CN100560119C - A kind of externally applied ointment of activating blood circulation and unblocking obstruction - Google Patents
A kind of externally applied ointment of activating blood circulation and unblocking obstruction Download PDFInfo
- Publication number
- CN100560119C CN100560119C CNB2007100001659A CN200710000165A CN100560119C CN 100560119 C CN100560119 C CN 100560119C CN B2007100001659 A CNB2007100001659 A CN B2007100001659A CN 200710000165 A CN200710000165 A CN 200710000165A CN 100560119 C CN100560119 C CN 100560119C
- Authority
- CN
- China
- Prior art keywords
- radix
- parts
- herba
- rhizoma
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of externally applied ointment of activating blood circulation and unblocking obstruction, the preparation raw material of the active component that described plaster is contained is: Radix Aconiti Preparata 0.5-2 part, Radix Aconiti Kusnezoffii Preparata 0.5-2 part, Rhizoma Et Radix Notopterygii 1-3 part, Radix Angelicae Pubescentis 1-3 part, Radix Saposhnikoviae 1-3 part, Radix Gentianae Macrophyllae 0.5-2 part, Cortex Acanthopancis 0.5-2 part, Cortex Cinnamomi 0.5-2 part, Radix Angelicae Dahuricae 1-3 part, Rhizoma Atractylodis 0.5-2 part, Rhizoma Dioscoreae Septemlobae 0.5-2 part, Olibanum 1-3 part, Myrrha 1-3 part, Eupolyphaga Seu Steleophaga 1-3 part, Sanguis Draxonis 1-3 part, Rhizoma Chuanxiong 1-3 part, Flos Carthami 1-3 part, Radix Angelicae Sinensis 1-3 part, Radix Paeoniae Rubra 2-6 part, Lignum Sappan 1-3 part, Herba Artemisiae Anomalae 1-3 part, Radix Aucklandiae 0.5-2 part, Squama Manis (stir-baking in sand) 1-3 part, iron wire Herba speranskiae tuberculatae 1-3 part, Herba Lycopodii 1-3 part, Herba Erodii 1-3 part, Radix Achyranthis Bidentatae 0.5-2 part, Radix Dipsaci 1-3 part, Rhizoma Drynariae 1-3 part, Radix Paeoniae Alba 1-3 part, Flos Caryophylli 0.5-2 part, Herba Dendrobii 0.5-2 part.Its expelling wind and cold, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain is used for the arthromyodynia wind-cold-damp retention, obstruction of collaterals by blood stasis disease.
Description
Technical field
The present invention relates to a kind of externally applied ointment of activating blood circulation and unblocking obstruction.
Background technology
Osteoarthritis claims osteoarthritis, degenerative osteoarthritis, hyperosteogeny again, is commonly called as " bony spur ".Osteoarthritis belongs to sick category such as the traditional Chinese medical science " arthromyodynia ", " rheumatism involving the bone ", " lumbago ".Western medical treatment is many with Therapeutic Method such as antiinflammation pain-stopping pharmaceutical, hyaluronate sodium intra-articular injection therapy, glucocorticoid office envelope therapy, operative therapys.External application of Chinese medicine treatment osteoarthritis, functions dispelling wind and clearing away cold, removing dampness, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain often have clinical efficacy preferably.
The osteoarthritis disease is located can make the property of medicine go into space between skin and muscles from fur with plaster outer plaster at muscle, joint, passages through which vital energy circulates etc., dredge the meridian passage, and taking medicine more has favourable one side.Common plaster has:
(1) SHANGSHI ZHITONG GAO (rubber plaster): function wind dispelling cold expelling, eliminating dampness and dredging channels, promoting blood circulation and stopping pain.Earlier skin is cleaned with warm water during use and dry, be affixed on the affected part, plaster is massaged, it is bonded on the skin with palm.All to rubber plaster allergy, skin erosion has sepage person and wound to merge suppuration person, should not paste usefulness.
Similarly also have Unguentum Moschus et Os Tigris, Qinghai Emplastrum Moschus, pain-relieving plaster for arthritis etc. with its function.
(2) dog skin plaster (plaster): function functions dispelling wind and clearing away cold, removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral pain relieving.During use plaster heated softening after, be affixed on the affected part.
Similarly also have ten thousand clever muscles and bones cream, ZHUIFENG GAO, Herba Erodii cream etc. with its function, also can select for use.
(3) cold loosing (powder) pulled out in military force: function expelling wind and removing dampness, activating yang to invigorate blood circulation, alleviating pain and detumescence.Time spent gets it filled in right amount, with Ovum Gallus domesticus album eliminating cold for resuscitation water or human milk and medicine furnishing pasty state slightly, is split on the paraffin paper, is affixed on acupuncture point or affected part.Note during use avoiding cold and uncooked food, not oral administration.Skin pastes unavailable washing in the medicine place 10 days.Umbilicus wheel, arch of the foot etc. are located to paste usefulness.Child, weak and edema person avoid usefulness.
(4) five tigers loose (powders): function and military force are pulled out cold diffusing identical, mix well with Chinese liquor during use, spread on the affected part.Except that external application, this also oral administration that looses.Each 6g is with warm yellow wine or warm water delivery service.
Above-mentioned plaster all has certain limitation, and the patient expects that better plaster appears on the market.
Summary of the invention
The technical issues that need to address of the present invention just are to overcome the defective of prior art, and a kind of externally applied ointment of activating blood circulation and unblocking obstruction is provided, its expelling wind and cold, and blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain is used for the arthromyodynia wind-cold-damp retention, obstruction of collaterals by blood stasis disease.Disease is seen arthralgia, is met cold increasing the weight of, the joint joint stuffiness, and limbs are heavy, morning is stiff or the rest posterior joint is stiff, and the light red tongue tongue is white, deep-thready pulse.Knee osteoarthritis is seen above-mentioned disease person.
For addressing the above problem, the present invention adopts following technical scheme:
The externally applied ointment of a kind of activating blood circulation and unblocking obstruction of the present invention, the preparation raw material of the active component that described plaster is contained is (weight ratio): Radix Aconiti Preparata 0.5-2 part, Radix Aconiti Kusnezoffii Preparata 0.5-2 part, Rhizoma Et Radix Notopterygii 1-3 part, Radix Angelicae Pubescentis 1-3 part, Radix Saposhnikoviae 1-3 part, Radix Gentianae Macrophyllae 0.5-2 part, Cortex Acanthopancis 0.5-2 part, Cortex Cinnamomi 0.5-2 part, Radix Angelicae Dahuricae 1-3 part, Rhizoma Atractylodis 0.5-2 part, Rhizoma Dioscoreae Septemlobae 0.5-2 part, Olibanum 1-3 part, Myrrha 1-3 part, Eupolyphaga Seu Steleophaga 1-3 part, Sanguis Draxonis 1-3 part, Rhizoma Chuanxiong 1-3 part, Flos Carthami 1-3 part, Radix Angelicae Sinensis 1-3 part, Radix Paeoniae Rubra 2-6 part, Lignum Sappan 1-3 part, Herba Artemisiae Anomalae 1-3 part, Radix Aucklandiae 0.5-2 part, Squama Manis (stir-baking in sand) 1-3 part, iron wire Herba speranskiae tuberculatae 1-3 part, Herba Lycopodii 1-3 part, Herba Erodii 1-3 part, Radix Achyranthis Bidentatae 0.5-2 part, Radix Dipsaci 1-3 part, Rhizoma Drynariae 1-3 part, Radix Paeoniae Alba 1-3 part, Flos Caryophylli 0.5-2 part, Herba Dendrobii 0.5-2 part.
