CN106491882A - A kind of Yao medicinal composition and preparation method thereof - Google Patents

A kind of Yao medicinal composition and preparation method thereof Download PDF

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Publication number
CN106491882A
CN106491882A CN201611216487.2A CN201611216487A CN106491882A CN 106491882 A CN106491882 A CN 106491882A CN 201611216487 A CN201611216487 A CN 201611216487A CN 106491882 A CN106491882 A CN 106491882A
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parts
medicinal composition
treatment
wind
yao medicinal
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张曼
戴建业
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Guangxi University of Chinese Medicine
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Guangxi University of Chinese Medicine
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11—Pteridophyta or Filicophyta (ferns)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/19—Acanthaceae (Acanthus family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/26—Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/264—Aristolochia (Dutchman's pipe)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/59—Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The invention provides a kind of Yao medicinal composition, is obtained through ethanol water extraction by the solid material for including following weight portion：Enter 1～4 part of mountain tiger, go up a hill 1～4 part of tiger, 1～4 part of operculina turpethum, its 1～4 part of brill, calabash bore 1～4 part, 1～4 part of DAJIEGU wind, walk 1～4 part of blood wind, 0.5～3 part of the Cortex Eucommiae, 0.5～3 part of Radix Cyathulae, 0.5～3 part of Herba Taxilli, 0.5～3 part of Rhizoma Cibotii, 0.5～3 part of Flos Carthami, 0.1～1 part of Eupolyphaga Seu Steleophaga, 0.1～1 part of Semen Persicae, 0.1～1 part of Olibanum, 0.1～1 part of Myrrha.The Yao medicinal composition that the present invention is provided has clear and definite relieving pain and activating blood circulation effect, can be used in the treatment of prolapse of lumbar intervertebral disc pain, have no adverse reaction in clinical practice and treatment cost is relatively low, and Western medicine and external treatment of Chinese medicine therapeutic alliance prolapse of lumbar intervertebral disc can be substituted.

Description

A kind of Yao medicinal composition and preparation method thereof
Technical field
The present invention relates to precious jade medicine technical field, and in particular to a kind of Yao medicinal composition and preparation method thereof.
Background technology
Prolapse of lumbar intervertebral disc is a kind of common clinical and frequently-occurring disease, and lumbago and skelalgia is modal symptom, is more common in Adult and old people, are, because of intervertebral disc, degeneration, fibrous ring destruction, Nucleus pulposus, stimulation and pressuring neural root occur And a kind of clinical syndrome that cauda equina nerve is showed.
The treatment meanss of prolapse of lumbar intervertebral disc are a lot, are broadly divided into operative treatment, three class of expectant treatment and transdermal therapeutic. With increasing for standard procedures Therapy study, its curative effect causes extensive concern, common diskectomy alleviate intervertebral disc Herniation lumbago, but postoperative 20% patient still has pain, 7%～15% patient with operation that lumbar surgery failure occurs comprehensively Levy.Expectant treatment mostly is individualized treatment, including：Lie up, local maneuver, hot compress, traction, physical therapy, lumbodorsal muscles exercises；Anxious Property phase manna dehydration of alcohols；Oral analgesic, non-steroidal anti-inflammatory drug, neurotrophy medicine etc..Transdermal therapeutic technology be between A kind for the treatment of meanss between operative treatment and expectant treatment, mainly include chemonucleolysis, intervertebral disc Laser decompression (PLDD), Percutaneous endoscopic laser Percutaneous Lum-bar diskectomy (PELD), the intradiscal electrothermal treatment (IDET) and epidural steroid injection provided Therapy.
