CN102755538B - Lavipeditum traditional Chinese medicine composition for lowering blood pressure and preparation method thereof - Google Patents
Lavipeditum traditional Chinese medicine composition for lowering blood pressure and preparation method thereof Download PDFInfo
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- CN102755538B CN102755538B CN201210248352.XA CN201210248352A CN102755538B CN 102755538 B CN102755538 B CN 102755538B CN 201210248352 A CN201210248352 A CN 201210248352A CN 102755538 B CN102755538 B CN 102755538B
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Abstract
The invention discloses a lavipeditum traditional Chinese medicine composition for lowering blood pressure and a preparation method thereof. The lavipeditum traditional Chinese medicine composition for lowering blood pressure is prepared from 20-45 parts of radix achyranthis bidentatae, 15-20 parts of gastrodia tuber, 15-20 parts of uncaria, 15-20 parts of Evodia rutaecarpa and 5-10 parts of cinnamon, wherein the fineness of the radix achyranthis bidentatae, gastrodia tuber, uncaria, Evodia rutaecarpa and cinnamon is respectively 300-1000 meshes. The lavipeditum traditional Chinese medicine composition for lowering blood pressure can be prepared by coarse crushing, fine crushing and ultrafine crushing. The lavipeditum traditional Chinese medicine composition for lowering blood pressure can lower the blood pressure by being added into hot water for lavipeditum, has obvious blood pressure lowering effects on common traditional Chinese medicine symptoms caused by liver hyperactivity, qi deficiency, phlegm stagnation and phlegm dampness, and can obviously improve the symptom of headaches by hypertension. The lavipeditum traditional Chinese medicine composition for lowering blood pressure has the advantages of convenient material taking, low price, high safety and no side effect, is simple to use, and thus, is an ideal new traditional Chinese medicine for treating hypertension.
Description
Technical field
The present invention relates to Chinese medicine composition, be specifically related to a kind ofly prevent and treat hypertensive Chinese medicine composition and preparation method thereof for foot.
Background technology
Hypertension refers to that systolic arterial pressure and/or diastolic pressure increase under quiescent condition, be a kind of with arterial pressure rising for feature, can with the systemic disease of the functional or organic change of heart, blood vessel, brain and kidney and other organs.At present, population of China hypertension total prevalence rate is about 11.26%, estimates that about there are 1.26 hundred million hyperpietics in the whole nation, and in increase trend.Prevalence is relevant to the age, within 30 ~ 34 years old, is 4.64%, and within 35 ~ 44 years old, being 8.22%, 45 ~ 54 years old is 18.0%, within 55 ~ 64 years old, be 29.4%, 65 ~ 74 years old is 41.9%, within more than 75 years old, is 51.2%.China steps into aging society just gradually, and senile hypertension sufferer is very high, and hypertension also has the trend suffering from patient's rejuvenation increasingly.Show according to investigations, crowd's hypertension awareness, treatment rate, control rate are respectively 30.2%, 24.7%, 6.1%, are still in reduced levels, are worth drawing attention.
Western medicine depressor is various in style, and antihypertensive effect is obvious, but its side effect is many, and can not effectively prevent hypertension from recurring and symptom management progress.External treatment with Chinese medicine theory has the history of thousands of years, in very long development process and long-term clinical practice, have accumulated many preciousnesses, rich experience.Chinese medicine has convenience of drawing materials, uses simply, low price, has no side effect, safe and reliable advantage, and exploitation can the Chinese medicine composition of blood pressure lowering be significant, and for preventing target organ caused by hypertension, especially the infringement of the vitals such as the heart, brain, kidney is significant.
