CN100591348C - Medicated brassiere for preventing against hyperplasia of mammary gland and breast lump and nodule - Google Patents

Abstract

The invention relates to a medicinal brassiere for preventing women's mammary gland hyperplasia plexus, which is prepared from Chinese herbal materials including oldenlandia, rhizome of Chinese paris,dandelion, prepared nutgrass flatsedge rhizome, selfheal, seaweed, seed of cowherb, eupatene, boneol, and far infrared ceramic powder.

Description

The medicated brassiere of preventing against hyperplasia of mammary gland and breast lump and nodule

Technical field

The present invention relates to the Chinese crude drug is a kind of medicated brassiere that can preventing against hyperplasia of mammary gland and breast lump and nodule that raw material is made.

Technical background

Mastopathy is women's height morbidity, and mammary gland inflammatory diseases, cyclomastopathy, mammary gland are good, malignant tumor etc. falls ill in recent years and rising year by year.Raising along with people's material, the level of cultural life, because the change of living habit, environmental factors, dietary structure not normal, physics, chemical irritation, and unbalance (feelings will problem) all multifactor impacts of people's spiritual phychology, all can be in human development's different phase, hormone, QI and blood also play different variations with mammary gland.The breast lesion kind is a lot, but mammary gland tumor, the tuberosity general indication of all kinds of pathological changes of mammary gland often.(women of 80%-90% goes to seek medical advice with the breast tumor appearance).

But be not breast tumor all be cancer, as: benign tumor, " cyclomastopathy ", the swollen thing of inflammatory etc.But also just like continuous " atypical hyperplasia " that takes place, can canceration take place then and continued growth.The mammary gland tumor of Fa Xianing has often surpassed the concealment phase (being the subclinical phase) of breast carcinoma clinically.

Cyclomastopathy is the breast epithelium hypertrophy just, is commonly called as " cyclomastopathy ".It is the process that expansion, hypertrophy and capsule based on lobules of mammary gland and stage casing, latter end conduit sexually revise.The endocrine dysfunction of this sick generation, development and ovary is relevant.When the metabolism imbalance of excretory estrogen and progestogen periodically, there is superfluous estrogen in the body, the imbalance of mammary gland body hypertrophy and recuperation be can make, and then breast duct epithelium hyperplasia or mammary gland tissue hyperemia, edema made, the mammary gland volume increases.Periodically pain can be arranged, the confusion and the physiological hypertrophy of breast structures such as regard agitation.(should check and have or not mammary gland tumor or local organization plumpness to be pimple sample or lesser tubercle etc.).As when further developing mammary gland severe hypertrophy, " in the lobule " tip conduit obviously expansion becomes folliculus swollen (full of liquid in the capsule), and inspection can contact the harder lump of quality and a plurality of tuberosity, also nipple discharge can occur.

Canceration might take place in height cyclomastopathy and atypical hyperplasia, also is one of important risk factor that takes place breast carcinoma.The danger that breast carcinoma then takes place the women who family history of breast cancer is arranged or do not give birth to obviously increases, so will pay attention to the prevention and control of " precancerous lesion " of breast carcinoma.Mammary gland fibroma (traditional Chinese medical science claims " nodules of the breast ", is benign tumor) is seen adolescence 18-25 year woman's lump in breast more, and diameter is many at 1-3 centimetre.In addition, common lumps such as intracanalicular papilloma, mammary duct ectasia tumor, mammary fat tumor, mammary gland hamartoma, mammary gland leiomyoma, mammary gland lymphoma differ in size at 1-8 centimetre.Though be optimum breast tumor, the possibility of cancerating is arranged, must strengthen the prevention and control idea, with better protection oneself.

Breast carcinoma improving day by day, has accounted for first in the female tumor at the many geographic sickness rate of China.Its characteristics are: 1) sickness rate obviously raises; 2) onset peak obviously shifts to an earlier date, to be advanced to one's mid-30s; 3) onset peak longer duration develops into peak age in 35-70 year in 1996 from the 45-60 peak age in year in 1976.Other national breast cancer incidence is also all in rising trend, and increasing degree is 15%-30%.Illustrate that breast cancer incidence is on the rise, its gesture is extremely urgent.Must carry out multinomial effectively preventing as early as possible, as: new drug control and life prevention and control measure etc.