Preferably, the preparation raw material of the active component that plaster of the present invention is contained is (weight ratio): 1 part of Radix Aconiti Preparata, 1 part of Radix Aconiti Kusnezoffii Preparata, 2 parts of Rhizoma Et Radix Notopterygiis, 2 parts of Radix Angelicae Pubescentiss, 2 parts of Radix Saposhnikoviaes, 1 part of Radix Gentianae Macrophyllae, 1 part of Cortex Acanthopancis, 1 part of Cortex Cinnamomi, 2 parts of the Radixs Angelicae Dahuricae, 1 part of Rhizoma Atractylodis, 1 part of Rhizoma Dioscoreae Septemlobae, 2 parts of Olibanums, 2 parts of Myrrhas, 2 parts of Eupolyphaga Seu Steleophagas, 2 parts of Sanguis Draxonis, 2 parts of Rhizoma Chuanxiongs, 2 parts on Flos Carthami, 2 parts of Radix Angelicae Sinensis, 4 parts of Radix Paeoniae Rubra, 2 parts of Lignum Sappans, 2 parts of Herba Artemisiae Anomalaes, 1 part of the Radix Aucklandiae, 2 parts of Squama Maniss (stir-baking in sand), 2 parts of iron wire Herba speranskiae tuberculataes, 2 parts of Herba Lycopodiis, 2 parts of Herba Erodiis, 1 part of Radix Achyranthis Bidentatae, 2 parts of Radix Dipsacis, 2 parts of Rhizoma Drynariae, 2 parts of the Radix Paeoniae Albas, 1.2 parts of Flos Caryophyllis, 1 part of Herba Dendrobii.
The present invention discloses a kind of method for preparing the externally applied ointment of described activating blood circulation and unblocking obstruction, it comprises the following steps:
1), weighing: press row weight portion proportioning weighting raw materials: 1 part of Radix Aconiti Preparata, 1 part of Radix Aconiti Kusnezoffii Preparata, 2 parts of Rhizoma Et Radix Notopterygiis, 2 parts of Radix Angelicae Pubescentiss, 2 parts of Radix Saposhnikoviaes, 1 part of Radix Gentianae Macrophyllae, 1 part of Cortex Acanthopancis, 1 part of Cortex Cinnamomi, 2 parts of the Radixs Angelicae Dahuricae, 1 part of Rhizoma Atractylodis, 1 part of Rhizoma Dioscoreae Septemlobae, 2 parts of Olibanums, 2 parts of Myrrhas, 2 parts of Eupolyphaga Seu Steleophagas, 2 parts of Sanguis Draxonis, 2 parts of Rhizoma Chuanxiongs, 2 parts on Flos Carthami, 2 parts of Radix Angelicae Sinensis, 4 parts of Radix Paeoniae Rubra, 2 parts of Lignum Sappans, 2 parts of Herba Artemisiae Anomalaes, 1 part of the Radix Aucklandiae, 2 parts of Squama Maniss (stir-baking in sand), 2 parts of iron wire Herba speranskiae tuberculataes, 2 parts of Herba Lycopodiis, 2 parts of Herba Erodiis, 1 part of Radix Achyranthis Bidentatae, 2 parts of Radix Dipsacis, 2 parts of Rhizoma Drynariae, 2 parts of the Radix Paeoniae Albas, 1.2 parts of Flos Caryophyllis, 1 part of Herba Dendrobii;
2), Sanguis Draxonis powder is broken into fine powder, standby;
3), Cortex Cinnamomi, Olibanum, Myrrha, Flos Caryophylli, Rhizoma Atractylodis add 10 times of water gagings of its weight, soaked overnight was extracted volatile oil 8 hours with steam distillation, removed the aqueous solution after the distillation, collected volatile oil, and is standby;
4), all the other 26 flavor medicines, give as one thinks fit cataclasm, add 600 parts of warm in advance 110 ℃ edible vegetable oils, Squama Manis (stir-baking in sand) earlier, Eupolyphaga Seu Steleophaga, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Cortex Acanthopancis, Herba Dendrobii Rhizoma Dioscoreae Septemlobae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Dipsaci, the Radix Paeoniae Alba, Lignum Sappan, Radix Angelicae Sinensis, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, the Radix Aucklandiae, continue to be heated to 180 ℃, add Herba Erodii, the iron wire Herba speranskiae tuberculatae, Herba Lycopodii, Herba Artemisiae Anomalae adds Flos Carthami after a while again with fried, medical material is fried withered, remove slag, filter, the refining of medicine oil is to dripping into pearl, other gets 300 parts of Plumbum preparatium, add in the oil, stir evenly, receive cream, cream is soaked in the water, after getting 70 ℃ of fusings of cream usefulness slow fire, add step 2) fine powder of dragons blood of preparation and the volatile oil of step 3) preparation, stir evenly, share on cloth, promptly.
The present invention is the black plaster that spreads out on cloth, expelling wind and cold, and blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain is used for the arthromyodynia wind-cold-damp retention, obstruction of collaterals by blood stasis disease.Disease is seen arthralgia, is met cold increasing the weight of, the joint joint stuffiness, and limbs are heavy, morning is stiff or the rest posterior joint is stiff, and the light red tongue tongue is white, deep-thready pulse.Knee osteoarthritis is seen above-mentioned disease person.External, it is softening to heat, and is affixed on the affected part, pastes for one time 1, and five are once, and anemia of pregnant woman and skin injury, allergy sufferers are avoided usefulness.It is 12g or 15g that every plaster contains the active drug net weight.The present invention is airtight, put shady and cool dry place, and effect duration is 2 years.
