CN101040927B - 一种内服治疗强直性脊柱炎的中药组合物 - Google Patents
一种内服治疗强直性脊柱炎的中药组合物 Download PDFInfo
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Abstract
本发明公开了一种内服治疗强直性脊柱炎的中药组合物，属中药领域。该种内服治疗强直性脊柱炎的中药组合物，由丹参、骨碎补、桂枝、羌活、秦艽、防风、独活、威灵仙、细辛、鸡血藤、防己、青风藤、伸筋草、白芍、狗脊、苍术、雷公藤、甘草、鹿衔草、鳖甲和地龙按一定重量份配制而成。水煎服每日1剂。本发明将上述药物组合后，其药效具有协同作用，该种内服治疗强直性脊柱炎的中药组合物配方合理，具有超强的药效，直达病灶，舒经通络、祛风燥湿、活血镇痛，具有的显著疗效。为纯中药制剂，不含任何激素，无依赖性，无毒副作用，大大缩短了治疗期，克服了传统疗法长期服药的弊端。
Description
技术领域
本发明涉及一种内服治疗强直性脊柱炎的中药组合物，属中药领域。
背景技术
强直性脊柱炎虽是西医诊断名词，但祖国医学(即中医)对其早有认识。强直性脊柱炎属中医“痹症”的范畴，已有数千年的文字记载，其发病率致残率日渐增高，是目前国内外医学界极为关注的课题。该病又有“二号癌症”之称，其临床诊断依据有：1、下背疼痛持续三个月，活动后减轻，休息后无缓解；2、腰椎侧弯和前后活动受限；3、扩胸度较正常年龄组及性别组减少；4、单侧III-VI级或双侧II-III级骶髂关节炎。
中医认为“风寒湿三气杂至，合而为痹”，为痹证总的外因。其内因与禀赋不足，肾、督阳虚有关；外因感受寒湿或湿热之邪为主，或与外伤后淤血内阻督脉有关。由于素体虚弱，风寒湿热之外邪乘虚而入，内外合邪，阳气不化，寒邪内蕴，着于筋骨，影响筋骨的营养淖泽，闭阻经络，气血不畅，发为本病。
从辨证上多数医家认为，主要为肾虚寒证及风寒湿邪淤阻之证，总为本虚标实之证。根据证而论治，则以滋补肝肾、补肾强督、扶正祛邪为基本大法。在论治中因邪之不同，而分别佐以祛风、散寒、祛湿、清热化痰、祛瘀通络等法，根据这些总的论治原则，各医家根据经验拟出一些经验方剂，在治疗中也虽有一定效果，但是并不是十分理想。
发明内容
本发明克服现有治疗的不足而提供一种内服治疗强直性脊柱炎的中药组合物，全部选用天然中草药，能够有效治疗强直性脊柱炎的。
本发明的技术方案是：该种内服治疗强直性脊柱炎的中药组合物，其特征在于，制成有效成分的原料药按下述重量份为：丹参15～20、骨碎补10～15、桂枝8～12、羌活8～12、秦艽15～20、防风8～12、独活8～12、威灵仙8～12、细辛8～12、鸡血藤9～30、防己6～12、青风藤9～15、伸筋草10～20、白芍10～20、狗脊6～12、苍术8～12、雷公藤8～12、甘草8～12、鹿衔草9～15、鳖甲5～10和地龙5～10。
水煎服每日1剂，分2次服。两周为一疗程。
本发明的进一步技术方案是：该种内服治疗强直性脊柱炎的中药组合物，其特征在于，制成有效成分的原料药按下述重量份为：丹参20、骨碎补12、桂枝10、羌活10、秦艽18、防风10、独活10、威灵仙10、细辛10、鸡血藤20、防己10、青风藤12、伸筋草15、白芍15、狗脊10、苍术10、雷公藤10、甘草10、鹿衔草12、鳖甲8和地龙8。
水煎服每日1剂，分2次服。两周为一疗程。
药理作用：
丹参：祛瘀止痛，活血通经，清心除烦。用于月经不调、经闭痛经、症瘕积聚、胸腹刺痛、热痹疼痛、疮疡肿痛、肝脾肿大、心绞痛。
骨碎补：补肾，活血，止血。治肾虚久泻及腰痛，风湿痹痛，齿痛，耳鸣，跌打闪挫、骨伤，阑尾炎，斑秃，鸡眼。
桂枝：发汗解肌，温通经脉，助阳化气，平冲降气。用于风寒感冒，脘腹冷痛，血寒经闭，关节痹痛，痰饮，水肿，心悸，奔豚。
羌活：散寒，祛风，除湿，止痛。用于风寒感冒头痛，风湿痹痛，肩背酸痛。
秦艽：祛风除湿，和血舒筋，清热利尿。治风湿痹痛；筋骨拘挛，黄疸，便血，骨蒸潮热，小儿疳热，小便不利。
