CN101000307B - High precision scanning imaging device for surface plasma resonance biological sensor - Google Patents
High precision scanning imaging device for surface plasma resonance biological sensor Download PDFInfo
- Publication number
- CN101000307B CN101000307B CN 200610095365 CN200610095365A CN101000307B CN 101000307 B CN101000307 B CN 101000307B CN 200610095365 CN200610095365 CN 200610095365 CN 200610095365 A CN200610095365 A CN 200610095365A CN 101000307 B CN101000307 B CN 101000307B
- Authority
- CN
- China
- Prior art keywords
- gear
- gearbox
- worm
- motor
- bid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
Abstract
The invention supplies small scale high precision scanning imaging device used in angle type surface plasma resonance. The scanning device includes control part, electric machine subdividing drive, step motor, speeding up box, image sensor. The control part controls electric machine running. The step motor supplies power for the speeding up box which is a driving system designed according to angle type SPR light path principle, has three grades driving that the first one is that electric machine input shaft and platelet finish retarded motion transfer with 29:1 speed reducing ratio by the first grade worm wheel; the second one is that the first grade straight gear cylindrical gear transfers the platelet motion to intermediate shaft, and keeps speed unchanged; the third one is that the first grade straight gear cylindrical gear transfers intermediate shaft motion to grail to realize 1:2 speeding up. The platelet and grail has the same rotating direction in the system. Scanning precision can reach 0.0001 degree. The device has the advantages of small volume, light weight, low processing cost, and convenient assemble and unassembled.
Description
Technical field
The invention belongs to surface plasma resonance biological sensor imaging device technology, be specifically related to be used for the surface plasmon resonance biosensor imaging device that prism-type is scanned into firing angle.
Background technology
The scanning of Kretshmann type SPR (surface plasma resonance) biology sensor detects principle: incident wavelength is constant, changes incident angle, and reflected light can generate the SPR spectrum according to the change of incident angle, and wherein incident light source is a parallel beam.SPR composes demonstration: reflected light is the darkest in SPR resonance angle there.Detect is exactly to draw different testing results according to the darkest point of SPR spectrum glazed thread.Testing process needs imageing sensor can follow and catch image accurately, with the angle of the dim spot of each sample light intensity in Computer Analysis its image sequence.
At present, being used for the surface plasmon resonance biosensor imaging method has imaging device a variety of and of the present invention that an invention disclosed patent is similarly arranged, and number of patent application is 200510053510.6.The described mechanical scanning system of this patent comprises optical table, connection rod set, slide block, guide rail, screw rod, motor, angular displacement sensor and pull bar.Wherein, connection rod set is made up of four connecting rods, four connecting rod besieged city rhombuses, and four connecting rods can be that rotate in the axle center to connect point.Light source and array photodiode are placed on company of connection rod set respectively and put on the connecting rod of both sides, promptly are positioned at the incident and the reflected light path of optical prism; Optical prism and surface plasma resonance chip portfolio are on optical table.Another connects some realization image angle scanning the pulling connection rod set.The sensitivity of this device is decided by motor and the minimum distinguishable angular displacement of angular displacement sensor, reaches 0.001, and the brachium of its connecting rod has determined that measurement range is limited, with regard to this point, also is inflexible for angle scanning.
Summary of the invention
At the prior art above shortcomings, the present invention discloses a kind of high precision scanning imaging device that is used for the angle type surface plasma resonance biological sensor, wherein gearbox adopts the drive mechanism of gear match, volume is little, whole device precision can reach 0.0001 degree, the scope of scanning is without any restriction, and can guarantee that imageing sensor can follow reflected light accurately.
Technical scheme of the present invention is as follows:
The device that the present invention proposes is made up of controller, motor segmentation driving, stepper motor and gearbox and imageing sensor.Controller connects the segmentation drive unit by control line, the running that controller can the control step motor, and the angle value of reading scan.The motor segmentation drives and connects and drive stepping motor, and it is 200 segmentations that the motor segmentation drives.The output shaft transferring power of stepper motor is given gearbox, and stepper motor is a composite stepper motor, does the power input of gearbox.Shallow bid on the gearbox is placed prism, and imageing sensor (can adopt CMOS camera or CCD camera) is installed on the deep bid of gearbox, guarantees that the sensor of acceptance pattern picture is accurately followed reflected light.Improvement of the present invention is that gearbox has been adopted worm and gear and three grades of drive mechanisms of gear: the first order has adopted the worm and gear transmission of space transmission, makes motor input shaft and shallow bid finish the retarded motion transmission by the one-level turbine and worm, reduction gear ratio 29: 1.Wherein worm screw directly is connected by shaft joint with stepper motor, and worm screw drives worm gear and rotates, and worm gear directly is connected by key with the shallow bid axle, drives the shallow bid axle and rotates; Second level transmission is the commutation drive mechanism, adopts the one-level spur gear that the motion of shallow bid is delivered to intermediate shaft, and velocity magnitude remains unchanged.By the second level spur gear and the same number of teeth spur gear engagement that is installed on the intermediate shaft that are installed on the shallow bid axle; Third level transmission is the speedup drive mechanism, adopts one-level straight cylinder gear that rotatablely moving of intermediate shaft is delivered to deep bid, realizes 1: 2 speedup.Be to be meshed with a small Spur gear that is installed on the deep bid axle by a large straight gear of installing on the intermediate shaft, the gear ratio of big small Spur gear is 2: 1.