Summary of the invention
The object of the present invention is to provide a kind of lavipeditum traditional Chinese medicine composition of blood pressure lowering, said composition adopts micropowder technology preparation, effective ingredient stripping is more abundant and rapid, obviously can improve hypertension headache syndromes after adopting the lavipeditum traditional Chinese medicine composition foot bath of this blood pressure lowering, antihypertensive effect is obvious, especially remarkable to the antihypertensive effect of the TCM Syndrome Type of the most normal hyperactivity of liver-fire, qi-asthenia phlegm stasis of blood type, phlegm-damp heap soil or fertilizer over and around the roots Sheng type.
Technical scheme of the present invention is:
A kind of lavipeditum traditional Chinese medicine composition of blood pressure lowering, the lavipeditum traditional Chinese medicine composition of this blood pressure lowering is made up of Radix Achyranthis Bidentatae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Fructus Evodiae, Cortex Cinnamomi, each component counts Radix Achyranthis Bidentatae 20 ~ 45 parts, 15 ~ 20 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 15 ~ 20 parts, Fructus Evodiae 15 ~ 20 parts, Cortex Cinnamomi 5 ~ 10 parts by weight, and the fineness of above-mentioned each component is 300 order ~ 1000 orders.Adopt superfine communication technique to pulverize each component and both can improve cell-wall breaking ratio (being greater than 95%), specific surface area, effective ingredient dissolution, bioavailability, pharmacological action can be strengthened again, reduce dosage, save medical material and protection herb resource.
Preferably, above-mentioned each component counts Radix Achyranthis Bidentatae 35 parts, 15 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 15 parts, Fructus Evodiae 15 parts, Cortex Cinnamomi 10 parts by weight.
Below the effect of component each in formula of the present invention is briefly described:
Radix Achyranthis Bidentatae, Cortex Cinnamomi energy blood-activating and qi-promoting are promoted blood circulation, liver and kidney tonifying; Fructus Evodiae energy dispersing the stagnated live-QI to relieve the stagnation of QI, draw irritability and decline, gas pathogenic fire reducing also falls; Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis energy clearing away heat and relieving the wind syndrome, suppressing the hyperactive liver and subsiding YANG.
Another object of the present invention is to the preparation method of the lavipeditum traditional Chinese medicine composition providing above-mentioned blood pressure lowering, it comprises the following steps:
1) Radix Achyranthis Bidentatae of formula ratio, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Fructus Evodiae, Cortex Cinnamomi is got;
2) coarse pulverization: the traditional Chinese medicine powder of step 1) is broken to particle diameter and is less than 180 μm;
3) fine powder is broken: by step 2) traditional Chinese medicine powder that obtains is broken to by 250 mesh sieves;
4) micronizing: super micro crushing of Chinese medicinal material step 3) obtained is extremely by 300 mesh sieves, and particle diameter is less than 10um, makes micronizing Chinese powder medicine.
Preferably, the method for micronizing that step 4) uses is comminution by gas stream, ball mill pulverizing, vibrations pulverizing, Ultrasonic Pulverization, one or both in centrifugal pulverizing combine.
The lavipeditum traditional Chinese medicine composition of blood pressure lowering of the present invention have following two kinds of usings method:
The first using method: the lavipeditum traditional Chinese medicine composition of getting blood pressure lowering of the present invention, adds boiling water and stirs, and waits to be cooled to (general summer is 38 ~ 41 DEG C, and winter is 41 ~ 43 DEG C) foot bath at the temperature of suitable human foot contact, once a day.
The second using method: the lavipeditum traditional Chinese medicine composition of getting blood pressure lowering of the present invention, after adding water boil, waits to be cooled to (general summer is 38 ~ 41 DEG C, and winter is 41 ~ 43 DEG C) foot bath at the temperature of suitable human foot contact, once a day.
The invention has the beneficial effects as follows:
The lavipeditum traditional Chinese medicine composition of blood pressure lowering of the present invention can blood pressure lowering by adding in hot water foot bath, especially remarkable to the antihypertensive effect of the TCM Syndrome Type of modal liver high Sheng type, qi-asthenia phlegm stasis of blood type, phlegm-damp heap soil or fertilizer over and around the roots Sheng type, improve obviously to hypertension headache syndromes, and draw materials conveniently, use simple, low price, safety have no side effect, and are a kind of traditional Chinese medical science new drugs of ideal Hypertension.