Summary of the invention:

The objective of the invention is to screen liver-smoothing, qi-regulating, blood circulation promoting and blood stasis dispelling, the network that stimulates the menstrual flow away, hard masses softening and resolving, benefiting QI and nourishing blood, spleen invigorating heat clearing away, eliminating inflammation and expelling toxin, relieving pain by regulating nutrient QI, the Chinese crude drug of breast enlargement beauty treatment.A kind of medicated brassiere that can preventing against hyperplasia of mammary gland and breast lump and nodule is provided.

In order to reach purpose of the present invention, think that according to motherland's medicine and pharmacology " the liver spleen is disgruntled, deficiency of both QI and blood " can form positive QI-insufficiency, zang-fu disharmony, so that qi depression to blood stasis, it is poly-that expectorant coagulates poison, satisfies into lump.Breast is liver stomach passages through which vital energy circulates area-covered, so control through opinion from liver stomach two.Based on dispersing liver-energy, clearing away stomach-heat, " general rule is not bitterly " is so should be aided with the lactogenesis eliminating stagnation, that is: galactostasis, latex dust stasis-depressed liver-energy dispersing and QI regulating.Lactogenesis eliminating stagnation or clearing stomach detoxifcation are with lactogenesis and battalion.

Above traditional Chinese medical science argument can be interpreted as with modern medicine: exist superfluous estrogen in the body, make the hypertrophy and the recuperation imbalance of mammary gland body of gland, and cause the hyperplasia of breast duct epithelium.(as: height hypertrophy and the canceration that atypical hyperplasia took place)

The traditional Chinese medical science is described, stagnation of QI due to depression of the liver, and mammary swelling, mastalgia, irritated irritability is had a dizzy spell, and costalgias uncomfortable in chest etc. are " liver and gall " two networks and move.Dialectical is " stagnation of liver-QI " or " the strong spleen of liver is weak " (edema person is arranged), is the main pathogenesis cause of disease of woman mammary gland disease.

Its main diseases of breast lesion is because " qi depression to blood stasis " (as seen Evolution of Tongue Inspection of TCM has the body of the tongue petechia).Its reason is the pathological change of circulation of mammary gland body fluid and substance metabolism.Be furtherly: estrogen definitely or relatively too much be accompanied by mammary gland tissue to comparison responsive, promptly cause each age group bilateral symmetric property to occur or the one-sided mammary gland of unsymmetry increases, and tuberosity, lump form.Select liver-smoothing, qi-regulating, blood circulation promoting and blood stasis dispelling, network stimulates the menstrual flow away, hard masses softening and resolving, benefiting QI and nourishing blood, spleen invigorating heat clearing away, eliminating inflammation and expelling toxin, the Chinese crude drug of relieving pain by regulating nutrient QI is a raw material, and the far infrared ceramic powder composition of medicine that add to improve immunocompetence is made in the bra or directly be coated in the approach of bra internal layer with transdermal administration.

Take following technical scheme: a kind of medicated brassiere of preventing against hyperplasia of mammary gland and breast lump and nodule, comprise bra, it is characterized in that making the bra raw materials of effective components and consist of:

Herba Hedyotidis Diffusae 5g～30g Rhizoma Paridis 5g～25g Herba Taraxaci 5g～25g Rhizoma Cyperi (processed) 3g～15g

Spica Prunellae 5g～30g Sargassum 5g～20g Semen Vaccariae 3g～15g Herba Lycopi 3g～20g

Borneolum Syntheticum 0.05g～0.3g far infrared ceramic powder 1.8g～3g.

The medicated brassiere of described preventing against hyperplasia of mammary gland and breast lump and nodule comprises bra, it is characterized in that making bra medicated cushion raw materials of effective components and consists of:

Herba Hedyotidis Diffusae 8g Rhizoma Paridis 5g Herba Taraxaci 6g Rhizoma Cyperi (processed) 3g Spica Prunellae 5g

Sargassum 5g Semen Vaccariae 3g Herba Lycopi 5g Borneolum Syntheticum 0.1g far infrared ceramic powder 1g.