The scanning accuracy of this device is by the common decision of turbine and worm reduction gear ratio in micro-stepping driving of stepping motor and the first order drive mechanism.Guaranteeing to improve the segmentation of stepper motor under the equal high precision condition in design, thereby reducing the design difficulty of gearbox first order deceleration system.The gear match is adopted in the design of gearbox, and processing cost is low, and easy accessibility is easy to process, stable drive.Its design can realize the wide region scanning of 360 degree, and sweep velocity is controlled by controller, is a kind of cost-effective imaging scanner.
Description of drawings
Fig. 1 is the structured flowchart of this device.
Fig. 2 is a gearbox drive mechanism schematic diagram;
Fig. 3 is the fundamental diagram of this device.
Embodiment
Referring to Fig. 1, this high precision scanning imaging device is made of controller, motor segmentation driving, stepper motor, gearbox, imageing sensor.Controller connects the motor segmentation by control line and drives, segmentation drives and connects and drive stepping motor, and the output shaft transferring power of stepper motor is given gearbox, and imageing sensor adopts CMOS camera or CCD camera, be installed on the deep bid of gearbox, the shallow bid on the gearbox is placed prism.
Referring to Fig. 2, the gearbox of this device has adopted worm and gear and three grades of drive mechanisms of gear, first order transmission is the layout and the easy accessibility of synchronous motor for convenience, adopt the worm and gear transmission of space transmission, worm screw 2 directly is connected by shaft joint with stepper motor, worm screw 2 drives worm gear 1 and rotates, and worm gear 1 directly is connected by key with the shallow bid axle, therefore drives the shallow bid axle and rotates.Second level transmission is the commutation transmission, the purpose of this grade transmission is for guaranteeing that deep bid axle and turning to of shallow bid axle are same direction, the ratio of gear of this grade transmission is 1, be that second level input spur gear 3 on the shallow bid axle is the identical cylindrical gear of the number of teeth with tooth sector 9 on the intermediate shaft 7, the realization transmission is meshing with each other.Third level transmission realizes 1: 2 ratio of gear, the number of teeth that is the deep bid third level input spur gear 8 on the intermediate shaft is 2 times of the number of teeth of the spur gear 4 on the deep bid axle, this level is the speedup transmission, guarantee that deep bid 5 rotating speeds are 2 times of shallow bid 6 rotating speeds, so that the imageing sensor 10 on the deep bid 5 is accurately followed the reflected light of the optical prism 11 on the shallow bid 6.
Referring to Fig. 3, the course of work of this device, incident single mode light takes place in the laser instrument 12 in the diagram, and wavelength is certain.Light becomes the parallel beam with certain area through concavees lens 13 and convex lens 14 time; 15 of first polaroids are inclined to one side, and second polaroid 16 is regulated the brightness of light beams; At this moment, light beam enters optical prism 11, takes place after a series of light reaction, and emergent ray is beaten on the imageing sensor 10 that receives light.Above said be the stroke of light in light path, actual device need change the incident angle that light beam enters optical prism 11, thereby obtains a series of image.The following process of automatic angle scanning process: the running of figure middle controller control step motor, the power of stepper motor drive shallow bid 6 runnings on the gearbox 17, and speed is ω.Incident beam is with the running of the speed of ω with respect to shallow bid, and light is through after the prismatic refraction, emergent ray be 2 ω with respect to the earth speed.So have only when deep bid 5 rotating speeds are 2 ω, put the motion that thereon imageing sensor can accurately be followed its emergent ray.
Claims (2)
1. a compact high precision scanned imagery device that is used for the angle type surface plasma resonance biological sensor is made of controller, motor segmentation driving, stepper motor, gearbox, imageing sensor; Controller connects the motor segmentation by control line and drives, and the motor segmentation drives and connects and drive stepping motor, and the output shaft transferring power of stepper motor is given gearbox, and imageing sensor is installed on the deep bid of gearbox, and the shallow bid on the gearbox is placed prism; It is characterized in that: gearbox has adopted worm and gear and three grades of drive mechanisms of gear, the first order has adopted the worm and gear transmission of space transmission, worm screw directly is connected by shaft joint with stepper motor, worm screw drives worm gear and rotates, worm gear directly is connected by key with the shallow bid axle, drive the shallow bid axle and rotate, make motor input shaft and shallow bid finish the retarded motion transmission by the first-stage worm gear worm screw; Second level transmission is the commutation drive mechanism, by the second level spur gear and the same number of teeth spur gear engagement that is installed on the intermediate shaft that are installed on the shallow bid axle; Third level transmission is the speedup drive mechanism, be to mesh with a small Spur gear that is installed on the deep bid axle by a large straight gear of installing on the intermediate shaft, the gear ratio of big small Spur gear is 2: 1, making the deep bid rotating speed is 2 times of shallow bid rotating speed, so that the imageing sensor on the deep bid is accurately followed the emergent ray of the prism on the shallow bid, thereby realize that 360 spend the scanning of scopes.
