CN101019982A - Medicine for treating chronic pelvic inflammation and its prepn - Google Patents
Medicine for treating chronic pelvic inflammation and its prepn Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses one kind of medicine for treating chronic pelvic inflammation. The medicine is prepared with glabrous greenbrier rhizome, red sage, selfheal, dandelion, plantain seed and other four kinds of Chinese medicinal materials. It is prepared into granule through extraction, percolating, decocting, filtering, concentrating, pelletizing, drying and finishing. The present invention has unique recipe, unique preparation process and obvious curative effect.
Description
Technical field the invention belongs to technical field of Chinese medicines, relates to a kind of medicine for the treatment of chronic pelvic inflammatory disease and preparation method thereof.
Background technology chronic pelvic inflammatory disease Chinese medical discrimination belongs to knot person in the wet stasis of blood, and disease abdomen is as follows weighed down the pain that expands, and lumbosacral aching pain increases the weight of after the fatigue of being everlasting, the sexual intercourse and before and after the menstruation, profuse leukorrhea, yellow thick frowziness, rectal tenesmus, low thermal fluctuation, the heavy sensation of the body limb is tired, constipation or not well, the anxious number pain of frequent micturition.Be one of the most common clinically frequently-occurring disease of women, at present, the chronic pelvic inflammatory disease medicine is more, but mostly is Western medicine greatly.So far, the side effect that the long-term excessive use of medicine of western medicine chronic pelvic inflammatory disease is brought is obvious to all, directly influences numerous women's physical and mental health, directly brings spirit and burden economically for patient and family.
Summary of the invention the objective of the invention is to provide a kind of removing damp-heat that has at chronic pelvic inflammatory disease " knot in the wet stasis of blood " disease type, and blood stasis-eliminating and stagnation-dissipating, treating both the principal and secondary aspects of a disease, bioavailability height, preparation method are simply treated medicine of chronic pelvic inflammatory disease and preparation method thereof.
The objective of the invention is according to pathogenetic understanding and the Therapeutic Principle thereof of motherland's traditional medicine chronic pelvic inflammatory disease, with reference to modern pharmacological research, therefrom filter out removing damp-heat, the natural Chinese medicinal herb of blood stasis-eliminating and stagnation-dissipating, press the Chinese medical theory prescription, make the effect of its performance the chronic pelvic inflammatory disease treating both the principal and secondary aspects of a disease.
Medicine of the present invention is the medicament of being made by the following weight proportion raw material
Rhizoma Smilacis Glabrae 400-600, Radix Salviae Miltiorrhizae 200-300, Spica Prunellae 200-300, Herba Taraxaci 250-350, the sub-200-300 of car fare, Rhizoma Dioscoreae Hypoglaucae 150-200, Cortex Eucommiae 150-200, Radix Notoginseng 50-100, Rhizoma Chuanxiong 80-120;
The formula optimization weight proportion of preparation medicine of the present invention is
Rhizoma Smilacis Glabrae 450-550, Radix Salviae Miltiorrhizae 250-280, Spica Prunellae 250-280, Herba Taraxaci 300-340, the sub-250-280 of car fare, Rhizoma Dioscoreae Hypoglaucae 160-180, Cortex Eucommiae 160-180, Radix Notoginseng 60-80, Rhizoma Chuanxiong 90-110;
The prescription optimum weight proportioning of preparation medicine of the present invention is
Rhizoma Smilacis Glabrae 500, Radix Salviae Miltiorrhizae 266.7, Spica Prunellae 266.7 Herba Taraxacis 333.3, car fare 266.7, Rhizoma Dioscoreae Hypoglaucae 166.7, the Cortex Eucommiae 166.7, Radix Notoginseng 66.7, Rhizoma Chuanxiong 100;
The preparation method that above-mentioned each component is made medicine of the present invention is:
Get the said components Radix Salviae Miltiorrhizae powder and be broken into 80 order coarse powder, with the alcohol dipping of 1.5 times of weight proportions 90% (v/v) 24 hours, add 90% (v/v) alcoholic solution percolation again, fast 1-3ml/min filters, collecting percolate is 5 times of amounts of crude drug weight, the first liquid of filtering of 1 times of amount of crude drug weight is standby, and all the other percolates reclaim ethanol, and medicinal liquid and medicinal residues are standby; Get Rhizoma Chuanxiong, the Cortex Eucommiae, Radix Notoginseng and car fare, add 70% (v/v) alcohol dipping 24 hours of 5 times of weight of crude drug at every turn, at room temperature flood 3 times, merge impregnation liquid, reclaim ethanol, medicinal liquid and medicinal residues are standby; The medicinal residues of Poria, Spica Prunellae, Herba Taraxaci, Rhizoma Dioscoreae Hypoglaucae and above-mentioned Radix Salviae Miltiorrhizae decoction dregs, Rhizoma Chuanxiong etc. fetch earth, the water that adds 10 times of weight, decoct 3 times, each 1 hour, collecting decoction filters, and concentrates, the medicinal liquid that adds danshen solution behind the above-mentioned recovery ethanol and Rhizoma Chuanxiong etc., continue to be evaporated to density in the time of 50 ℃ and be 1.20 clear paste, drying under reduced pressure, dry extract, press 4: 1 adding adjuvants of crude drug weight again, said adjuvant is an Icing Sugar: the weight proportion of dextrin=3: 1, pulverize then, and cross 80 mesh sieves, mixing gets dry extract; Make granule with just the filter ethanol of liquid and 80% (v/v) of Radix Salviae Miltiorrhizae, drying, granulate, packing promptly gets medicine of the present invention.
Said medicine of the present invention can be made into capsule or tablet.
Details are as follows for the meridian distribution of property and flavor of all medicines of the present invention: Rhizoma Smilacis Glabrae is the block rhizome of Liliaceae perennial evergreen liana smilacis glabra, has heat-clearing and toxic substances removing, the effect in the sharp joint of dehumidifying, be commonly used to clinically treat herpes simplex swollen,
Eczema, scrofula,
Syphilis,
Rheumatic feverDiseases such as puckery pain of the dark coloured urine that the arthralgia that numbness causes, joint stuffiness, damp invasion of lower energizer cause and leucorrhea abnormal also can be separated hydrargyrum
PoisonRadix Salviae Miltiorrhizae: the bitter in the mouth red complexion is flat, specially goes into percardium blood stasis dispelling blood, tissue regeneration promoting blood, blood circulation promoting and blood stasis dispelling, nourishing blood to tranquillize the mind sedate promoting blood circulation; Spica Prunellae: be herbaceos perennial, the anthocyanin that contains Spica Prunellae glycoside, ursolic acid, oleanolic acid, globulariacitrin, hyperin, a-fenchone, delphinidin and cyanidin, it is cold in nature, bitter in the mouth, suffering, function cures mainly: relieve inflammation or internal heat tomorrow, mass dissipating and swelling eliminating is used for conjunctival congestion and swelling pain, order pearl nyctalgia, headache is dizzy, scrofula is sick, mastalgia, thyromegaly, hypertension etc.; Herba Taraxaci: being the Compositae herbaceos perennial, is the conventional medicament of heat-clearing and toxic substances removing, and functions such as lung heat clearing, eliminating stagnation eliminating carbuncle, yin nourishing removing heat from blood, Shujin teeth consolidating, lactogenesis benefit essence are arranged, and modern medicine thinks that Herba Taraxaci has good anti-infectious function; Car fare: sweet in the mouth, cold in nature has the effect of inducing diuresis for treating stranguria syndrome, clearing away heat to improve acuity of vision, expelling phlegm for arresting cough; Rhizoma Dioscoreae Hypoglaucae: be the dry rhizome of Dioscoreaceae plant powder back of the body Rhizoma Dioscoreae or Rhizoma Dioscoreae Septemlobae, its bitter in the mouth, flat is returned liver, stomach, urinary bladder channel, has dampness removing and goes turbidly, and the function of the eliminating impediment that dispels the wind cures mainly nebulousurine, leukorrhagia, rheumatic arthralgia, articular instability, lumbocrural pain; The Cortex Eucommiae: be