Up to the present, for the western medicine toxic and side effects of prolapse of lumbar intervertebral disc are larger, patient compliance is not high.Through Skin treatment technology effect is preferable, but cost is higher, brings larger economic pressures to patient.And lie up, local maneuver, heat The external treatment of Chinese medicine curative effects such as deposited, traction, physical therapy, lumbodorsal muscles exercises preferably, but need use in conjunction, monotherapy effect on driving birds is not good. Although external treatment of Chinese medicine combines Western medicine to the therapeutic effect of prolapse of lumbar intervertebral disc relatively preferably, associated with Western medicine pain relieving with When can also bring stronger toxic and side effects, and there is drug resistance and additive.Therefore, a kind of good effect and secondary work are lacked at present With little treatment prolapse of lumbar intervertebral disc pain medication.
Content of the invention
In view of this, it is an object of the invention to provide a kind of precious jade medicine combination that can treat prolapse of lumbar intervertebral disc pain Thing, therapeutic effect are good, and toxic and side effects are little.
In order to realize that foregoing invention purpose, the present invention provide technical scheme below：
The invention provides a kind of Yao medicinal composition, is extracted through ethanol water by the solid material for including following weight portion Obtain：Enter 1～4 part of mountain tiger, go up a hill 1～4 part of tiger, 1～4 part of operculina turpethum, day bore 1～4 part, and calabash bores 1～4 part, DAJIEGU wind 1 ～4 parts, 1～4 part of blood wind is walked, 0.5～3 part of the Cortex Eucommiae, 0.5～3 part of Radix Cyathulae, 0.5～3 part of Herba Taxilli, 0.5～3 part of Rhizoma Cibotii are red 0.5～3 part is spent, 0.1～1 part of Eupolyphaga Seu Steleophaga, 0.1～1 part of Semen Persicae, 0.1～1 part of Olibanum, 0.1～1 part of Myrrha.
Preferably, the Yao medicinal composition is obtained through ethanol water extraction by the solid material for including following weight portion： Enter 2 parts of mountain tiger, go up a hill 2 parts of tiger, 2 parts of operculina turpethum, day bore 2 parts, and calabash bores 2 parts, and 2 parts of DAJIEGU wind walks 2 parts of blood wind, the Cortex Eucommiae 1 Part, 1 part of Radix Cyathulae, 1 part of Herba Taxilli, 1 part of Rhizoma Cibotii, 1 part of Flos Carthami, 0.5 part of Eupolyphaga Seu Steleophaga, 0.5 part of Semen Persicae, 0.5 part of Olibanum, Myrrha 0.5 part.
Present invention also offers a kind of preparation method of Yao medicinal composition described in above-mentioned technical proposal, comprises the following steps：
(1) dry after crush solid material；
(2) adopt volumetric concentration for 35～50% ethanol water to the dried solid material extraction 28～ 42d, the lixiviating solution that the extraction is obtained are Yao medicinal composition.
Preferably, the granularity that crushes in step (1) is 18～35 mesh.
Preferably, it is infrared drying to dry in step (1).
Preferably, in step (2), the volumetric concentration of ethanol water is 40～45%.
Preferably, it is characterised in that in step (2), ethanol water is 8～13 with the volume ratio of solid material:1.
Preferably, in the leaching process of step (2), daily acid soil is stirred 1 time in 1～7d, 8d starts every Acid soil is stirred 1 time every 7d.
Compared with prior art, the present invention has advantages below to the present invention：
The Yao medicinal composition that the present invention is provided is to carry out jointly compatibility according to precious jade medicine and pharmacology principle with reference to theory of Chinese medical science, wherein To enter mountain tiger, the tiger that goes up a hill as principal agent, operculina turpethum, day brill, calabash brill, DAJIEGU wind, the Cortex Eucommiae, Radix Cyathulae, Herba Taxilli, Rhizoma Cibotii be with Medicine, walks blood wind, Flos Carthami, Eupolyphaga Seu Steleophaga, Semen Persicae, Olibanum, Myrrha for leading the way medicine, and the common compatibility of each medicine has obtained that there is clear and definite pain relieving The Yao medicinal composition of promoting blood circulation.
