CN100584359C - Medicine for treating fatness and its complication - Google Patents
Medicine for treating fatness and its complication Download PDFInfo
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- CN100584359C CN100584359C CN200610069655A CN200610069655A CN100584359C CN 100584359 C CN100584359 C CN 100584359C CN 200610069655 A CN200610069655 A CN 200610069655A CN 200610069655 A CN200610069655 A CN 200610069655A CN 100584359 C CN100584359 C CN 100584359C
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Abstract
The present invention belongs to a medicine technology field and discloses a medicine for obesity with hypertension and hyperlipidemia diseases and the preparation method thereof. The medicine is mainly made up of Semen Cassiae, chrysanthemum, Salvia miltiorrhiza and hawthorn according to certain weight ratio. The medicine can be made into any acceptable dosage form on clinic or pharmacy and an oral dosage form is in priority. The medicine has the effects of calming liver, resting wind, clearing heat, activating blood, dredging collaterals and reducing blood lipid; the medicine is applied to obesity with hypertension and hyperlipidemia diseases.
Description
1, technical field
The invention belongs to medical technical field, be specifically related to a kind of medicine that is used for fat accompanied with hypertension, hyperlipidemia and preparation method thereof.
2, background technology
Along with the raising of people's living standard, obese people is on the increase, and it is attractive in appearance that obesity has not only influenced human body, and can also cause diseases such as hypertension, hyperlipidemia, diabetes, coronary heart disease, and human body health is brought very big threat.The hypertension that obesity is often followed, hyperlipidemia are common clinicals, and both are closely related.A large amount of research datas show that many hypertensive patients are with lipid metabolic disorder, and the content of blood cholesterol and triglyceride significantly increases than the normal person, and high density lipoprotein, cholesterol level are then lower.On the other hand, the also normal complicated hypertension of many hyperlipemias, both are cause effect relation.Hypertension mainly is by liver, the heart, kidney, imbalance of YIN and YANG, wind, fire, expectorant and interact due to.Therefore, except that suppressing the hyperactive liver and subsiding YANG, vital energy regualting and blood circulation-promoting, heat clearing away blood stasis dispelling are the hypertensive effective ways of treatment.Hyperlipidemia can cause that blood " glues " " thick " " stasis of blood " phenomenon that " stagnates ", in the course of time, lumen of vessels is narrowed down, and thrombosis causes apoplexy, hemiplegia, myocardial infarction, cerebral infarction when serious.Both play an important role in arteriosclerosis, coronary heart disease, pathogenic mechanism of obesity, have caused people's common concern.Cardiovascular and cerebrovascular disease has become first killer of harm health of people in China, and hypertension, hyperlipidemia are the main inducing of cardiovascular and cerebrovascular disease, and therefore, the blood fat-reducing blood pressure-decreasing medicine of development determined curative effect becomes the task of top priority of control cardiovascular and cerebrovascular disease.
The chemical antihypertensive fat-reducing medicament is taken for a long time and is had side effect on the market, and costs an arm and a leg, and has increased the weight of patient's financial burden.The Chinese patent medicine kind is various, but big multimass is stable inadequately, and effect is not ideal enough.
Semen Cassiae is the dry mature seed of leguminous plant Semen Cassiae Cassia obtusifolia L. or little Semen Cassiae Cassia tora L..Sweet in the mouth, hardship, salty, cold nature.Return liver, large intestine channel.The effect that clearing away heat to improve acuity of vision is arranged.Be used for the puckery pain of conjunctival congestion, the many tears of photophobia, it is dizzy to have a headache, poor vision.
Flos Chrysanthemi is the dry capitulum of feverfew chrysanthemum Chrysanthemum morifolium Ramat..Sweet in the mouth, hardship, cold nature.Return lung, Liver Channel.Diffusing wind heat clearing away is arranged, the effect that suppressing the hyperactive liver makes eye bright.Be used for anemopyretic cold, it is dizzy to have a headache, conjunctival congestion and swelling pain, and eyes is dim-sighted.
Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia miltiorrhiza Bge..Bitter in the mouth, cold nature.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing is arranged, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire.Be used for menoxenia, amenorrhea dysmenorrhea ， WEIJIA is gathered, breast ventral spine pain, and pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Fructus Crataegi is the dry mature fruit of plant Fructus Pyri Pashiae Crataeguspinnatifida Bge.var.major N.E.Br. of the little section of rose or Fructus Crataegi Crataeguspinnatifida Bge..Sour in the mouth, sweet, slightly warm in nature.Return spleen, stomach, Liver Channel.Promoting digestion and invigorating the stomach is arranged, the effect of circulation of qi promoting dissipating blood stasis.Be used for meat stagnation, gastral cavilty distension, dysentery stomachache, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.
At present, utilize the interaction of Semen Cassiae, Flos Chrysanthemi, Radix Salviae Miltiorrhizae and Fructus Crataegi, composition of prescription is used to prepare the medicine for the treatment of fat accompanied with hypertension, hyperlipidemia, does not appear in the newspapers as yet.
3, summary of the invention
In order to meet clinical needs, enlarge medicine variety, the invention provides medicine of a kind of prescription science, the fat accompanied with hypertension of preparation treatment simple, determined curative effect, hyperlipidemia and preparation method thereof.
It is the important pathogenesis that fat accompanied with hypertension, hyperlipidemia form that imbalance of YIN and YANG, phlegm-damp are stopped up Sheng, and pathological changes is liver.Semen Cassiae liver heat removing and eyesight improving in the medicine of the present invention, Flos Chrysanthemi dispelling wind and heat pathogens, suppressing the hyperactive liver make eye bright, heat-clearing and toxic substances removing, and the principal agent of both sides of being has direct decompression lipid-lowering effect; Radix Salviae Miltiorrhizae promoting blood flow to regulate menstruation, removing heat from blood eliminating carbuncle, hawthorn digesting eliminate indigestion, circulation of qi promoting dissipating blood stasis, both blood-activating and qi-promoting blood stasis dispellings, auxiliary principal agent amounts to the curative effect of falling fat accompanied with hypertension, hyperlipidemia.
The consumption of each crude drug of medicine of the present invention is that the inventor sums up out through a large amount of groping, and each crude drug consumption all has curative effect preferably in the following portions by weight scope:
10～50 parts of Semen Cassiaes, 5～25 parts of Flos Chrysanthemis, 10～50 parts of Radix Salviae Miltiorrhizaes, 5～25 parts of Fructus Crataegis.
The parts by weight of each crude drug of medicine of the present invention are preferably:
20～40 parts of Semen Cassiaes, 10～20 parts of Flos Chrysanthemis, 20～40 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Fructus Crataegis.
The optimum weight umber of each crude drug of medicine of the present invention is:
30 parts of Semen Cassiaes, 15 parts of Flos Chrysanthemis, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of Fructus Crataegis.
The crude drug of medicine of the present invention is by weight as proportioning, can increase or reduce according to corresponding proportion when producing, and can kilogram be unit as large-scale production, or be unit with the ton that small-scale production also can restrain and be unit, and weight can increase or reduce.The weight proportion of medicine material medicine of the present invention obtains through science screening, and for especial patient, the ratio of can corresponding adjustment forming increases or reduce being no more than 100%.
Said medicine can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional formulation.For example, these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Also these crude drug decocting together can be taken decocting liquid; Better bring into play drug effect for each crude drug that makes this medicine, the invention provides following selection process, but these can not limit protection scope of the present invention.
The preparation method of medicine activity component of the present invention may further comprise the steps:
1) take by weighing Semen Cassiae, Flos Chrysanthemi, Radix Salviae Miltiorrhizae, the Fructus Crataegi of described parts by weight, standby;
2) Radix Salviae Miltiorrhizae, the Semen Cassiae that weighs up added alcohol reflux, the extracting solution decompression recycling ethanol is not to there being the alcohol flavor, and heating is concentrated into thick paste;
3) Flos Chrysanthemi, the Fructus Crataegi that weighs up decocted with water, filter, filtrate is concentrated into finite concentration, precipitate with ethanol, and cold preservation filters, and decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized, and gets the active component of medicine of the present invention.
