CN101010087B - 用于制备金属有机盐的高收率和快速的合成方法 - Google Patents

用于制备金属有机盐的高收率和快速的合成方法 Download PDF

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Publication number
CN101010087B
CN101010087B CN2005800226577A CN200580022657A CN101010087B CN 101010087 B CN101010087 B CN 101010087B CN 2005800226577 A CN2005800226577 A CN 2005800226577A CN 200580022657 A CN200580022657 A CN 200580022657A CN 101010087 B CN101010087 B CN 101010087B
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China
Prior art keywords
strontium
acid
salts
salt
glutamate
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Expired - Fee Related
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CN2005800226577A
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English (en)
Chinese (zh)
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CN101010087A (zh
Inventor
斯蒂芬·克里斯戈
延斯·E·T·安德森
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Osteologix AS
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Osteologix AS
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Priority claimed from PCT/DK2004/000326 external-priority patent/WO2004098617A2/en
Priority claimed from PCT/DK2004/000328 external-priority patent/WO2004098619A2/en
Priority claimed from PCT/DK2004/000327 external-priority patent/WO2004098618A2/en
Application filed by Osteologix AS filed Critical Osteologix AS
Publication of CN101010087A publication Critical patent/CN101010087A/zh
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Publication of CN101010087B publication Critical patent/CN101010087B/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/08—Malonic acid

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2005800226577A 2004-05-06 2005-05-05 用于制备金属有机盐的高收率和快速的合成方法 Expired - Fee Related CN101010087B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
PCT/DK2004/000326 WO2004098617A2 (en) 2003-05-07 2004-05-06 Controlled release composition containing a strontium salt
DKPCT/DK2004/000328 2004-05-06
DKPCT/DK2004/000326 2004-05-06
DKPCT/DK2004/000327 2004-05-06
PCT/DK2004/000328 WO2004098619A2 (en) 2003-05-07 2004-05-06 Treating cartilage / bone conditions with water-soluble strontium salts
PCT/DK2004/000327 WO2004098618A2 (en) 2003-05-07 2004-05-06 Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions
DKPA200401708 2004-11-05
DKPA200401708 2004-11-05
PCT/DK2005/000307 WO2005108339A2 (en) 2004-05-06 2005-05-05 High yield and rapid syntheses methods for producing metallo-organic salts

Publications (2)

Publication Number Publication Date
CN101010087A CN101010087A (zh) 2007-08-01
CN101010087B true CN101010087B (zh) 2012-06-27

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CN2005800226577A Expired - Fee Related CN101010087B (zh) 2004-05-06 2005-05-05 用于制备金属有机盐的高收率和快速的合成方法

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Country Link
US (2) US7589235B2 (enExample)
EP (1) EP1744770A2 (enExample)
JP (1) JP4954867B2 (enExample)
KR (1) KR20110124317A (enExample)
CN (1) CN101010087B (enExample)
AU (1) AU2005240257B2 (enExample)
CA (1) CA2565840A1 (enExample)
WO (1) WO2005108339A2 (enExample)