The specific embodiment
Embodiment 1
1), weighing: press following proportioning weighting raw materials: Radix Aconiti Preparata 50g, Radix Aconiti Kusnezoffii Preparata 50g, Rhizoma Et Radix Notopterygii 100g, Radix Angelicae Pubescentis 100g, Radix Saposhnikoviae 100g, Radix Gentianae Macrophyllae 50g, Cortex Acanthopancis 50g, Cortex Cinnamomi 50g, Radix Angelicae Dahuricae 100g, Rhizoma Atractylodis 50g, Rhizoma Dioscoreae Septemlobae 50g, Olibanum 100g, Myrrha 100g, Eupolyphaga Seu Steleophaga 100g, Sanguis Draxonis 100g, Rhizoma Chuanxiong 100g, Flos Carthami 100g, Radix Angelicae Sinensis 100g, Radix Paeoniae Rubra 200g, Lignum Sappan 100g, Herba Artemisiae Anomalae 100g, Radix Aucklandiae 50g, Squama Manis (stir-baking in sand) 100g, iron wire Herba speranskiae tuberculatae 100g, Herba Lycopodii 100g, Herba Erodii 100g, Radix Achyranthis Bidentatae 50g, Radix Dipsaci 100g, Rhizoma Drynariae 100g, Radix Paeoniae Alba 100g, Flos Caryophylli 60g, Herba Dendrobii 50g;
2), Sanguis Draxonis powder is broken into fine powder, standby;
3), Cortex Cinnamomi, Olibanum, Myrrha, Flos Caryophylli, Rhizoma Atractylodis add 10 times of water gagings of its weight, soaked overnight was extracted volatile oil 8 hours with steam distillation, removed the aqueous solution after the distillation, collected volatile oil, and is standby;
4), all the other 26 flavor medicines, give as one thinks fit cataclasm, add warm in advance 110 ℃ edible vegetable oil 30000g, Squama Manis (stir-baking in sand) earlier, Eupolyphaga Seu Steleophaga, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Cortex Acanthopancis, Herba Dendrobii Rhizoma Dioscoreae Septemlobae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Dipsaci, the Radix Paeoniae Alba, Lignum Sappan, Radix Angelicae Sinensis, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, the Radix Aucklandiae, continue to be heated to 180 ℃, add Herba Erodii, the iron wire Herba speranskiae tuberculatae, Herba Lycopodii, Herba Artemisiae Anomalae adds Flos Carthami after a while again with fried, medical material is fried withered, remove slag, filter, the refining of medicine oil is to dripping into pearl, other gets Plumbum preparatium 15000g, add in the oil, stir evenly, receive cream, cream is soaked in the water, after getting 70 ℃ of fusings of cream usefulness slow fire, add step 2) fine powder of dragons blood of preparation and the volatile oil of step 3) preparation, stir evenly, share on cloth, promptly.
By above-mentioned preparation method, prepare the following example by the crude drug proportioning of following embodiment
Embodiment 2
0.5 part of Radix Aconiti Preparata, 2 parts of Radix Aconiti Kusnezoffii Preparatas, 1 part of Rhizoma Et Radix Notopterygii, 3 parts of Radix Angelicae Pubescentiss, 1 part of Radix Saposhnikoviae, 2 parts of Radix Gentianae Macrophyllae, 0.5 part of Cortex Acanthopancis, 2 parts of Cortex Cinnamomis, 1 part of the Radix Angelicae Dahuricae, 2 parts of Rhizoma Atractylodis, 0.5 part of Rhizoma Dioscoreae Septemlobae, 3 parts of Olibanums, 1 part of Myrrha, 3 parts of Eupolyphaga Seu Steleophagas, 1 part of Sanguis Draxonis, 3 parts of Rhizoma Chuanxiongs, 1 part on Flos Carthami, 3 parts of Radix Angelicae Sinensis, 2 parts of Radix Paeoniae Rubra, 3 parts of Lignum Sappans, 1 part of Herba Artemisiae Anomalae, 2 parts of the Radix Aucklandiae, 1 part of Squama Manis (stir-baking in sand), 3 parts of iron wire Herba speranskiae tuberculataes, 1 part of Herba Lycopodii, 3 parts of Herba Erodiis, 0.5 part of Radix Achyranthis Bidentatae, 3 parts of Radix Dipsacis, 1 part of Rhizoma Drynariae, 3 parts of the Radix Paeoniae Albas, 0.5 part of Flos Caryophylli, 2 parts of Herba Dendrobiis.
Embodiment 3
2 parts of Radix Aconiti Preparatas, 0.5 part of Radix Aconiti Kusnezoffii Preparata, 3 parts of Rhizoma Et Radix Notopterygiis, 1 part of Radix Angelicae Pubescentis, 3 parts of Radix Saposhnikoviaes, 0.5 part of Radix Gentianae Macrophyllae, 2 parts of Cortex Acanthopanciss, 0.5 part of Cortex Cinnamomi, 3 parts of the Radixs Angelicae Dahuricae, 0.5 part of Rhizoma Atractylodis, 2 parts of Rhizoma Dioscoreae Septemlobaes, 1 part of Olibanum, 3 parts of Myrrhas, 1 part of Eupolyphaga Seu Steleophaga, 3 parts of Sanguis Draxonis, 1 part of Rhizoma Chuanxiong, 3 parts on Flos Carthami, 1 part of Radix Angelicae Sinensis, 6 parts of Radix Paeoniae Rubra, 1 part of Lignum Sappan, 3 parts of Herba Artemisiae Anomalaes, 0.5 part of the Radix Aucklandiae, 3 parts of Squama Maniss (stir-baking in sand), 1 part of iron wire Herba speranskiae tuberculatae, 3 parts of Herba Lycopodiis, 1 part of Herba Erodii, 2 parts of Radix Achyranthis Bidentataes, 1 part of Radix Dipsaci, 3 parts of Rhizoma Drynariae, 1 part of the Radix Paeoniae Alba, 2 parts of Flos Caryophyllis, 0.5 part of Herba Dendrobii.
Embodiment 4 differentiates example
Get the plaster 5g of embodiment 1 preparation, subtract brokenly, add ethanol 15ml, reflux 30 minutes is put coldly, gets ethanol liquid, and evaporate to dryness, residue add ethanol 1ml makes dissolving, as need testing solution.Other gets Sanguis Draxonis control medicinal material 10mg, and the 1ml that adds diethyl ether makes dissolving, in contrast medical material solution.According to thin layer chromatography (an appendix VI of Chinese Pharmacopoeia version in 2005 B) test, draw each 10 μ l of above-mentioned two kinds of solution, put respectively on same silica gel g thin-layer plate, be developing solvent with chloroform-methanol (19: 1), launch, take out, dry, inspect under the daylight.In the test sample chromatograph, with the corresponding position of control medicinal material chromatograph on, show the speckle of same color.
Check:
Softening point of the present invention is measured according to softening point of ointment algoscopy (an appendix XII of Chinese Pharmacopoeia version in 2005 D), should be not less than 53 ℃.
Other should meet every regulation relevant under the plaster item (an appendix I of Chinese Pharmacopoeia version in 2005 P).
Embodiment 5 curative effect examples
(1) patient's sex distribution (table 1)
Table 1: patient's sex situation analysis
Learn by statistics and handle (x
2Check) x
2=1.319, p＞0.05, there was no significant difference has comparability between group.
(2) patient age distribution (table 2)
Table 2: patient age distribution situation
Learn by statistics and handle (x
2Check) x
2=2.251, p＞0.05, (t check) t=1.087, p＞0.05, there was no significant difference has comparability between group.
