CN102512527B - Traditional Chinese medicine composition for treating post-stroke depression - Google Patents
Traditional Chinese medicine composition for treating post-stroke depression Download PDFInfo
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- CN102512527B CN102512527B CN 201110460077 CN201110460077A CN102512527B CN 102512527 B CN102512527 B CN 102512527B CN 201110460077 CN201110460077 CN 201110460077 CN 201110460077 A CN201110460077 A CN 201110460077A CN 102512527 B CN102512527 B CN 102512527B
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Abstract
The invention discloses a traditional Chinese medicine composite for treating post-stroke depression. From the traditional theory of traditional Chinese medicine, the post-stroke depression has the characteristics of deprementia and acroparalysis, and belongs to blood stagnancy of the six kinds of stasis. Thereby, traditional Chinese medicines with effects of tonifying spleen and qi, nourishing heart, soothing nerves, reducing phlegm, resuscitating, removing stasis and freeing channels are selected by the traditional Chinese medicine composite for treating the post-stroke depression, such as orange peel, pericarpium citri reticulatae viride, citrus chirocarpus, fructus citri, lignum dalbergiae odoriferae, ossa draconis, spina date seed, Caulis Polygoni Multiflori, musk, Fructus Ziziphi Jujubae and scorpio. The traditional Chinese medicines are prepared into a decoction by a preparation room of the hospital, and proved by clinical tests, the total effective rate is 96.7 percent. Not only is the depressed mood of a patient effectively improved, but also the neurologic function recovery is promoted. The traditional Chinese medicine composite for treating the post-stroke depression does not have obvious adverse reactions, and is worthy of clinically popularizing and applying.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of Post-apoplectic.
Background technology
Apoplexy claims again acute cerebrovascular disease, comprises cerebral hemorrhage, cerebral infarction etc.Apoplexy is except the harm that health is caused because of hemiplegia, aphasis, and all listless performances can appear in many convalescent patients, and sustainable existence, have seriously affected patient's quality of life and prognosis.According to statistics, the patient who merges depression after the apoplexy accounts for 40%～67% of apoplexy.
Because the Post-apoplectic incidence rate is higher, the persistent period is longer, and patient's cold feet to the treatment obstacles, affects its thorough rehabilitation.Modern medicine adopts Western medicine tricyclic antidepressants, selective serotonin reuptake inhibitor etc. to treat more, and all the side reaction in various degree because of its existence makes easily abandoning cure of patient's endurable.Treatment by Chinese herbs is from organic conception, and by determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, symptomatic treatment has no side effect with it, and stable curative effect is worthy of popularization.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition for the treatment of Post-apoplectic.From Traditional Chinese medical theory, the Post-apoplectic spirit depressing, quadriplegia is characteristics, belongs to the blood stagnation in the six kinds of stagnation-syndromes, is " strongly fragrant disease " combination of syndromes with " apoplexy ".Chinese traditional treatment should take should invigorating the spleen and benefiting QI, tranquilizing by nourishing the heart, hold concurrently waking up the patient from unconsciousness by dissipating phlegm, the silt collateral dredging of dispelling be as the rule for the treatment of.
The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment Post-apoplectic is made by the Chinese medicine of following weight portion: Pericarpium Citri tangerinae 10-15 part, Pericarpium Citri Reticulatae Viride 8-12 part, Fructus Citri Sarcodactylis 10-15 part, Fructus Citri 7-9 part, Lignum Dalbergiae Odoriferae 9-14 part, Os Draconis 10-15 part, Semen Ziziphi Spinosae 9-14 part, Caulis Polygoni Multiflori 6-8 part, Moschus 5-7 part, Fructus Jujubae 10-15 part, Scorpio 7-9 part.
Preferably, the Chinese medicine composition of this treatment Post-apoplectic is made by the Chinese medicine of following weight portion: 13 parts of Pericarpium Citri tangerinaes, 10 parts on Pericarpium Citri Reticulatae Viride, 13 parts of Fructus Citri Sarcodactylis, 8 parts of Fructus Citris, 12 parts of Lignum Dalbergiae Odoriferaes, 13 parts of Os Draconis, 12 parts of Semen Ziziphi Spinosaes, 7 parts of Caulis Polygoni Multiflori, 6 parts in Moschus, 13 parts in Fructus Jujubae, 8 parts of Scorpios.
During Pericarpium Citri tangerinae is regulated the flow of vital energy and is transferred in the side, drying dampness to eliminate phlegm; Pericarpium Citri Reticulatae Viride, Fructus Citri Sarcodactylis liver-smoothing, qi-regulating and stomach and alleviating pain, removing food stagnancyization stagnate; The Fructus Citri depressed liver-energy dispersing and QI regulating, the chest stuffiness relieving reduces phlegm, the dehumidifying and in; The Lignum Dalbergiae Odoriferae removing stasis to stop bleeding, regulating QI to relieve pain; The Os Draconis tranquillizing the mind by relieving convulsion, suppressing the hyperactive liver and subsiding YANG; The Semen Ziziphi Spinosae the liver benefiting that nourishes heart, the arresting sweating of calming the nerves; The Caulis Polygoni Multiflori tranquilizing by nourishing the heart, dispelling wind and removing obstruction in the collateral; The Moschus refreshment of having one's ideas straightened out, promoting blood circulation to remove obstruction in the collateral; The Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind relaxes the property of medicine; Scorpio endogenous wind stopping relieving convulsion, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.
