s,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)O[C@H](CO)[C@H]1OC[C@H](O)[C@H]1O FGUZFFWTBWJBIL-XWVZOOPGSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- JXTHNDFMNIQAHM-UHFFFAOYSA-N dichloroacetic acid Chemical compound OC(=O)C(Cl)Cl JXTHNDFMNIQAHM-UHFFFAOYSA-N 0.000 description 1
- 229960005215 dichloroacetic acid Drugs 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 description 1
- 229910000271 hectorite Inorganic materials 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 150000004609 retinol derivatives Chemical class 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 229940057429 sorbitan isostearate Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 150000003700 vitamin C derivatives Chemical class 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
Disclosed are a base composition for anti-wrinkle of lips capable of being stably mixed with other lipstick components when it is added to a lipstick, a lipstick including the same, and a manufacturing method thereof. The base composition for anti-wrinkle of lips is manufactured by mixing asiaticoside, which is an active component for anti-wrinkle of lips, with a base comprising galactosylceramide, cholesterol, polyhydric alcohol and liquid oil. The lipstick including the base composition for anti-wrinkle of lips according to the present invention can have a very excellent anti-wrinkle effect upon its application to the lips, and also be safely used nearly without irritation to in sensitive skin tissues of the lips since the asiaticoside which is the active component for anti-wrinkle is stably maintained in the lipstick.
Description
Technical field
The present invention relates to a kind of its can be when being added into lip pomade with the blended base composition that is used for anti-wrinkle of lips of other stable components, comprise lip pomade of said composition and preparation method thereof.
Background technology
Usually, lip composition is made up of the oiliness composition and the pigment composition that comprise oil and wax, and the oiliness composition provides bating effect and suitable sensation, and pigment presents multicolour.
The horny layer of known because lip is significantly lower than the thin of common skin and its nature moisturizing factor and water content, so lip has the fluid loss characteristics than high several times of other skin.Therefore, carry out the moistening effect of many effort, and carry out many effort to present multicolour with the improvement lip.
Yet, as mentioned above, because the skin dehydration of lip is rapid, so under environmental condition, in lip skin histology and its tissue that closes on, form wrinkle easily as dry weather.Therefore, developed and played the physiologically active that promotes lip skin lip pomade with the effect that improves the anti-wrinkle of lips effect.
Japanese Unexamined Patent Publication No H4-117317 discloses a kind of beauty treatment material that is used for anti-wrinkle of lips, and it comprises retinol ester derivant, vitamin C and derivant thereof, vitamin E and derivant thereof, vitamin B
2And derivant and oil.Yet the retinol derivatives that is contained in this beauty treatment material is different from the retinol with anti-wrinkle effect fully, so this derivant is because its active disappearance and can not play the effect that presents anti-wrinkle effect.Because its small stability and effect when simply mixing with oil base are so vitamin C derivatives can not present the anti-wrinkle effect of lip effectively.
Equally, Korean Patent Publication No. 2002-0003480 discloses a kind of water soluble polypeptide that comprises to play crease-resistant and lip pomade moistening effect on lip.Yet, according to the lip pomade of this invention should comprise as stearic acid and other fatty acid and as sorbitan isostearate and other surfactant to stablize the crease-resistant active component water soluble polypeptide composition in the lip pomade, it can increase the probability of the sensitive skin tissue stimulation that causes lip.
In addition, Korean Patent Publication No. 10-0262176 has proposed a kind of comprising as retinol, tretinoin and other biostearin wrinkle and the toughness (toughness) to prevent lip.Yet, when being exposed to air for a long time or being applied to lip, because the biostearin composition to the less stable of Oxidation and easily oxidized, causes its loss of activity.Therefore, the problem of biostearin composition is passing anti-wrinkle effect variation in time.