防风：发表，祛风，胜湿，止痛，解痉。治外感风寒，头痛，目眩，项强、风寒湿痹，骨节酸痛，四肢挛急，破伤风。
独活：辛、苦，微温。归肾、膀胱经。祛风除湿，通痹止痛。用于风寒湿痹，腰膝疼痛，少阴伏风头痛。
威灵仙：风湿，通经络，消痰涎，散癖积。治痛风、顽痹、腰膝冷痛、脚气、疟疾、症瘕积聚、破伤风、扁桃体炎、诸骨鲠咽。
细辛：祛风，散寒，行水，开窍。治风冷头痛，鼻渊，牙痛，痰饮咳逆，风湿痹痛。
鸡血藤：苦、甘，温。归肝、肾经。功能主治：补血，活血，通络。用于月经不调，血虚萎黄，麻木瘫痪，风湿痹痛。
防己：苦，寒。归膀胱、肺经。利水消肿，祛风止痛。用于水肿脚气，小便不利，湿疹疮毒，风湿痹痛；高血压。
青风藤：苦、辛归肝、脾经，祛风湿，通经络，利小便。用于风湿痹痛，关节肿胀，麻痹瘙痒。
伸筋草：祛风散寒，除湿消肿，舒筋活血。治风寒湿痹，关节酸痛，皮肤麻木，四肢软弱，水肿，跌打损伤。
白芍：养血柔肝，缓中止痛，敛阴收汗。治胸腹胁肋疼痛，泻痢腹痛，自汗盗汗，阴虚发热，月经不调，崩漏，带下。
狗脊：苦、甘，温。归肝、肾经。补肝肾，强腰脊，祛风湿。用于腰膝酸软，下肢无力，风湿痹痛。
苍术：健脾，燥湿，解郁，辟秽，散寒解表。治湿盛困脾，倦怠嗜卧，脘痞腹胀，食欲不振，呕吐，泄泻，痢疾，疟疾，痰饮，水肿，时气感冒，风寒湿痹，足痿，夜盲。
雷公藤：苦、辛，凉。大毒。归肝、脾、肺经。败毒抗癌、祛湿散结。
鹿衔草：甘、苦，温。归肝、肾经。祛风湿，强筋骨，止血。用于风湿痹痛，腰膝无力，月经过多，久咳劳嗽。
甘草：和中缓急，润肺，解毒，调和诸药。治脾胃虚弱，食少，腹痛便溏，劳倦发热，肺痿咳嗽，心悸，惊厥；生用，治咽喉肿痛，消化性溃疡，痈疽疮疡，解药毒及食物中毒。
地龙：咸寒。清热，镇痉，利尿，解毒。治热病惊狂、小儿惊风、咳喘、头痛目赤、咽喉肿痛、小便不通、风湿关节疼痛，半身不遂等症。
鳖甲：养明清热，平肝熄风，软坚散结。治劳热骨蒸，阴虚风动，劳疟疟母，症瘕痃癖，经闭经漏，小儿惊痫。
本发明将上述药物组合后，其药效具有协同作用，该种内服治疗强直性脊柱炎的中药组合物配方合理，具有超强的药效，直达病灶，舒经通络、祛风燥湿、活血镇痛，具有的显著疗效。为纯中药制剂，不含任何激素，无依赖性，无毒副作用，大大缩短了治疗期，克服了传统疗法长期服药的弊端。
典型病例：
例一：高某，男，29岁，患者本人因腰部疼痛半年在当地确诊强直性脊柱炎，病史已经3年了。这3年来，他的腰部一直疼痛，病情逐步加重，因为病情发展，下蹲有困难，在多家医院用柳旦、甲胺碟呤、还有中药进行治疗，疗效不好，采用该种内服治疗强直性脊柱炎的中药组合物，治疗一个月后，病情明显好转了，腰也不疼了，活动也灵活了，精神好多了，两个月后病情处于稳定状态。
例二：林某，男，26岁，患者2004年因腰痛，晨僵、由踝关节疼痛在当地医院确诊为强直性脊柱炎住院治疗，曾用西药柳氮磺嘧啶每日8片，甲胺碟呤每周4片，扶它林25毫克每日三次治疗，住院一个月腰痛晨僵减轻出院，出院后仍服用以上药物治疗。半年后病情再次复发，腰痛晨僵明显加重，行走困难，骶髂关节X光片诊断病情加重，通过腰椎X光片诊断病灶以累及腰椎关节，血沉105，C反应蛋白明显升高，确诊为强直性脊柱炎活动期后，在当地医院采用中西药结合治疗，病情没有明显改善，后在多家医院就医，病情时轻时重，每与春秋气候变化病情反复加重，腰部疼痛僵直，夜间剧痛明显，白天活动后减轻，并伴随病情进展以累及到胸椎、颈椎多处关节活动受限。采用该种内服治疗强直性脊柱炎的中药组合物治疗，一个月后，腰背疼痛、僵直、活动受限均有明显改善，经治疗10个月后，疼痛、僵直消失、腰椎、胸椎转动灵活，下蹲明显改善，病情基本康复，停药后医嘱注意保暖、御寒，坚持合理体育运动。停药后随访1年病情未复发。
