CN101045082A - Preparing method for medicine liquid in compound red-rooted salvia soft capsule - Google Patents
Preparing method for medicine liquid in compound red-rooted salvia soft capsule Download PDFInfo
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- CN101045082A CN101045082A CN 200610025364 CN200610025364A CN101045082A CN 101045082 A CN101045082 A CN 101045082A CN 200610025364 CN200610025364 CN 200610025364 CN 200610025364 A CN200610025364 A CN 200610025364A CN 101045082 A CN101045082 A CN 101045082A
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- salviae miltiorrhizae
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Abstract
A liquid medicine contained in the compound red sage softcapsule for treating coronary heart disease is prepared from red sage root through supercritical extracting and conventional extracting. Its content of danshenone is greatly increased.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to a kind of preparation method of compound Salviae Miltiorrhizae soft capsule content medicinal liquid.
Technical background
Coronary heart disease is that coronary atherosclerosis causes myocardial ischemia-anoxemia and the heart disease that causes, is a kind of commonly encountered diseases of serious harm middle-aged and elderly people health, and in the crowd of China more than 40 years old, sickness rate accounts for first of annual case fatality rate up to 3～7%.
The compound Salviae Miltiorrhizae soft capsule be by Radix Salviae Miltiorrhizae, Radix Notoginseng, Borneolum Syntheticum in conjunction with onset, have blood circulation promoting and blood stasis dispelling, the effect of regulating QI to relieve pain, the clinical thoracic obstruction that is used for caused by energy stagnation and blood stasis, uncomfortable in chest, pareordia twinge that disease is seen; Angina pectoris is seen above-mentioned patient.Principal agent in the Radix Salviae Miltiorrhizae side of being; its active component comprises two parts; a part is water soluble ingredient (is representative with the salvianolic acid B); a part is liposoluble constituent (is representative with the TANSHINONES); wherein the cardiovascular pharmacological effect of TANSHINONES comprises: the sclerosis of anti-tremulous pulse wrinkle sample; dwindle myocardial infarction area; reduce the myocardial oxygen consumption rate; anti-arrhythmia; to myocardial protective effect; hemorrhagic shock is poured into the protective effect of kidney loss and again to protecting neuron from acute etc.; so TANSHINONES plays very large effect in the treatment of coronary heart disease, the treatment of coronary heart disease had meaning.
Radix Salviae Miltiorrhizae is with ethanol and water extraction in the compound Salviae Miltiorrhizae soft capsule preparation technology, there is very big problem, because TANSHINONES is fat-soluble, water or ethanol can not extract fully, extract temperature required height in addition, heat time heating time is long, and the effective ingredient failure loss will be bigger relatively, so influenced the curative effect of medicine to a certain extent.Therefore we carry out process modification to the compound Salviae Miltiorrhizae soft capsule, thereby increase content of effective, strengthen the curative effect of medicine.
Summary of the invention
The present invention combines China's Chinese medicine with the modern pharmaceutical technology, adopt advanced supercritical carbon dioxide extraction method, fully extracts active ingredient, has increased effective component content.It is characterized in that:
Its prescription (by weight percentage) is: Radix Salviae Miltiorrhizae 75.12%, Radix Notoginseng 23.54%, Borneolum Syntheticum 1.34%, above medical material is commercially available.
Its preparation technology is:
1) Radix Salviae Miltiorrhizae extraction
Take by weighing Radix Salviae Miltiorrhizae 75.12% by formula ratio, pulverize, add the 80%-95% soak with ethanol 0.5-15h that 0.5-2 doubly measures, under 20-80 ℃, 10-40MPa, use supercritical carbon dioxide extraction 1-2h, the extract collection, standby.
2) ethanol extraction
Take by weighing Radix Notoginseng 23.54% by formula ratio, pulverize, merge with above-mentioned Radix Salviae Miltiorrhizae extraction slag, add 60% ± 20 alcohol reflux twice, each 1.5 ± 0.5 hours, extracting solution merged, and filtered, and is standby.
3) water extract-alcohol precipitation
Above-mentioned ethanol extraction slag adds twice of pure water reflux, extract,, each 2 ± 0.5 hours, extracting solution merges, and filters, and is concentrated into proportion 1.2 ± 0.2, cooling, add 85% ± 10 ethanol to alcoholic degree 70% under stirring fast, placed 12 hours, alcohol deposit fluid and Radix Salviae Miltiorrhizae extract and ethanol extract merge, reclaim ethanol and be concentrated into proportion 1.2 ± 0.2, standby.
4) preparation
Take by weighing Borneolum Syntheticum 1.34% by formula ratio, be ground into fine powder, admix in the above-mentioned extractum, promptly.
To sum up, technology of the present invention is with supercritical extraction method TANSHINONES to be extracted fully earlier, has avoided long-time extraction of former process high-temperature and the TANSHINONES that causes is decomposed and destroyed, and the content of the compound Salviae Miltiorrhizae soft capsule content TANSHINONES that makes is significantly increased.
The compound Salviae Miltiorrhizae soft capsule content that makes with the inventive method is carried out active component Tanshinone I I as test sample
AAssay, measurement result is 0.28%, exceeds one times nearly than the compound Salviae Miltiorrhizae soft capsule content TANSHINONES content 0.15% that makes with former technology.
Compound Salviae Miltiorrhizae soft capsule content of the present invention, adopt supercritical carbon dioxide extraction method, the active ingredient TANSHINONES content in the prescription is improved greatly, strengthened the curative effect of medicine, more be applicable to clinical treatment coronary heart disease, have very high social benefit and economic benefit.
The specific embodiment
Below the present invention is further described.
Embodiment 1
Prescription: Radix Salviae Miltiorrhizae 450g, Radix Notoginseng 141g, Borneolum Syntheticum 8g.
Preparation method: take by weighing Radix Salviae Miltiorrhizae 450g respectively by formula ratio, pulverize, add the 80% soak with ethanol 0.5h of 300g, under 30 ℃, 15MPa, use supercritical carbon dioxide extraction 1h, the extract collection, standby; Take by weighing Radix Notoginseng 141g by formula ratio, pulverize, merge with above-mentioned Radix Salviae Miltiorrhizae extraction slag, add 50% alcohol reflux twice, each 1 hour, extracting solution merged, and filtered, and is standby; Above-mentioned ethanol extraction slag adds twice of pure water reflux, extract,, each 1.5 hours, extracting solution merges, and filters, and is concentrated into proportion 1.05, cooling, add 75% ethanol to alcoholic degree 70% under stirring fast, placed 12 hours, alcohol deposit fluid and Radix Salviae Miltiorrhizae extract and ethanol extract merge, reclaim ethanol and be concentrated into proportion 1.05, standby; Take by weighing Borneolum Syntheticum 8g by formula ratio, be ground into fine powder, admix in the above-mentioned extractum, promptly.
Embodiment 2
Radix Salviae Miltiorrhizae 450g, Radix Notoginseng 141g, Borneolum Syntheticum 8g.
Preparation method: take by weighing Radix Salviae Miltiorrhizae 450g respectively by formula ratio, pulverize, add the 90% soak with ethanol 1h of 600g, under 50 ℃, 25MPa, use supercritical carbon dioxide extraction 1.5h, the extract collection, standby; Take by weighing Radix Notoginseng 141g by formula ratio, pulverize, merge with above-mentioned Radix Salviae Miltiorrhizae extraction slag, add 65% alcohol reflux twice, each 1.5 hours, extracting solution merged, and filtered, and is standby; Above-mentioned ethanol extraction slag adds twice of pure water reflux, extract,, each 2 hours, extracting solution merges, and filters, and is concentrated into proportion 1.15, cooling, add 85% ethanol to alcoholic degree 70% under stirring fast, placed 12 hours, alcohol deposit fluid and Radix Salviae Miltiorrhizae extract and ethanol extract merge, reclaim ethanol and be concentrated into proportion 1.15, standby; Take by weighing Borneolum Syntheticum 8g by formula ratio, be ground into fine powder, admix in the above-mentioned extractum, promptly.
Embodiment 3
Radix Salviae Miltiorrhizae 450g, Radix Notoginseng 141g, Borneolum Syntheticum 8g.
Preparation method: take by weighing Radix Salviae Miltiorrhizae 450g respectively by formula ratio, pulverize, add the 95% soak with ethanol 1.5h of 900g, under 75 ℃, 35MPa, use supercritical carbon dioxide extraction 2h, the extract collection, standby; Take by weighing Radix Notoginseng 141g by formula ratio, pulverize, merge with above-mentioned Radix Salviae Miltiorrhizae extraction slag, add 80% alcohol reflux twice, each 2 hours, extracting solution merged, and filtered, and is standby; Above-mentioned ethanol extraction slag adds twice of pure water reflux, extract,, each 2.5 hours, extracting solution merges, and filters, and is concentrated into proportion 1.25, cooling, add 95% ethanol to alcoholic degree 70% under stirring fast, placed 12 hours, alcohol deposit fluid and Radix Salviae Miltiorrhizae extract and ethanol extract merge, reclaim ethanol and be concentrated into proportion 1.25, standby; Take by weighing Borneolum Syntheticum 8g by formula ratio, be ground into fine powder, admix in the above-mentioned extractum, promptly.
Claims (1)
1, a kind of preparation method of compound Salviae Miltiorrhizae soft capsule content is characterized in that:
Its prescription (by weight percentage) is: Radix Salviae Miltiorrhizae 75.12%, Radix Notoginseng 23.54%, Borneolum Syntheticum 1.34%, above medical material is commercially available.
Its preparation technology is:
1) Radix Salviae Miltiorrhizae extraction
Take by weighing Radix Salviae Miltiorrhizae 75.12% by formula ratio, pulverize, add 0.5-2 and doubly measure 80%-95% soak with ethanol 0.5-15h, under 20-80 ℃, 10-40MPa, use supercritical carbon dioxide extraction 1-2h, the extract collection, standby.
2) ethanol extraction
Take by weighing Radix Notoginseng 23.54% by formula ratio, pulverize, merge with above-mentioned Radix Salviae Miltiorrhizae extraction slag, add 60% ± 20 alcohol reflux twice, each 1.5 ± 0.5 hours, extracting solution merged, and filtered, and is standby.
3) water extract-alcohol precipitation
Above-mentioned ethanol extraction slag adds twice of pure water reflux, extract,, each 2 ± 0.5 hours, extracting solution merges, and filters, and is concentrated into proportion 1.2 ± 0.2, cooling, add 85% ± 10 ethanol to alcoholic degree 70% under stirring fast, placed 12 hours, alcohol deposit fluid and Radix Salviae Miltiorrhizae extract and ethanol extract merge, reclaim ethanol and be concentrated into proportion 1.2 ± 0.2, standby.
4) preparation
Take by weighing Borneolum Syntheticum 1.34% by formula ratio, be ground into fine powder, admix in the above-mentioned extractum, promptly.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610025364 CN101045082A (en) | 2006-03-31 | 2006-03-31 | Preparing method for medicine liquid in compound red-rooted salvia soft capsule |
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| CN 200610025364 CN101045082A (en) | 2006-03-31 | 2006-03-31 | Preparing method for medicine liquid in compound red-rooted salvia soft capsule |
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| CN101045082A true CN101045082A (en) | 2007-10-03 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103349707A (en) * | 2013-07-23 | 2013-10-16 | 宁波立华制药有限公司 | Method for preparing eight-treasure granules |
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- 2006-03-31 CN CN 200610025364 patent/CN101045082A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103349707A (en) * | 2013-07-23 | 2013-10-16 | 宁波立华制药有限公司 | Method for preparing eight-treasure granules |
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