Manufacturing method for above mentioned medicine, preferred steps is:
1) take by weighing Semen Cassiae, Flos Chrysanthemi, Radix Salviae Miltiorrhizae, the Fructus Crataegi of described parts by weight, standby;
2) Radix Salviae Miltiorrhizae, the Semen Cassiae that weighs up added 70% alcohol reflux secondary, add 8 times of amounts of alcohol for the first time, refluxed 2 hours, add 6 times of amounts of alcohol for the second time, refluxed 1 hour, merge extractive liquid, filters, and decompression filtrate recycling ethanol is to not having the alcohol flavor and being concentrated into thick paste;
3) Flos Chrysanthemi, the Fructus Crataegi that weighs up decocted with water secondary, amount of water is 8 times of amounts, decocted 3 hours for the first time, decocted collecting decoction 2 hours for the second time, filter, it is 1.10～1.15 that filtrate is concentrated into relative density, and adding ethanol is 60% precipitate with ethanol to containing the alcohol amount, and cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized, and gets the active component of medicine of the present invention.
Medicine of the present invention has the effect of suppressing the hyperactive liver to relieve the wind syndrome heat clearing away, promoting blood circulation to remove obstruction in the collateral blood fat reducing, is applicable to that obesity is with hyperlipidemia, hyperpietic.
The active component of medicine of the present invention can add various conventional adjuvant required when preparing different dosage form, be prepared into clinically any or pharmaceutically acceptable dosage form as diluent, excipient, filler, binding agent, wetting agent, disintegrating agent, absorption enhancer, surfactant, absorption carrier, lubricant etc. with the method for Chinese medicinal of routine, the preferred oral dosage form is as tablet, capsule, soft capsule, dispersible tablet, chewable tablet, oral cavity disintegration tablet, oral liquid, granule, drop pill, slow releasing tablet, slow releasing capsule, controlled release tablet, controlled release capsule etc.
Medicine of the present invention is when making oral formulations, and selectable filler has: starch, Icing Sugar, calcium phosphate, calcium sulfate two water things, dextrin, microcrystalline Cellulose, lactose, pregelatinized Starch, mannitol etc.; Selectable binding agent has: sodium carboxymethyl cellulose, PVP-K30, hydroxypropyl cellulose, starch slurry, methylcellulose, ethyl cellulose, hypromellose, gelling starch etc.; Selectable disintegrating agent has: dried starch, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose etc.; Selectable lubricant has: magnesium stearate, Pulvis Talci, sodium lauryl sulphate, micropowder silica gel etc.
The advantage of medicine of the present invention is:
(1) provides a kind of medicine that is used for the treatment of fat accompanied with hypertension, hyperlipidemia, increased the clinical application kind, satisfied clinical needs.
(2) pharmacological evaluation shows, medicine of the present invention can significantly reduce body weight, Lee ' s index, fat coefficient and the blood pressure of fat hypertension, hyperlipemia rat, show, the medicine of making by Semen Cassiae, Flos Chrysanthemi, Radix Salviae Miltiorrhizae and Fructus Crataegi, be used for the treatment of fat accompanied with hypertension, hyperlipidemia, drug effect is remarkable, and consequently those skilled in the art institute is beyond thought.
(3) the present invention can be made into various oral formulations, also can be directly used in decoction.
(4) pharmaceutical preparation of the present invention is simple, and mass discrepancy is little between the different batches medicine, and drug quality is uniform and stable.
Below routine by experiment beneficial effect of further setting forth the medicine of making by Semen Cassiae, Flos Chrysanthemi, Radix Salviae Miltiorrhizae and Fructus Crataegi.
