CN104208526A - Medicine for treating migraine - Google Patents

Abstract

The invention discloses a medicine for treating migraine, aims to provide a medicine with small side effect and excellent treatment effect, and belongs to the technical field of traditional Chinese medicines. The medicine is prepared from the following components in parts by weight: 20-40 parts of wolfberry, 5-15 parts of chrysanthemum, 5-15 parts of felwort, 20-40 parts of nacre mother of pearl, 5-15 parts of fructus viticis, 5-15 parts of ligusticum, 4-8 parts of radix angelicae, 5-15 parts of notopterygium root, 5-15 parts of pinellia ternata, 5-15 parts of rhizoma atractylodis macrocephalae, 5-15 parts of gastrodia elata, 20-40 parts of salviae miltiorrhizae, 5-10 parts of ligusticum wallichii, 5-10 parts of angelica sinensis, 5-10 parts of asarum, 5-10 parts of rhizoma smilacis glabrae and 5-10 parts of centipede.

Description

One treats migrainous medicine

Technical field

The invention discloses one and treat migrainous medicine, belong to technical field of Chinese medicines.

Background technology

Migraine is a kind of commonly encountered diseases, and be the headache that ictal neurovascular disorders causes, its cause of disease and pathogeny are still not clear.With endocrine, diet, heredity, Nervous and Mental Factors, the factors such as high light, hunger, noise, fatigue and climate change are relevant, with the inclined side repeatedly occurred or bilatenal headache for feature.

From traditional traditional Chinese medical science angle, migraine attack reason has 4 points to have a kind of viewpoint to think: 1, depression of liver-QI: due to anxious state of mind, angry troubled thoughts, stagnation of QI impairing the liver, and irritability is lost in catharsis, and QI rising in reverse order violates head, makes head QI and blood can not be smooth, causes migraine; 2, hyperactive liver-YANG causing syndrome of liver-wind: the hepatic and renal YIN deficiency usually, if any sleep disorder or psychentonia, makes excessive rising of liver-YANG, excess of YANG wind-transformation, upsets head and empties part, cause migraine; 3, wind-phlegm helps road: weakness of the spleen and stomach, interior raw phlegm-damp, or diseases caused by exogenous pathogenic factor ailment said due to cold or exposure, and wind holds phlegm-damp under the arm, upper criminal's head, the circulation of retardance mechanism of qi, so that clear sun not life, and turbid YIN failing to descend, causes migraine; 4, insufficiency of vital energy and blood: due to congenital defect, lacks of proper care after one's birth, insufficiency of generating and transforming QI and blood, can not on give in brain, headache loses nutrition and forms migraine.This patient is in the majority with adolescence, there is no special effect medicine therapeutic so far.

Summary of the invention

For above-mentioned deficiency, the invention provides a kind of side effect little, the medicine that treatment migraine is respond well.

The invention provides one and treat migrainous medicine, be made up of the component of following weight parts: Fructus Lycii 20-40 part, Flos Chrysanthemi 5-15 part, Radix Gentianae 5-15 part, Concha Margaritifera 20-40 part, Fructus Viticis 5-15 part, Rhizoma Ligustici 5-15 part, Radix Angelicae Dahuricae 4-8 part, Rhizoma Et Radix Notopterygii 5-15 part, Rhizoma Pinelliae 5-15 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Rhizoma Gastrodiae 5-15 part, Radix Salviae Miltiorrhizae 20-40 part, Rhizoma Chuanxiong 5-10 part, Radix Angelicae Sinensis 5-10 part, Herba Asari 5-10 part, Rhizoma Smilacis Glabrae 5-10 part, Scolopendra 5-10 part.

As preferably, be made up of the component of following weight parts: be made up of the component of following weight parts: Fructus Lycii 25-35 part, Flos Chrysanthemi 8-12 part, Radix Gentianae 8-12 part, Concha Margaritifera 25-35 part, Fructus Viticis 8-12 part, Rhizoma Ligustici 8-12 part, Radix Angelicae Dahuricae 4-8 part, Rhizoma Et Radix Notopterygii 8-12 part, Rhizoma Pinelliae 8-12 part, Rhizoma Atractylodis Macrocephalae 8-12 part, Rhizoma Gastrodiae 8-12 part, Radix Salviae Miltiorrhizae 25-35 part, Rhizoma Chuanxiong 7-9 part, Radix Angelicae Sinensis 7-9 part, Herba Asari 7-9 part, Rhizoma Smilacis Glabrae 7-9 part, Scolopendra 7-9 part.