Precious jade medicine and pharmacology think, drug smell have that wind makes score, " person is pure and slow for wind, and hitter is dry and anxious ".Expelling wind drug have gentle, Heibei provincial opera internal organs function is acted on；Laxative is then acted on more flowing swiftly, takes effect speed victory, with the high effect by pathogen.The precious jade that the present invention is provided In drug composition, in principal agent, enter mountain tiger, the tiger that goes up a hill special heat-clearing and toxic substances removing, reducing swelling and alleviating pain；Making up a prescription, middle operculina turpethum, day are bored, calabash is bored and is Laxative makes no pain by smooth breath, reduces pain with promoting flow of QI and blood as work(, and DAJIEGU wind, the Cortex Eucommiae, Radix Cyathulae, Herba Taxilli and Rhizoma Cibotii are Expelling wind drug based on inducing diuresis to remove edema, liver and kidney tonifying is made the strong fortune of taste and is swollen；Walk blood wind, Flos Carthami, Eupolyphaga Seu Steleophaga, Semen Persicae, Olibanum, Myrrha is medicine of leading the way, and to guide principal agent, make up a prescription arrival diseased region so as to concentrates on affected part to play most powerful medicine.
Clinical trial shows, the Yao medicinal composition that the present invention is provided and external treatment of Chinese medicine therapeutic alliance prolapse of lumbar intervertebral disc Pain relief effective percentage be 85%, for external treatment of tcm, effective percentage improves 10%, combines outside the traditional Chinese medical science with Western medicine The curative effect of method for the treatment of is without significant difference；Oswestry Disability indexes scoring (ODI) dropped to 6.22 ± 2.45 at 6 months, Visual analogue scale (VAS) dropped to 2.5 ± 0.7 at 6 months, and the curative effect relative to external treatment of tcm has significance difference, with west The curative effect of medicine joint external treatment of Chinese medicine is without significant difference.It can be seen that, there is the Yao medicinal composition that the present invention is provided clear and definite pain relieving to live Blood is acted on, and be can be used in the treatment of prolapse of lumbar intervertebral disc pain, and can be substituted Western medicine and combined with external treatment of Chinese medicine and control Treat prolapse of lumbar intervertebral disc.
Meanwhile, when the Yao medicinal composition that the present invention is provided is with external treatment of Chinese medicine therapeutic alliance prolapse of lumbar intervertebral disc, patient Without obvious untoward reaction, and then there is 6.67% patient untoward reaction occur when Western medicine and external treatment of Chinese medicine therapeutic alliance, Show that the Yao medicinal composition of present invention offer has no adverse reaction, the quality of life of patient can be significantly improved.
The Yao medicinal composition and the minimum of external treatment of Chinese medicine co-therapy prolapse of lumbar intervertebral disc that the present invention is provided is treated into This analysis statistical result is 721.3 ± 14.8 yuan, and the cost for combining Western medicine relative to external treatment of Chinese medicine reduces 41%, shows this The Yao medicinal composition that invention is provided can effectively reduce the medical expense of patients with lumbar disc herniation.
Specific embodiment
The invention provides a kind of Yao medicinal composition, is extracted through ethanol water by the solid material for including following weight portion Obtain：Enter 1～4 part of mountain tiger, go up a hill 1～4 part of tiger, 1～4 part of operculina turpethum, day bore 1～4 part, and calabash bores 1～4 part, DAJIEGU wind 1 ～4 parts, 1～4 part of blood wind is walked, 0.5～3 part of the Cortex Eucommiae, 0.5～3 part of Radix Cyathulae, 0.5～3 part of Herba Taxilli, 0.5～3 part of Rhizoma Cibotii are red 0.5～3 part is spent, 0.1～1 part of Eupolyphaga Seu Steleophaga, 0.1～1 part of Semen Persicae, 0.1～1 part of Olibanum, 0.1～1 part of Myrrha.