Detailed description of the invention
Below by specific embodiment, lavipeditum traditional Chinese medicine composition of a kind of blood pressure lowering of the present invention and preparation method thereof is described in further detail.
Embodiment 1
A lavipeditum traditional Chinese medicine composition for blood pressure lowering, it is obtained by following methods:
1) Radix Achyranthis Bidentatae 35 parts, 15 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 15 parts, Fructus Evodiae 15 parts, Cortex Cinnamomi 10 parts is got by weight;
2) coarse pulverization: the traditional Chinese medicine powder of step 1) is broken to particle diameter and is less than 180 μm;
3) fine powder is broken: by step 2) Chinese crude drug that obtains adopts airflow pulverization method to be crushed to by 250 mesh sieves;
4) micronizing: super micro crushing of Chinese medicinal material step 3) obtained is extremely by 300 mesh sieves, and particle diameter is less than 10um, makes micronizing Chinese powder medicine, obtains the lavipeditum traditional Chinese medicine composition of blood pressure lowering of the present invention.
Embodiment 2
A lavipeditum traditional Chinese medicine composition for blood pressure lowering, it is obtained by following methods:
1) Radix Achyranthis Bidentatae 45 parts, 15 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 20 parts, Fructus Evodiae 15 parts, Cortex Cinnamomi 5 parts is got by weight;
2) coarse pulverization: the traditional Chinese medicine powder of step 1) is broken to particle diameter and is less than 180 μm;
3) fine powder is broken: by step 2) Chinese crude drug that the obtains method that adopts ball mill pulverizing and vibrations to pulverize is crushed to by 250 mesh sieves;
4) micronizing: super micro crushing of Chinese medicinal material step 3) obtained is extremely by 300 mesh sieves, and particle diameter is less than 10um, makes micronizing Chinese powder medicine, obtains the lavipeditum traditional Chinese medicine composition of blood pressure lowering of the present invention.
Embodiment 3
A lavipeditum traditional Chinese medicine composition for blood pressure lowering, it is obtained by following methods:
1) Radix Achyranthis Bidentatae 25 parts, 20 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 20 parts, Fructus Evodiae 15 parts, Cortex Cinnamomi 10 parts is got by weight;
2) coarse pulverization: the traditional Chinese medicine powder of step 1) is broken to particle diameter and is less than 180 μm;
3) fine powder is broken: by step 2) Chinese crude drug that obtains adopts Ultrasonic Pulverization method to be crushed to by 250 mesh sieves;
4) micronizing: super micro crushing of Chinese medicinal material step 3) obtained is extremely by 300 mesh sieves, and particle diameter is less than 10um, makes micronizing Chinese powder medicine, obtains the lavipeditum traditional Chinese medicine composition of blood pressure lowering of the present invention.
Embodiment 4 clinical trial
1. test group: include 30 routine inpatients in, wherein male l6 example, female l4 example; 36 ~ 75 years old age, average (63.7 ± 7.6) year; The course of disease 1.0 ~ 15.5 years, average (8.8 ± 0.5) year; By Western medicine diagnose standard diagnostic results be: hypertension I level 5 example, II grade of 16 example, III grade of 9 example; By tcm diagnosis standard diagnostic results be: hyperactivity of liver-fire 4 example, type of deficiency of YIN leading to hyper activity of YANG 18 example, deficiency of both YIN and YANG 3 example, phlegm-damp stops up Sheng type 5 example.
