CN101010317A - 作为磷脂酰肌醇（pi）3－激酶抑制剂的2,4,6－三取代的嘧啶及其在癌症治疗中的用途 - Google Patents
作为磷脂酰肌醇（pi）3－激酶抑制剂的2,4,6－三取代的嘧啶及其在癌症治疗中的用途 Download PDFInfo
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- CN101010317A CN101010317A CNA2005800297623A CN200580029762A CN101010317A CN 101010317 A CN101010317 A CN 101010317A CN A2005800297623 A CNA2005800297623 A CN A2005800297623A CN 200580029762 A CN200580029762 A CN 200580029762A CN 101010317 A CN101010317 A CN 101010317A
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- 238000011282 treatment Methods 0.000 title claims description 34
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- 239000003814 drug Substances 0.000 claims abstract description 30
- 125000000217 alkyl group Chemical group 0.000 claims description 692
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 129
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- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 81
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- ODFJOVXVLFUVNQ-UHFFFAOYSA-N acetarsol Chemical compound CC(=O)NC1=CC([As](O)(O)=O)=CC=C1O ODFJOVXVLFUVNQ-UHFFFAOYSA-N 0.000 claims description 41
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- 229910052717 sulfur Inorganic materials 0.000 claims description 19
- 125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 claims description 18
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- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 16
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- 125000001731 2-cyanoethyl group Chemical group [H]C([H])(*)C([H])([H])C#N 0.000 claims description 10
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- Heart & Thoracic Surgery (AREA)
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- Pain & Pain Management (AREA)
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Applications Claiming Priority (2)
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| GB0415367.2 | 2004-07-09 | ||
| GBGB0415367.2A GB0415367D0 (en) | 2004-07-09 | 2004-07-09 | Pyrimidine derivatives |
Publications (1)
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|---|---|
| CN101010317A true CN101010317A (zh) | 2007-08-01 |
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| CNA2005800297623A Pending CN101010317A (zh) | 2004-07-09 | 2005-07-07 | 作为磷脂酰肌醇（pi）3－激酶抑制剂的2,4,6－三取代的嘧啶及其在癌症治疗中的用途 |
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| EP (1) | EP1778681A1 (enExample) |
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| CN (1) | CN101010317A (enExample) |
| AR (1) | AR049712A1 (enExample) |
| AU (1) | AU2005261555A1 (enExample) |
| BR (1) | BRPI0513056A (enExample) |
| CA (1) | CA2571756A1 (enExample) |
| GB (1) | GB0415367D0 (enExample) |
| IL (1) | IL180138A0 (enExample) |
| MX (1) | MX2007000118A (enExample) |
| NO (1) | NO20070681L (enExample) |
| RU (1) | RU2007104838A (enExample) |
| TW (1) | TW200618801A (enExample) |
| UY (1) | UY29009A1 (enExample) |
| WO (1) | WO2006005918A1 (enExample) |
| ZA (1) | ZA200700060B (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104718203A (zh) * | 2012-08-17 | 2015-06-17 | 国家科学研究中心 | 三取代吡啶并[3,2-d]嘧啶及其制备方法和治疗用途 |
| CN105143209A (zh) * | 2013-03-14 | 2015-12-09 | 诺华股份有限公司 | 作为激酶抑制剂的联芳基酰胺化合物 |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0415364D0 (en) | 2004-07-09 | 2004-08-11 | Astrazeneca Ab | Pyrimidine derivatives |
| GB0520657D0 (en) | 2005-10-11 | 2005-11-16 | Ludwig Inst Cancer Res | Pharmaceutical compounds |
| GB0525081D0 (en) * | 2005-12-09 | 2006-01-18 | Astrazeneca Ab | Pyrimidine derivatives |
| GB0525080D0 (en) * | 2005-12-09 | 2006-01-18 | Astrazeneca Ab | Pyrimidine derivatives |
| GB0616747D0 (en) * | 2006-08-24 | 2006-10-04 | Astrazeneca Ab | Novel compounds |
| WO2007080382A1 (en) * | 2006-01-11 | 2007-07-19 | Astrazeneca Ab | Morpholino pyrimidine derivatives and their use in therapy |
| CA2660758A1 (en) | 2006-08-24 | 2008-02-27 | Astrazeneca Ab | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
| JP2010501537A (ja) * | 2006-08-24 | 2010-01-21 | アストラゼネカ アクチボラグ | 増殖性障害の治療に有用なモルホリノピリミジン誘導体 |
| WO2008032041A1 (en) * | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | Pyrimidine derivatives having inhibitory activity against pi3k enzymes |