Preferably, the Yao medicinal composition is obtained through ethanol water extraction by the solid material for including following weight portion： Enter 2 parts of mountain tiger, go up a hill 2 parts of tiger, 2 parts of operculina turpethum, day bore 2 parts, and calabash bores 2 parts, and 2 parts of DAJIEGU wind walks 2 parts of blood wind, the Cortex Eucommiae 1 Part, 1 part of Radix Cyathulae, 1 part of Herba Taxilli, 1 part of Rhizoma Cibotii, 1 part of Flos Carthami, 0.5 part of Eupolyphaga Seu Steleophaga, 0.5 part of Semen Persicae, 0.5 part of Olibanum, Myrrha 0.5 part.
Enter mountain tiger：Also known as Radix Zanthoxyli, Pericarpium Zanthoxyli, it is dry root, the stem of Rutaceae zanthoxylum nitidum；In the precious jade medicine that the present invention is provided For principal agent in compositionss, it is laxative, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, promoting blood circulation to remove blood stasis.
Go up a hill tiger：Also known as Ramulus et Folium Pittospori kobuskiani, pittosporm root, mountain and sea paulownia, it is the seed of Pittosporaceae sea gold.There is provided in the present invention For principal agent in Yao medicinal composition, it is laxative, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, promoting blood circulation to remove blood stasis, killing parasites for relieving itching.
Operculina turpethum：Also known as Herba Lycopodii, Caulis Tinosporae, it is the stem of Menispermaceae Tinospora sinensis；In the precious jade medicine group that the present invention is provided For making up a prescription in compound, it is laxative, relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and removing dampness, reducing swelling and alleviating pain.
Its brill：It is the tuber of Aristolochia kwangsi dutchmanspipe root.For making up a prescription in the Yao medicinal composition that the present invention is provided, it is to beat Medicine, heat-clearing and toxic substances removing, inducing diuresis to remove edema, pain relieving.
Calabash is bored：Also known as stone Scolopendra, Teng Ju is climbed, it is that Araeceae Herba Pothi Chinensis dry herb；In the precious jade that the present invention is provided For making up a prescription in drug composition, it is laxative, heat-clearing and toxic substances removing, cooling blood for hemostasis, inducing diuresis to remove edema.
DAJIEGU wind：Also known as Ramulus Et Folium Adhatodae Vasicae, long-living wood, it is the Herb of the black leaf Rhizoma seu Herba Elatostematis stewardii of acanthaceous plant.In present invention offer Yao medicinal composition in for making up a prescription, be expelling wind drug, promoting blood circulation to remove blood stasis, reunion of fractured tendons and bones, subduing swelling and relieving pain.
In the present invention, Cortex Eucommiae liver and kidney tonifying, strengthening the tendons and bones；Radix Cyathulae, Herba Taxilli, Rhizoma Cibotii energy invigorating the liver and kidney, strong waist and knee are removed Rheumatism, vessel conditioning, Radix Cyathulae and diuretic wet；In the Yao medicinal composition that the present invention is provided, for making up a prescription.
Walk blood wind：It is the root of rutaceae Radix Toddaliae Asiaticae；In the Yao medicinal composition that the present invention is provided, for medicine of leading the way, For laxative, expelling wind and removing dampness, promoting blood circulation to remove blood stasis, hemostasis and pain-relieving.
In the present invention, Olibanum, Myrrha, Eupolyphaga Seu Steleophaga, Flos Carthami, Semen Persicae blood circulation promoting and blood stasis dispelling lead to stagnant, promoting the circulation of QI for relieving swelling pain relieving, play work altogether Blood blood stasis dispelling, reducing swelling and alleviating pain, Bu Shen Zhuang waist, the work(of promoting the flow of QI in the collateral by warming the meridian；In the Yao medicinal composition that the present invention is provided, for medicine of leading the way.
The present invention is to entering mountain tiger, the tiger that goes up a hill, operculina turpethum, day brill, calabash brill, DAJIEGU wind, Du described in above-mentioned technical proposal Secondary, Radix Cyathulae, Herba Taxilli, Rhizoma Cibotii, the source for walking blood wind, Olibanum, Myrrha, Eupolyphaga Seu Steleophaga, Flos Carthami and Semen Persicae do not have special limit Fixed, using above-mentioned raw materials commercial goods well known to those skilled in the art.