The medicated brassiere of described preventing against hyperplasia of mammary gland and breast lump and nodule is characterized in that said medicated cushion sandwiches the bra internal layer or directly medicine is distributed in the onesize area of bra internal layer and medicated cushion.

The preparation method of the medicated brassiere of described preventing against hyperplasia of mammary gland and breast lump and nodule is characterized in that:

1, with Herba Hedyotidis Diffusae, Herba Taraxaci, Spica Prunellae, Sargassum medicinal material coarse powder 30 order, input adds in the percolation jar of Vltrasonic device, add a cover after stirring with medical material equivalent solvent 90% ethanol and make its moistening and the 1～4h that expands, dynamic ultrasound device control percolation flow velocity is 1～3ml/min, at any time add solvent to percolate colourless, tasteless till, drying, the temperature limit is below 60 ℃;

2, with the Herba Lycopi with 3.5 times of 95% alcohol reflux 50min, reclaim ethanol, with the refining back of flocculate and clarify method add 100 order Borneolum Syntheticums and 140 order far infrared ceramic powder mixings standby;

3, with Rhizoma Paridis, Rhizoma Cyperi (processed), Semen Vaccariae water extraction 2 times, amount of water is 4-8 times, decocting time 1-3h, merging filtrate, being evaporated to relative density is the extractum of 1.15-1.20 (60-75 ℃ of mensuration), adds 90% ethanol by 1: 1 and makes determining alcohol reach 60%, filtrate recycling ethanol, reconcentration becomes thick paste, 60 ℃ of dryings, and it is standby to beat powder 100 orders;

4, prescription is standby with all medicine stirring and evenly mixings in proportion;

5, make commercially available bra A cup large size: the clean pastille 41.1g of one-sided cover, medicine is evenly distributed in the medicated cushion, medicated cushion top 9cm, the wide 5cm of following 15cm, making 1.2～2.5cm grid fixes, medicated cushion sandwiches in the bra or directly medicine is distributed in the onesize area of bra internal layer and medicated cushion, makes 1.2～2.5cm grid at the bra internal layer and fixes; B cup medium size: the clean pastille 36.1g of one-sided cover, the wide 4cm of the following 14cm of medicated cushion top 8cm; C cup trumpet: the clean pastille 31.1g of one-sided cover, the wide 3cm of the following 13cm of medicated cushion top 7cm; D cup little number: the clean pastille 26.1g of one-sided cover, the wide 2cm of the following 12cm of medicated cushion top 6cm exceeds;

Effect of the present invention: the medicated brassiere of this product preventing against hyperplasia of mammary gland and breast lump and nodule is a transdermal administration through the natural Chinese medicine composition of screening, and is promptly economical and practical, removed the total disadvantage-toxic and side effects and the untoward reaction of other administration route again.Preparation method advanced person, rationally, simple (medicated powder is inserted in the pure pin muslin bag of sealing and is presented the profile medicated bra medicated cushion similar to conventional bra), be convenient to patient's acceptance and use next to the shin, tool aromatic refrigerant abnormal smells from the patient is beneficial to absorption; The bioavailability height, the skin care tissue, nontoxic, have no side effect, nonirritant has no adverse reaction.Not only can prevent and treat multiple mastopathy, and comfortable attractive in appearance.

The specific embodiment

Embodiment 1: the medicated brassiere (trade name: the flat bra of newborn disease) of preparation preventing against hyperplasia of mammary gland and breast lump and nodule

A, prescription: Herba Hedyotidis Diffusae 80g Rhizoma Paridis 50g Herba Taraxaci 60g Rhizoma Cyperi (processed) 30g

Spica Prunellae 50g Sargassum 50g Semen Vaccariae 30g Herba Lycopi 50g

Borneolum Syntheticum 1g far infrared ceramic powder 10g

B, preparation method:

1, with Herba Hedyotidis Diffusae, Herba Taraxaci, Spica Prunellae, Sargassum medicinal material coarse powder 30 order, input adds in the percolation jar of Vltrasonic device, add a cover after stirring with medical material equivalent solvent 90% ethanol and make its moistening and the 1～4h that expands, dynamic ultrasound device control percolation flow velocity is 1～3ml/min, at any time add the solvent agent to percolate colourless, tasteless till, drying, the temperature limit is below 60 ℃;

2, with the Herba Lycopi with 3.5 times of 95% alcohol reflux 50min, reclaim ethanol, with the refining back of flocculate and clarify method add 100 order Borneolum Syntheticums and 140 order far infrared ceramic powder mixings standby;

3, with Rhizoma Paridis, Rhizoma Cyperi (processed), Semen Vaccariae water extraction 2 times, amount of water is 4-8 times, decocting time 1-3h, merging filtrate, being evaporated to relative density is the extractum of 1.15-1.20 (60-75 ℃ of mensuration), adds 90% ethanol by 1: 1 and makes determining alcohol reach 60%, filtrate recycling ethanol, reconcentration becomes thick paste, 60 ℃ of dryings, and it is standby to beat powder 100 orders;

4, prescription is standby with all medicine stirring and evenly mixings in proportion;

5, make the clean pastille 41.1g (one-sided cover) of commercially available bra A cup (large size) with medicine uniform distribution 9cm on top, the wide 5cm medicated cushion of following 15cm make 1.2～2.5cm grid fixedly medicated cushion sandwich the bra internal layer or direct medicine be distributed in the onesize area of bra internal layer and medicated cushion, make 1.2～2.5cm grid and fix; The wide 4cm of B cup (medium size) the following 14cm of clean pastille 36.1g (one-sided cover) top 8cm; The wide 3cm of C cup (trumpet) the following 13cm of clean pastille 31.1g (one-sided cover) top 7cm; The wide 2cm of D cup (little number) the following 12cm of clean pastille 26.1g (one-sided cover) top 6cm exceeds; Usage: change new medicated cushion with my wish, during replacing medicated cushion is put into the medicated bra base layers and get final product.The medicated cushion absorbing sweat of breathing freely does not lose its effect.But the unavailable water washing, in order to avoid eliminate the efficacy of a drug.

Embodiment 2: the medicated brassiere of preventing against hyperplasia of mammary gland and breast lump and nodule (trade name: the flat bra of newborn disease)

Clinical trial: experimenter's part patient is not through treatment, after once therapist (comprising the clothes contraceptive) is advised drug withdrawal, tried the medicated brassiere of subjects wearing preventing against hyperplasia of mammary gland and breast lump and nodule (trade name: the flat bra of newborn disease) 15～25 days.

A: prevention and control group (prevention mastopathy), before and after using, all check through the near infrared ray image

(there is the breast disease family history in the main suit to 534 people to nineteen eighty-three 16 years old to 56 years old women to be tried out " this product " (the flat medicated brassiere of newborn disease) in 1980, mammary gland twinge in menstrual period, distending pain person), use this product 1-3 after, through the generaI investigation, do not see that mammary gland tumor, tuberosity and other mammary gland abnormity take place, mastalgia disappears.

1991 to 1999 to 18 years old to 69 years old women this product on probation (screen obesity, adolescence mastalgia respectively, take contraceptive, endocrine disturbance's disease person), 797 people, after using this product half a year-9 year, through generaI investigation, do not see the mammary gland abnormity focus, the prevention and control effect that this product is certain to having of mastopathy is described.

2003 to 2005 to 24 years old to 45 years old women (healthy women, no mastopathy person) 507 people, use this product 2-3 after, development of breast is good, skin is moist, all comes from the breast enlargement beauty treatment through the inquiry experimenter, the wish of disease-prevention health, obtain imitate satisfied.

B: treatment group

Screening is tried the women in generaI investigation, the age between 16 years old to 66 years old, through look, palpation, disease history inquire and B ultrasound, far infrared images, picture of mammary gland x-ray radiography (indivedual patients are through CT scan) 1-2 item have been got rid of cancerous protuberance, qualitatively have been benign tumors, tuberosity.