As preferably, be made up of the component of following weight parts: Fructus Lycii 30 parts, Flos Chrysanthemi 10 parts, Radix Gentianae 10 parts, Concha Margaritifera 30 parts, Fructus Viticis 10 parts, Rhizoma Ligustici 10 parts, the Radix Angelicae Dahuricae 6 parts, Rhizoma Et Radix Notopterygii 10 parts, the Rhizoma Pinelliae 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 10 parts, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 30 parts, Rhizoma Chuanxiong 8 parts, Radix Angelicae Sinensis 8 parts, Herba Asari 8 parts, Rhizoma Smilacis Glabrae 8 parts, Scolopendra 8 parts.

The migrainous medicine for the treatment of provided by the invention cures mainly: migraine (angioneurotic headache).Send out when disease sees headache, send out then severe headache, pain synophrys rib, or traction ophthalmalgia; Or be partial to side, or all over the face all bitterly, its pain is as thorn, pain in fixed position, or giddy is heavy, and breast gastral cavity painful abdominal mass is vexed, vomiting and nausea sputum, pale tongue, white and thin fur, deep and stringy pulse or heavy.

Detailed description of the invention

In order to better understand, implementing claim of the present invention, below in conjunction with specific embodiment, claim of the present invention is described in further detail, but the present invention is not limited to following embodiment, but is limited with claim.

Embodiment 1

The one provided treats migrainous medicine, is made up of the component of following weight parts: Fructus Lycii 20 parts, Flos Chrysanthemi 5 parts, Radix Gentianae 5 parts, Concha Margaritifera 20 parts, Fructus Viticis 5 parts, Rhizoma Ligustici 5 parts, the Radix Angelicae Dahuricae 4 parts, Rhizoma Et Radix Notopterygii 5 parts, the Rhizoma Pinelliae 5 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, 5 parts, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 20 parts, Rhizoma Chuanxiong 5 parts, Radix Angelicae Sinensis 5 parts, Herba Asari 5 parts, Rhizoma Smilacis Glabrae 5 parts, Scolopendra 5 parts.

Embodiment 2

The one provided treats migrainous medicine, is made up of the component of following weight parts: Fructus Lycii 40 parts, Flos Chrysanthemi 15 parts, Radix Gentianae 15 parts, Concha Margaritifera 40 parts, Fructus Viticis 15 parts, Rhizoma Ligustici 15 parts, the Radix Angelicae Dahuricae 8 parts, Rhizoma Et Radix Notopterygii 15 parts, the Rhizoma Pinelliae 15 parts, the Rhizoma Atractylodis Macrocephalae 15 parts, 15 parts, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 40 parts, Rhizoma Chuanxiong 10 parts, Radix Angelicae Sinensis 10 parts, Herba Asari 10 parts, Rhizoma Smilacis Glabrae 10 parts, Scolopendra 10 parts.

Embodiment 3

The one provided treats migrainous medicine, is made up of the component of following weight parts: Fructus Lycii 25 parts, Flos Chrysanthemi 8 parts, Radix Gentianae 8 parts, Concha Margaritifera 25 parts, Fructus Viticis 8 parts, Rhizoma Ligustici 8 parts, the Radix Angelicae Dahuricae 4 parts, Rhizoma Et Radix Notopterygii 8 parts, the Rhizoma Pinelliae 8 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, 8 parts, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 25 parts, Rhizoma Chuanxiong 7 parts, Radix Angelicae Sinensis 7 parts, Herba Asari 7 parts, Rhizoma Smilacis Glabrae 7 parts, Scolopendra 7 parts.

Embodiment 4

The one provided treats migrainous medicine, is made up of the component of following weight parts: Fructus Lycii 30 parts, Flos Chrysanthemi 10 parts, Radix Gentianae 10 parts, Concha Margaritifera 30 parts, Fructus Viticis 10 parts, Rhizoma Ligustici 10 parts, the Radix Angelicae Dahuricae 6 parts, Rhizoma Et Radix Notopterygii 10 parts, the Rhizoma Pinelliae 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 10 parts, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 30 parts, Rhizoma Chuanxiong 8 parts, Radix Angelicae Sinensis 8 parts, Herba Asari 8 parts, Rhizoma Smilacis Glabrae 8 parts, Scolopendra 8 parts.