deciduous tree, be used as medicine, be rare medicinal herbs with bark, leaves, also be one of conventional Chinese medicine, Shennong's Herbal is classified it as top grade, points out " clothes can be made light of one's life by commiting suicide anti-old for a long time ", the Cortex Eucommiae property of medicine is steady, is used for the treatment of hypertension, and effects such as lumbago and skelalgia, threatened abortion are remarkable.Radix Notoginseng: have another name called Radix Notoginseng, be Araliaceae, root, flower are used as medicine, and dissipating blood stasis hemostasis, reducing swelling and alleviating pain effect are arranged; Rhizoma Chuanxiong: acrid in the mouth is warm in nature, is good at the activating QI to alleviate the depression pain relieving, is gas medicine in the blood, it is kind strongly fragrant that " book on Chinese herbal medicine converge with speech) " calls its function " the up head, following regulating menstruation water, middle relieving stagnation; Fei Dizhi blood is meritorious; show that god tests also and control gas, " woman, and menopathy is how relevant with melancholia, so being gynecological, Rhizoma Chuanxiong uses medicine always, according to modern pharmacological research, Rhizoma Chuanxiong extractum can make uterus tension force increase, and shrinks to strengthen.
Medicine of the present invention is a pure Chinese medicinal preparation, according to the theory of Chinese medical science prescription, selects that medicine is reasonable, dosage form is advanced, removing damp-heat, and blood stasis-eliminating and stagnation-dissipating, treating both the principal and secondary aspects of a disease have significant curative effect to the treatment chronic pelvic inflammatory disease.
Medicament capsule of the present invention is an oral medicine, names to be the scorching recovering particles of Pu a kind of reed mentioned in ancient books basin.
Clinical drug of the present invention is taken the result and is shown, following advantage is arranged:
1, to select natural plant for use be raw material in the present invention, and each component meets the pharmaceutical control law regulation, utilizes the comprehensive function treatment chronic pelvic inflammatory disease of the medicine of respectively distinguishing the flavor of, and no chemicals is nontoxic to human body, has no side effect, and is safe and reliable.
2, room temperature extraction of the present invention, drying under reduced pressure, granulate, effective ingredient scatters and disappears few, and the curative effect height is cheap, taking convenience, no any discomfort disease.
3, medicine of the present invention is obvious to treatment chronic pelvic inflammatory disease curative effect.
4, clinical drug of the present invention is observed, and can replace the medicine of other treatment chronic pelvic inflammatory disease.
5, medicine of the present invention has the effect of removing damp-heat blood stasis-eliminating and stagnation-dissipating, observes from a large amount of clinical trial, is a kind of specific drug of new treatment chronic pelvic inflammatory disease.
For showing the therapeutic effect of medicine of the present invention to chronic pelvic inflammatory disease, the present invention is through the clinical observation of 1000 routine chronic pelvic inflammatory disease systems, and select medical history, the state of an illness, age and suitable undergoing chronic pelvic inflammation 100 examples of traditional therapy to organize as a comparison, wherein the age is 30～70 years old, course of disease February～1 year.Test group: the conventional medicine of stopping using, take medicine of the present invention; Matched group: take conventional medicine.Observation period is 1 month, and 10 days is a course of treatment, and totally 3 courses of treatment, drug withdrawal is checked after half a year, does not have recurrence and is produce effects, and sb.'s illness took a favorable turn is evident as effectively, and it is not obvious that sb.'s illness took a favorable turn is invalid.
Instructions of taking: each 10g, one day 3 times, warm water delivery service.Clinical test results sees Table 1.
