CN101031653A - 大环内酯化合物的分离方法 - Google Patents

大环内酯化合物的分离方法 Download PDF

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Publication number
CN101031653A
CN101031653A CNA2005800301101A CN200580030110A CN101031653A CN 101031653 A CN101031653 A CN 101031653A CN A2005800301101 A CNA2005800301101 A CN A2005800301101A CN 200580030110 A CN200580030110 A CN 200580030110A CN 101031653 A CN101031653 A CN 101031653A
Authority
CN
China
Prior art keywords
method described
water
macrocyclic lactone
acetone
toluene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800301101A
Other languages
English (en)
Chinese (zh)
Inventor
M·布奇塔
L·茨瓦克
J·萨特克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ivax Pharmaceuticals sro
Original Assignee
Ivax Pharmaceuticals sro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Pharmaceuticals sro filed Critical Ivax Pharmaceuticals sro
Publication of CN101031653A publication Critical patent/CN101031653A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA2005800301101A 2004-09-10 2005-09-09 大环内酯化合物的分离方法 Pending CN101031653A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60875204P 2004-09-10 2004-09-10
US60/608,752 2004-09-10

Publications (1)

Publication Number Publication Date
CN101031653A true CN101031653A (zh) 2007-09-05

Family

ID=35976583

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2005800302532A Pending CN101031654A (zh) 2004-09-10 2005-09-09 结晶他克莫司的分离方法
CNA2005800301101A Pending CN101031653A (zh) 2004-09-10 2005-09-09 大环内酯化合物的分离方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CNA2005800302532A Pending CN101031654A (zh) 2004-09-10 2005-09-09 结晶他克莫司的分离方法

Country Status (9)

Country Link
US (1) US20080269479A1 (pt)
EP (1) EP1805317A2 (pt)
JP (1) JP2008512125A (pt)
KR (1) KR20070057915A (pt)
CN (2) CN101031654A (pt)
BR (1) BRPI0515699A (pt)
CA (1) CA2580123A1 (pt)
IL (1) IL181425A0 (pt)
WO (1) WO2006031661A2 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007523069A (ja) * 2004-12-01 2007-08-16 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ 非吸湿性及び粉末性非晶質ピメクロリマス
CN108929335B (zh) * 2018-08-31 2021-07-20 福建省微生物研究所 一种他克莫司粗晶的制备方法
CN112390817B (zh) * 2019-08-19 2023-07-07 鲁南制药集团股份有限公司 一种盐析萃取他克莫司发酵液的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA737247B (en) * 1972-09-29 1975-04-30 Ayerst Mckenna & Harrison Rapamycin and process of preparation
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
KR970002037B1 (ko) * 1994-12-09 1997-02-21 농촌진흥청 들깨유로부터 α-리놀렌산(ALA)을 분리, 정제하는 방법
TR200103360T2 (tr) * 1999-05-25 2002-10-21 Fujisawa Pharmaceutical Co., Ltd. Benzer organik bileşikleri ayırma yöntemi.
PL374059A1 (en) * 2002-02-13 2005-09-19 Teva Gyogyszergyar Reszvenytarsasag Method for extracting a macrolide from biomatter
AU2003269473A1 (en) * 2003-08-26 2005-03-10 Biocon Limited A process for the recovery of substantially pure tricyclic macrolide
US7473366B2 (en) * 2003-12-05 2009-01-06 Biocon Limited Process for the purification of macrolides

Also Published As

Publication number Publication date
WO2006031661A2 (en) 2006-03-23
BRPI0515699A (pt) 2008-07-29
WO2006031661A3 (en) 2006-05-04
CA2580123A1 (en) 2006-03-23
EP1805317A2 (en) 2007-07-11
JP2008512125A (ja) 2008-04-24
KR20070057915A (ko) 2007-06-07
CN101031654A (zh) 2007-09-05
US20080269479A1 (en) 2008-10-30
IL181425A0 (en) 2007-07-04

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Legal Events

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Open date: 20070905