At present, the asiaticoside as the material with excellent anti-wrinkle effect has caused concern (referring to Korean Patent Publication No. 2001-88095).Asiaticoside is the natural materials that extracts from Herba Centellae (Centella asiatica) etc., have the excellent synthetic effect of promotion collagen, so it shows the stimulation to skin hardly.Yet the problem of asiaticoside is that it with is not mainly mixed by the lip pomade stable components that becomes to be grouped into as the oil and the oiliness of wax.
Summary of the invention
Therefore, design the present invention is to solve prior art problems, thereby the purpose of this invention is to provide a kind of base composition that is used for anti-wrinkle of lips, it has excellent anti-wrinkle effect, and because it stably remains crease-resistant active component in lip pomade when asiaticoside mixes with other lip pomade composition, can also be used safely, and do not shown stimulation lip sensitive skin tissue; A kind of lip pomade that comprises this base composition; And preparation method thereof.
For achieving the above object, the invention provides a kind of base composition that is used for anti-wrinkle of lips, in said composition, mix with the basis that comprises galactosyl ceramide, cholesterol, polyhydric alcohol and liquid oil as the asiaticoside that is used for the anti-wrinkle of lips active component.By this base composition being added in the lip composition of forming by the oiliness composition and the pigment that comprise wax and oil, it is mixed equably, then the products therefrom mold is become the reservation shape of lip pomade, and with this base composition that is used for anti-wrinkle of lips in order to the preparation lip pomade.Because asiaticoside stably remains crease-resistant active component in the lip pomade of preparation,, and can not present stimulation to lip sensitive skin tissue so the lip pomade of preparation presents sufficient anti-wrinkle of lips effect.
The specific embodiment
Hereinafter will describe preferred implementation of the present invention in detail.
Asiaticoside is represented that by following Chemical formula 1 it is the chemical compound (C with excellent anti-wrinkle effect
48H
78O
19, mean molecule quantity: 959.15), because the natural materials (referring to Korean Patent Publication No. 1990-13974) for from Herba Centellae and other, extracting, so it shows the stimulation to skin hardly.
＜Chemical formula 1 〉
Yet, as mentioned above, asiaticoside itself owing to its water solublity be difficult to other mainly by the lip pomade stable components mixing that comprises that the oil and the oiliness of wax become to be grouped into, so be not easy in lip pomade, use.
Therefore, the inventor has carried out multiple effort, so developed a kind of base composition that is used for anti-wrinkle of lips that comprises stable asiaticoside by asiaticoside is mixed with the basis that comprises galactosyl ceramide, cholesterol, polyhydric alcohol and liquid oil.Because even asiaticoside also stably remains in the base composition when mixing with other lip pomade composition, so this base composition that is used for anti-wrinkle of lips of the present invention presents the special crease-resistant effect of asiaticoside.
The anti-wrinkle of lips active component asiaticoside that mixes and stably be present in the base composition that is used for anti-wrinkle of lips of the present invention presents excellent security to human body and to the stability of Oxidation.Therefore, even the long-time back lip pomade that comprises asiaticoside of the present invention that uses also can continue stably to present anti-wrinkle effect.Preferably, based on the gross weight of the base composition that is used for anti-wrinkle of lips, the content of asiaticoside is 0.01～20wt%.If the content of asiaticoside is lower than 0.01wt%, it can not present anti-wrinkle effect because content of active component is little, and if its content surpasses 20wt%, it is difficult to present stability when this base composition mixes with lip pomade.
And galactosyl ceramide is a kind of chemical compound that has and play the cutin composition analog structure of the effect of controlling water evaporates in skin, and it has remarkable result for stable hydrophilic asiaticoside and following polyol component.Preferably, the scope with 1～60wt% of the base composition that is used for anti-wrinkle of lips adds galactosyl ceramide.If the content of galactosyl ceramide is lower than 1wt%, it is difficult to stablize effectively water solublity asiaticoside and polyol component in the lip pomade when base composition is mixed with lip pomade, if and asiaticoside surpasses 60wt%, can greatly increase and be used for the blended lip pomade of base composition of anti-wrinkle of lips and the viscosity of this base composition.