(3) course of disease distribution (table 3)
Table 3: patient's course of disease situation
Learn by statistics and handle (x
2Check) x
2=1.858, p＞0.05, (t check) t=0.063, p＞0.05, there was no significant difference has comparability between group.
(4) X line state of an illness classification (table 4)
Table 4: patient X line state of an illness classification situation
Learn by statistics and handle (x
2Check) x
2=1.199, p＞0.05, there was no significant difference has comparability between group.
(5) tcm syndrome analysis (table 5, table 6)
Table 5: tcm syndrome total mark comparison before observation group and matched group are treated (
± SD)
Learn by statistics and handle (t check) t=0.063, p＞0.05, there was no significant difference has comparability between group.
Traditional Chinese medical science disease subitem comparison before table 6 observation group and matched group are treated (
± SD)
(6) knee joint function situation analysis (table 7, table 8)
Table 7: observation group and the comparison of matched group treatment knee joint function total mark (
± SD)
Learn by statistics and handle (t check) t=0.160, p＞0.05, there was no significant difference. comparability is arranged between group.
Table 8: observation group and the comparison of matched group treatment knee joint function situation subitem (
± SD)
Two, diagnostic criteria
(1) Western medicine diagnose standard
The osteoarthritis frequently-occurring disease is in positions such as neck, waist, knee joints, and wherein knee osteoarthritis more sees, so this checking plan is formulated the checking plan with knee osteoarthritis.This plan is with reference to formulations such as " the clinical research guidelines (version in 2002) of new Chinese medicine treatment osteoarthritis ".
1, knee osteoarthritis diagnostic criteria
(1) there was gonalgia on preceding month most of dates.
(2) the bone sound is arranged during joint motion.
(3) morning deadlock＜30 minutes.
(4) the X line shows edge, joint hyperosteogeny.
(5) age was more than or equal to 40 years old.
(6) the bone hypertrophy is shown in the knee joint inspection.
*Osteoarthritis exists as 1,2,3,5 or 1,2,6 or 1,5,6 or 1,4 existence.
2, osteoarthritis radiology state of an illness grade scale (kellgren and lawrence method are divided into 5 grades)
0 grade: for normally.
The I level: the joint space is suspicious to narrow down, and has hyperosteogeny.
The II level: obvious hyperosteogeny is arranged, and the joint space can narrow down.
The III level: the moderate hyperosteogeny, the joint space narrows down more obvious, has hardening to change.
The IV level: a large amount of hyperosteogenys, the joint space obviously narrows down, serious hardening pathological changes and obviously lopsided.
(2) Chinese medical discrimination
The arthromyodynia wind-cold-damp retention, congestion resistance network card.Disease is seen arthralgia, is met cold increasing the weight of, the joint joint stuffiness, and limbs are heavy, morning is stiff or the rest posterior joint is stiff, and the light red tongue tongue is white, deep-thready pulse.Knee osteoarthritis is seen above-mentioned patient.
Three, case is selected
1, includes the case standard in
(1) meets primary disease Western medicine diagnose standard;
(2) meet primary disease Chinese medical discrimination standard;
(3) age is in 40-70 year;
(4) X ray examination I-III level person.
2, get rid of the case standard
(1) age is below 40 or more than 70 years old;
(2) Secondary cases osteoarthritis, the acute synovial membrane of secondary, articular cavity has episome person;
(3) gestation or women breast-feeding their children, allergic constitution or to this medicine allergy sufferers;
(4) intercurrent disease has influence on the joint person, as psoriasis, syphilis neuralgia, ochronosis, metabolic osteopathy, acute injury etc.;
(5) the X line is IV level changer;
(6) merge the severe cardiac cerebrovascular, serious primary disease person such as liver, kidney and hemopoietic system, psychotic.
Four, test method
1, random packet, controlled trial, each 60 example of observation group and matched group.
2, administrated method
The ointment of (A) observation group: embodiment 1 preparation, external, heating is affixed on the affected part after softening, pastes 1 time on the five one time 1.
(B) matched group: dog skin plaster (P500 of Chinese Pharmacopoeia), external is pasted 1 time on the five one time 1.
3, the course of treatment: one month.
4, anemia of pregnant woman, allergic constitution person and damaged skin person avoid usefulness.
5, inactive other related drugs and Therapeutic Method during the checking.
6, write down observed project and index by fixing doctor during the checking, patient and family members have been emphasized compliance.
7, close observation contingent untoward reaction.
8, during the bilateral knee arthropathy, with the heavy knee joint statistics of arthralgia.
Five, observation index
(1) safety indexes
1, irritated and irritant reaction is observed (observed and recorded in observation group's therapeutic process).
2, blood, urine, just routine test (each inspection record of back is treated once before treating by observation group).
3, electrocardiogram, liver function (ALT), renal function (BUN, Cr) are checked (each inspection record of back is treated once before treating by observation group).
(2) health giving quality observation (observed and recorded once weekly)
1, tcm symptom, sign.
2, knee joint function evaluation.
3, the X sheet (in view of a month course of treatment focus imageology be difficult to change, so index only as diagnosis before treating with).