Clinical data
1, physical data 120 routine patients with cerebral apoplexy are my section's inpatient, are divided at random each 60 example for the treatment of group and matched group, treatment group man 32 examples, women 28 examples; 37 years old-81 years old age, average 56.5 years old; The course of disease 15.0 ± 1.2 years; Cerebral infarction 35 examples, cerebral hemorrhage 25 examples.Matched group man 33 examples, women 27 examples; 37.5-80 years old step of age, 57 years old mean age; The course of disease 16.0 ± 1.1 years; Cerebral infarction 38 examples, cerebral hemorrhage 22 examples.Two groups of physical data are close, have comparability (P＞0.05).
2, all cases of diagnostic criteria all meet the 4th national cerebrovascular academic conference " all kinds of diagnosis and treatment of cerebrovascular diseases Standard Key " [1], meet " Chinese Spirit Obstacles classification and diagnostic criteria (CCMD-3) " criteria for depression were, get rid of and merge the heart, liver, renal insufficiency, language and faculty of understanding obstacle person.
3, the oral Chinese medicine composition of the present invention of Therapeutic Method treatment group.Pericarpium Citri tangerinae 13g, Pericarpium Citri Reticulatae Viride 10g, Fructus Citri Sarcodactylis 13g, Fructus Citri 8g, Lignum Dalbergiae Odoriferae 12g, Os Draconis 13g, Semen Ziziphi Spinosae 12g, Caulis Polygoni Multiflori 7g, Moschus 6g, Fructus Jujubae 13g, Scorpio 8g.The above Chinese medicine decocting 300ml that takes concoction, minute 2 morning and evenings are oral.Matched group adopts the fluoxetine sheet, 20g/d, per morning decoction being taken at a draught.Two groups of patients are all take 1 month as 1 course for the treatment of.
4, the order of severity total points of efficacy assessment standard employing Hamilton depressive scale (HAMD) evaluation depressive disorder＜8 are that 〉=8 are divided into slight depression without depressed, and 〉=17 are divided into the moderate depression, and 〉=24 are divided into the moderate depression.Minute rate that subtracts of HAMD total points is assessed a curative effect, subtracts the front total points of minute rate=treatment-rear total points of the treatment/front total points for the treatment of * 100%, subtracts a minute rate 〉=75% for fully recovering, and 〉=50% is produce effects, and 〉=25% is effective, and＜25% is invalid.
5, statistical result after therapeutic outcome treatment course for the treatment of: treatment group 60 examples, 32 examples of wherein fully recovering (53.3%), produce effects 12 examples (20.0%), effective 14 examples (23.3%), invalid 2 examples (3.3%), total effective rate 96.7%; Matched group 60 examples, 21 examples of wherein fully recovering (35.0%), produce effects 13 examples (21.7%), effective 15 examples (25.0%), invalid 11 examples (18.3%), total effective rate 81.7%.
Treatment group is without obvious toxicity, and matched group gastrointestinal reaction 5 examples are felt sick, anorexia 7 examples, 3 examples of having a headache, 1 example of having a sleepless night, dizzy 2 examples.
The specific embodiment
Embodiment one: take by weighing Pericarpium Citri tangerinae 13g, Pericarpium Citri Reticulatae Viride 10g, Fructus Citri Sarcodactylis 13g, Fructus Citri 8g, Lignum Dalbergiae Odoriferae 12g, Os Draconis 13g, Semen Ziziphi Spinosae 12g, Caulis Polygoni Multiflori 7g, Moschus 6g, Fructus Jujubae 13g, Scorpio 8g.The above Chinese medicine decocting 300ml that takes concoction, minute 2 morning and evenings are oral.Matched group adopts the fluoxetine sheet, 20g/d, per morning decoction being taken at a draught.
Embodiment two: take by weighing Pericarpium Citri tangerinae 10g, Pericarpium Citri Reticulatae Viride 12g, Fructus Citri Sarcodactylis 10g, Fructus Citri 9g, Lignum Dalbergiae Odoriferae 14g, Os Draconis 10g, Semen Ziziphi Spinosae 14g, Caulis Polygoni Multiflori 6g, Moschus 7g, Fructus Jujubae 10g, Scorpio 9g.The above Chinese medicine decocting 300ml that takes concoction, minute 2 morning and evenings are oral.Matched group adopts the fluoxetine sheet, 20g/d, per morning decoction being taken at a draught.
Embodiment three: take by weighing Pericarpium Citri tangerinae 15g, Pericarpium Citri Reticulatae Viride 8g, Fructus Citri Sarcodactylis 15g, Fructus Citri 7g, Lignum Dalbergiae Odoriferae 9g, Os Draconis 15g, Semen Ziziphi Spinosae 9g, Caulis Polygoni Multiflori 8g, Moschus 5g, Fructus Jujubae 15g, Scorpio 7g.The above Chinese medicine decocting 300ml that takes concoction, minute 2 morning and evenings are oral.Matched group adopts the fluoxetine sheet, 20g/d, per morning decoction being taken at a draught.
Claims (1)
1. Chinese medicine composition for the treatment of Post-apoplectic is characterized in that this Chinese medicine composition made by the Chinese medicine of following weight portion: Pericarpium Citri tangerinae 13g, Pericarpium Citri Reticulatae Viride 10g, Fructus Citri Sarcodactylis 13g, Fructus Citri 8g, Lignum Dalbergiae Odoriferae 12g, Os Draconis 13g, Semen Ziziphi Spinosae 12g, Caulis Polygoni Multiflori 7g, Moschus 6g, Fructus Jujubae 13g, Scorpio 8g.
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| CN 201110460077 CN102512527B (en) | 2011-12-26 | 2011-12-26 | Traditional Chinese medicine composition for treating post-stroke depression |
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Granted publication date: 20130424 Termination date: 20131226 |