Table 1: take medicine of the present invention (the scorching recovering particles of Pu Ling basin) and take the observation of curative effect of conventional medicine to undergoing chronic pelvic inflammation.
| Group | Case load | Produce effects (routine number) | Effectively (routine number) | Invalid (routine number) | Total effective rate (%) |
| Test group | 1000 | 839 | ?161 | ?0 | ?100 |
| Matched group | 100 | 0 | ?73 | ?22 | ?73..0 |
| T | 2.53 | ?5.51 | ?2.35 | ?3.78 | |
| P | ＜0.05 | ＜0.05 | ?＜0.05 | ?＜0.05 | ?＜0.05 |
As can be seen from Table 1, medicine of the present invention (the scorching recovering particles of Pu Ling basin) to 1000 routine undergoing chronic pelvic inflammation, is obtained 839 examples that have of significant curative effect, accounts for 83.9.8%; That takes a turn for the better has 161 examples, accounts for 16.1%; Total effective rate reaches 100%.
The specific embodiment
Embodiment 1: take by weighing raw material (Kg) by following proportioning:
Rhizoma Smilacis Glabrae 400, Radix Salviae Miltiorrhizae 200, Spica Prunellae 200, Herba Taraxaci 250, car fare 2000, Rhizoma Dioscoreae Hypoglaucae 150, the Cortex Eucommiae 150, Radix Notoginseng 50, Rhizoma Chuanxiong 80;
Preparation method is as follows:
Get the said components Radix Salviae Miltiorrhizae powder and be broken into 80 order coarse powder, with the alcohol dipping of 1.5 times of weight proportions 90% (v/v) 24 hours, add 90% (v/v) alcoholic solution percolation again, fast 1-3ml/min filters, collecting percolate is 5 times of amounts of crude drug weight, the first liquid of filtering of 1 times of amount of crude drug weight is standby, and all the other percolates reclaim ethanol, and medicinal liquid and medicinal residues are standby; Get Rhizoma Chuanxiong, the Cortex Eucommiae, Radix Notoginseng and car fare, add 70% (v/v) alcohol dipping 24 hours of 5 times of weight of crude drug at every turn, at room temperature flood 3 times, merge impregnation liquid, reclaim ethanol, medicinal liquid and medicinal residues are standby; The medicinal residues of Poria, Spica Prunellae, Herba Taraxaci, Rhizoma Dioscoreae Hypoglaucae and above-mentioned Radix Salviae Miltiorrhizae decoction dregs, Rhizoma Chuanxiong etc. fetch earth, the water that adds 10 times of weight, decoct 3 times, each 1 hour, collecting decoction filters, and concentrates, the medicinal liquid that adds danshen solution behind the above-mentioned recovery ethanol and Rhizoma Chuanxiong etc., continue to be evaporated to density in the time of 50 ℃ and be 1.20 clear paste, drying under reduced pressure, dry extract, press 4: 1 adding adjuvants of crude drug weight again, said adjuvant is an Icing Sugar: the weight proportion of dextrin=3: 1, pulverize then, and cross 80 mesh sieves, mixing gets dry extract; Make granule with just the filter ethanol of liquid and 80% (v/v) of Radix Salviae Miltiorrhizae, drying, granulate, packing promptly gets medicine of the present invention.
Embodiment 2: according to embodiment 1, and the Poria 600Kg that fetches earth, Radix Salviae Miltiorrhizae 300Kg, Spica Prunellae 300Kg, Herba Taraxaci 350Kg, the sub-300Kg of car fare, Rhizoma Dioscoreae Hypoglaucae 200Kg, Cortex Eucommiae 200Kg, Radix Notoginseng 100Kg, Rhizoma Chuanxiong 120Kg.
Embodiment 3: according to embodiment 1, and the Poria 500Kg that fetches earth, Radix Salviae Miltiorrhizae 266.7Kg, Spica Prunellae 266.7Kg Herba Taraxaci 333.3Kg, the sub-266.7Kg of car fare, Rhizoma Dioscoreae Hypoglaucae 166.7Kg, Cortex Eucommiae 166.7Kg, Radix Notoginseng 66.7Kg, Rhizoma Chuanxiong 100Kg.
The every gram of this product contains Radix Salviae Miltiorrhizae with Tanshinone I I
A(C
19H
18O
3) meter, must not be less than 0.18mg.
Claims (5)
1, a kind of medicine for the treatment of chronic pelvic inflammatory disease is characterized in that it is made by the following weight proportion raw material: Rhizoma Smilacis Glabrae 400-600, Radix Salviae Miltiorrhizae 200-300, Spica Prunellae 200-300, Herba Taraxaci 250-350, the sub-200-300 of car fare, Rhizoma Dioscoreae Hypoglaucae 150-200, Cortex Eucommiae 150-200, Radix Notoginseng 50-100, Rhizoma Chuanxiong 80-120; Through extraction, percolation, medicinal liquid and medicinal residues decocting liquid, filtration, concentrate, granulate, dry, granulate and the granule made.
2, the medicine of treatment chronic pelvic inflammatory disease according to claim 1, wherein the weight proportion of various raw materials is: Rhizoma Smilacis Glabrae 450-550, Radix Salviae Miltiorrhizae 250-280, Spica Prunellae 250-280, Herba Taraxaci 300-340, the sub-250-280 of car fare, Rhizoma Dioscoreae Hypoglaucae 160-180, Cortex Eucommiae 160-180, Radix Notoginseng 60-80, Rhizoma Chuanxiong 90-110.
3, the medicine of treatment chronic pelvic inflammatory disease according to claim 1, wherein the weight proportion of various raw materials is: Rhizoma Smilacis Glabrae 500, Radix Salviae Miltiorrhizae 266.7, Spica Prunellae 266.7 Herba Taraxacis 333.3, car fare 266.7, Rhizoma Dioscoreae Hypoglaucae 166.7, the Cortex Eucommiae 166.7, Radix Notoginseng 66.7, Rhizoma Chuanxiong 100.
4, according to the preparation method of the medicine of claim 1,2 or 3 described treatment chronic pelvic inflammatory diseases, it is characterized in that getting the said components Radix Salviae Miltiorrhizae powder and be broken into 80 order coarse powder, with the alcohol dipping of 1.5 times of weight proportions 90% (v/v) 24 hours, power 90% (v/v) alcoholic solution percolation again, the fast 1-3ml/min that filters, collecting percolate is 5 times of amounts of crude drug weight, the first liquid of filtering of 1 times of amount of crude drug weight is standby, all the other percolates reclaim ethanol, and medicinal liquid and medicinal residues are standby; Get Rhizoma Chuanxiong, the Cortex Eucommiae, Radix Notoginseng and car fare, add 70% (v/v) alcohol dipping 24 hours of 5 times of weight of crude drug at every turn, at room temperature flood 3 times, merge impregnation liquid, reclaim ethanol, medicinal liquid and medicinal residues are standby; The medicinal residues of Poria, Spica Prunellae, Herba Taraxaci, Rhizoma Dioscoreae Hypoglaucae and above-mentioned Radix Salviae Miltiorrhizae decoction dregs, Rhizoma Chuanxiong etc. fetch earth, the water that adds 10 times of weight, decoct 3 times, each 1 hour, collecting decoction filters, and concentrates, the medicinal liquid that adds danshen solution behind the above-mentioned recovery ethanol and Rhizoma Chuanxiong etc., continue to be evaporated to density in the time of 50 ℃ and be 1.20 clear paste, drying under reduced pressure, dry extract, press 4: 1 adding adjuvants of crude drug weight again, said adjuvant is an Icing Sugar: the weight proportion of dextrin=3: 1, pulverize then, and cross 80 mesh sieves, mixing gets dry extract; Make granule with just the filter ethanol of liquid and 80% (v/v) of Radix Salviae Miltiorrhizae, drying, granulate, packing promptly gets medicine of the present invention.
5,, it is characterized in that said dosage form can be made into capsule or tablet according to the medicine of claim 1,2 or 3 described treatment chronic pelvic inflammatory diseases.
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