Be selected from and be willing to accept this product examination person of controlling 286 people, nullipara 67 people are wherein arranged, through Aborter's (comprising artificial abortion) 56 people, take contraceptive (2-7) 94 people for a long time, the still poor person of suckling (time is shorter, and milk is of poor quality) 35 people, person 34 people that have the family history of breast cancer.Above patient 92% all has in various degree " transverse invasion of hyperactive liver-QI, be willing to unsuccessful ", the syndrome that feelings will is gloomy.According to the inspection of the tongue of traditional Chinese medical science arteries and veins, features such as " qi depression to blood stasis ", " disorder of QI and blood ", " incoordination between the liver and spleen, incoordination between the liver and stomach " are arranged all.

Effect is observed

Before this product is executed and is controlled:

1, mammary gland is gone up 2-5 centimetre of (being diagnosed as cyclomastopathy) person of quadrant lump 45 examples outward

2, nipple discharge, and extend to 1-3 centimetre of big tuberosity (transparent and milky discharge does not have courageous and upright and one-sided nipple discharge) (being diagnosed as the gland cyclomastopathy) person 87 examples

3, multiple tuberosity (impression: cyclomastopathy, fibroadenosis phase) person's 31 examples

4, mammary gland tumor or local organization thicken (menstruation irregularis, periodically distending pain of the breast) person's 94 examples

5, the body of gland conduit increases, and lobules of mammary gland quantity increases, and can touch and grain of rice sample tuberosity (impression: person's 29 examples simple property cyclomastopathy)

Effect behind the Shi Zhi:

A) check after 2 months, the swollen thing of 39 examples disappears, and 6 examples are softening

B) check after 3 months, 72 routine lumps disappear, and 7 examples are softening

C) check after 5 months, 27 routine tuberositys dissipate, soften, and 4 examples do not heal

D) check after 1 month, 81 routine lumps disappear, and 13 examples are softening

E) check after 1 month, 27 routine tuberositys disappear, and 2 examples are softening

Conclusion: above result of the test shows that the bra of prevention and control mammary glands in women tuberosity mammary gland tumor has liver-smoothing, qi-regulating, blood circulation promoting and blood stasis dispelling; the network that stimulates the menstrual flow away, hard masses softening and resolving, benefiting QI and nourishing blood; the spleen invigorating heat clearing away; eliminating inflammation and expelling toxin, the relieving pain by regulating nutrient QI effect has the tangible mammary gland body of gland that improves; the breast lobule; conduit; nipple; the circulation of mammary areola physiology; strengthen the metabolism of mammary gland biochemical substances; endocrine regulation body fluid improves immunity, and protection skin of mammary gland tissue; eliminate abnormal flavour; the breast enlargement function of bodybuilding is applicable to: youth woman, middle-aged women; the mammary swelling mastalgia; latex dust is obstructed, mammary gland tumor, breast nodule; qi depression to blood stasis; the endocrine disturbance, insufficiency of vital energy and blood, prevention and control are unmarried and married; adolescence; the pregnancy women breast lesion.

Embodiment 2: the medicated brassiere of preventing against hyperplasia of mammary gland and breast lump and nodule (trade name: the drug efficacy study test flat bra of newborn disease):

Experimenter's part patient was tried after once therapist (comprising the clothes contraceptive) is advised drug withdrawal not through treatment, the medicated brassiere of subjects wearing preventing against hyperplasia of mammary gland and breast lump and nodule (trade name: measure after the flat bra of newborn disease) 15 days:

Count its 24 hours PAs, the result distinguishes significantly to some extent at the skin of mammary gland permeability of all ages and classes section.Though female mammary gland skin is (as the distribution and the density of appendages) difference to some extent structurally, transdermal absorption factor is also more close, (seeing scale 2)

The Several Factors of this product in mammary gland absorption administration

1) traditional Chinese medical science is thought: percutaneous drug delivery has the unique magical effect that follows through the cave approach, in mammary gland (meridians that the inside and outside upper and lower quadrant area of mammary gland is liver, spleen, gallbladder, stomach, the important path at acupuncture point.So,, can bring into play higher drug action to follow through walking the network approach to this zone Transdermal absorption administration.