2. high precision scanning imaging device according to claim 1 is characterized in that: imageing sensor adopts CMOS camera or CCD camera.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610095365 CN101000307B (en) | 2006-12-27 | 2006-12-27 | High precision scanning imaging device for surface plasma resonance biological sensor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610095365 CN101000307B (en) | 2006-12-27 | 2006-12-27 | High precision scanning imaging device for surface plasma resonance biological sensor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101000307A CN101000307A (en) | 2007-07-18 |
| CN101000307B true CN101000307B (en) | 2010-12-08 |
Family
ID=38692364
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610095365 Expired - Fee Related CN101000307B (en) | 2006-12-27 | 2006-12-27 | High precision scanning imaging device for surface plasma resonance biological sensor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101000307B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106124524B (en) * | 2016-06-22 | 2023-10-13 | 滨州医学院 | Intelligent optical diaphragm on-line detection equipment |
| CN115228519A (en) * | 2022-06-30 | 2022-10-25 | 晶准生物医学（深圳）有限公司 | Droplet generation drive mechanism |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5438247A (en) * | 1992-08-31 | 1995-08-01 | Samsung Electronics Co., Ltd. | Ultrasonic sensor scanning apparatus and method for detecting objects by use of the scanning apparatus |
| CN1356666A (en) * | 2001-10-12 | 2002-07-03 | 力捷电脑股份有限公司 | Elastic energy accumulation type scanner and its scan method |
| US6460261B1 (en) * | 1999-11-18 | 2002-10-08 | Mitutoyo Corporation | V-groove shape measuring method and apparatus by using rotary table |
-
2006
- 2006-12-27 CN CN 200610095365 patent/CN101000307B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5438247A (en) * | 1992-08-31 | 1995-08-01 | Samsung Electronics Co., Ltd. | Ultrasonic sensor scanning apparatus and method for detecting objects by use of the scanning apparatus |
| US6460261B1 (en) * | 1999-11-18 | 2002-10-08 | Mitutoyo Corporation | V-groove shape measuring method and apparatus by using rotary table |
| CN1356666A (en) * | 2001-10-12 | 2002-07-03 | 力捷电脑股份有限公司 | Elastic energy accumulation type scanner and its scan method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101000307A (en) | 2007-07-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103477209B (en) | For the system and method for phase control of throwing light in fluorescent microscope | |
| CN102692347A (en) | Camera automatic regulating image acquisition device and method for fatigue crack propagation test | |
| CN111584415A (en) | Alignment system for wafer bonding | |
| CN110849289A (en) | Double-camera parallel confocal differential microscopic 3D morphology measurement device and method | |
| CN1115546C (en) | Surface three-dimensional appearance testing method and equipment | |
| CN103808707A (en) | Spectroscopic apparatus and spectroscopic light source | |
| CN111412863B (en) | Parallel chromatic confocal three-dimensional morphology optical measurement system | |
| CN102419473A (en) | Imaging method and microscope device | |
| CN104034258A (en) | Galvanometer Scanned Camera With Variable Focus And Method | |
| CN102540439B (en) | Confocal axial scanning device and confocal axial scanning method based on reflection type liquid crystal spatial light modulator | |
| CN110360949B (en) | Multifunctional holographic interference measurement system | |
| CN112066910A (en) | Monocular three-dimensional measurement system based on plane mirror automatic rotating platform | |
| CN101000307B (en) | High precision scanning imaging device for surface plasma resonance biological sensor | |
| CN1709195A (en) | Real-time imaging optical coherent endoscope system | |
| CN210922541U (en) | Double-camera parallel confocal differential microscopic 3D morphology measuring device | |
| CN1395677A (en) | Method and arrangement for optically detecting position of moveable mirror | |
| CN1940533A (en) | Differential refractometer and its adjusting method | |
| CN205192445U (en) | Optics three -dimensional imaging device | |
| CN106556570A (en) | For the apparatus and method of the three-dimensional infrared imaging to surface | |
| CN1170183C (en) | High-speed laser-confocal scanning microscopic imaging apparatus | |
| CN1358999A (en) | Automatic focus regulator for laser cofocal scanner | |
| CN1412538A (en) | Broad-band light source signal detection method and its detector | |
| CN2575604Y (en) | Outdoor metering display box | |
| CN103424843A (en) | Total internal reflection in-situ lighting device and control method thereof | |
| CN1419147A (en) | Automatic focusing regulation method and device for multiple variable ptial imaging system of 3D object |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20101208 Termination date: 20111227 |