Six, clinical efficacy evaluation criteria
(1) tcm syndrome sxemiquantitative standards of grading
1, arthralgia
Normally: no joint pain 0 minute
Slightly: only movable back pain, pain is lighter 2 minutes
Moderate: also pain during rest, but pain do not continue does not still influence operate as normal or lived 4 fens
Severe: pain during rest, pain influence orthobiosis or worked 6 fens
2, meet cold increasing the weight of
Normally: pain is met cold nothing and was increased the weight of 0 fen
Slightly: pain is met cold slightly increasing the weight of 1 fen
Moderate: pain is met to tremble with fear to have and is increased the weight of 2 fens
Severe: pain is met cold obviously increasing the weight of 3 fens
3, joint joint stuffiness
Normally: no joint stuffiness 0 minute
Slightly: joint motion is slightly limited, and range of motion reduces＜1/3 1 fen
Moderate: joint motion is limited slightly, and range of motion reduces 〉=1/3 2 fen
Severe: joint motion is limited slightly, and range of motion reduces 〉=2/3, even stiff 3 minutes
4, limbs are heavy
Normally: heavy 0 minute of no limbs
Slightly: heavy 1 minute of the little feel limbs of idol
Moderate: often limbs are heavy 2 minutes
Severe: limbs are heavy does not desire movable 3 minutes
5, morning, the deadlock or the back of having a rest were stiff
Normally: no morning stiff or stiff 0 minute of the back of having a rest
Slightly: sense of discomfort is arranged, and movable slightly back disappeared 1 fen
Moderate: have morning stiff or the back of having a rest is stiff, alleviated after the activity slightly 2 fens
Severe: morning is obviously stiff or the back of having a rest is stiff, can not alleviate after the activity 3 fens
(2) knee joint function classification semidefinite quantitative criteria
Pain or discomfort when 1, lie up night
Normally: pain or discomfort were 0 minute when lay up no night
Slightly: pain or discomfort 1 minute is arranged by chance
Moderate: the time pain is arranged 2 minutes
Severe: pain is 3 minutes again and again
2, morning, the deadlock or the back pain of getting up increased the weight of
Normally: no morning, the stiff or back pain of getting up increased the weight of 0 fen
Slightly: sense of discomfort is arranged, and movable slightly back disappeared 1 fen
Moderate: pain is arranged, alleviated after the activity slightly 2 fens
Severe: pain is obvious, can not alleviate after the activity 3 fens
Pain or discomfort when 3, walking
Normally: pain or discomfort are 0 minute when having walking
Slightly: long-distance walking (〉=1km) back occurs 1 fen
Moderate: the short distance walking (＜1km) back occurs 2 fens
Severe: once the pain of walking, walking back pain increased the weight of 3 fens
4, pain or discomfort when stand in the seat
Normally: pain or discomfort are 0 minute when stand in the seat of having no way of
Slightly: mild pain or discomfort 1 minute is arranged
Moderate: pain or obviously uncomfortable, but need not help 2 fens
Severe: pain is obvious, wants help 3 fens
5, maximum travel distance (can accompany the pain walking)
Normally: 0 minute
Slightly: 〉=1km, but limited 1 minute
Moderate: 300m-1km 2 minutes
Severe:＜300m 3 minutes
6, daily routines
Normally: 0 minute
Slightly: idol was had any problem 1 fen
Moderate: in time, had any problem 2 fens
Severe: can not daily routines 3 minutes
7, go upstairs
Normally: 0 minute
Slightly: energy 1 minute
Moderate: difficulty 2 minutes
Severe: can not 3 minutes
8, go downstairs
Normally: 0 minute
Slightly: energy 1 minute
Moderate: difficulty 2 minutes
Severe: can not 3 minutes
9, squat down or flexed knee
Normally: 0 minute
Slightly: energy 1 minute
Moderate: difficulty 2 minutes
Severe: can not 3 minutes
10, on the road surface of injustice, walk
Normally: 0 minute
Slightly: energy 1 minute
Moderate: difficulty 2 minutes
Severe: can not 3 minutes
Seven, curative effect determinate standard
Computing formula (nimodipine method): [integration before (integration before the treatment-treatment back integration) ÷ treatment] * 100%
(1) tcm syndrome curative effect judging standard:
1, clinic control: tcm clinical practice symptom, sign disappear or basic the disappearance, and the syndrome integration reduces 〉=95%.
2, produce effects: tcm clinical practice symptom, sign are obviously improved, and the syndrome integration reduces 〉=70%,＜95%.
3, effective: tcm clinical practice symptom, sign all take a favorable turn, and the syndrome integration reduces 30%,＜70%.
4, invalid: tcm clinical practice symptom, sign all do not have obvious improvement, even increase the weight of, the syndrome integration reduces less than 30%.
(2) knee joint function curative effect judging standard
1, clinic control: transference cures such as pain, the knee joint activity is normal, and the evaluation integration reduces 〉=95%.
2, produce effects: transference cures such as pain, the knee joint activity is not limited, and the evaluation integration reduces 〉=70%,＜95%.
3, effective: pain symptom disappears substantially, and the knee joint activity is slightly limited, and the evaluation integration reduces 〉=30%,＜70%.
4, invalid: symptom such as pain and knee joint function do not have obvious improvement, even increase the weight of, the evaluation integration reduces 30%.
Eight, observed result
(1) observation group and matched group tcm syndrome curative effect statistics and relatively (table 9, table 10)
Table 9: observation group and matched group tcm syndrome curative effect are added up and are compared
Curative effect relatively (rank test) between observation group and matched group, Z=2.432 by analysis, p＜0.05.
Last table explanation, observation group and matched group tcm syndrome curative effect compare, and observation group is better than matched group, and learning by statistics to handle has significant difference.
Table 10: observation group and the comparison of matched group tcm syndrome integration (
± SD)
Before treating, matched group treats back relatively (t check): t=11.098, p＜0.01.
Before treating, observation group treats back relatively (t check): t=13.976, p＜0.01.
Treat back difference relatively (t check) before treating between two groups: t=2.756, p＜0.01.
Last table explanation, observation group and matched group all can obviously improve tcm symptom, and observation group is better than matched group, and learning by statistics to handle has significant difference.
(2) observation group and matched group tcm symptom and sign subitem curative effect compares (table 11, table 12)
Table 11: symptom and sign are improved degree analyzing relatively after observation group and the treatment of control group
Last table explanation, observation group and matched group compare:
(1) two group all can obviously be improved the arthralgia symptom, and observation group is better than matched group, and learning by statistics to handle has significant difference (P＜0.05).
(2) two groups of equal can improvement are met cold increasing the weight of, the joint joint stuffiness, and limbs are heavy, morning is stiff or the stiff symptom in back of having a rest, but observation group and matched group are suitable, and handle there was no significant difference (P＞0.05) by statistics.
Table 12: observation group and matched group cardinal symptom and the comparison of sign curative effect subitem integration (
± SD)
Last table explanation, observation group and matched group compare:
(1) two group all can obviously be improved the arthralgia symptom, and observation group is better than matched group, and learning by statistics to handle has significant difference (p＜0.01).
(2) two groups all can obviously be improved the stiff or stiff symptom in back of having a rest in morning, and observation group is better than matched group, learn by statistics to handle that there were significant differences (p＜0.05).
(3) two groups of equal can improvement are met cold increasing the weight of, the joint joint stuffiness, and the heavy symptom of limbs, but observation group and matched group are suitable, learn by statistics and handle there was no significant difference (p＞0.05).
As can be known from the above table, tcm symptom all has improvement after observation group and treatment of control group, especially improve arthralgia and morning deadlock or the stiff symptom of rest posterior joint aspect, observation group is better than matched group.Point out the arthralgia pain cream of invigorating blood circulation effectively to improve clinical symptoms.
(3) observation group and matched group knee joint function curative effect statistics and relatively (table 13, table 14)
Table 13: observation group and matched group knee joint function curative effect are added up and are compared
Curative effect relatively (be lost and check) between observation group and matched group, z=3.030 by analysis, P＜0.01.
Last table explanation, observation group and matched group knee joint function curative effect compare, and observation group is better than matched group, and learning by statistics to handle has significant difference.
Table 14: observation group and the comparison of matched group knee joint function curative effect integration (
± SD)
Before treating, matched group treats back relatively (t check): t=10.831, p＜0.01.
Before treating, observation group treats back relatively (t check): t=15.127, p＜0.01.
Treat back difference relatively (t check) before treating between two groups: t=3.684, p＜0.01.
Last table explanation, observation group and matched group all can obviously improve knee joint function, and observation group is better than matched group, and learning by statistics to handle has significant difference.
