CN101011436A - Medical usage of total phytosterone from achyranthes - Google Patents
Medical usage of total phytosterone from achyranthes Download PDFInfo
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- CN101011436A CN101011436A CN 200710019605 CN200710019605A CN101011436A CN 101011436 A CN101011436 A CN 101011436A CN 200710019605 CN200710019605 CN 200710019605 CN 200710019605 A CN200710019605 A CN 200710019605A CN 101011436 A CN101011436 A CN 101011436A
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- radix achyranthis
- achyranthis bidentatae
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- sterone
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Abstract
The invention relates to a method for using inokosterone to prepare the drug or health product used to treat fatty liver and reduce fatty. The inokosterone comprises the effective components of achyranthes, as ecdysis steron and rubrosterone, which can treat fatty liver and reduce fatty, with fewer side effect.
Description
Technical field
The present invention relates to the purposes of Radix Achyranthis Bidentatae total sterone in pharmaceutical field, relate in particular to the application in preparation lowering blood-fat and reducing weight medicine or health product, and the application in preparation treatment or prevention fatty liver medicine or health product.
Background technology
Radix Achyranthis Bidentatae (Achyranthes bidentata BI.) has another name called Radix Achyranthis Bidentatae, and chicken tibia is the root of amaranthaceous plant, perennial herb, and cultivation or wild in the hill roadside was excavated when stem and leaf is withered winter, removed clean fibrous root, earth, dried to trim to medicinal.Main product in the Hunan, ground such as Hubei, Henan, Sichuan, Guizhou.Radix Achyranthis Bidentatae is a Chinese medicine, its sweet in the mouth picric acid, and property is flat, goes into liver, kidney channel.Has invigorating the liver and kidney, bone and muscle strengthening, the effect of promoting blood circulation to remove obstruction in the collateral.Cure mainly: amenorrhea due to stagnation of blood, dysmenorrhea, menstruation are not withered, traumatic injury, waist knee joint are soft, spasm of the limbs, haematemesis, epistaxis, gonorrhea hematuria, gingival swelling and pain, sore throat, carbuncle etc.Sterone is one of Radix Achyranthis Bidentatae effective ingredient, mainly contains ecdysterone, inokosterone, rubrosterone etc." the research progress of phytoecdysone " that Xu Xiuying, Zheng Yimin, Wang Long write (biology magazine, 2005.122 (2) it is as follows: 12～15 pages) to disclose the effect of ecdysterone: give the oral ecdysterone of rabbit every day every 5～20mg, continue can significantly to suppress in 10～12 weeks the serum total cholesterol that the hypercholesterolemia feed causes and the increase of free cholesterol.
Summary of the invention
The object of the present invention is to provide the new purposes of Radix Achyranthis Bidentatae total sterone, i.e. new application in the preparation medicine.
For achieving the above object, first kind of technical scheme that the present invention adopts is: the application of Radix Achyranthis Bidentatae total sterone in preparation lowering blood-fat and reducing weight medicine or health product.Particularly content is in the application of the Radix Achyranthis Bidentatae total sterone more than 50% in preparation lowering blood-fat and reducing weight medicine or health product." blood fat reducing " in described " lowering blood-fat and reducing weight " is meant blood fat reducing.
For achieving the above object, second kind of technical scheme that the present invention adopts is: the application of Radix Achyranthis Bidentatae total sterone in preparation treatment or prevention fatty liver medicine or health product.Particularly content is in the application of the Radix Achyranthis Bidentatae total sterone more than 50% in preparation treatment or prevention fatty liver medicine or health product.
The Radix Achyranthis Bidentatae total sterone is meant the summation of the contained sterone of Radix Achyranthis Bidentatae effective site, mainly contains ecdysterone, inokosterone, compositions such as rubrosterone.
We find that in the research to the Radix Achyranthis Bidentatae total sterone Radix Achyranthis Bidentatae total sterone composition can metabolism be natural estrogen in human body, this estrogen has functions of lowering blood-fat and reducing weight, particularly have the effect of treatment or prevention fatty liver.Be illustrated with animal experiment (the Radix Achyranthis Bidentatae total sterone is to rat treatment or prevention fatty liver and functions of lowering blood-fat and reducing weight) below:
80 of SPF level SD male rats, body weight 180g～200g, rat is after buying back adaptation 1 week of raising, therefrom randomly draw 10 basic matched groups of conduct, [prescription is the feed normal feedstuff: Fructus Hordei Vulgaris powder 20%, dehydrated vegetable (removing the cabbage of moisture content) 10%, Semen Glycines powder 20%, yeast 1%, bone meal 5%, corn 16%, wheat bran 16%, fish flour 10%, Sal 2%], other 70 as high fat group feed high lipid food [promptly replace behind the bean cake in the prescription as normal feedstuff with casein, high lipid food is 76.2% normal feedstuff, 12% big oil, 10% sucrose, 1.5% cholesterol, 0.3% Fel Sus domestica salt].Freely drink water and ingest after February, greater than the normal feedstuff group rat average weight criterion that to add 1.4 standard deviations be obese rat, filter out 40 of fat rat models according to the average weight of feed high lipid food rat.These 40 obese rats are divided into fat matched group (irritating the stomach normal saline) and basic, normal, high 3 Radix Achyranthis Bidentatae total sterone groups (dosage is respectively 25mg/kg BW, 50mg/kg BW and 100mg/kgBW, irritates stomach and gives) at random by body weight.Each group all continues to feed high lipid food, weighs weekly.The back femoral artery blood sampling of 4 weeks detects every index.Triglyceride (TG), T-CHOL (TC), HDL-C (HDL-C) are measured with biochemistry analyzer and matched reagent with enzyme process.Adopt SPSS12.0 software, data are with mean ± standard deviation (x ± s) describe.
Table 1 Radix Achyranthis Bidentatae total sterone is to the influence (mmol/L) of obese rat blood fat
| Group | TG | TC | HDL | |
| The basis matched group | 10 | 2.15±0.44 | 2.16±0.36 | 1.25±0.27 |
| Fat matched group | 10 | 3.19±0.41# | 3.95±0.42# | 0.85±0.18 |
| Radix Achyranthis Bidentatae total sterone (25mg/kg) | 10 | 3.18±0.40# | 3.53±0.32# | 0.91±0.34 |
| Radix Achyranthis Bidentatae total sterone (50mg/kg) | 10 | 3.02±0.26*# | 2.97±0.40* | 0.95±0.36* |
| Radix Achyranthis Bidentatae total sterone (100mg/kg) | 10 | 2.63±0.41* | 2.25±0.31* | 0.97±0.28* |
Annotate: compare * P＜0.05 with fat matched group; Compare #P＜0.05 with basic matched group.
Table 2 Radix Achyranthis Bidentatae total sterone is to high-fat fatty liver liver tissues of rats middle finger target influence (n=10)
| Group | TC (mg/g wet tissue) | TG (mg/g wet tissue) | The heavy coefficient (g/100g) of liver |
| Fat matched group | 2.68±0.35 | 25.17±2.15 | 2.86±0.23 |
| Radix Achyranthis Bidentatae total sterone 100mg/kg group | 1.70±0.11 * | 12.57±3.10 * | 2.28±0.17 * |
Annotate: compare * P＜0.05 with fat matched group; N represents every group of rat quantity.
Table 1 result shows that the Radix Achyranthis Bidentatae total sterone can significantly reduce obese rat blood TG and TC level when 50mg/kg and 100mg/kg, rising HDL-C level.Table 2 result shows that the Radix Achyranthis Bidentatae total sterone can significantly reduce the content of TG and TC in the high-fat fatty liver liver tissues of rats, reduces the heavy coefficient of liver simultaneously.Above result clearly illustrates that: the Radix Achyranthis Bidentatae total sterone has better therapeutic effect to high-fat fatty liver.
Table 3 Radix Achyranthis Bidentatae total sterone is to the influence (g) of obese rat body weight
| Group | The 0th week | The 2nd week | The 4th week | |
| The basis matched group | 10 | 349.1±38.8 | 369.2±43.2 | 380.4±26.5 |
| Fat matched group | 10 | 458.3±38.4 | 498.6±42.1 | 526.7±43.7 |
| Radix Achyranthis Bidentatae total sterone (25mg/kg) | 10 | 465.5±33.9 | 477.5±20.3* | 488.2±33.7* |
| Radix Achyranthis Bidentatae total sterone (50mg/kg) | 10 | 460.9±38.7 | 455.1±45.1* | 471.1±31.9* |
| Radix Achyranthis Bidentatae total sterone (100mg/kg) | 10 | 450.4±31.0 | 452.3±35.6* | 448.6±37.7* |
Annotate: compare * P＜0.05 with fat matched group.
Table 3 shows that the Radix Achyranthis Bidentatae total sterone can significantly reduce the body weight of obese rat, shows good functions of lowering blood-fat and reducing weight.
Clinical fat-reducing example: in the fat-reducing special outpatient clinic, select 37 routine simple obesity patients to carry out observation of curative effect as the weight-reducing experiment volunteer.Diagnostic criteria is according to most popular Body Mass Index (BMI) in the world, be body weight (kg) divided by height (m) square, adopt the suggestion of Asian adults weight classification, be that BMI 18.5～22.9 is for normal, 〉=23.0 is overweight, wherein 23.0～24.9 is dangerous increasing, and 25.0～29.9 is I degree obesity (moderate), and 〉=30.0 is II degree obesity (seriously).Minimum 34 years old of patient age, maximum 66 years old, average 47 years old; Wherein male 11 examples, women 26 examples; Fat 24 examples of I degree wherein, fat 13 examples of II degree.The Secondary Obesity that eliminating is caused by diseases such as hypothalamus, adrenal gland, hypophysis, thyroid.Therapeutic Method: oral from the each 2-3 grain of Radix Acanthopanacis Bidentatae (processed) total sterone capsule (content is the 200-300mg/ grain), every day 3 times, 1 month was 1 course of treatment, with 2 months observe the curative effect that exceed.Therapeutic outcome: formulate standard with reference to Chinese combination of Chinese and Western medicine obesity research group third revision: produce effects: during the treatment end more than the weight loss 5kg; Effectively: weight loss 3～5kg when treatment finishes; Invalid: weight loss did not reach above-mentioned standard person when treatment finished.Among the 37 routine obeisity patients, produce effects 11 examples: weight average alleviated more than 3～6kg in every month, and blood fat (mainly being triglyceride) obviously descends; Effective 23 examples: weight average alleviated 2～3kg in every month, and blood fat decreased than originally; Invalid 3 examples: it is not obvious to lose weight, every month below 2kg in addition the weightening finish, Blood Lipid is not obvious.Effective percentage is 91.9%.
In a word, result of study shows: during as medicine, adopt oral way to take the Radix Achyranthis Bidentatae total sterone, can be used for treatment and prevention fatty liver and lowering blood-fat and reducing weight.Dose is 15～35mg/kgd
-1If, become body weight for humans by 70 kilograms of calculating, then dose is 1.0～2.5g/d
-1During as health product, adult's dose is 0.2～0.3g/d
-1Get final product.
The Radix Achyranthis Bidentatae total sterone is when preparation treatment and prevention fatty liver and lowering blood-fat and reducing weight medicine or health product, mainly make peroral dosage form, as tablet, oral liquid, capsule, powder, pill, granule etc., its pharmaceutical technology all is mature technique, and its dosage form does not affect the treatment.
Advantage of the present invention is: based on the effective site of Radix Achyranthis Bidentatae total sterone, have and treat and prevent fatty liver and functions of lowering blood-fat and reducing weight preferably, safety, toxic and side effects are little.
The specific embodiment
Below in conjunction with embodiment the present invention is further described:
Embodiment one:
1, the preparation of Radix Achyranthis Bidentatae total sterone
It is an amount of to get the Radix Achyranthis Bidentatae decoction pieces, in 1kg medical material 20L water ratio, and 90～100 ℃ of decocting in water 3 times, each 2.5 hours.Filter the back and collect Radix Acanthopanacis Bidentatae extraction liquid.Last D type macroporous adsorptive resins, absorption flow velocity 1BV/min is saturated to resin absorption.To the effluent clear, use 10BV (C with the water rinse resin
2H
5OH)=85% ethanol elution, elution flow rate 0.5BV/min, eluent is dried to constant weight.Be Radix Achyranthis Bidentatae effective site, yield is no less than 0.15% (Radix Achyranthis Bidentatae total sterone content is more than 60%).
2, adopt the Radix Achyranthis Bidentatae total sterone to be prepared into medicament, take to human body by oral way, dose is controlled at 15～35mg/kgd
-1If, become body weight for humans by 70 kilograms of calculating, then dose is 1.0～2.5g/d
-1, have and treat and prevent fatty liver and functions of lowering blood-fat and reducing weight preferably, and safety, toxic and side effects is little.Medicament is mainly made peroral dosage form, and as tablet, oral liquid, capsule, powder, pill, granule etc., its pharmaceutical technology all is mature technique, and its dosage form does not affect the treatment.
Embodiment two: the Radix Achyranthis Bidentatae total sterone of preparation in the foregoing description one is made health product, take to human body by oral way, dose is at 0.2～0.3g/d
-1, have and prevent fatty liver and functions of lowering blood-fat and reducing weight preferably, and safety, toxic and side effects is little.
The foregoing description only is explanation technical conceive of the present invention and characteristics, and its purpose is to allow the personage who is familiar with this technology can understand content of the present invention and enforcement according to this, can not limit protection scope of the present invention with this.All equivalences that spirit is done according to the present invention change or modify, and all should be encompassed within protection scope of the present invention.
Claims (4)
1, the application of Radix Achyranthis Bidentatae total sterone in preparation lowering blood-fat and reducing weight medicine or health product.
2, application according to claim 1 is characterized in that: content is in the application of the Radix Achyranthis Bidentatae total sterone more than 50% in preparation lowering blood-fat and reducing weight medicine or health product.
3, the application of Radix Achyranthis Bidentatae total sterone in preparation treatment and prevention fatty liver medicine or health product.
4, application according to claim 3 is characterized in that: content is in the application of the Radix Achyranthis Bidentatae total sterone more than 50% in preparation treatment and prevention fatty liver medicine or health product.
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| CN 200710019605 CN101011436A (en) | 2007-01-20 | 2007-01-20 | Medical usage of total phytosterone from achyranthes |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8236359B2 (en) * | 2007-11-30 | 2012-08-07 | Institut Biophytis Sas | Use of phytoecdysones in the preparation of a composition for acting on the metabolic syndrome |
| US20170071955A1 (en) * | 2011-11-10 | 2017-03-16 | Biophytis Sa | Method of stabilizing weight after a weight-loss diet using phytoecdysones |
| US20170136041A1 (en) * | 2011-12-13 | 2017-05-18 | Biophytis Sa | Method of improving the muscle quality of obese and/or sarcopenic mammals using phytoecdysones |
-
2007
- 2007-01-20 CN CN 200710019605 patent/CN101011436A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8236359B2 (en) * | 2007-11-30 | 2012-08-07 | Institut Biophytis Sas | Use of phytoecdysones in the preparation of a composition for acting on the metabolic syndrome |
| AU2008332981B2 (en) * | 2007-11-30 | 2014-06-12 | Biophytis | Use of phytoecdysones in the preparation of a composition for acting on metabolic syndrome |
| US20170071955A1 (en) * | 2011-11-10 | 2017-03-16 | Biophytis Sa | Method of stabilizing weight after a weight-loss diet using phytoecdysones |
| US20170136041A1 (en) * | 2011-12-13 | 2017-05-18 | Biophytis Sa | Method of improving the muscle quality of obese and/or sarcopenic mammals using phytoecdysones |
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Open date: 20070808 |