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US20060216358A1 (en) * 2003-05-07 2006-09-28 Christian Hansen Controlled release composition containing a strontium salt
AU2005216596B2 (en) 2004-02-26 2011-03-24 Osteologix A/S Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions
PT2319581E (pt) 2004-11-26 2015-06-30 Ucl Business Plc Composições compreendendo ornitina e fenilacetato ou fenilbutirato para tratamento de encefalopatia hepática
KR100878140B1 (ko) * 2007-01-29 2009-01-12 한미약품 주식회사 아토바스타틴의 스트론튬염 또는 이의 수화물, 및 이를포함하는 약학 조성물
CN101327203B (zh) * 2007-06-19 2011-03-30 惠州市昆泰精细化工有限公司 没食子酸螯合物组合物及其应用
ES2791524T3 (es) 2009-04-03 2020-11-04 Ocera Therapeutics Inc Fenilacetato de L-ornitina y métodos de elaboración del mismo
EP3517110A1 (en) 2009-06-08 2019-07-31 UCL Business PLC Treatment of inflammation using l-ornithine phenylacetate
FR2963837B1 (fr) * 2010-08-10 2012-08-31 Air Liquide Traitement a niveaux multiples pour optimiser une ou plusieurs unites de separation de fluides
EP2625162B1 (en) 2010-10-06 2019-03-13 Ocera Therapeutics, Inc. Methods of making l-ornithine phenyl acetate
EP2530068A1 (en) 2011-05-31 2012-12-05 Lacer, S.A. New strontium salts, synthesis and use thereof in the treatment of osteoporosis
CN103173845B (zh) * 2012-01-12 2015-06-03 江苏爱特恩高分子材料有限公司 一种对苯二甲酸金属盐晶须的生产方法与应用
RU2564858C1 (ru) * 2014-06-04 2015-10-10 Закрытое акционерное общество "ЭКОС-1" Способ получения безводного формиата стронция
BR112017010761B1 (pt) 2014-11-24 2022-10-18 Ucl Business Plc Tratamento de doenças associadas à ativação de célula estrelada hepática com o uso de terapias de redução de amônia
JP6464475B2 (ja) * 2015-03-02 2019-02-06 清水建設株式会社 放射性ストロンチウムの分析方法
CA2995823A1 (en) 2015-08-18 2017-02-23 Ocera Therapeutics, Inc. Treatment and prevention of muscle loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate
WO2018084959A2 (en) 2016-09-30 2018-05-11 Nelson Deanna J Pharmaceutical quality strontium l-lactate
CN106699781B (zh) * 2016-12-16 2018-11-16 商丘师范学院 基于衣康酸-吡嗪混合配体的锌(ii)荧光材料及制备方法
EP3621947A4 (en) 2017-05-11 2021-03-10 Ocera Therapeutics, Inc. L-ORNITHINE PHENYLACETATE MANUFACTURING PROCESSES
CN114410396A (zh) 2017-06-27 2022-04-29 埃科莱布美国股份有限公司 洗衣应用中的无磷过渡金属控制
CN108047155A (zh) * 2017-11-29 2018-05-18 浙江震元制药有限公司 一种双芳基取代的异恶唑化合物的定向制备方法及用途
WO2019217790A1 (en) * 2018-05-11 2019-11-14 Premex, Inc. Process for quantification of metal amino acid chelates in solutions and solids
SG11202102204PA (en) * 2018-09-25 2021-04-29 Ponce De Leon Health Designated Activity Company Process of making calcium alpha-ketoglutarate
CN109444277B (zh) * 2018-10-29 2021-05-11 郑州大学第一附属医院 代谢标志物在制备胶质瘤诊断试剂盒方面的应用
CN109622238B (zh) * 2018-12-18 2020-07-17 商洛学院 一种用于从金红石重选中矿中浮选回收金红石的药剂组合
CN110668934A (zh) * 2019-10-14 2020-01-10 惠州市志海新威科技有限公司 一种酒石酸锌的制备方法及其在稳定剂中的应用
CN114479098B (zh) * 2021-12-17 2023-05-23 广东石油化工学院 一种可控微介孔金属有机框架hkust-1材料及其制备方法和应用

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Also Published As

Publication number Publication date
EP1744770A2 (en) 2007-01-24
US7589235B2 (en) 2009-09-15
WO2005108339A3 (en) 2005-12-29
AU2005240257B2 (en) 2011-11-24
AU2005240257A1 (en) 2005-11-17
JP2007536288A (ja) 2007-12-13
KR20110124317A (ko) 2011-11-16
US8183409B2 (en) 2012-05-22
US20090291926A1 (en) 2009-11-26
WO2005108339A2 (en) 2005-11-17
US20070282127A1 (en) 2007-12-06
CA2565840A1 (en) 2005-11-17
CN101010087A (zh) 2007-08-01
JP4954867B2 (ja) 2012-06-20

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