(4) observation group and matched group knee joint function are analyzed curative effect relatively (table 15)
Table 15: observation group and the comparison of matched group knee joint function curative effect subitem integration (
± SD)
Last table explanation, observation group and matched group compare:
(1) two group all can obviously be improved pain or discomfort, daily routines when stand in the seat in the knee joint function, goes upstairs and squat down or the flexed knee item, and observation group is better than matched group, and learning by statistics to handle has significant difference (P＜0.01).
(2) two groups all obviously to improve morning in the knee joint function stiff or the back pain of getting up increases the weight of, walking on pain or discomfort when walk, maximum travel distance and the uneven road surface. and observation group is better than matched group, and learning processing by statistics has significant difference (P＜0.05).
Pain or uncomfortable and the item of going downstairs when lie up (3) the two groups of nights that all can improve in the knee joint function, but observation group and matched group are suitable, learn by statistics and handle there was no significant difference (P＞0.05).
As can be known from the above table, through observation group and treatment of control group patella function improvement is arranged all, especially the morning in improving knee joint function stiff or the back pain of getting up increases the weight of, pain or discomfort when walk, when stand in the seat pain or discomfort, maximum travel distance, daily life, go upstairs, squat down or flexed knee and aspect the road surface of the injustice walking item, observation group is better than matched group.Point out the arthralgia pain cream of invigorating blood circulation effectively to improve knee joint function.
(5) observation group and matched group passive flexion and extension test statistics and comparison (table 16, table 17)
Table 16: observation group and the comparison of matched group passive flexion and extension test situation (
± SD) (mm/h)
Before treating, matched group treats back relatively (t check): t=2.309, p＜0.05.
Before treating, observation group treats back relatively (t check): t=3.578, p＜0.01.
Treat back difference relatively (t check) before treating between two groups: t=0.933, p＞0.05.
Last table explanation, observation group and matched group all can obviously improve the passive flexion and extension test, but observation group and matched group are suitable, learn by statistics and handle no significant difference.
Table 17: the number of degrees situation comparison of observation group and matched group joint degree of bending and stretching (
± SD) (%)
Before treating, matched group treats back relatively (t check): t=2.236, p＜0.05.
Before treating, observation group treats back relatively (t check): t=5.047, p＜0.01.
Treat back difference relatively (t check) before treating between two groups: t=2.996, p＜0.01.
Last table explanation, observation group and matched group be the number of degrees of the obvious joint of energy degree of bending and stretching all, and observation group is better than matched group, and learning by statistics to handle has explicitly difference.
(6) safety is observed
During clinical verification, the 60 routine patients of observation group have been carried out the safety observation, all there are not local excitation and anaphylaxis, menses (RBC, Hb, WBC), urine, just routine examination, electrocardiogram.Liver function (ALT), renal function (BUN, Cr) are checked, do not find untoward reaction (table 18).
Analysis of adverse reactions before and after the treatment of table 18 observation group
During clinical verification, 60 routine patients are organized in checking carried out the safety observation, find to invigorate blood circulation arthralgia pain cream before and after the treatment to routine blood test, routine urinalysis, just routine, electrocardiogram, liver function and renal dysfunction, other do not find physical and chemical index unusually and untoward reaction, during verifying, there are 2 routine patient WBC normal by transferring to unusually, 1 routine patient is 10.1, analyzes its checking front and back data, no clinical meaning, 1 routine patient is 10.4, may be relevant with arthritis; Have 1 routine patient's routine urinalysis normal by transferring to unusually, the patient occulted blood+1 between menstrual period; There is routine patient's electrocardiogram normal, because accidental natural disposition premature beat before the treatment by transferring to unusually; There are 2 routine patient's liver function ALT normal by transferring to unusually, routine patient's upper respiratory tract infection, 1 routine patient may be relevant with diet in addition; Have a routine patient WBC unusual by normally transferring to, treatment back WBC is 10.2, patient's upper respiratory tract infection, just oral pioneer IV antiinflammatory symptomatic treatment; Have 1 routine patient's liver function ALT unusual by normally transferring to, treatment back ALT is normal, may be relevant with diet.Some index was all undesired before and after the part patient treatment was arranged, but all than taking a turn for the better to some extent before the treatment, did not cause the state of an illness to increase the weight of.
(7) model case
Case one
Liu XX, the woman, 50 years old, the patient before 2 years no any obvious inducement the right gonalgia appears, in time, has and increases the weight of, and obeys analgesia anti-inflammation medicine certainly and alleviates, without systematic treating.Increased the weight of because of the right gonalgia behind the hyperactivity before one week, being satisfied on June 19th, 2005 comes me institute to go to a doctor, disease is seen: right knee joint is gently swollen, and pain is lighter, and joint motion is slightly limited, have a rest or play posterior joint morning sense of discomfort is arranged, movable slightly back disappears, and pain is obvious when stand in the seat, squats down or difficulty during flexed knee, the few tongue of red tongue, stringy pulse.Check: the right gonalgia, the activity postemphasis alleviates after the rest, the passive flexion and extension test: bend 120 °, stretch 0 °, patella grinding test (+), X-ray sheet show the inboard gap turn narrow of right knee joint.Be diagnosed as knee joint osseous arthritis wind chill blockage, congestion resistance network card.Give plaster of the present invention, external, heating is affixed on the affected part after softening, one time one subsides, five are once.After treating for 4 weeks, the stiff or back stiff transference cure in morning of having a rest of arthralgia, joint joint stuffiness, morning, it is normal that daily functional activity recovers, passive flexion and extension test: bend 130 °, stretch 0 °, patella grinding test (-), the efficacy determination clinic control, the security inspection no abnormality seen.
Case two
Xiao XX, the man, 55 years old, the patient before 5 years right knee joint pain appears, after increase the weight of gradually.Increase the weight of in the tired pain of cause in January, movable unfavorable, do not feel any better from the clothes ibuprofen, then just control the institute in me on June 19th, 2005, disease is seen: the right gonalgia is obvious, and movable back pain increases the weight of, rest pain is not alleviated, have a rest or to play posterior joint morning stiff, often limbs are heavy, squat, stair activity and difficulty in walking.Check: right tenderness in knee, the osteoarthrosis friction sound is arranged, the passive flexion and extension test: bend 120 °, stretch 15 °, patella grinding test (+), X-ray sheet show that right knee joint gap is not wide, and sour jujube is sharp keen between the tibia ankle.Be diagnosed as knee joint osseous arthritis wind chill blockage, congestion resistance network card.Award plaster of the present invention, external, heating is affixed on the affected part after softening, one time one subsides, five are once.After treating for 4 weeks, morning deadlock, meet coldly increase the weight of, the heavy transference cure of limbs, pain obviously alleviates, it is normal that daily functional activity recovers, the passive flexion and extension test: bend 120 °, stretch 5 °, patella grinding test (+), efficacy determination is effective, the security inspection no abnormality seen.