例三：李某，男，22岁，患者患强直性脊柱炎2年，腰背部疼痛僵硬，下肢踝关节红肿疼痛，走路困难，HLA-B27报告阳性，骶髂关节X光片部分模糊不清，符合强直性脊柱炎诊断标准，病情诊断清楚后，因了解该病会导致致残，精神上悲观失望，四处求医，病情没有根本好转，由于上大学，家在农村，因病导致经济拮据，考虑长期服用柳氮磺嘧啶副作用较大，只能服用一些消炎止痛药缓解疼痛对症治疗。后来采用该种内服治疗强直性脊柱炎的中药组合物治疗，一疗程病情明显减轻，腰背部疼痛晨僵明显改善，下肢踝关节肿胀消失，并可进行少量活动，病情改善，精神好转了许多，3个疗程后，疼痛僵直完全消失，身体基本恢复正常，后巩固治疗半年后完全康复，经随访3年病情没有出现反复，去年复查骶髂关节X光片，模糊不清的炎性病变已完全消失。终告痊愈。
例四：孙某，男，25岁，患强直性脊柱炎两年，2006年春病情加重，在当地医院确诊强直性脊柱炎活动期，血沉81、C反应蛋白明显升高，腰背部疼痛晨僵、左下肢踝关节、足根部肌腱肿胀疼痛，不能走路，在当地医院住院治疗，使用甲胺碟呤、柳氮磺嘧啶、扶它林、帕扶林、强地松等治疗，一个月后出院，出院后腰背部疼痛晨僵仍然明显，足根部仍然肿胀疼痛，走路困难，后采用该种内服治疗强直性脊柱炎的中药组合物治疗，用药一个疗程症状有所减轻，同时停用甲胺碟呤，强地松减量，三个疗程后症状明显改善，强地松激素已经完全停用，病情没有出现反弹现象，治疗半年后，停用消炎镇痛类药物后，腰背部疼痛晨僵、足根部肿胀疼痛，症状完全消失，血沉、C反应蛋白化验指标恢复正常。改用益肾通痹丸巩固治疗3个月。目前临床症状完全消失，各项指标恢复正常，从事体育活动后身体一切正常，终告痊愈。、
具体实施方式
例一：一种内服治疗强直性脊柱炎的中药组合物，制成有效成分的原料药按下述重量份为：丹参15、骨碎补10、桂枝8、羌活8、秦艽15、防风8、独活8、威灵仙8、细辛8、鸡血藤9、防己6、青风藤9、伸筋草10、白芍10、狗脊6、苍术8、雷公藤8、甘草8、鹿衔草9、鳖甲5和地龙5。
水煎服每日1剂，分2次服。两周为一疗程。
例二：一种内服治疗强直性脊柱炎的中药组合物，制成有效成分的原料药按下述重量份为：丹参20、骨碎补15、桂枝12、羌活12、秦艽20、防风12、独活12、威灵仙12、细辛12、鸡血藤30、防己12、青风藤15、伸筋草20、白芍20、狗脊12、苍术12、雷公藤12、甘草12、鹿衔草15、鳖甲10和地龙10。
水煎服每日1剂，分2次服。两周为一疗程。
例三：一种内服治疗强直性脊柱炎的中药组合物，制成有效成分的原料药按下述重量份为：丹参18、骨碎补13、桂枝10、羌活12、秦艽18、防风11、独活9、威灵仙10、细辛11、鸡血藤15、防己8、青风藤14、伸筋草16、白芍18、狗脊11、苍术10、雷公藤9、甘草11、鹿衔草10、鳖甲6和地龙6。
水煎服每日1剂，分2次服。两周为一疗程。
例四：一种内服治疗强直性脊柱炎的中药组合物，制成有效成分的原料药按下述重量份为：丹参20、骨碎补12、桂枝10、羌活10、秦艽18、防风10、独活10、威灵仙10、细辛10、鸡血藤20、防己10、青风藤12、伸筋草15、白芍15、狗脊10、苍术10、雷公藤10、甘草10、鹿衔草12、鳖甲8和地龙8。
水煎服每日1剂，分2次服。两周为一疗程。
Claims (2)
1.一种内服治疗强直性脊柱炎的中药组合物，其特征在于，制成有效成分的原料药按下述重量份为：丹参15～20、骨碎补10～15、桂枝8～12、羌活8～12、秦艽15～20、防风8～12、独活8～12、威灵仙8～12、细辛8～12、鸡血藤9～30、防己6～12、青风藤9～15、伸筋草10～20、白芍10～20、狗脊6～12、苍术8～12、雷公藤8～12、甘草8～12、鹿衔草9～15、鳖甲5～10和地龙5～10。
2.根据权利要求1所述的一种内服治疗强直性脊柱炎的中药组合物，其特征在于，制成有效成分的原料药按下述重量份为：丹参20、骨碎补12、桂枝10、羌活10、秦艽18、防风10、独活10、威灵仙10、细辛10、鸡血藤20、防己10、青风藤12、伸筋草15、白芍15、狗脊10、苍术10、雷公藤10、甘草10、鹿衔草12、鳖甲8和地龙8。
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