CN100575355C - 烷基次膦酸酯的制备方法 - Google Patents

烷基次膦酸酯的制备方法 Download PDF

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Publication number
CN100575355C
CN100575355C CN200580030435A CN200580030435A CN100575355C CN 100575355 C CN100575355 C CN 100575355C CN 200580030435 A CN200580030435 A CN 200580030435A CN 200580030435 A CN200580030435 A CN 200580030435A CN 100575355 C CN100575355 C CN 100575355C
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CN
China
Prior art keywords
acid
ethyl
hypophosphite
equivalents
toluene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN200580030435A
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English (en)
Chinese (zh)
Other versions
CN101018794A (zh
Inventor
M·尼尔森
M·特林
J·沃克特梅斯特
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AstraZeneca AB
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AstraZeneca AB
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Publication of CN101018794A publication Critical patent/CN101018794A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
    • C07F9/4808—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof the acid moiety containing a substituent or structure which is considered as characteristic
    • C07F9/4816—Acyclic saturated acids or derivatices which can have further substituents on alkyl

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200580030435A 2004-09-13 2005-09-12 烷基次膦酸酯的制备方法 Expired - Fee Related CN100575355C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE04021994 2004-09-13
SE0402199A SE0402199D0 (sv) 2004-09-13 2004-09-13 New process I

Publications (2)

Publication Number Publication Date
CN101018794A CN101018794A (zh) 2007-08-15
CN100575355C true CN100575355C (zh) 2009-12-30

Family

ID=33157526

Family Applications (1)

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CN200580030435A Expired - Fee Related CN100575355C (zh) 2004-09-13 2005-09-12 烷基次膦酸酯的制备方法

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US (1) US7557234B2 (enExample)
EP (1) EP1791851B1 (enExample)
JP (1) JP2008512451A (enExample)
CN (1) CN100575355C (enExample)
AT (1) ATE490259T1 (enExample)
DE (1) DE602005025140D1 (enExample)
SE (1) SE0402199D0 (enExample)
WO (1) WO2006031180A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103755605B (zh) * 2013-12-30 2016-08-17 中国科学院上海硅酸盐研究所 对己硫基苯甲醛的制备方法
CN103980306B (zh) * 2014-04-28 2017-02-15 湖南大学 一种以含p(o)‑oh类化合物制备次膦酸/亚膦酸/磷酸酯类化合物的方法
TW201840578A (zh) * 2017-02-22 2018-11-16 以色列商亞當阿甘公司 製備甲基膦酸丁基酯的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307362A2 (en) * 1987-09-11 1989-03-15 Ciba-Geigy Ag Process for the manufacture of aliphatylphosphinic acid derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8728483D0 (en) * 1987-12-04 1988-01-13 Ciba Geigy Ag Chemical compounds
US20040167330A1 (en) 2001-07-17 2004-08-26 Ivan Lukes Novel chelating agents and conjugates thereof, their synthesis and use as diagnois and therapeutic agents
ATE422891T1 (de) * 2004-06-25 2009-03-15 Univ Sydney Neurologisch aktive verbindungen

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0307362A2 (en) * 1987-09-11 1989-03-15 Ciba-Geigy Ag Process for the manufacture of aliphatylphosphinic acid derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
A novel and convenient preparation of hypophosphite esters. Deprele S.,Montchamp J.Journal of Organometallic Chemistry,Vol.643-644. 2002 *
Synthesis of hypophosphite esters from orthocarbonylcompounds.Fitch,S.J.J.Am.Chem.Soc,Vol.86. 1964 *

Also Published As

Publication number Publication date
EP1791851B1 (en) 2010-12-01
ATE490259T1 (de) 2010-12-15
EP1791851A4 (en) 2010-03-10
SE0402199D0 (sv) 2004-09-13
JP2008512451A (ja) 2008-04-24
WO2006031180A1 (en) 2006-03-23
EP1791851A1 (en) 2007-06-06
US7557234B2 (en) 2009-07-07
DE602005025140D1 (de) 2011-01-13
US20080319231A1 (en) 2008-12-25
CN101018794A (zh) 2007-08-15

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Granted publication date: 20091230

Termination date: 20120912