2. matched group: include 30 routine inpatients in, wherein male l4 example, female 16 example; 41 ~ 73 years old age, average (64.7 ± 8.3) year; The course of disease 1.5 ~ 12.2 years, average (7.9 ± 0.5) year; By Western medicine diagnose standard diagnostic results be: hypertension I level 6 example, II grade of l4 example, III grade of l0 example; By tcm diagnosis standard diagnostic results be: hyperactivity of liver-fire 3 example, type of deficiency of YIN leading to hyper activity of YANG l6 example, deficiency of both YIN and YANG 4 example, phlegm-damp stops up Sheng type 7 example.
Test group and matched group two groups of patient data compare there was no significant difference, have comparability.
3. diagnostic criteria: Western medicine diagnose is with reference to " 1999WHO/ISH hypertension process guide ", tcm diagnosis, with reference to " the new Chinese medicine Hypertension guideline of clinical investigations " of Ministry of Public Health promulgation in 1993, is divided into hyperactivity of liver-fire, type of deficiency of YIN leading to hyper activity of YANG, deficiency of both YIN and YANG type, phlegm-damp to stop up Sheng type.
4. Therapeutic Method:
4.1 test group: test group takes An Bowei/irbesartan 150mg qd every day at upper and lower noon orally by each foot bath of the lavipeditum traditional Chinese medicine composition of blood pressure lowering of the present invention 1 time.Concrete grammar is: the lavipeditum traditional Chinese medicine composition 250g getting blood pressure lowering of the present invention, add boiling water 2000mL to stir, under warm (summer 38 ~ 4l DEG C, winter 4l ~ 43 DEG C) condition, pour foot bath 30min in constant temperature foot bathing basin into, every day 2 times, lie up after foot bath, unified measure flat sleeping left upper arm blood pressure with Omron electric sphygmomanometer, respectively at before foot bath, foot bath terminates rear 1h and respectively measures 1 time, observe patient during foot bath at any time react and make a record, the course for the treatment of is 2 weeks.
4.2 matched groups: matched group takes An Bowei/irbesartan 150mg qd orally, every day at the upper and lower noon is by each foot bath of warm water 1 time.Specific practice is: the warm water (summer 38 ~ 4l DEG C getting proper temperature, winter 4l ~ 43 DEG C), pour foot bath 30min in constant temperature foot bathing basin into, every day 2 times, lie up after foot bath, unified measure flat sleeping left upper arm blood pressure with Omron electric sphygmomanometer, respectively at before foot bath, foot bath terminates rear 1h and respectively measures 1 time, observe patient during foot bath at any time react and make a record, the course for the treatment of is 2 weeks.
5 observation index:
5.1 blood pressures: blood pressure change situation before and after treatment
5.2 clinical symptoms and sign: the change of headache, dizzy, uncomfortable in chest, cardiopalmus, heart rate, tongue fur, arteries and veins.
5.3 untoward reaction situations.
6 curative effect judging standards
6.1 blood pressure lowering standards: " the new Chinese medicine Hypertension guideline of clinical investigations " criterion of therapeutical effect of promulgating with reference to Ministry of Public Health.
Effective: diastolic pressure more than decline l0mmHg, and reach normal range; Though diastolic pressure does not drop to normally, decline 20mmHg or more; Wherein 1 must be possessed.
Effective: diastolic pressure is declined by less than l0mmHg, but drop to normal range; Diastolic pressure comparatively treats front decline l0 ~ 19mmHg, but does not reach normal range; Systolic pressure comparatively treats front more than decline 30mmHg; Wherein 1 must be possessed.
Invalid: not reach above standard.
6.2 clinical symptoms criterions of therapeutical effect
Effective: original symptom disappears completely or significantly alleviates;
Effective: cardinal symptom major part disappears or alleviates;
Invalid: before and after treatment, symptom is without alleviating.
7 result of the tests
The contrast of antihypertensive effect after 7.1 test group and matched group patient treatment, in table 1.
The contrast (mmHg) of antihypertensive effect after table 1 test group and matched group patient treatment
* compare before controlling with same group, 1. P<0.05; # compares with matched group, P<0.05.