And cholesterol presents the deliquescent effect of raising galactosyl ceramide in the basis that is used for anti-wrinkle of lips.Preferably, content of cholesterol is 0.1～40wt%.If content of cholesterol is lower than 0.1wt%, it is insufficient to have an above-mentioned effect, and if content of cholesterol surpasses 4wt%, the viscosity that is used for the basis of anti-wrinkle of lips can greatly increase.
Simultaneously, polyhydric alcohol has the known moistening effect of prior art, and it also has the effect at the basis uniform dissolution asiaticoside that is used for anti-wrinkle of lips.This polyhydric alcohol includes but not limited to glycerol, 1,3 butylene glycol, dipropylene glycol, sorbitol etc.According to the stability of water solublity asiaticoside and polyhydric alcohol, preferably use polyhydric alcohol with the amount of 0.1～60wt% of the basis that is used for anti-wrinkle of lips.
Also comprise and be the oil of liquid under the room temperature being used for crease-resistant basis, and this liquid oil can comprise and is the oil based on hydrocarbon of liquid, the oil based on ester, higher alcohol in the lip pomade under the normally used room temperature.Preferably, the content of described liquid oil is 0.1～50wt%, and it can keep the stability of the suitable viscosity of basis and water solublity asiaticoside and polyhydric alcohol in this scope.
By the uniform mixing mentioned component, promptly asiaticoside, galactosyl ceramide, cholesterol, polyhydric alcohol and liquid oil prepare the base composition that is used for anti-wrinkle of lips.Then, can add the conventional lip composition of forming by the oiliness composition and the pigment that comprise wax and oil as active component by this base composition that will be used for anti-wrinkle of lips, it is mixed equably, and become the reservation shape of lip pomade form to prepare lip pomade the mold of gained mixture with anti-wrinkle of lips function.Based on the gross weight of lip pomade, preferably will be used for the base composition adding lip composition of anti-wrinkle of lips with the content of 0.1～50wt%.If the content of base composition is lower than 0.1wt%, its content owing to the active component asiaticoside is low to have inadequate anti-wrinkle of lips effect, if and it surpasses 50wt%, because the viscosity of lip pomade itself can excessively increase, and therefore can hinder the inherent availability of lip pomade, so it is undesirable.
Except the above-mentioned base composition that is used for anti-wrinkle of lips, under the prerequisite that does not depart from purpose of the present invention, can in described lip pomade, add the wax that usually adds lip pomade, oil, pigment, ultraviolet light screener, dispersant etc.
Though the skin of lip is subject to the various environmental influences as dry weather, therefore and because it is obviously thin and the natural moisture preserving component content is lower and wrinkling easily than other common skin, but because asiaticoside stably remains crease-resistant active component in lip pomade, so when it was applied to the skin of lip, the lip pomade of the present invention that comprises the base composition of being made up of mentioned component that is used for anti-wrinkle of lips presented very excellent anti-wrinkle of lips effect and excellent cutaneous safety.In addition because be contained in the base composition that is used for anti-wrinkle of lips preserve moisture composition equally with mix for other lip pomade stable components of oil base, so lip pomade of the present invention can present sufficient moistening effect when it is applied to lip.
Hereinafter will describe preferred implementation of the present invention in detail.Therefore, the description of Ti Chuing here is a preferred embodiment, and it only is used for illustrative purposes and does not plan to limit the scope of the invention, so should be appreciated that, under prerequisite without departing from the spirit and scope of the present invention, can carry out other replacement and change to it.Should be appreciated that,, will fully describe preferred implementation of the present invention as conspicuous to those skilled in the art.
Under 80 ℃,, list in composition in the following table 1 by uniform mixing and prepare the base composition that is used for anti-wrinkle of lips (A～D) according to their content (wt%).