2) skin: moisture content of skin is the key factor that percutaneous is given the way.Keratin and moisture in the keratodermatitis (perspiration is interior) have certain binding ability, horny layer can absorb moisture to make skin hydration and atomizing, cause that promptly corneocyte expands, and make short texture, and percutaneous permeability strengthens.

3) medicine factor: this product has been screened and can have been caused that the skin of mammary gland barrier changes, improve pieces and sebaceous gland approach and lower the resistance of cortex to infiltration, and add the promotion solvent, (penetration performance is good) is with safety, stable, isostatic rate of release, be easy to discharge, strengthen infiltration.

For promoting the skin of mammary gland tissue to absorb, this product is selected for use and is good at the network that stimulates the menstrual flow away, and the natural Chinese medicinal herb that fragrance is walked to scurry is top grade, and has suitably improved drug level (dosage), makes cortex absorb capacity, improves effect.

4) heat effect: the thermodynamic behaviour of medicine, ionized state forms, time of contact potential difference and partial Brownian movement phenomenon, drug microparticles and mammary gland friction of motion frequency, women's thoracic respiration feature, the effect of Percutaneous absorption enhancer etc. is the significant nuances of this product effect.

Table 1: the poor experiment of part that Chinese medicine medicated bra (the flat bra of newborn disease) percutaneous absorbs

Skin part	Absorb the composition of medicine percentage rate
		Mammary gland	42
Scrotum	45
		The palm of the hand	1.97
Foot	36
		Ankle	22
The forearm inboard	15
		The omoplate ditch	19
Umbilicus	48

Table 2: all ages and classes experimenter is to the Transdermal absorption (the urine Chinese medicine response rate) of this product medicine

The experimenter	Age	The composition of medicine PA
			1	18	44.5
2	19	44.5
			3	20	42.2
4	22	43
			5	24	43.5
6	26	42.2
			7	29	42.2

Continuous table 2: all ages and classes experimenter is to the Transdermal absorption (the urine Chinese medicine response rate) of this product medicine

8	31	40.5
			9	35	41.1
10	38	41.3
			11	40	40.7
12	42	40.1
			13	45	40.3
14	48	39
			15	50	37.7
16	55	31.3
			17	58	30.1
18	62	27.4
			19	65	26.7

Medicated brassiere is that the combination Chinese herbal medicine is refined into powder, be closed in the cloth bag of the strong pure pin cotton of absorption, place the medicated bra internal layer, next to the shin in the mammary gland body surface with through the position, cave, through absorptions such as skin surfaces, act on local microcirculation in the human body, enter the body circulation, thereby performance is local and the drug effect of whole body, reaches the generation and the development of control mastopathy.

It comes from tcm clinical efficacy, exterior-applied formulation, and the scope of application of external therapy of Chinese herb in disease prevention and control and treatment application, will brought into play irreplaceable effect in continuous expansion at present.Medicated brassiere is filled up medical effect in the woman article changing the simple property of women's medicated bra, for domestic and international numerous women have started the utility of preventing and curing diseases.

This product is a transdermal administration, newly wards off other administration route, and is promptly economical and practical, removed the total disadvantage-toxic and side effects and the untoward reaction of other administration route again.

This product administration can avoid

1, factors such as pH and enzyme reduce the individual variation that causes thus to the degraded of medicine and the first pass effect of liver in the gastrointestinal

2, the may command medicine enters intravital speed, keeps stable blood concentration, and " peak valley phenomenon " appears in the blood drug level of having avoided other medication to cause.

3, a drug can make medicine enter human body from constant speed for a long time, plays the effect of long-acting slow-release.

4, reduce its side effect, easy to use, can use (administration) at any time or stop using, discontinue medication.Be applicable to that a variety of causes is difficult for oral, injecting drug use and patients with surgical.

5, by skin, through the cave local absorption, the group effect of sensible complete body is arranged, regulate sick, physiology and develop the balance of effect.

6, this route of administration can reach effective blood drug level, that is: pharmacological action is strong, and dosage is little, and dosage is few, and drug half-life is short, need to suit long-term prophylactic treatment person, and it is long to reach chronic disease and differentiation phase, the control of the focus of the vicious cycle change of disease.

7, big than the oral medication effect, little to gastrointestinal irritation, avoid the inactivation of medicine etc.

Claims (3)

1, a kind of medicated brassiere of preventing against hyperplasia of mammary gland and breast lump and nodule, it is characterized in that the bra medicated cushion that medicine is made sandwiches the internal layer of bra body, perhaps directly medicine is distributed in the onesize area of the internal layer of bra body and medicated cushion, the raw material of described effective ingredient consists of: Herba Hedyotidis Diffusae 5g～30g, Rhizoma Paridis 5g～25g, Herba Taraxaci 5g～25g, Rhizoma Cyperi (processed) 3g～15g, Spica Prunellae 5g～30g, Sargassum 5g～20g, Semen Vaccariae 3g～15g, Herba Lycopi 3g～20g, Borneolum Syntheticum 0.05g～0.3g, far infrared ceramic powder 1.8g～3g.

2, a kind of medicated brassiere of preventing against hyperplasia of mammary gland and breast lump and nodule is characterized in that the bra medicated cushion that medicine is made sandwiches the internal layer of bra body, perhaps directly medicine is distributed in the onesize area of the internal layer of bra body and medicated cushion, the raw material of described effective ingredient consists of: Herba Hedyotidis Diffusae 8g, Rhizoma Paridis 5g, Herba Taraxaci 6g, Rhizoma Cyperi (processed) 3g, Spica Prunellae 5g, Sargassum 5g, Semen Vaccariae 3g, Herba Lycopi 5g, Borneolum Syntheticum 0.1g, far infrared ceramic powder 1g.

3, the preparation method of the medicated brassiere of preventing against hyperplasia of mammary gland and breast lump and nodule according to claim 1 and 2 is characterized in that:

A, with Herba Hedyotidis Diffusae, Herba Taraxaci, Spica Prunellae, Sargassum medicinal material coarse powder 30 orders, input adds in the percolation jar of Vltrasonic device, add a cover after stirring with medical material equivalent solvent 90% ethanol and make its moistening and the 1～4h that expands, dynamic ultrasound device control percolation flow velocity is 1～3ml/min, at any time add solvent to percolate colourless, tasteless till, drying, the temperature limit is below 60 ℃;

B, with the Herba Lycopi with 3.5 times of 95% alcohol reflux 50min, reclaim ethanol, with the refining back of flocculate and clarify method add 100 order Borneolum Syntheticums and 140 order far infrared ceramic powder mixings standby;

C, with Rhizoma Paridis, Rhizoma Cyperi (processed), Semen Vaccariae water extraction 2 times, amount of water is 4-8 times, decocting time 1-3h, merging filtrate is evaporated to extractum, its relative density 60-75 ℃ of mensuration is 1.15-1.20, added 90% ethanol by 1: 1 and make determining alcohol reach 60%, filtrate recycling ethanol, reconcentration becomes thick paste, 60 ℃ of dryings, it is standby to beat powder 100 orders;

D, all medicine stirring and evenly mixings is standby in the raw materials of effective components ratio of the medicated brassiere of claim 1 or 2 described preventing against hyperplasia of mammary gland and breast lump and nodule;

E, the medicine of above-mentioned D step drug prepared is evenly distributed in the medicated cushion, making 1.2～2.5cm grid fixes, medicated cushion is sandwiched the internal layer of bra body, perhaps above-mentioned D step drug prepared directly is distributed in the onesize area of the internal layer of bra body and medicated cushion, making 1.2～2.5cm grid fixes, make bra, wherein commercially available bra

A cup large size: the clean pastille 41.1g of one-sided cover, medicated cushion top 9cm, the wide 5cm of following 15cm; B cup medium size: the clean pastille 36.1g of one-sided cover, the wide 4cm of the following 14cm of medicated cushion top 8cm; C cup trumpet: the clean pastille 31.1g of one-sided cover, the wide 3cm of the following 13cm of medicated cushion top 7cm; D cup little number: the clean pastille 26.1g of one-sided cover, the wide 2cm of the following 12cm of medicated cushion top 6cm.