1. plaster of the present invention is a pure Chinese medicinal preparation, clinical verification shows, plaster treatment knee joint osseous arthritis of the present invention, and the patient who belongs to arthromyodynia wind chill blockage, congestion resistance network card has curative effect preferably, statistical result is: in the 60 routine cases, tcm syndrome curative effect total effective rate is 91.7%, clinic control 4 examples wherein, and the clinic control rate is 6.7%, produce effects 25 examples, existing efficient is 41.7%, effective 26 examples, and effective percentage is 43.3%; Knee joint function curative effect total effective rate is 90.0%, clinic control 3 examples wherein, and the clinic control rate is 5.0%, produce effects 24 examples, obvious effective rate is 40.0%, effective 27 examples, effective percentage is 45.0%, observation group also can obviously improve clinical symptoms and knee joint function.
2. the effect of plaster treatment arthromyodynia wind chill blockage of the present invention, congestion resistance network card knee joint osseous arthritis obviously is better than contrasting the medicine dog skin plaster, plaster tcm syndrome total effective rate 91.7% of the present invention, dog skin plaster tcm syndrome total effective rate 90.0%, its traditional Chinese medical science therapeutic effect of syndrome have significant difference (P＜0.05); Plaster knee joint function total effective rate 90.0% of the present invention, dog skin plaster knee joint function effective percentage 76.7%, its knee joint function curative effect has significant difference (P＜0.01); Tcm symptom and knee joint function can be alleviated and improve to plaster group of the present invention and dog skin plaster group relatively more effectively.Therefore as seen, plaster group of the present invention is at clinical efficacy with improve and all obviously be better than the dog skin plaster group aspect the symptom.
3. plaster of the present invention is at the clinical verification viewing duration, and each safety is observed before and after treatment, does not see obvious adverse reaction, the prompting drug safety.
The present invention is not limited to above-mentioned preferred forms, and other any identical with the present invention or akin products that anyone draws under enlightenment of the present invention all drop within protection scope of the present invention.
Claims (3)
1, a kind of externally applied ointment of activating blood circulation and unblocking obstruction, it is characterized in that: the preparation raw material and the weight ratio thereof of the active component that described plaster is contained are: Radix Aconiti Preparata 0.5-2 part, Radix Aconiti Kusnezoffii Preparata 0.5-2 part, Rhizoma Et Radix Notopterygii 1-3 part, Radix Angelicae Pubescentis 1-3 part, Radix Saposhnikoviae 1-3 part, Radix Gentianae Macrophyllae 0.5-2 part, Cortex Acanthopancis 0.5-2 part, Cortex Cinnamomi 0.5-2 part, Radix Angelicae Dahuricae 1-3 part, Rhizoma Atractylodis 0.5-2 part, Dioscorea septemloba Thunb.
0.5-2 part, Olibanum 1-3 part, Myrrha 1-3 part, Eupolyphaga Seu Steleophaga 1-3 part, Sanguis Draxonis 1-3 part, Rhizoma Chuanxiong 1-3 part, Flos Carthami 1-3 part, Radix Angelicae Sinensis 1-3 part, Radix Paeoniae Rubra 2-6 part, Lignum Sappan 1-3 part, Herba Artemisiae Anomalae 1-3 part, Radix Aucklandiae 0.5-2 part, stir-baking in sand Squama Manis 1-3 part, iron wire Herba speranskiae tuberculatae 1-3 part, Herba Lycopodii 1-3 part, Herba Erodii 1-3 part, Radix Achyranthis Bidentatae 0.5-2 part, Radix Dipsaci 1-3 part, Rhizoma Drynariae 1-3 part, Radix Paeoniae Alba 1-3 part, Flos Caryophylli 0.5-2 part, Herba Dendrobii 0.5-2 part.
2, the externally applied ointment of activating blood circulation and unblocking obstruction as claimed in claim 1, it is characterized in that: the preparation raw material and the weight ratio thereof of the active component that described plaster is contained are: 1 part of Radix Aconiti Preparata, 1 part of Radix Aconiti Kusnezoffii Preparata, 2 parts of Rhizoma Et Radix Notopterygiis, 2 parts of Radix Angelicae Pubescentiss, 2 parts of Radix Saposhnikoviaes, 1 part of Radix Gentianae Macrophyllae, 1 part of Cortex Acanthopancis, 1 part of Cortex Cinnamomi, 2 parts of the Radixs Angelicae Dahuricae, 1 part of Rhizoma Atractylodis, Dioscorea septemloba Thunb.
1 part, 2 parts of Olibanums, 2 parts of Myrrhas, 2 parts of Eupolyphaga Seu Steleophagas, 2 parts of Sanguis Draxonis, 2 parts of Rhizoma Chuanxiongs, 2 parts on Flos Carthami, 2 parts of Radix Angelicae Sinensis, 4 parts of Radix Paeoniae Rubra, 2 parts of Lignum Sappans, 2 parts of Herba Artemisiae Anomalaes, 1 part of the Radix Aucklandiae, 2 parts of stir-baking in sand Squama Maniss, 2 parts of iron wire Herba speranskiae tuberculataes, 2 parts of Herba Lycopodiis, 2 parts of Herba Erodiis, 1 part of Radix Achyranthis Bidentatae, 2 parts of Radix Dipsacis, 2 parts of Rhizoma Drynariae, 2 parts of the Radix Paeoniae Albas, 1.2 parts of Flos Caryophyllis, 1 part of Herba Dendrobii.
3, a kind of method for preparing the externally applied ointment of activating blood circulation and unblocking obstruction as claimed in claim 2 is characterized in that it comprises the following steps:
1), weighing: press row weight portion proportioning weighting raw materials: 1 part of Radix Aconiti Preparata, 1 part of Radix Aconiti Kusnezoffii Preparata, 2 parts of Rhizoma Et Radix Notopterygiis, 2 parts of Radix Angelicae Pubescentiss, 2 parts of Radix Saposhnikoviaes, 1 part of Radix Gentianae Macrophyllae, 1 part of Cortex Acanthopancis, 1 part of Cortex Cinnamomi, 2 parts of the Radixs Angelicae Dahuricae, 1 part of Rhizoma Atractylodis, Dioscorea septemloba Thunb.
1 part, 2 parts of Olibanums, 2 parts of Myrrhas, 2 parts of Eupolyphaga Seu Steleophagas, 2 parts of Sanguis Draxonis, 2 parts of Rhizoma Chuanxiongs, 2 parts on Flos Carthami, 2 parts of Radix Angelicae Sinensis, 4 parts of Radix Paeoniae Rubra, 2 parts of Lignum Sappans, 2 parts of Herba Artemisiae Anomalaes, 1 part of the Radix Aucklandiae, 2 parts of stir-baking in sand Squama Maniss, 2 parts of iron wire Herba speranskiae tuberculataes, 2 parts of Herba Lycopodiis, 2 parts of Herba Erodiis, 1 part of Radix Achyranthis Bidentatae, 2 parts of Radix Dipsacis, 2 parts of Rhizoma Drynariae, 2 parts of the Radix Paeoniae Albas, 1.2 parts of Flos Caryophyllis, 1 part of Herba Dendrobii;
2), Sanguis Draxonis powder is broken into fine powder, standby;
3), Cortex Cinnamomi, Olibanum, Myrrha, Flos Caryophylli, Rhizoma Atractylodis add 10 times of water gagings of its weight, soaked overnight was extracted volatile oil 8 hours with steam distillation, removed the aqueous solution after the distillation, collected volatile oil, and is standby;
4), all the other 26 flavor medicines, give as one thinks fit cataclasmly, adds 600 parts of warm in advance 110 ℃ edible vegetable oils, earlier time stir-baking in sand Squama Manis, Eupolyphaga Seu Steleophaga, Radix Paeoniae Rubra, Radix Achyranthis Bidentatae, Cortex Acanthopancis, Herba Dendrobii, Dioscorea septemloba Thunb.
, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Gentianae Macrophyllae, Radix Aconiti Preparata, Radix Aconiti Kusnezoffii Preparata, Radix Dipsaci, the Radix Paeoniae Alba, Lignum Sappan, Radix Angelicae Sinensis, Rhizoma Drynariae, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, the Radix Aucklandiae, continue to be heated to 180 ℃, add Herba Erodii, iron wire Herba speranskiae tuberculatae, Herba Lycopodii, Herba Artemisiae Anomalae with fried, add Flos Carthami after a while again, medical material is fried withered, remove slag, filter, the refining of medicine oil is to dripping into pearl, and other gets 300 parts of Plumbum preparatium, adds in the oil, stir evenly, receive cream, cream be soaked in the water, get cream with 70 ℃ of fusings of slow fire after, add step 2) fine powder of dragons blood of preparation and the volatile oil of step 3) preparation, stir evenly, share on cloth, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007100001659A CN100560119C (en) | 2007-01-09 | 2007-01-09 | A kind of externally applied ointment of activating blood circulation and unblocking obstruction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007100001659A CN100560119C (en) | 2007-01-09 | 2007-01-09 | A kind of externally applied ointment of activating blood circulation and unblocking obstruction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1994430A CN1994430A (en) | 2007-07-11 |
| CN100560119C true CN100560119C (en) | 2009-11-18 |
Family
ID=38249686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2007100001659A Active CN100560119C (en) | 2007-01-09 | 2007-01-09 | A kind of externally applied ointment of activating blood circulation and unblocking obstruction |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100560119C (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225138B (en) * | 2011-06-24 | 2012-11-21 | 南京中医药大学 | Traditional Chinese medicine composition for treating fracture and preparation method and application thereof |
| CN103263621B (en) * | 2013-06-05 | 2015-08-19 | 张中建 | A kind of pharmaceutical composition for the treatment of lumbar spondylosis |
| CN103550345B (en) * | 2013-11-15 | 2015-08-26 | 张丽 | A kind of medicated wine for the treatment of rheumatalgia |
| CN103736060B (en) * | 2014-01-09 | 2016-08-17 | 贵州康琦药械有限公司 | Lumbago plaster and preparation method thereof |
| CN103977268A (en) * | 2014-04-28 | 2014-08-13 | 广西健宝石斛有限责任公司 | External injury-healing ointment |
| CN104383026A (en) * | 2014-12-11 | 2015-03-04 | 李学存 | Traditional Chinese medicine wine for promoting tissue regeneration and bone setting and preparation method of traditional Chinese medicine wine |
| CN105560447A (en) * | 2014-12-11 | 2016-05-11 | 李学存 | Preparation method of ointment with efficacy of promoting granulation and setting fracture |
| CN105641373A (en) * | 2016-01-15 | 2016-06-08 | 王萍 | Paste with effects of promoting blood circulation to remove meridian obstruction and relieving pain and preparation method thereof |
| CN105561270B (en) * | 2016-01-21 | 2019-08-02 | 陈运柏 | A kind of external application analgesic Chinese herbal medicine and preparation method thereof |
| CN107375723A (en) * | 2017-09-05 | 2017-11-24 | 陈东发 | A kind of black plaster and preparation method thereof |
| CN108498664A (en) * | 2018-05-29 | 2018-09-07 | 王建立 | It is a kind of to treat pain and formula and preparation method thereof promoting blood circulation and removing blood stasis |
| CN108686083A (en) * | 2018-08-13 | 2018-10-23 | 庞栋升 | A kind of external Miao medicine liquid and preparation method thereof for treating pain |
-
2007
- 2007-01-09 CN CNB2007100001659A patent/CN100560119C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN1994430A (en) | 2007-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100560119C (en) | A kind of externally applied ointment of activating blood circulation and unblocking obstruction | |
| CN101780254A (en) | Traditional Chinese medicine compound for treating intestinal tumor and preparation method thereof | |
| CN106236854A (en) | The Chinese medicine composition of a kind for the treatment of of arthritis and application thereof | |
| CN102895460A (en) | Traditional Chinese medicine composition for fracture and soft tissue injury | |
| CN102727697B (en) | Traditional Chinese medicine composition for treating bone fracture, preparation method and mass detection method of traditional Chinese medicine composition | |
| CN104815318A (en) | Traditional Chinese medicine preparation for treating gout | |
| CN1853679A (en) | Medicinal composition for treating cervical spondylosis and preparation thereof | |
| CN103720851A (en) | Traditional Chinese medicinal decoction for treating osteoproliferation | |
| CN104107288A (en) | Sinew-relaxing collateral-activating pill | |
| CN103610982A (en) | Medicine for treating rheumatic arthritis | |
| CN103271961B (en) | Preparation for treating rheumatic bone diseases | |
| CN102805816B (en) | Drug composition for treating senium primary osteoarthritis and preparation method thereof | |
| CN105943700B (en) | The Chinese medicine composition and its preparation method and application of numbness is led in a kind of kidney tonifying | |
| CN105169279A (en) | Traditional Chinese medicine composition for treating knee joint bone hyperplasia | |
| CN102872287A (en) | Traditional Chinese medicine composition for treating femoral head necrosis and preparation method thereof | |
| CN103989968A (en) | Oral traditional Chinese medicinal composition for treating cervical spinal stenosis | |
| CN115624582B (en) | New prescription for treating knee pain and preparation method and application thereof | |
| CN106491882A (en) | A kind of Yao medicinal composition and preparation method thereof | |
| CN102526678A (en) | Plaster for treating rheumatoid bone diseases | |
| CN109010682B (en) | Traditional Chinese medicine composition for treating central nervous function damage and warming governor vessel, eliminating turbid pathogen and dredging collaterals | |
| CN101264268B (en) | Proprietary Chinese medicine for treating tumor | |
| CN1325103C (en) | Tendon and bone strengthening capsule | |
| CN102125603A (en) | Traditional Chinese medicinal preparation for treating intervertebral disc herniation | |
| CN105770358A (en) | Traditional Chinese medicine composition for treating geriatric fracture and method for preparing traditional Chinese medicine composition | |
| CN106138775A (en) | A kind of Chinese medicine composition treating rheumatic arthritis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |