CN100584365C - Pharmaceutical composition for treating acne - Google Patents
Pharmaceutical composition for treating acne Download PDFInfo
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- CN100584365C CN100584365C CN200610144320A CN200610144320A CN100584365C CN 100584365 C CN100584365 C CN 100584365C CN 200610144320 A CN200610144320 A CN 200610144320A CN 200610144320 A CN200610144320 A CN 200610144320A CN 100584365 C CN100584365 C CN 100584365C
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- radix
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Abstract
Disclosed is a medicinal composition for treating acne and method for application, wherein the composition comprises Chinese medicinal herbs of alkanna tinctoria, Philippine violet herb, rhubarb horsetails, goldthread root, dahurian angelica root, myrrh, astragalus root, licorice root, sulfur and antibiotic drugs, the method for medicament application consists of removing sebaceous gland deposits by means of physical methods, then cleaning the wounds with hydrogen peroxide.
Description
One, technical field:
The present invention relates to medicine or cosmetics technical field, in particular for the pharmaceutical composition of treatment acne.
Two, background technology:
Said composition comprises Chinese medicine and antibiotics enoxacin, ciprofloxacin, lincomycin and clindamycins such as Radix Arnebiae (Radix Lithospermi), Herba Violae, Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, Myrrha, the Radix Astragali, Radix Glycyrrhizae and sulfur.
Lithospermum heat clearing away class medicine has removing heat from blood, an effect of rash of invigorating blood circulation, detoxify, and antiinflammatory, hemostasis, analgesic, blood sugar lowering, effect such as antibiotic are arranged, and the clinical carbuncle sore that is used for is burst and do not closed up the treatment of various dermatosis secondary infection.
Herba Violae belongs to heat clearing away class medicine, has the effect of heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, and effects such as antibiotic, antiviral, antiendotoxin, the clinical treatment that is used for the treatment of furuncle and skin infection are arranged.
Radix Et Rhizoma Rhei has another name called Radix Et Rhizoma Rhei, belongs to rushing down the lower class medicine, has heat and toxic materials clearing away, clearing away heat-fire, blood circulation promoting and blood stasis dispelling, detoxifcation, antibiotic effect, internal, external haemorrhage, tangible anastalsis is all arranged, and estrogen-like effects is arranged, external can be treated seborrheic dermatitis, is the medicine commonly used of treatment pathopyretic ulcer.
Coptis heat clearing away class medicine has heat clearing and damp drying, the effect of eliminating fire and detoxication, the clinical carbuncle furuncle that is used for the treatment of, outstanding kind treatment furunculosis; Broad-spectrum antiseptic, antiinflammatory, antiulcer etc.
The Radix Angelicae Dahuricae belongs to the class medicine that induces sweat, and has the effect of the diffusing wind that induces sweat, understand things pain-stopping, dampness leukorrhagia stopping, detumescence and apocenosis, and can break stagnated blood, change loses pus, goes face defect scar.
The bdellium medicine for promoting blood circulation and dispelling blood stasis has blood fat reducing, convergence, antiinflammatory, analgesia, effect such as antibiotic, clinical promoting blood circulation and stopping pain, detumescence and promoting granulation, skin infection carbuncle and the dermatosis etc. of being used for.
Astragalus QI invigorating class medicine has the effect of invigorating QI to consolidate the body surface resistance, diuresis, poison holding, evacuation of pus, expelling pus and promoting granulation, clinical weak, the anorexia and loose stool of the deficiency of vital energy that is used for, carbuncle is difficult bursts, burst for a long time do not hold back, interior-heat is quenched one's thirst etc., external can be improved looks.
Glycyrrhiza invigorating the spleen and benefiting QI class medicine has coordinating the actions of various ingredients in a prescription, separates the effect of hundred poison of drug, and the poisoning due to some drugs, food, interior metabolism product and the bacteriotoxin is all had certain Detoxication; Modern study: Radix Glycyrrhizae has adrenocortical hormone sample function, coordinates substance metabolism, and enhancing body is to the adaptive capacity of adverse circumstances, and has effects such as antiulcer, antiinflammatory, antitumor, antitussive, blood fat reducing; Oral administration, but also external.
Sulfur belongs to the detoxifcation parasite killing, and dampness removing to stop itchin class medicine has the detoxifcation killing parasites for relieving itching, mends the effect of fiery supporing yang relieving constipation, also has the eliminating carbuncle eliminating stagnation, receives skin ulcer and holds back mouth, softening epidermis, the effect of dissolving cutin.
Application contains Chinese medicine Radix Arnebiae (Radix Lithospermi), Herba Violae, Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, Myrrha, the Radix Astragali, Radix Glycyrrhizae and sulfur and antibiotics enoxacin, ciprofloxacin, lincomycin and clindamycin are known as the compositions of active component, but with Chinese medicine Radix Arnebiae (Radix Lithospermi), Herba Violae, Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, Myrrha, the Radix Astragali, Radix Glycyrrhizae and sulfur and antibiotics enoxacin, ciprofloxacin, lincomycin and clindamycin compatibility are not reported as yet as the compositions of treatment acne.
The key factor of acne morbidity is that androgen and smegma are hyperfunction, abnormal cornification of pilosebaceous duct, the effect of the multiple quasi-microorganism of pilosebaceous unit and inflammation and host's immunoreation, struvite skin lesion such as pustule, pimple, tuberosity, acne and cyst occur, skin lesion mostly occurs at positions such as face, breast, the back ofs the body, brings the misery of the spirit and the human body to the patient, and obstinate, outbreak influences patient's routine work, studying and living repeatedly.
The medicine of current treatment acne or cosmetics kind are a lot, but all have unsatisfactory part in various degree, and be long as the course of treatment, cure rate is low, relapse rate is high and expense is all very expensive.
Three, summary of the invention:
In order to overcome the shortcoming and defect of existing Retinoids, Retin-A, Renova, Accutane, the invention provides a kind of compositions, said composition is burst by Chinese medicine Radix Arnebiae (Radix Lithospermi) treatment carbuncle sore and is not closed up various dermatosis secondary infection; Herba Violae treatment furuncle and skin infection; Radix Et Rhizoma Rhei clearing away heat-fire, activating blood and removing stasis, detoxifcation, hemostasis, anti-, antibacterial and estrogen-like effects; Rhizoma Coptidis is kind controls furunculosis and broad-spectrum antiseptic, antiinflammatory, antiulcer effect; The Radix Angelicae Dahuricae induce sweat diffusing wind, understand things pain-stopping, dampness leukorrhagia stopping, detumescence and apocenosis, broken stagnated blood is changed and is lost pus, goes the effect of face defect scar; Myrrha blood fat reducing, convergence, antiinflammatory, analgesia, antibiotic, promoting blood circulation and stopping pain, detumescence and promoting granulation, control effects such as skin infection carbuncle; Radix Astragali invigorating QI to consolidate the body surface resistance, poison holding, evacuation of pus, expelling pus and promoting granulation, treatment carbuncle difficulty are burst, and burst for a long time and do not hold back, also have beautification function; More have Radix Glycyrrhizae to play coordinating the actions of various ingredients in a prescription, separate hundred poison of drug, separate metabolism toxin and bacteriotoxic effect, its adrenocortical hormone sample function works to promote the performance drug effect to other medicines, and antagonism can not occur; Sulfur eliminating carbuncle eliminating stagnation, receipts skin ulcer are held back mouth, softening epidermis, the effect of dissolving cutin; Enoxacin, ciprofloxacin, effects such as lincomycin and clindamycin treatment soft tissue infection; Cooperative compensating treatment acne.
Because the result of broad research, the inventor has found the novel combination of Radix Arnebiae (Radix Lithospermi), Herba Violae, Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, Myrrha, the Radix Astragali, Radix Glycyrrhizae and sulfur and antibiotics ciprofloxacin or clindamycin, this novel tissue has synergism for the treatment acne, this synergism makes all medicines give full play to effect, shortened the course of treatment, cure rate improves, relapse rate descends, have cosmetic result concurrently, be convenient to clinical using, have no side effect, wherein antibiotics is selected from enoxacin, ciprofloxacin, lincomycin and clindamycin.
The invention provides the pharmaceutical composition that is used for the treatment of acne, it comprises Radix Arnebiae (Radix Lithospermi), Herba Violae, Radix Et Rhizoma Rhei, Rhizoma Coptidis, the Radix Angelicae Dahuricae, Myrrha, the Radix Astragali, Radix Glycyrrhizae and sulfur as active princlple, respectively distinguishing the flavor of in the compositions, each medical material market is all available at home for Chinese crude drug, and its extract has the professional production manufacturer production.
The present invention respectively distinguishes the flavor of Chinese medicine can be with its extract as raw material, by the present invention's Chinese medicine extract effective dose of respectively distinguishing the flavor of, in whole crude drug is by weight ratio: Radix Arnebiae (Radix Lithospermi): 15-50g; Herba Violae: 20-60g; Radix Et Rhizoma Rhei: 20-60g; Rhizoma Coptidis: 5-30g; The Radix Angelicae Dahuricae: 20-50g; Myrrha: 15-50g; The Radix Astragali: 20-50g; Radix Glycyrrhizae: 20-50g; Sulfur: 2-12g; Antibiotics is by weight ratio: enoxacin: 0.3-3g; Ciprofloxacin: 0.1-3g; Lincomycin: 0.2-5g; Clindamycin: 0.1-3g.
Compositions of the present invention can be pressed the dispenser of series preparation form, for example: inuncts, powder, lotion, unguentum sticks agent, powder, tablet mixes and prepares with known drug carrier, adjuvant and additive, is prepared by usual way.
Advantage of the present invention is, compositions has significant effect to the treatment acne, and the compositions each component has good synergism, rapid-action, short treating period, cost of drugs is low, cure rate is high, and relapse rate is low, have cosmetic result, no incompatibility concurrently, have no adverse reaction and toxic and side effects sufficient raw.
Be described in further detail the present invention below by reference example:
The stasis of blood that following embodiment gets rid of in the sebaceous gland with physical method earlier before dispenser is amassed thing, the hydrogen peroxide debridement of reuse pharmacopeia normal concentration.
Embodiment 1: prescription: (by whole crude drug)
Radix Arnebiae (Radix Lithospermi): 25g; Herba Violae: 35g;
Radix Et Rhizoma Rhei: 30g; Rhizoma Coptidis: 15g;
The Radix Angelicae Dahuricae: 25g; Myrrha: 30g;
The Radix Astragali: 30g; Radix Glycyrrhizae: 30g.
Each medicine of prescription is morcelled mixing be immersed among the 75% ethanol 500ml, soak 7 days after-filtration, make tincture, wipe the affected part every day outward 3 times, general 7 days produce effects can be cured in 20 days.
Embodiment 2: prescription: (by whole crude drug)
Radix Arnebiae (Radix Lithospermi): 25g; Herba Violae: 35g;
Radix Et Rhizoma Rhei: 30g; Rhizoma Coptidis: 15g;
The Radix Angelicae Dahuricae: 25g; Myrrha: 30g;
The Radix Astragali: 30g; Radix Glycyrrhizae: 30g;
Sulfur: 8g.
Each medicine of prescription is standby after purifying, use Shi Jiawu times of weight portion eliminating cold for resuscitation water, sterile gauze is immersed in the liquid medicine, the gauze that will soak liquid medicine again sticks on affected part, and each 20-30 minute, every day 3 times.
Compositions of the present invention is used checking through over one hundred example, effective percentage 100%, and cure rate is more than 95%.
Embodiment 3: it is made with following bulk drugs:
Radix Arnebiae (Radix Lithospermi): 25g; Herba Violae: 35g;
Radix Et Rhizoma Rhei: 30g; Rhizoma Coptidis: 15g;
The Radix Angelicae Dahuricae: 25g; Myrrha: 30g;
The Radix Astragali: 30g; Radix Glycyrrhizae: 30g.
Above medicine adds clindamycin 1g after purifying, Mel is an amount of, makes unguentum, and when using, on disease damage face, every day, affected part of exterior coating was 3 times with paste application, and general 5 days produce effects can be cured in 15 days.
Embodiment 4: it is made with following bulk drugs:
Radix Arnebiae (Radix Lithospermi): 25g; Herba Violae: 35g;
Radix Et Rhizoma Rhei: 30g; Rhizoma Coptidis: 15g;
The Radix Angelicae Dahuricae: 25g; Myrrha: 30g;
The Radix Astragali: 30g; Radix Glycyrrhizae: 30g.
Sulfur: 8g.
Above medicine adds ciprofloxacin 1.5g after purifying, Mel is an amount of, makes unguentum, and when using, on disease damage face, every day, affected part of exterior coating was 3 times with paste application, and general 5 days produce effects can be cured in 15 days.Compositions of the present invention is used checking through over one hundred example, effective percentage 100%, and cure rate is more than 95%.
Claims (4)
1, a kind of pharmaceutical composition that is used for the treatment of acne is characterized in that, it is pressed column weight amount proportioning by following bulk drugs and makes:
Radix Arnebiae (Radix Lithospermi) 15-50g; Herba Violae 20-60g;
Radix Et Rhizoma Rhei 20-60g; Rhizoma Coptidis 5-30g;
Radix Angelicae Dahuricae 20-50g; Myrrha 15-50g;
Radix Astragali 20-50g; Radix Glycyrrhizae 20-50g;
Antibiotic 0-5g;
Wherein antibiotic is selected from enoxacin, ciprofloxacin, lincomycin and clindamycin.
2, a kind of pharmaceutical composition that is used for the treatment of acne is characterized in that, it is pressed column weight amount proportioning by following bulk drugs and makes:
Radix Arnebiae (Radix Lithospermi) 15-50g; Herba Violae 20-60g;
Radix Et Rhizoma Rhei 20-60g; Rhizoma Coptidis 5-30g;
Radix Angelicae Dahuricae 20-50g; Myrrha 15-50g;
Radix Astragali 20-50g; Radix Glycyrrhizae 20-50g;
Sulfur 2-12g; Antibiotic 0-5g;
Wherein antibiotic is selected from enoxacin, ciprofloxacin, lincomycin and clindamycin.
3, the pharmaceutical composition that is used for the treatment of acne according to claim 1 and 2 is characterized in that, described antibiotic weight proportion is:
(1) enoxacin: 0.3-3g;
(2) ciprofloxacin: 0.1-3g;
(3) lincomycin: 0.2-5g;
(4) clindamycin: 0.1-3g.
4, the pharmaceutical composition that is used for the treatment of acne according to claim 1 and 2, it is characterized in that: it is inuncts, or powder, or lotion, or unguentum, or sticks agent, or powder, or tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610144320A CN100584365C (en) | 2006-12-01 | 2006-12-01 | Pharmaceutical composition for treating acne |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610144320A CN100584365C (en) | 2006-12-01 | 2006-12-01 | Pharmaceutical composition for treating acne |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1970024A CN1970024A (en) | 2007-05-30 |
| CN100584365C true CN100584365C (en) | 2010-01-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200610144320A Expired - Fee Related CN100584365C (en) | 2006-12-01 | 2006-12-01 | Pharmaceutical composition for treating acne |
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| Country | Link |
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| CN (1) | CN100584365C (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1356108A (en) * | 2000-12-08 | 2002-07-03 | 王宗宽 | Medicine for treating acne and its preparing process |
| CN1739638A (en) * | 2005-08-31 | 2006-03-01 | 赵运荣 | Medicine for treating dermatosis and its prepn |
| CN1297751C (en) * | 1999-09-24 | 2007-01-31 | 松下电器产业株式会社 | Impeller for fun, fun therewith and air conditioner with the fun |
-
2006
- 2006-12-01 CN CN200610144320A patent/CN100584365C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1297751C (en) * | 1999-09-24 | 2007-01-31 | 松下电器产业株式会社 | Impeller for fun, fun therewith and air conditioner with the fun |
| CN1356108A (en) * | 2000-12-08 | 2002-07-03 | 王宗宽 | Medicine for treating acne and its preparing process |
| CN1739638A (en) * | 2005-08-31 | 2006-03-01 | 赵运荣 | Medicine for treating dermatosis and its prepn |
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| Publication number | Publication date |
|---|---|
| CN1970024A (en) | 2007-05-30 |
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| SE01 | Entry into force of request for substantive examination | ||
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Granted publication date: 20100127 Termination date: 20101201 |