CN101044882A - Mineral feed additive for prevention and control of fowl influenza - Google Patents

Abstract

A mineral additive of forage for preventing and treating fowl' s influenza is prepared from Chinese medical stone, nano-Ag liquid, vegetative extracts, chitin, and sesame oil through proportional mixing and granulating.

Description

A kind of mineral feed additive for prevention and control of fowl influenza

Technical field

The present invention relates to a kind of composite drug that is used for preventing avian influenza viruses such as chicken, duck, as adding product in the animal and fowl fodder, and its production and application.

Background technology

H 5 N 1 avian influenza subtype influenza virus is a kind of acute high lethal infectious disease that causes bird, mainly occurs in poultry such as chicken, duck and the wild bird animal body, and the mankind have also infected this kind virus now, and especially in recent years, global bird flu broke out even more serious.So, Ying Jiji prevention and control in addition.The history that bird flu is found surplus in the of existing 100 year, still, today, the mankind did not grasp anti-control techniques in full force and effect as yet, and the prevention and control means of bird flu at present mainly are to vaccinate and use antiviral drugs to animal.These methods exist many problems to be difficult to solve.

One: antiviral drugs is along with general and long-term use of medication, and influenza virus produces the serious resistance to the action of a drug to this class medicine, does not have positive effect in the application of prevention and control of fowl influenza virus.

Two: vaccine is difficult to the control H5N1 virus.If employed vaccine is consistent with the hypotype of the virus of invasion and attack; then vaccine reaches more than 90 percent the protective effect of poultry; but, isolated avian influenza virus at present and had 15 kinds of H antigens and 9 kinds of N antigens; the various combination of two kinds of antigens; can form up to a hundred blood serum subtypes, and popular virus subtype is extremely unstable; this has brought very big difficulty for the development and the prevention and control of vaccine to produce " drift ", and that is to say with the vaccine prevention and control of fowl influenza also has insecure one side.

Three: vaccinating to animal is the main means of present birds flu-preventing outburst, livestock and poultry can be not dead, can survive with surviving, edible for people, so humanly eaten these not dead meats whatever will be, can produce what sequelae? report according to interrelated data: " ' vaccinate to fowl poultry kind, wait and adorn one piece of time bomb to the mankind ".So the prevention and control to bird flu H 5 N 1 should be taked effective, safe precautionary measures, can prevention and control of fowl influenza break out can prevent to infect human influenza again, can guarantee human edible non-harmful meat simultaneously again.

The present invention by as above-mentioned aim invent design, a kind of replacement vaccine product is not had an injection, and without antibiotic, is used for the product of prevention and control of fowl influenza H5N1 virus.

Choices of raw materials and effect thereof:

One: (1) medical stone effect and characteristics:

The function mineral material is very abundant in China, the mineral matter of have functional diseases prevention, curing the disease is used already, as medical stone, be used for the general just use of additive for farm animal feed, since ancient times, China just is applied in medical stone in the medicine, the history of existing 2000-3000, enroll the prescription document, the big physician's Li Shizhen (1518-1593 A.D.) of the Ming Dynasty is shown＜Compendium of Materia Medica〉middle record " sweet, warm, nontoxic all the ulcer carbuncle on the back that cure mainly of medical stone ".China publishes nineteen twenty-one and 1969＜the Chinese medical voluminous dictionary in addition 〉, nineteen fifty-three＜Prescriptions for Universal Relief, nineteen fifty-seven goes out＜the mineral historical data of Compendium of Materia Medica and published modern age＜Li Shizhen (1518-1593 A.D.) research etc. book medical stone is all had record.According to relevant researcher's introduction, the existing national and region medical stone research organization of Japan calls healthy remedies to medical stone, can regulate human body metabolism, increase appetite, promote circulation, daf molecule, medical stone has also obtained extensive use aspect aquaculture especially.

Four effects greatly of medical stone:

1: adsorptivity is strong: it has porous, the off-bottom effect of huge surface area, and the effect of the physics of generation chemistry, a neutron and two electronics coupled are arranged in adsorption process, medical stone is two electronics coupled, it has been confirmed to be sponge shape porous mass in electron microscope, so remain very strong suction-operated, exchange interaction.And absorption heavy metal effect arranged.

2: the effect of stripping mineral matter: mineral matter is the indispensable trace element of organism, it is very important to the drinking water that earns a bare living, have and suppress bacterium and the organic effect of absorption, it can discharge various trace elements automatically in water, supply with the water mineral.

3: regulate water quality: the opinion with mineral matter such as iron, magnesium, fluorine, its then stripping when not existing in the water on the contrary, exists in the water when too much that it then adsorbs.This effect is relevant with PH, except water too acid and too alkalescence, drops into medical stone in water purification, adopts investing method when most cases (alkalescence), adopts endless form can make water near neutral when a few cases (acidity).And, make water after the circulation several times of medical stone layer, even the water yield more also can be regulated PH.

4: make the oxygen in water amount abundant: medical stone can play very effective effect to aerobe.

Medical stone is to the effect of livestock and poultry:

1, at the bottom of the death rate

2, prevent diarrhoea

3, guarantee that the intestines function is normal

4, prevent intestinal tympanites

5, improve the quality of meat

6, improve required quality of the fodder

7, prevent poultry overstrain and pecking at each other

8, eliminate the drainage peculiar smell

Two, 1), the purposes of silver ion and effect:

Silver is a kind of best anti-biotic material, people just bring into use from the ancient times, it is found that the water that retains with silver and the molten device of copper is not perishable, imperial palace reached and was accustomed to using silver chopstick when your rich has a meal again afterwards, among the peoplely make ornaments with silver again and wear, China is among the people to recognize that very early silver has antibacterial action.

The antibiotic mechanism of silver ion and compound thereof: the silver ion haptoreaction, cause the total composition of microorganism to destroy or the production dysfunction.When the silver ion of trace reaches the microbial cell film, electronegative because of the latter, rely on Coulomb attraction, both jails, Gu absorption, silver ion penetration cell wall enters in the cell, and with the SH radical reaction, make protein coagulating, destroy the activity of cell synzyme, cell is lost the division growth ability and death.Silver ion can also destroy microorganisms electric transmission system, respiratory system and substance delivery system.

2), the security of silver ion:

Silver is indispensable element in the body inner tissue, small amount of silver is harmless to human body, too much silver becomes in some soluble compounds circulation in vivo, become silver-colored spot everywhere with black granule calmness at last, but the silver-colored spot of this kind is harmless to body, after moisture silver calculating needs 40 years as day absorption 0.04mg/L, just can reach maximum 0.9 gram that the clothes collargol produces silver-colored spot.Water with argentiferous 1mg/L is fed big white mouse, takes the photograph silver-colored 0.5mg/kg every day, and the people of suitable 50 kg body weight obeys 25mg every day.The bimester after no change.

Three: plant essence and effect:

Plant essence has been selected Radix Isatidis, folium isatidis, honeysuckle, Centipeda minima, five kinds of raw materials of garlic powder for use through screening.Its interaction energy reaches anti-inflammatory, clearing and activating the channels and collaterals, promoting blood circulation and removing blood stasis, detoxifcation is set upright, qi and blood two is solid purpose.

Summary of the invention:

According to the as above effect characteristics of material, the object of the present invention is to provide poultry such as a kind of chicken, duck that avian influenza virus H 5 N 1 is had the product of remarkable prevention and control effect, is to form with the granulation that is mixed of medical stone superfine powder and nanometer silvering solution, plant essence, binding agent chitin, flavor enhancement.

Take following technical scheme in order to realize above-mentioned invention:

The composition of birds flu-preventing virus of the present invention: form by medical stone, sodium rice silvering solution, plant essence, chitin, sesame oil, soy meal.Form by ratio of weight and the number of copies:

(1), described medical stone is by the good Maifanitum of grade, source, sky, Tongliao, place of production medical stone Co., Ltd provides fineness: 6 microns, kind: former stone flour, consumption: 70-90 part.

(2), described nanometer silvering solution, Science and Technology Ltd. provides specification by the positive sodium rice in Shanghai, Shanghai: 5000ppm, approximately 15000mg/kg.Consumption: 100 parts of medical stone weight are added 0.0005-0.001 part nanometer silvering solution.

(3), described plant essence gross weight: 15-20 part, respectively as follows: Isatis Root 3-4 part; Dyers Woad Leaf 3-4 part; Honeysuckle Flower 2-3 part; Centipeda minima powder 3-4 part; Garlic 4-5;

(4), sesame oil 0.1-0.5 part; Soy meal 1-2 part; Chitin 1-5 part; Preparation method of composition of the present invention and step are as follows:

With the medical stone powder, the nanometer silvering solution, plant essence powder, chitin powder and add the 10-20% water of the gross weight of described material stir, and carry out homogeneous with high-shear homogenizer again, after make 20-40 purpose particle, promptly make product.

The present invention will be further elaborated with embodiment:

Embodiment 1:

With 70 parts of medical stones; 0.0004 part of nanometer silvering solution; 15 parts in plant essence powder; 1 part of chitin; 0.2 part in sesame oil; 1 part of soy meal; Add 10 parts in water, stir, carry out homogeneous, manufacture 20-40 purpose particle with high-shear homogenizer again, get finished product.

Embodiment 2:

With 80 parts of medical stones; 0.001 part of Nano Silver; 20 parts of plant essences; 3 parts of chitins; 0.5 part in sesame oil; 2 parts of soy meals; Add 20 parts in water, stir, carry out homogeneous with high-shear homogenizer.Make the particle of 20-40 then, get finished product.

The full price standard feed of feed factory preparation adds additive anharmonic ratio part of the present invention and is:

The feeding standard preparation of China poultry:

Embodiment 3:

(1), poultry growth period is at 100 parts of the standard feeds in 0-4 age in week, compounding additive 0.5-1 of the present invention.

(2), poultry growth period is at 100 kilograms of the standard feeds in 5-8 age in week, compounding additive 1-1.5 of the present invention kilogram.

Embodiment 4:

The U.S. (NRC) forage standard preparation:

(1) poultry growth period is at 0-3 100 kilograms of compounding additive 0.3-0.6 of the present invention of standard feed kilogram in age in week.

(2), poultry growth period is at 4-6 100 kilograms of compounding additive 0.6-0.9 of the present invention of standard feed kilogram in age in week.

(3) poultry growth period is at 7-8 100 kilograms of compounding additive 0.9-1.5 of the present invention of standard feed kilogram in age in week.

Preliminary experiment results of the present invention:

The technology of the present invention (mineral additive for feed is to the killing effect of H 5 N 1 avian influenza hypotype disease degree) is tested through the Ministry of Agriculture animal influenza emphasis open laboratory.Adopting Klein-Defors to suspend kills and the infection experiment method, the research mineral additive for feed is under variable concentrations, respectively with H 5 N 1 avian influenza subtype virus (9 to 1) in vitro test, the result shows, this additive of variable concentrations to the kill efficiency of sick degree be 99.9%, 99%, etc. have certain effect of killing the virus.(seeing the annex explanation for details)

The characteristics of feed addictive of the present invention and economy:

(1), contain less than 50 nanometer-level silver ion powders in the additive, and With positive charge, and avian influenza virus is generally sphere, and straight warp is 80-120 Nanometer, and with negative electrical charge, so silver ion is easy to attract avian flu Poison destroys its DNA and makes its deactivation and reproducible not. Belong to the physical action knot Really, without any drug ingedient, do not develop immunity to drugs, chase after viricidal Ability, also silver ion belong to not dead soldier, kill a virus, from Come out in its cell, go again to kill another virus, worker like this goes round and begins again Do. When excreting, in ight soil, still can continue kill bacteria and virus.

(2), contain the medical stone composition in the additive, in the adjustable moving object PH value makes digestive system keep alkali, is unfavorable for virus existence.

(3) contain plant essence in the additive, have anti-inflammatory, the work of stimulating the menstrual flow Network, promoting blood circulation and removing blood stasis, detoxifcation is set upright, qi and blood two is solid effect can prolong anti-The time that body exists, improve immunity.

(4), changed the side effect of traditional vaccinate.

(5), improve meat Egg―qualites, minimizing meat egg size tenor.

(6), with bird flu be controlled at break out before, anti-as main to give, tool Powerful Social benefit and economic benefit is arranged.

(7), material price of the present invention is low, easily purchases every poultry Only increase the red cent cost every day, use antibiotic and vaccine cheap Many, and security is good.

Claims (1)

1, the invention discloses the feed addictive composition of a kind of prevention, control avian influenza virus: form by medical stone, sodium rice silvering solution, plant essence, chitin, sesame oil, soy meal.Form by ratio of weight and the number of copies:

(1), described medical stone is by the good Maifanitum of grade, 6 microns former stone flours of fineness, consumption: 70-90 part.

(2), described nanometer silvering solution specification: 5000ppm, (15000mg/kg).Consumption is that 100 parts of medical stone weight add 0.0005-0.001 part nanometer silvering solution.

(3), described plant essence gross weight: 15-20 part, respectively as follows: Isatis Root 3-4 part; Dyers Woad Leaf 3-4 part; Honeysuckle Flower 2-3 part; Centipeda minima powder 3-4 part; Garlic 4-5;

(4), sesame oil 0.1-0.5 part; Soy meal 1-2 part; Chitin 1-5 part; Preparation method and step are as follows:

With the medical stone powder, the nanometer silvering solution, plant essence powder, chitin powder and add the 10-20% water of the gross weight of described material stir, and carry out homogeneous with high-shear homogenizer again, after make 20-40 purpose particle, promptly make product.