Table 1
| Composition | The base composition that is used for anti-wrinkle of lips | |||
| A | B | C | D | |
| Asiaticoside | 1 | 5 | 10 | 15 |
| Glycerol | 39 | 60 | 50 | 50 |
| Galactosyl ceramide | 15 | 15 | 20 | 20 |
| Cholesterol | 15 | 5 | 10 | 10 |
| Three isooctyl acid glycerol (triisooctanoin) | 30 | 15 | 10 | 5 |
| Amount to | 100 | |||
Based on amount listed in the following table 2, gained is used for the base composition of anti-wrinkle of lips, and (the listed composition 1～12 of A～D) and following table 2 to wherein adding composition 13, disperses and froth breaking then 80 ℃ of following uniform dissolution.Then, composition 14 is added wherein and uniform dissolution with the lip composition of preparation embodiment 1～7 and comparative example 1～3.
Table 2
| Composition | Embodiment | Comparative example | ||||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 1 | 2 | 3 | |
| 1. be used for crease-resistant basis A | 5.0 | - | - | - | - | - | - | - | - | - |
| 2. be used for crease-resistant basis B | - | 5.0 | - | - | - | - | - | - | - | - |
| 3. be used for crease-resistant basis C | - | - | 5.0 | - | 1.0 | 10.0 | 20.0 | - | - | - |
| 4. be used for crease-resistant basis D | - | - | - | 5.0 | - | - | - | - | - | - |
| 5. ceresine | 16.0 | 16.0 | 16.0 | 16.0 | 16.0 | 16.0 | 16.0 | 16.0 | 16.0 | 16.0 |
| 6. wool grease | 7.0 | 7.0 | 7.0 | 7.0 | 7.0 | 7.0 | 7.0 | 7.0 | 7.0 | 7.0 |
| 7. two glycerol, three isostearates | 60.2 | 60.2 | 60.2 | 60.2 | 64.2 | 55.2 | 45.2 | 65.2 | 50.2 | 65.0 |
| The oronain hectorite draws in 8 departments | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
| 9. glycerol | - | - | - | - | - | - | - | - | 10.0 | - |
| 10. sorbitan oleate | - | - | - | - | - | - | - | - | 5.0 | - |
| 11. retinol | - | - | - | - | - | - | - | - | - | 0.2 |
| 12. antiseptic | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 |
| 13. pigment | 11.0 | 11.0 | 11.0 | 11.0 | 11.0 | 11.0 | 11.0 | 11.0 | 11.0 | 11.0 |
| 14. aromatic | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
| Amount to | 100 | |||||||||
To become reservation shape according to the lip composition mold of embodiment 1～7 and comparative example 1～3 preparation with the preparation lip pomade, and according to the quality of following standard evaluation lip pomade.
The anti-wrinkle effect of lip
To repeat to be applied to 100 20 to quadragenarian women according to the lip pomade of embodiment 1～7 and comparative example 1～3 preparation all around, estimate the anti-wrinkle effect of using the front/rear lip of lip pomade by the make up artist then, as follows:
The anti-wrinkle effect of-lip does not have or variation (0/100～97/3) slightly: *
The anti-wrinkle effect of-lip is improved (96/4～86/14): △ a little
The anti-wrinkle effect of-lip is obviously improved (85/15～70/30): zero
Not-(anti-wrinkle effect of number/lip of the improved people of anti-wrinkle effect of lip does not have the people's of variation number)
The stability of crease-resistant composition
All the components except composition 13 is homodisperse in embodiment 1～7 and comparative example 1～3, and water soluble dyestuffs is added to show the precipitation of water soluble ingredient as indicator for blue No. 1, firmly disperses then and froth breaking.Compositions behind the froth breaking is put into test tube, and 80 ℃ kept 10 minutes, were cooled to room temperature, estimated the dispersion stabilization of the water soluble ingredient that is used for anti-wrinkle of lips in the lip pomade then, as follows:
-good: zero (stable and be not used in crease-resistant water soluble ingredient precipitation)
-not poor: △ (being used for crease-resistant water soluble ingredient precipitates a little)
-relatively poor: * (very unstable, as to be used for crease-resistant water soluble ingredient and to precipitate in a large number)
Safety evaluatio
The animal patch test that carries out 48 hours with Cavia porcellus is to estimate irritable level.