Arbitrary component among above embodiment 1 to 4, is decocted in water for oral dose.First medicine cold water is soaked in right amount and soak into a rear decoction in about, dose is decocted twice, head and is decocted with high heat after (temperature is higher) is fried boiling and decoct 20-25 minute, after leaching juice with slow fire (temperature is lower), add water and appropriate two to decoct, 15-20 minute at a simmer after intense fire is fried boiling, leaching juice, two boil medicine juice mixing, about total amount is about 200-400 milliliter, every day takes potion, and every agent divides two to take, and early after ante cibum and supper, one hour each decoction being taken warmly is once.

Migraine (angioneurotic headache) has another name called migraine, its pain outbreak, and pain gesture is more acute, or left or right, or connects and order tooth, and just like ordinary person bitterly only, " Zhang Shi doctor is logical " is called its " pain is of a specified duration endlessly, makes us losing order ".Always lose with diseases caused by exogenous pathogenic factor and control, the heresy of wind and cold checks meridians, or feelings will is smooth, depression of liver-QI, qi depression to blood stasis, stasis blocking venation, or being invaded by exogenous pathogen raw expectorant is turbid for a long time, block passages through which vital energy circulates, pathogen upward attacking orifices in head, few sun faints cloudy two caused by the disorder of meridian-QI.Control to grow lower clear on, acupuncture-stimulating blood stasis dispersing, wind-expelling pain-stopping.On clear under Qi chrysanthemum, Radix Gentianae taste in side, Rhizoma Et Radix Notopterygii, Fructus Viticis, Rhizoma Ligustici, Scolopendra wind-damp dispelling cold expelling heresy, the Rhizoma Pinelliae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis invigorating the spleen and replenishing QI reduce phlegm, Radix Salviae Miltiorrhizae, Rhizoma Gastrodiae, Concha Margaritifera promoting blood circulation by removing wind ease pain, and all medicines share, and grow in lower meaning to play, acupuncture-stimulating blood stasis dispersing, the effect of wind-expelling pain-stopping.

Clinical data

1.1 diagnostic criterias: formulate the outbreak that (1) has more than 5 times according to International Headache association diagnostic criteria in 1988; (2) if do not treated, each pain lasts 4-72 hour; (3) have following among at least two features 1. one-sided 2. pulsation 3. in or severe 4. because of upper downstairs or similar activity increase the weight of; (4) at least there is following one between stage of attack 1. feel sick and/or vomit 2. photophobia fearness sound; (5) organic disease such as Cerebral hemorrhage, subarachnoid hemorrhage, cerebroma.

Scoring method [1] in " new Chinese medicine guideline of clinical investigations " it " new Chinese medicine treats migrainous guideline of clinical investigations " that pain degree adopts State Drug Administration to develop and publish, integration >=7 are divided into slightly, integration >=12 are divided into moderate, and integration >=17 are divided into severe.

1.2 physical data: this organizes outpatient service and inpatient that 106 examples are our hospital, all meets migraine diagnostic criteria, and medical before monthly Headache attacks >=4 time, this pain analgesic or other Analgesic techniques, be divided into two groups at random.Treatment group 56 example, man 24 example, female 32 example; Age 18-70 year, average 42 years old; Course of disease March ~ 25 year, average 4 years; Pain degree moderate 26 example, severe 30 example.Matched group 50 example, man 20 example, female 30 example; Age 19-68 year, average 41 years old; Course of disease March ~ 29 year, average 3.5 years; Pain degree moderate 24 example, severe 26 example.Two groups of Genders, age, the course of disease, headache degree aspects are through statistical procedures, and there was no significant difference, has comparability (P>0.05).

2 treatment and observational techniques

2.1 Therapeutic Method:.First soaked in right amount by medicine cold water and soak into a rear decoction in about, dose is decocted twice, head and is decocted with high heat after (temperature is higher) is fried boiling and decoct 20-25 minute with slow fire (temperature is lower), after leaching juice, add water and appropriate two to decoct, 15-20 minute at a simmer after intense fire is fried boiling, leaching juice, two boil medicine juice mixing, about total amount is about 200-400 milliliter, every day takes potion, every agent divides two to take, early after ante cibum and supper one hour each decoction being taken warmly once, be used in conjunction 5 days, January is observed in drug withdrawal; As being clinical cure person, after drug withdrawal, follow up a case by regular visits to 3 months.