| CA2692720A1 (en) * | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Morpholino pyrimidine derivatives used in diseases linked to mtor kinase and/or pi3k |
| TWI555746B (zh) * | 2009-12-28 | 2016-11-01 | 財團法人生物技術開發中心 | 作為ｍＴＯＲ及ＰＩ３Ｋ抑制劑之新穎嘧啶化合物 |
| SA111320519B1 (ar) | 2010-06-11 | 2014-07-02 | Astrazeneca Ab | مركبات بيريميدينيل للاستخدام كمثبطات atr |
| HK1213251A1 (zh) | 2013-03-14 | 2016-06-30 | Novartis Ag | 作为突变idh抑制剂的3-嘧啶-4-基-恶唑烷-2-酮化合物 |
| UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
| CA3037456A1 (en) | 2016-09-19 | 2018-03-22 | Novartis Ag | Therapeutic combinations comprising a raf inhibitor and a erk inhibitor |
| IL270224B1 (en) | 2017-05-02 | 2024-04-01 | Novartis Ag | Combination therapy employing trametinib and a defined raf inhibitor |
| JP2021510152A (ja) * | 2018-01-04 | 2021-04-15 | 北京大学深▲ヂェン▼研究生院Ｐｅｋｉｎｇ Ｕｎｉｖｅｒｓｉｔｙ Ｓｈｅｎｚｈｅｎ Ｇｒａｄｕａｔｅ Ｓｃｈｏｏｌ | Ｌｓｄ１とｈｄａｃとを標的として同時に阻害する化合物及びその用途 |
| EP4563150A3 (en) | 2019-05-13 | 2025-07-23 | Novartis AG | New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl) isonicotinamide as raf inhibitors for the treatment of cancer |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19836697A1 (de) * | 1998-08-13 | 2000-02-17 | Hoechst Marion Roussel De Gmbh | Substituierte 4-Amino-2-aryl-pyrimidine, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| CN1186324C (zh) * | 2000-04-27 | 2005-01-26 | 山之内制药株式会社 | 稠合杂芳基衍生物 |
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2004
- 2004-07-09 GB GBGB0415367.2A patent/GB0415367D0/en not_active Ceased
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2005
- 2005-07-07 MX MX2007000118A patent/MX2007000118A/es not_active Application Discontinuation
- 2005-07-07 BR BRPI0513056-5A patent/BRPI0513056A/pt not_active Application Discontinuation
- 2005-07-07 KR KR1020077003207A patent/KR20070032810A/ko not_active Withdrawn
- 2005-07-07 US US11/630,676 patent/US20080051401A1/en not_active Abandoned
- 2005-07-07 CA CA002571756A patent/CA2571756A1/en not_active Abandoned
- 2005-07-07 AU AU2005261555A patent/AU2005261555A1/en not_active Abandoned
- 2005-07-07 WO PCT/GB2005/002678 patent/WO2006005918A1/en not_active Ceased
- 2005-07-07 EP EP05759085A patent/EP1778681A1/en not_active Withdrawn
- 2005-07-07 CN CNA2005800297623A patent/CN101010317A/zh active Pending
- 2005-07-07 RU RU2007104838/04A patent/RU2007104838A/ru not_active Application Discontinuation
- 2005-07-07 JP JP2007519885A patent/JP2008505877A/ja active Pending
- 2005-07-08 TW TW094123251A patent/TW200618801A/zh unknown
- 2005-07-08 AR ARP050102852A patent/AR049712A1/es unknown
- 2005-07-08 UY UY29009A patent/UY29009A1/es not_active Application Discontinuation
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- 2006-12-17 IL IL180138A patent/IL180138A0/en unknown
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2007
- 2007-01-02 ZA ZA200700060A patent/ZA200700060B/en unknown
- 2007-02-06 NO NO20070681A patent/NO20070681L/no not_active Application Discontinuation
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104718203A (zh) * | 2012-08-17 | 2015-06-17 | 国家科学研究中心 | 三取代吡啶并[3,2-d]嘧啶及其制备方法和治疗用途 |
| CN105143209A (zh) * | 2013-03-14 | 2015-12-09 | 诺华股份有限公司 | 作为激酶抑制剂的联芳基酰胺化合物 |
| CN105143209B (zh) * | 2013-03-14 | 2018-03-13 | 诺华股份有限公司 | 作为激酶抑制剂的联芳基酰胺化合物 |
| CN108467369A (zh) * | 2013-03-14 | 2018-08-31 | 诺华股份有限公司 | 作为激酶抑制剂的联芳基酰胺化合物 |
| TWI662025B (zh) * | 2013-03-14 | 2019-06-11 | 瑞士商諾華公司 | 用作激酶抑制劑的二芳基醯胺化合物 |
| CN108467369B (zh) * | 2013-03-14 | 2021-08-20 | 诺华股份有限公司 | 作为激酶抑制剂的联芳基酰胺化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| UY29009A1 (es) | 2006-02-24 |
| NO20070681L (no) | 2007-03-21 |
| AU2005261555A1 (en) | 2006-01-19 |
| RU2007104838A (ru) | 2008-08-27 |
| CA2571756A1 (en) | 2006-01-19 |
| EP1778681A1 (en) | 2007-05-02 |
| WO2006005918A1 (en) | 2006-01-19 |
| TW200618801A (en) | 2006-06-16 |
| GB0415367D0 (en) | 2004-08-11 |
| MX2007000118A (es) | 2007-03-09 |
| KR20070032810A (ko) | 2007-03-22 |
| JP2008505877A (ja) | 2008-02-28 |
| BRPI0513056A (pt) | 2008-04-22 |
| US20080051401A1 (en) | 2008-02-28 |
| AR049712A1 (es) | 2006-08-30 |
| ZA200700060B (en) | 2008-06-25 |
| IL180138A0 (en) | 2007-06-03 |
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