Present invention also offers a kind of preparation method of Yao medicinal composition described in above-mentioned technical proposal, comprises the following steps：
(1) dry after crush solid material；
(2) adopt volumetric concentration for 35～50% ethanol water to the dried solid material extraction 28～ 42d, the lixiviating solution that the extraction is obtained are Yao medicinal composition.
The present invention is dried after solid material is crushed.The present invention does not have special restriction to the method for the crushing, Using Chinese crude drug grinding mode well known to those skilled in the art.In the present invention, the solid material is ground into powder Shape, is preferably crushed to 18～35 mesh, more preferably 20 mesh.
In the present invention, solid material drying to water content is preferably less than 5% by the drying, is preferably dried to water content For 4.5～1%.Drying mode of the present invention is preferably infrared drying, can also play bactericidal action while drying.
The dried solid material is mixed extraction with the ethanol water that volumetric concentration is 35～50% by the present invention 28～42d, extracts the lixiviating solution for obtaining and is Yao medicinal composition.The volumetric concentration of ethanol water of the present invention is preferably 40 ～45%, more preferably 42%.In the present invention, the ethanol water is 8～13 with dried solid material volume ratio: 1, preferably 10:1.
Extraction of the present invention is preferably carried out at normal temperatures, need not carry out extra heating or cooling.In the present invention, institute State extraction time and be preferably 30～40d, more preferably 35d.In leaching process of the present invention, preferably daily in 1～7d Acid soil is stirred 1 time, 8d starts to stir acid soil 1 time every 7d.Acid soil is stirred in the present invention It is in order that solid material contacts the content for more fully improving active substance in lixiviating solution with lixiviating solution.
In the present invention, preferably will filter after the liquid phase component for obtaining standing after the extraction, obtain lixiviating solution.The present invention The standing refers to and stands acid soil to clarification that the time of the standing is preferably 5～10h, more preferably 6～8h.
The present invention does not have any restriction to the filter type, using filter type well known in the art, such as filter paper Filtration, filtered through gauze.
The Yao medicinal composition that the present invention is provided is used for when treating prolapse of lumbar intervertebral disc, oral 2～3 times daily, and every time 50 ～100ml.Diet Radix Raphani, radish cabbage and tea during taking Yao medicinal composition of the present invention, this is because precious jade medicine of the present invention The raw material of compositionss includes liver and kidney tonifying, the Cortex Eucommiae of strengthening the tendons and bones, Radix Cyathulae, Herba Taxilli, Rhizoma Cibotii, due to Radix Raphani, radish cabbage special Circulation of qi promoting, based on rushing down, using rear, halves the curative effect of tonification medicine；Contain tannic acid in Folium Camelliae sinensis, can affect when taken with Chinese medicine together Absorption of the human body to effective ingredient, lessens the curative effect.
Embodiment in below in conjunction with the present invention, to the present invention in technical scheme be clearly and completely described.Aobvious So, described embodiment is only a part of embodiment of the invention, rather than whole embodiment.Reality in based on the present invention Example is applied, the every other embodiment obtained under the premise of creative work is not made by those of ordinary skill in the art all belongs to In the scope of protection of the invention.
Embodiment 1
Take the solid material of following weight portion：Enter 2 parts of mountain tiger, go up a hill 2 parts of tiger, 2 parts of operculina turpethum, day bore 2 parts, and calabash bores 2 Part, 2 parts of DAJIEGU wind walks 2 parts of blood wind, 1 part of the Cortex Eucommiae, 1 part of Radix Cyathulae, 1 part of Herba Taxilli, 1 part of Rhizoma Cibotii, 1 part of Flos Carthami, Eupolyphaga Seu Steleophaga 0.5 part, 0.5 part of Semen Persicae, 0.5 part of 0.5 part of Olibanum and Myrrha are mixed after being crushed to 20 mesh respectively, and infrared drying is to solid The water content of raw material is less than 5%.It is 42% ethanol water according to volume ratio 10 by dried solid material and volumetric concentration: 1 ratio mixing extraction 35d, during extraction before daily acid soil is stirred 1 time in 7d, 8d starts every 7 days to extracting body System stirring 1 time, i.e. 14d, 28d, 35d are stirred 1 time to acid soil.Acid soil is stood 8h to clear after terminating by extraction Clearly, lixiviating solution, as Yao medicinal composition are obtained with 4 layers of filtered through gauze.