Experimental example: medicine of the present invention is to the effect of constitutional obese rat Weight-lossing antihypertensive, blood fat reducing
Laboratory animal and grouping: 6 ages in week, male original hypertensive rat was 38, and body weight 140～160g is divided into two groups at random: 6 of normal diet groups (general food group); 32 of nutrient fodder groups.Two groups of equal free diet are taken the photograph water.After 90 days (modeling phases), body weight is the hypertensive obesity rat model above the rat of general food group average weight 20% in the nutrient fodder group.
Filter out the rat of 20 modeling successes, it is divided into four groups at random: model group, the basic, normal, high dosage group of medicine of the present invention.
The feedstuff preparation:
Normal diet: experimental mouse complete feed;
Nutrient fodder: normal diet 60%, Adeps Sus domestica 12%, sucrose 5%, milk powder 5%, Semen arachidis hypogaeae 5%, egg 10%, Oleum Sesami 1%, Sal 2%.
Experimental drug and reagent:
Medicine of the present invention: according to the granule of making by Semen Cassiae, Flos Chrysanthemi, Radix Salviae Miltiorrhizae and Fructus Crataegi of the preparation method under the embodiment 3 preparation.
Experimental technique: medicine of the present invention is irritated stomach, and every day 1 time, dosage sees the following form.
Sample preparations: rat fasting 12h, lumbar injection 3% pentobarbital sodium (0.15ml/100g body weight) anesthesia, postcava is got blood, under the room temperature with the centrifugal 10min of 3500r/min, separation of serum; Get its ventral aorta distal end and fix paraffin embedding, section, HE dyeing with 0.2% glutaraldehyde, 4% paraformaldehyde, PBS dilution fixative; Open rat abdominal cavity and take out the peritoneum posterior fat pad, inhale the tissue fluid of going to the surface with filter paper.
Observation index:
1. Lee ' s index: electronic balance is regularly weighed, and measures the length of rat nose to anus simultaneously.Calculate Lee ' s index [body weight (g) 1/3 * 103/ height (cm)];
2. blood pressure: regularly measure the rat systolic pressure with RBP-1 type rat blood pressure instrument, 1 time weekly;
3. fat coefficient: claim weight in wet base with getting fat pad, calculate fat coefficient [fat pad weight (g)/body weight (g) * 100%];
4. blood fat: adopt automatic biochemistry analyzer to measure TC, TG, HDL-C, LDL-C;
Statistical method: measurement data is all with mean (x) ± standard deviation (s) expression.
Experimental result
1. relatively see Table 1 between exponential group of body weight and Lee ' s.
The body weight of model group and Lee ' s index all obviously raise (p＜0.05, p＜0.01) with respect to general food group, and the modeling success is described;
Each dosage group treatment back body weight of medicine of the present invention and Lee ' s index significantly reduce (p＜0.05, p＜0.01) with respect to model group; The height of the middle and high dosage group of the present invention is with respect to model group obviously raise (p＜0.05).
Table 1 different group body weight height and the exponential comparison of Lee ' s
Annotate:
#P＜0.05,
##Compare with general food group p＜0.01;
*P＜0.05,
*Compare with model group p＜0.01.
2. relatively see Table 2 between the group of abdominal cavity fat and fatty percent.
Table 2 is respectively organized the comparison (x ± s) of abdominal cavity fat and fat coefficient
Annotate:
#P＜0.05,
##Compare with general food group p＜0.01;
*P＜0.05,
*P＜0.01,
* *Compare with model group p＜0.001.
The abdominal cavity fat of model group and fat content in abdominal cavity are significantly higher than general food group (p＜0.01, p＜0.05);
Each dosage group treatment pneumoretroperitoneum fat of medicine of the present invention and fat content in abdominal cavity all significantly reduce (p＜0.05, p＜0.01, p＜0.001) with respect to model group.
3. respectively organize the variation of blood pressure in the experimentation
Respectively organize comparison (mmHg, the x ± s) of blood pressure before and after table 3 treatment
Annotate:
##Compare with general food group p＜0.01;
*Compare with model group p＜0.01.