-no irritability: zero (no erythema and edema)
-irritability: △ (causing very slight erythema and edema) a little
-moderate irritability: * (significantly erythema and edema)
The evaluation of moistening effect
In embodiment 1～7 and comparative example 1～3, prepare lip pomade by the base composition that is used for anti-wrinkle of lips for preparing by all the components of uniform dissolution except composition 12.The gained lip pomade is applied to eight experimenters' inner arm, being coated with back 3 hours by using the skin surface humidity tester to measure the variation of passing moisture-holding capacity in time, estimates moistening effect then.
-good: zero (after 3 hours, based on the initial coating time: water holding capacity increase at least 10%)
-not poor: △ (after 3 hours, based on the initial coating time: water holding capacity increases by 5～10%)
-relatively poor: * (after 3 hours, based on the initial coating time: the water holding capacity increase is lower than 5%)
The results are shown in the following table 3 of above-mentioned evaluation.
Table 3
| Project | Embodiment | Comparative example | ||||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 1 | 2 | 3 | |
| Anti-wrinkle effect | ○ | ○ | ○ | ○ | ○ | ○ | ○ | × | × | × |
| Moistening effect | ○ | ○ | ○ | ○ | △ | ○ | ○ | × | ○ | × |
| Safety | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | × | ○ |
| The stability of crease-resistant composition | ○ | ○ | ○ | ○ | ○ | ○ | ○ | - | - | × |
Result with reference to table 3, compare with the lip pomade of the lip pomade of the comparative example of only forming by conventional lip pomade composition oiliness basis 1 and use sorbitan oleate comparative example 2 that glycerol is stable, present excellent properties as anti-wrinkle of lips, moistening effect, safety etc. according to the lip pomade of the embodiment of the invention 1～7.
Its demonstration, the lip pomade of the comparative example of being made up of conventional ingredient 1 presents the crease-resistant and moistening effect of obvious variation, and the lip pomade that uses the surfactant sorbitan oleate comparative example 2 that glycerol is stable presents excellent moistening effect, but do not have anti-wrinkle effect, and have the problem of safety owing to the zest surfactant.And, because retinol can not stably be scattered in the lip pomade, so the simple lip pomade that adds as the comparative example 3 of crease-resistant composition of water solublity retinol can not be had anti-wrinkle effect effectively.On the other hand, the lip pomade that is used for anti-wrinkle of lips of preparation presents excellent anti-wrinkle of lips effect and excellent security and excellent moistening effect among the embodiment 1～7.
Industrial applicability
As mentioned above, although the skin of lip is subject to the various environmental influences such as dry weather, therefore and because it is obviously thin than other common skin and the natural moisture preserving component content is very low and wrinkling easily, but because asiaticosid stably remains crease-resistant active component in lipstick, so when it was applied to the skin of lip, the lipstick that comprises for the base composition of anti-wrinkle of lips according to the present invention helped to present very excellent anti-wrinkle of lips effect and excellent cutaneous safety. In addition, mix with stablizing for the lipstick of oil base because be contained in for the moisturizing composition of the base composition of anti-wrinkle of lips is same, so lipstick of the present invention helps to present sufficient moistening effect when it is applied to lip.
Claims (7)
1, a kind of base composition that is used for anti-wrinkle of lips, wherein, mix with the basis that comprises galactosyl ceramide, cholesterol, polyhydric alcohol and liquid oil as the asiaticoside of being represented by following Chemical formula 1 of anti-wrinkle of lips active component:
Chemical formula 1
2, the base composition that is used for anti-wrinkle of lips according to claim 1, wherein, based on the described gross weight that is used for the base composition of anti-wrinkle of lips, the content of described asiaticoside, galactosyl ceramide, cholesterol, polyhydric alcohol and liquid oil is respectively 0.01～20wt%, 1～60wt%, 0.1～40wt%, 0.1～60wt% and 0.1～50wt%.
3, a kind of lip pomade, it comprises as each described base composition of anti-wrinkle of lips that is used in claim 1 and 2 as active component.
4, lip pomade according to claim 3, wherein, based on the gross weight of described lip pomade, the described content that is used for the base composition of anti-wrinkle of lips is 0.1～50wt%.
5, a kind of method for preparing lip pomade, this method comprises:
(S1) uniform mixing asiaticoside, galactosyl ceramide, cholesterol, polyhydric alcohol and liquid oil are used for the base composition of anti-wrinkle of lips with preparation;
(S2) base composition that will be used for anti-wrinkle of lips adds the oiliness composition comprise to be become with line of oils by wax and the lip composition of pigment, then with its uniform mixing; And
(S3) the product mold of step (S2) is become the reservation shape of lip pomade.
6, the method for preparing lip pomade according to claim 5, wherein, based on the described gross weight that is used for the base composition of anti-wrinkle of lips, respectively with content mixed product Asiaticoside, galactosyl ceramide, cholesterol, polyhydric alcohol and the liquid oil of 0.01～20wt%, 1～60wt%, 0.1～40wt%, 0.1～60wt% and 0.1～50wt%.
7,, wherein,, add the base composition that is used for anti-wrinkle of lips of described step (S2) with the content of 0.1～50wt% based on the gross weight of described lip pomade according to each described method for preparing lip pomade in claim 5 and 6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/KR2004/002908 WO2006052037A1 (en) | 2004-11-10 | 2004-11-10 | Base composition for anti-wrinkle of lips, lipstick containing the same and manufacturing method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101056608A true CN101056608A (en) | 2007-10-17 |
| CN100546561C CN100546561C (en) | 2009-10-07 |
Family
ID=36336688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004800443714A Expired - Fee Related CN100546561C (en) | 2004-11-10 | 2004-11-10 | Be used for anti-wrinkle of lips base composition, comprise lip pomade of said composition and preparation method thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN100546561C (en) |
| WO (1) | WO2006052037A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840373A (en) * | 2015-04-28 | 2015-08-19 | 苏州药基美研医药科技有限公司 | Nursing product used for relieving dry lips |
| CN110787088A (en) * | 2019-11-28 | 2020-02-14 | 广州那比昂生物科技有限公司 | Basic composition for lip wrinkle fading and preparation method and application thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100194527B1 (en) * | 1996-12-20 | 1999-06-15 | 성재갑 | High Moisturizing Lipstick Composition |
| KR100611884B1 (en) * | 2000-03-10 | 2006-08-11 | 주식회사 엘지생활건강 | Pore tightening and reducing cosmetic composition |
| ITMI20011022A1 (en) * | 2001-05-17 | 2002-11-17 | Indena Spa | PHARMACEUTICAL AND COSMETIC COMPOSITIONS AGAINST SKIN AGING |
| KR20030047260A (en) * | 2001-12-10 | 2003-06-18 | 주식회사 엘지생활건강 | High moisturizing complex and lipstick composition containing the same |
| KR20030047258A (en) * | 2001-12-10 | 2003-06-18 | 주식회사 엘지생활건강 | Gel typed lip make up composition |
| KR20040040031A (en) * | 2002-11-06 | 2004-05-12 | 주식회사 엘지생활건강 | Lip make up composition |
-
2004
- 2004-11-10 WO PCT/KR2004/002908 patent/WO2006052037A1/en active Application Filing
- 2004-11-10 CN CNB2004800443714A patent/CN100546561C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104840373A (en) * | 2015-04-28 | 2015-08-19 | 苏州药基美研医药科技有限公司 | Nursing product used for relieving dry lips |
| CN110787088A (en) * | 2019-11-28 | 2020-02-14 | 广州那比昂生物科技有限公司 | Basic composition for lip wrinkle fading and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006052037A1 (en) | 2006-05-18 |
| CN100546561C (en) | 2009-10-07 |
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