Embodiment 2
Take the solid material of following weight portion：Enter 1 part of mountain tiger, go up a hill 1 part of tiger, 1 part of operculina turpethum, day bore 1 part, and calabash bores 1 Part, 1 part of DAJIEGU wind walks 1 part of blood wind, 0.5 part of the Cortex Eucommiae, 0.5 part of Radix Cyathulae, 0.5 part of Herba Taxilli, 0.5 part of Rhizoma Cibotii, Flos Carthami 0.5 0.1 part of part, 0.1 part of Eupolyphaga Seu Steleophaga, 0.1 part of Semen Persicae, 0.1 part of Olibanum and Myrrha, are mixed after being crushed to 18 mesh respectively, infrared baking Do to the water content of solid material and be less than 5%.By dried solid material and volumetric concentration be 35% ethanol water according to Volume ratio 8:1 ratio mixing extraction 28d, during extraction before daily acid soil is stirred 1 time in 7d, 8d started every 7 days 1 time, i.e. 14d, 28d are stirred to acid soil to stir acid soil 1 time.Acid soil is stood 5h extremely after terminating by extraction Clarification, is filtrated to get lixiviating solution, as Yao medicinal composition with fast grade filter paper.
Embodiment 3
Take the solid material of following weight portion：Enter 4 parts of mountain tiger, go up a hill 4 parts of tiger, 4 parts of operculina turpethum, day bore 4 parts, and calabash bores 4 Part, 4 parts of DAJIEGU wind walks 4 parts of blood wind, 3 parts of the Cortex Eucommiae, 3 parts of Radix Cyathulae, 3 parts of Herba Taxilli, 3 parts of Rhizoma Cibotii, 3 parts of Flos Carthami, Eupolyphaga Seu Steleophaga 1 Part, 1 part of Semen Persicae, 1 part of 1 part of Olibanum and Myrrha are mixed after being crushed to 35 mesh respectively, infrared drying to solid material aqueous Amount is less than 5%.It is 50% ethanol water according to volume ratio 13 by dried solid material and volumetric concentration:1 ratio is mixed Close extraction 42d, during extraction before daily acid soil is stirred 1 time in 7d, 8d starts to stir acid soil 1 time every 7 days, I.e. 14d, 28d, 35d, 42d are stirred 1 time to acid soil.Acid soil is stood 10h to clarification after terminating by extraction, Lixiviating solution, as Yao medicinal composition are obtained with 4 layers of filtered through gauze.
Embodiment 4
The clinical efficacy and its untoward reaction of Yao medicinal composition and Chinese medicine therapeutic alliance prolapse of lumbar intervertebral disc
1 data and method
Case is included
In the patient for meeting prolapse of lumbar intervertebral disc Western medicine diagnostic criteria that will be accepted for medical treatment from May, 2014～2016 year May Select the patient for meeting following condition：
(1) make a definite diagnosis through CT or MRI；
(2) age was more than for 18 one full year of life；
(3) scoliosis, waist physiology radians disappear, and have tenderness, and radiate to lower limb, waist active receiving by diseased region vertebra Limit；Lower limb involvement innervation area feels allergy or blunt, and course of disease elder may occur in which amyotrophy；Leg raising straight strengthens examination The positive is tested, knee joint, Achilles tendon reflex weaken or disappear, and big toe dorsiflexion power subtracts weak person；
And exclude the patient for meeting following any one：
(1) there are other diseases, syndrome or complication；
(2) associated treatment possible influential effect observation index have been received；
(3) with possible influential effect index observation, other physiology for judging or pathological condition；
(4) severe cardiac, liver, renal damage affect drug metabolism；
(6) characterizing population group：Anemia of pregnant woman, age of sucking, psychosiss, it is dangerously ill or the terminal stage of a disease.