Compare between the group of blood pressure: blood pressure does not have tangible difference (p＞0.05) before the obese rat treatment; The blood pressure of model group is significantly higher than general food group (p＜0.01); Blood pressure after each dosage group treatment of medicine of the present invention significantly reduces (p＜0.01) than model group.
4. compare between the group of blood fat
By table 4 as seen, cholesterol (TC): model group TC compares with general food group TC and significantly improves (p＜0.01); Each dosage group TC of medicine of the present invention compares with model group TC and all significantly reduces (p＜0.01).
Cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C): do not have significant difference (p＞0.05) statistically between each group.
Triglyceride (TG): model group TG compares with general food group TG and significantly improves (p＜0.01); Each dosage group TG of medicine of the present invention compares obvious reduction (p＜0.05, p＜0.01) with model group TG.
Table 4 is respectively organized comparison (mmol/L, the x ± s) of blood fat
Annotate:
##Compare with general food group p＜0.01;
*P＜0.05,
*Compare with model group p＜0.01.
Conclusion: as seen by above result, medicine of the present invention is at the body weight that has reduced fat hypertension, hyperlipemia rat in varying degrees, Lee ' s index, fat coefficient and blood pressure, show that medicine of the present invention has good blood pressure lowering, effect for reducing blood fat, fat-reducing effect is obvious.
4, the specific embodiment
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.But this should be interpreted as that the scope of the above-mentioned theme of the present invention only limits to following embodiment.All technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
Embodiment 1: the preparation of medicinal tablet of the present invention
Semen Cassiae 600g Flos Chrysanthemi 300g Radix Salviae Miltiorrhizae 600g Fructus Crataegi 300g
1) take by weighing Semen Cassiae, Flos Chrysanthemi, Radix Salviae Miltiorrhizae, the Fructus Crataegi of parts by weight, standby;
2) Radix Salviae Miltiorrhizae, the Semen Cassiae that weighs up added 70% alcohol reflux secondary, add 8 times of amounts of alcohol for the first time, refluxed 2 hours, add 6 times of amounts of alcohol for the second time, refluxed 1 hour, merge extractive liquid, filters, and decompression filtrate recycling ethanol is to not having the alcohol flavor and being concentrated into thick paste;
3) Flos Chrysanthemi, the Fructus Crataegi that weighs up decocted with water secondary, amount of water is 8 times of amounts, decocted 3 hours for the first time, decocted collecting decoction 2 hours for the second time, filter, it is 1.10～1.15 that filtrate is concentrated into relative density, and adding ethanol is 60% precipitate with ethanol to containing the alcohol amount, and cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized, and adds binding agent, disintegrating agent and lubricant and makes granule, and drying is pressed into 1000.
Embodiment 2: the preparation of medicine capsule of the present invention
Semen Cassiae 600g Flos Chrysanthemi 300g Radix Salviae Miltiorrhizae 600g Fructus Crataegi 300g
1) take by weighing Semen Cassiae, Flos Chrysanthemi, Radix Salviae Miltiorrhizae, the Fructus Crataegi of parts by weight, standby;
2) Radix Salviae Miltiorrhizae, the Semen Cassiae that weighs up added 70% alcohol reflux secondary, add 8 times of amounts of alcohol for the first time, refluxed 2 hours, add 6 times of amounts of alcohol for the second time, refluxed 1 hour, merge extractive liquid, filters, and decompression filtrate recycling ethanol is to not having the alcohol flavor and being concentrated into thick paste;
3) Flos Chrysanthemi, the Fructus Crataegi that weighs up decocted with water secondary, amount of water is 8 times of amounts, decocted 3 hours for the first time, decocted collecting decoction 2 hours for the second time, filter, it is 1.10～1.15 that filtrate is concentrated into relative density, and adding ethanol is 60% precipitate with ethanol to containing the alcohol amount, and cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized, and adds binding agent and makes granule, and drying is dressed up 1000 hard capsules.