As known from Table 1, test group is after the lavipeditum traditional Chinese medicine composition treatment of blood pressure lowering of the present invention, before and after treatment, there were significant differences for blood pressure, and treatment group diastolic pressure comparatively matched group diastolic pressure is lower, two groups of data compare and there is significant difference (P < 0.05), point out the lavipeditum traditional Chinese medicine composition of blood pressure lowering of the present invention to have to increase to reduce diastolic pressure effect.
7.2 test group and matched group patient person treat the contrast of rear clinical symptoms curative effect, in table 2.
As known from Table 2, test group is after the lavipeditum traditional Chinese medicine composition treatment of blood pressure lowering of the present invention, in clinical symptoms improvement, total effective rate is 96.7%, it is 76.7% that the clinical symptoms of matched group improves total effective rate, two groups of data compare and there is significant difference (P < 0.05), point out the lavipeditum traditional Chinese medicine composition of blood pressure lowering of the present invention effectively can improve clinical symptoms.
Above-described embodiment is only preferred case study on implementation of the present invention can not with this to limit protection scope of the present invention, and the change of any unsubstantiality that those skilled in the art does on the basis of invention is changed and replaced and all belongs to the present invention's scope required for protection.
Claims (3)
1. the lavipeditum traditional Chinese medicine composition of a blood pressure lowering, it is characterized in that: the lavipeditum traditional Chinese medicine composition of this blood pressure lowering is made up of Radix Achyranthis Bidentatae, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Fructus Evodiae, Cortex Cinnamomi, each component counts Radix Achyranthis Bidentatae 20 ~ 45 parts, 15 ~ 20 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 15 ~ 20 parts, Fructus Evodiae 15 ~ 20 parts, Cortex Cinnamomi 5 ~ 10 parts by weight, and the fineness of above-mentioned each component is 300 order ~ 1000 orders;
The preparation method of the lavipeditum traditional Chinese medicine composition of this blood pressure lowering comprises the steps:
1) Radix Achyranthis Bidentatae of formula ratio, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, Fructus Evodiae, Cortex Cinnamomi is got;
2) coarse pulverization: by step 1) traditional Chinese medicine powder be broken to particle diameter and be less than 180 μm;
3) fine powder is broken: by step 2) traditional Chinese medicine powder that obtains is broken to by 250 mesh sieves;
4) micronizing: by step 3) super micro crushing of Chinese medicinal material that obtains to by 300 mesh sieves, make micronizing Chinese powder medicine.
2. the lavipeditum traditional Chinese medicine composition of blood pressure lowering as claimed in claim 1, is characterized in that: each component counts Radix Achyranthis Bidentatae 35 parts, 15 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 15 parts, Fructus Evodiae 15 parts, Cortex Cinnamomi 10 parts by weight.
3. the lavipeditum traditional Chinese medicine composition of blood pressure lowering according to claim 1 and 2, is characterized in that: step 3) the broken method of the fine powder that uses is comminution by gas stream, ball mill pulverizing, vibrations pulverizing, Ultrasonic Pulverization, one or both in centrifugal pulverizing combine.
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| CN104887564A (en) * | 2015-05-14 | 2015-09-09 | 北京同仁堂安徽中药材有限公司 | Health care footbath powder for invigorating blood circulation and fending off cold and preparation method thereof |
| CN105055922B (en) * | 2015-08-27 | 2018-10-16 | 晋江龙华康复医院有限公司 | A kind of point-application prescription that treating hypertension and its application method |
| CN106138514A (en) * | 2016-08-02 | 2016-11-23 | 山东中医药大学附属医院 | A kind of Chinese medicine composition treating intermingled phlegm and blood stasis type hypertension and preparation method thereof |
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| CN101766759A (en) * | 2008-12-30 | 2010-07-07 | 戴建国 | Medicinal footbath liquor |
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