The oral flunarizine 5mg of matched group, 1 day 2 times, is used in conjunction 5 weeks; As being clinical cure person, after drug withdrawal, follow up a case by regular visits to 3 months.

2.2 observational techniques: the change of primary part observation times of headache, degree, persistent period and simultaneous phenomenon.

3 therapeutic outcomes

3.1 efficacy assessment standards: migraine curative effect determinate standard is formulated according to the curative effect determinate standard in " new Chinese medicine guideline of clinical investigations " [1] it " new Chinese medicine treatment migraine guideline of clinical investigations ".Clinical cure: after treatment, cephalagra disappears, and observation is not recurred in January again; Effective: after treatment, integration reduces more than 50%; Effective: after treatment, integration reduces 21% ~ 50%; Invalid: after treatment, integration reduces less than 20%; Onset time: it is onset time that integration reduces by 2 timesharing.

3.2 therapeutic outcomes: treatment group 56 example, clinical cure 39 example (69.64%), effective 12 examples (21.43%), effective 2 examples, invalid 3 examples, total effective rate 94.64%, cure in 39 examples and recur 4 examples in 3 months, recurrence rate after healing 10.26%, has no adverse reaction in therapeutic process; Matched group 50 example, clinical cure 12 example (24%), effective 14 examples (28%), effective 14 examples, invalid 10 examples, total effective rate 80%, cures in 12 examples and recurs 7 examples in 3 months, recurrence rate after healing 58.33%.Analyze through statistics Ridit, two groups of cure rates, total effective rates compare, and difference has significant (P<0.01), and treatment group curative effect is obviously better than matched group.Clinical application onset time, in effective 53 examples for the treatment of group, the shortest 1 day, the longest 6 days, average 2.24 ± 0.87 days; In effective 40 examples of matched group, the shortest 2 days, the longest 36 days, average 5.84 ± 2.13 days.Treatment group onset time is significantly shorter than matched group, two groups onset time difference have significance (P<0.01).And treatment group medical expense, recurrence rate after healing are obviously less than matched group.

4 Typical cases

Chapter so-and-so, man, 67 years old.Have a headache 7 years on the left of first visit main suit, increase the weight of to accompany more than ten days of cranial tinnitus, before more than ten skies there is left side headache in patient's unknown cause, and at clinic of unit measuring blood pressure 187/92mmHg, after taking nifedipine, blood pressure is down to normally, but headache does not subtract.Existing disease: left side temples pinprick sample, migrans severe pain, sent out morning about 4, pain cannot be fallen asleep, and companion's cranial tinnitus, giddy, feels sick indigestion and loss of appetite, and expectorant in vain sticky amount is many, and corpulent tongue is large, and have petechia at the bottom of limit, tongue is greasy in vain, stringy and hesitant pulse.Look into TCD: 1. hypertensive arteriosclerosis; 2. right front artery flow velocity speeds; 3. the whole end of RICA and artery blood flow rate on the low side.There is " hypertension " Shi Qinian, be diagnosed as " the traditional Chinese medical science: headache (phlegm stagnation in collateral, wind-yang and up-boring); Doctor trained in Western medicine: 1 migraine, 2 Hypertension stage Ⅲs, 3 cerebral arteriosclerosiss ", treat the promoting blood circulation and detoxication that reduces phlegm, dispelling wind and removing obstruction in the collateral pain relieving, after taking medicine of the present invention, several years headache is not so far reaccessed.

Migraine belongs to the traditional Chinese medical science " wind syndrome of head " category, belongs to headache due to internal injury." Standards of Diagnosis and Treatment headache " is said: " headache of many points, medical book, wind syndrome of head are two; ... shallow and nearly person's name headache; ... dark and farther is wind syndrome of head ", head be the mansion of sun " clear ", " confluence of all yang-channels ", headache because of, pathogenesis complicated, " headache of doctor's rock " is said: " head is the dividing of sun clearly; outward and six evil is invaded mutually; interior and six mansions, all can random its clearing heat in QI system through feeling pulse pathogen superinverse, fights with induced pain mutually ... ".Tcm clinical practice treatment nothing more than QI invigorating, nourish blood, invigorate blood circulation, dredging collateral, sensible, regulate the flow of vital energy, endogenous wind stopping (dispeling the wind), reduce phlegm, the method for the treatment of such as temperature compensation sending down the abnormal ascending QI; Doctor trained in Western medicine removes foreign genetic element about the migrainous cause of disease and pathogenesis, mainly contains (1) brain electrical acti and cerebral blood flow factor, and regional cerebral blood flow reduces, arteriospasm, and a long-term author also has cerebral thrombosis.(2) platelet and biochemical factors, platelet aggregation raises, material such as release 5-hydroxy tryptamine, arachidonic acid etc., 5-hydroxy tryptamine is that 5-hydroxyindoleacetic acid is discharged from urine through metabolism, and when affecting normal, 5-hydroxy tryptamine maintains the effect of the inside and outside arterial wall shrink tension of cranium; Arachidonic acid is converted into prostaglandin, and wherein PGE1 makes the outer strong diastole of blood vessel of cranium and produces inflammatory change.(3) dietary factor, picked-up cheese, the foods such as drinks, smoked fish, chocolate, facilitate the synthesis of prostaglandin.(4) endocrine factors.(5) other factors, direct stimulation, weather drastic change, not to have enough sleep etc. and can bring out.(2) according to the understanding to migraine Chinese and western medicine pathogenesis, have a headache except traditional " stagnation of QI and blood may bring about pain ", " not Rong Ze pain ", blood poison (as prostaglandin and so on) is had to cause a disease? can dispel bitterly by detoxifying, on traditional method for the treatment of basis, bold utilization detoxification Chinese traditional medicine treatment headache, found the Drug therapy migraine with promoting blood circulation and detoxication, dispelling wind and removing obstruction in the collateral, the lucid yang sending up that nourishes blood, tried out in clinical effectiveness good.

In side with Rhizoma Chuanxiong, Rhizoma Smilacis Glabrae for principal agent; Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping, " women's head-ornaments wind can not fault also " (amplification on Canon of Materia Medica); Rhizoma Smilacis Glabrae removing toxic substances, heat clearing away, dredging collateral, dehumidifying, in walking to express, search poison and leak, separate blood poison, dredging collateral road, can help again and control Rhizoma Chuanxiong, the pungent using warming therapy of Herba Asari, going property is taken, " book on Chinese herbal medicine justice ": " Rhizoma Smilacis Glabrae; dampness removing reduces phlegm and internal heat; can enter network is searched to pick and damp and hot accumulate poison ", and " the handed down from the older generations of the family side of Wan Shi " Rhizoma Smilacis Glabrae wine specially controls pathogenic wind pain and pathogenic wind-toxic sore tinea; Scolopendra is expellingged wind and relieving convulsion, removing toxic substances, eliminating stagnation, " Records of Tradition Chinese and Western Medicine in Combination ": " interior and internal organs, outer and meridians, all QI and blood cohesion parts all can open it for Scolopendra, the power steepest of walking to alter.The all poison of all skin infection all can disappear it "; Herba Asari wind-expelling pain-stopping, " book on Chinese herbal medicine newly organized ": " Herba Asari gas is turbid clearly and not, therefore kind the turbid descending gas and the lucid yang sending up gas, thus control headache as god also "; Chinese angelica blood supplementing, invigorate blood circulation, pain relieving, prevent the fraud of the pungent loose hematozemia of Rhizoma Chuanxiong, Herba Asari, " book on Chinese herbal medicine is just ": " Rhizoma Chuanxiong, its property is kind loose; ... sweet few with it; therefore loosely then to have a surplus, mend then not enough ... if three YANG-fire are stopped up in upper and pain person; must rise instead very, the not clear lifting of moderns, and but know that headache controlled by Rhizoma Chuanxiong, wrong also very."; all medicines share; invigorate blood circulation (Rhizoma Chuanxiong, Scolopendra, Rhizoma Smilacis Glabrae, Radix Angelicae Sinensis), (Radix Angelicae Sinensis) the lucid yang sending up (Herba Asari) that nourishes blood, removing toxic substances (Rhizoma Smilacis Glabrae, Scolopendra), dispel the wind (Rhizoma Chuanxiong, Herba Asari, Scolopendra) interlock with headache " stagnation of QI and blood may bring about pain ", " not Rong Ze pain ", " blood poison " three large pathogenesis silk silks; side's letter and justice is complete, therefore it is very prompt and lastingly to get effect.

About Herba Asari consumption, what tradition had " but money (3g) " says, refers in fact grind and does not take only money, " book on Chinese herbal medicine is not mentionleted alone ": " Herba Asari, if alone, can not more than half money an ancient type of spoon, at most unhappy plug, obstructed person is dead.If " enter decoct, commonly use to 10-15g, power is specially imitated and is grandly also had no untoward reaction, and Scolopendra, containing the effective ingredient of 2 kinds of similar Venenum apis, is decocted for a long time and effective ingredient degeneration can be caused to destroy and reduce drug effect, should grind and not take after mixing it with water, also need not abandon cephalopodium.The migrainous mechanism of we's treatment, except removing cerebral vasospasm, improve blood circulation, increase cerebral blood flow, reduce platelet aggregation, thus minimizing 5-hydroxy tryptamine, outside arachidonic release, bring out the food of migraine as cheese, smoked fish, drinks, the pungent savoury of chocolate system easily helps raw damp and hot, and Rhizoma Smilacis Glabrae (RHIZOMA SMILACIS GLABRAE) removing toxic substances, removing damp-heat, strengthening the spleen and stomach, to change patient damp-heat constitution, resist the impact of the damp and hot property of above food, to remove in blood prostaglandin and especially seemingly have effect in the harmful substance aspect such as PGE1, about the migrainous deep layer mechanism of utilization treatment, need further animal and pharmacological experiment study.

The present invention is according to traditional Chinese medical science traditional theory, and in conjunction with modern medicine viewpoint, through the migrainous Empirical formula for the treatment of that long-term clinical practice is summed up out, full side's reinforcement and elimination in combination, cool heat use, play promoting blood circulation and detoxication, the merit of dispelling wind and removing obstruction in the collateral, the lucid yang sending up that nourishes blood altogether.Clinical research shows, can obviously eliminate migraineur's headache syndromes, and clinical cure rate is 69.64%, and aobvious more rate is 91.1%, is obviously better than matched group (P<0.01).And recurrence rate after healing is starkly lower than matched group, and expense is low, without serious side effects.

Claims (3)

1. treat a migrainous medicine, it is characterized in that, be made up of the component of following weight parts: Fructus Lycii 20-40 part, Flos Chrysanthemi 5-15 part, Radix Gentianae 5-15 part, Concha Margaritifera 20-40 part, Fructus Viticis 5-15 part, Rhizoma Ligustici 5-15 part, Radix Angelicae Dahuricae 4-8 part, Rhizoma Et Radix Notopterygii 5-15 part, Rhizoma Pinelliae 5-15 part, Rhizoma Atractylodis Macrocephalae 5-15 part, Rhizoma Gastrodiae 5-15 part, Radix Salviae Miltiorrhizae 20-40 part, Rhizoma Chuanxiong 5-10 part, Radix Angelicae Sinensis 5-10 part, Herba Asari 5-10 part, Rhizoma Smilacis Glabrae 5-10 part, Scolopendra 5-10 part.

2. the migrainous medicine for the treatment of according to claim 1, is characterized in that, is made up of the component of following weight parts: Fructus Lycii 25-35 part, Flos Chrysanthemi 8-12 part, Radix Gentianae 8-12 part, Concha Margaritifera 25-35 part, Fructus Viticis 8-12 part, Rhizoma Ligustici 8-12 part, Radix Angelicae Dahuricae 4-8 part, Rhizoma Et Radix Notopterygii 8-12 part, Rhizoma Pinelliae 8-12 part, Rhizoma Atractylodis Macrocephalae 8-12 part, Rhizoma Gastrodiae 8-12 part, Radix Salviae Miltiorrhizae 25-35 part, Rhizoma Chuanxiong 7-9 part, Radix Angelicae Sinensis 7-9 part, Herba Asari 7-9 part, Rhizoma Smilacis Glabrae 7-9 part, Scolopendra 7-9 part.

3. the migrainous medicine for the treatment of according to claim 2, is characterized in that, is made up of the component of following weight parts: Fructus Lycii 30 parts, Flos Chrysanthemi 10 parts, Radix Gentianae 10 parts, Concha Margaritifera 30 parts, Fructus Viticis 10 parts, Rhizoma Ligustici 10 parts, the Radix Angelicae Dahuricae 6 parts, Rhizoma Et Radix Notopterygii 10 parts, the Rhizoma Pinelliae 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, 10 parts, Rhizoma Gastrodiae, Radix Salviae Miltiorrhizae 30 parts, Rhizoma Chuanxiong 8 parts, Radix Angelicae Sinensis 8 parts, Herba Asari 8 parts, Rhizoma Smilacis Glabrae 8 parts, Scolopendra 8 parts.