Embodiment 3: the preparation of medicinal granule of the present invention
Semen Cassiae 600g Flos Chrysanthemi 300g Radix Salviae Miltiorrhizae 600g Fructus Crataegi 300g
1) take by weighing Semen Cassiae, Flos Chrysanthemi, Radix Salviae Miltiorrhizae, the Fructus Crataegi of parts by weight, standby;
2) Radix Salviae Miltiorrhizae, the Semen Cassiae that weighs up added 70% alcohol reflux secondary, add 8 times of amounts of alcohol for the first time, refluxed 2 hours, add 6 times of amounts of alcohol for the second time, refluxed 1 hour, merge extractive liquid, filters, and decompression filtrate recycling ethanol is to not having the alcohol flavor and being concentrated into thick paste;
3) Flos Chrysanthemi, the Fructus Crataegi that weighs up decocted with water secondary, amount of water is 8 times of amounts, decocted 3 hours for the first time, decocted collecting decoction 2 hours for the second time, filter, it is 1.10～1.15 that filtrate is concentrated into relative density, and adding ethanol is 60% precipitate with ethanol to containing the alcohol amount, and cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized, and adding Icing Sugar, binding agent are made 1000 bag granules.
Embodiment 4: the preparation of medicinal soft capsule of the present invention
Semen Cassiae 450g Flos Chrysanthemi 225g Radix Salviae Miltiorrhizae 450g Fructus Crataegi 225g
1) take by weighing Semen Cassiae, Flos Chrysanthemi, Radix Salviae Miltiorrhizae, the Fructus Crataegi of parts by weight, standby;
2) Radix Salviae Miltiorrhizae, the Semen Cassiae that weighs up added 70% alcohol reflux secondary, add 8 times of amounts of alcohol for the first time, refluxed 2 hours, add 6 times of amounts of alcohol for the second time, refluxed 1 hour, merge extractive liquid, filters, and decompression filtrate recycling ethanol is to not having the alcohol flavor and being concentrated into thick paste;
3) Flos Chrysanthemi, the Fructus Crataegi that weighs up decocted with water secondary, amount of water is 8 times of amounts, decocted 3 hours for the first time, decocted collecting decoction 2 hours for the second time, filter, it is 1.10～1.15 that filtrate is concentrated into relative density, and adding ethanol is 60% precipitate with ethanol to containing the alcohol amount, and cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized, medicated powder, with soybean oil and soybean phospholipid, Cera Flava heating and melting, mixing is put coldly, adds medicated powder, is pressed into 1000 soft capsules.
Embodiment 5: the preparation of medicinal dropping ball of the present invention
Semen Cassiae 450g Flos Chrysanthemi 225g Radix Salviae Miltiorrhizae 450g Fructus Crataegi 225g
1) take by weighing Semen Cassiae, Flos Chrysanthemi, Radix Salviae Miltiorrhizae, the Fructus Crataegi of parts by weight, standby;
2) Radix Salviae Miltiorrhizae, the Semen Cassiae that weighs up added 70% alcohol reflux secondary, add 8 times of amounts of alcohol for the first time, refluxed 2 hours, add 6 times of amounts of alcohol for the second time, refluxed 1 hour, merge extractive liquid, filters, and decompression filtrate recycling ethanol is to not having the alcohol flavor and being concentrated into thick paste;
3) Flos Chrysanthemi, the Fructus Crataegi that weighs up decocted with water secondary, amount of water is 8 times of amounts, decocted 3 hours for the first time, decocted collecting decoction 2 hours for the second time, filter, it is 1.10～1.15 that filtrate is concentrated into relative density, and adding ethanol is 60% precipitate with ethanol to containing the alcohol amount, and cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized, medicated powder, with polyethylene glycol 6000 heating and melting in water-bath, treat to add medicated powder after whole fusions, stirring and dissolving, 60 mesh sieves filter, and keep 60 ℃ to splash in the liquid paraffin that is chilled to below 10 ℃ and make ball.
Claims (7)
1. a medicine that is used for fat accompanied with hypertension, hyperlipidemia is characterized in that, this medicine is made by the crude drug of following parts by weight: 10～50 parts of Semen Cassiaes, 5～25 parts of Flos Chrysanthemis, 10～50 parts of Radix Salviae Miltiorrhizaes, 5～25 parts of Fructus Crataegis.
2. medicine according to claim 1 is characterized in that, the parts by weight of each crude drug are: 20～40 parts of Semen Cassiaes, 10～20 parts of Flos Chrysanthemis, 20～40 parts of Radix Salviae Miltiorrhizaes, 10～20 parts of Fructus Crataegis.
3. medicine according to claim 2 is characterized in that, the parts by weight of each crude drug are: 30 parts of Semen Cassiaes, 15 parts of Flos Chrysanthemis, 30 parts of Radix Salviae Miltiorrhizaes, 15 parts of Fructus Crataegis.
4. the preparation method of the described arbitrary medicine of claim 1～3 may further comprise the steps:
1) take by weighing Semen Cassiae, Flos Chrysanthemi, Radix Salviae Miltiorrhizae, the Fructus Crataegi of described parts by weight, standby;
2) Radix Salviae Miltiorrhizae, the Semen Cassiae that weighs up added alcohol reflux, the extracting solution decompression recycling ethanol is not to there being the alcohol flavor, and heating is concentrated into thick paste;
3) Flos Chrysanthemi, the Fructus Crataegi that weighs up decocted with water, filter, filtrate is concentrated into finite concentration, precipitate with ethanol, and cold preservation filters, and decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized, and gets the active component of medicine.
5. the preparation method of medicine according to claim 4 may further comprise the steps:
1) take by weighing Semen Cassiae, Flos Chrysanthemi, Radix Salviae Miltiorrhizae, the Fructus Crataegi of described parts by weight, standby;
2) Radix Salviae Miltiorrhizae, the Semen Cassiae that weighs up added 70% alcohol reflux secondary, add 8 times of amounts of alcohol for the first time, refluxed 2 hours, add 6 times of amounts of alcohol for the second time, refluxed 1 hour, merge extractive liquid, filters, and decompression filtrate recycling ethanol is to not having the alcohol flavor and being concentrated into thick paste;
3) Flos Chrysanthemi, the Fructus Crataegi that weighs up decocted with water secondary, amount of water is 8 times of amounts, decocted 3 hours for the first time, decocted collecting decoction 2 hours for the second time, filter, it is 1.10～1.15 that filtrate is concentrated into relative density, and adding ethanol is 60% precipitate with ethanol to containing the alcohol amount, and cold preservation was left standstill 24 hours, filter, decompression filtrate recycling ethanol also is concentrated into thick paste;
4) merge two kinds of thick pastes, oven dry is pulverized, and gets the active component of medicine.
6. according to the described arbitrary medicine of claim 1～3, it is characterized in that this medicine can be made clinically any or pharmaceutically acceptable dosage form with mixing acceptable accessories.
7. medicine according to claim 6 is characterized in that this medicine can be made oral formulations with mixing acceptable accessories.
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| CN200610069655A CN100584359C (en) | 2006-08-04 | 2006-08-04 | Medicine for treating fatness and its complication |
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| CN200610069655A CN100584359C (en) | 2006-08-04 | 2006-08-04 | Medicine for treating fatness and its complication |
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| CN100584359C true CN100584359C (en) | 2010-01-27 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006837B (en) * | 2012-12-27 | 2014-03-26 | 天津凯镛药业有限公司 | Composition for reducing blood fat |
| CN107569558A (en) * | 2016-12-27 | 2018-01-12 | 鲁南制药集团股份有限公司 | New application of Yin Zhi Huang Chinese medicine composition and preparation method thereof |
| CN110870898A (en) * | 2018-09-03 | 2020-03-10 | 闫伟 | Medicine for treating hypertension |
| CN113440555A (en) * | 2021-07-13 | 2021-09-28 | 辽宁乾源健康管理有限公司 | Umbilical region drop for patients with hypertension and hyperlipidemia and preparation method thereof |
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2006
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