Informed Consent Form is signed after patient knows research contents, this project is included, qualified patient Totally 180.
1.2 cases are grouped
According to patient enter group order and itself wish is grouped, be divided into 3 groups, wherein give lumbar traction and massage Rehabilitation is 1 group, and oral Yao medicinal composition person is 2 groups, and person is 3 groups, per group each 60 to give western medicine.
1.3 physical data
Man 96, female 84 in all patients；Age：22～74 years old, average (48.2 ± 1.4) year；The course of disease：1 month～7 Year, average (6.8 ± 2.1) individual month.In aforementioned physical data, through statistical analysis, difference no statistical significance can for each group patient Preferable than property.
1.4 Therapeutic Method
1 group：Give lumbar traction and massage rehabilitation, on extension table, the state of an illness of physician in view patient, age and body The dynamics of voxel Quality Control system traction, the pull-in time, carries out lumbar traction treatment to patient：Once in a week, it is within two weeks a course for the treatment of； To each acupoint massage such as the paravertebral point of patient, Weizhong point, gb 34, the Kunlun 5 minutes, and patient lies supine, doctor is allowed to press Firmly patient's knee is while hold foot, carries out stretching bent to tempering patient's knee joint：Once a day, it is within two weeks a course for the treatment of.
2 groups：It is practiced the Yao medicinal composition that example 1 prepares on the basis of 1 group to be treated, 2 times a day, early, Evening is each once, each 100ml.
3 groups：Give indometacin tablets on the basis of 1 group, 25mg/ time, 3 times/d, patient takes the medicine until pain is delayed Solution, diclofenac 75mg/ time, 1 time/d, patient takes the medicine until pain relief.
Three groups with 8 weeks as 1 course for the treatment of.
1.5 observation index
Pain relief situation compares：According to World Health Organization (WHO) (WHO) for the classification situation of pain degree carries out 0-3 levels 4 grades of evaluations, wherein 3 grades is severe pain, needs to give analgesic drug product, 0 grade for completely painless, according to the pain of patient after treatment Pain change situation carries out effective, effective and invalid evaluation, and after wherein treatment 1-2d, 1 grade of person of pain relief is effective, treatment Even being invalid more than pain relief after 5d plus severe one, fall between as effective, effective percentage is calculated according to formula.
Effective percentage computing formula：
Oswestry Disability indexes (ODI) score：Before treating respectively, 2 months after treatment, 6 months differences after treatment Time period is scored using the scale, to observe its handicapped improvement situation, the scale cover pain, individual event ability with And personal integration capability three can content, if 0% prompting of its result is normal, closer to 100% prompt facility barrier Hinder more serious.
Visual analogue scale (VAS)：Before treatment, 2 months after treatment, after treatment, 6 months different time sections adopt the scale Lumbago and skelalgia is scored respectively, 0～10 point, wherein 0 point expression no pain.
Electromyogram in patients：Before treatment, 2 months after treatment, 6 monthly row Ipsilateral lower limb electromyographies after treatment, record Its common peroneal nerve and posterior tibial nerve F-waves of electromyography conduction velocity.
1.6 statistical method
Enumeration data in this research represents that with (mean ± standard deviation) check using t, measurement data is represented with mean, Checked using X2, with P<0.05 represents statistically significant.
2 results
2.1 pain relief situations compare
The effective percentage of 1 group of pain relief is 75.00%, and 2 groups is 85.00%, and 3 groups is 90.00%, compares with 1 group, 2,3 The pain relief effective percentage of group increases substantially, and pain disappearing time then shortens substantially, and difference has statistical significance (P<0.05).2 Compare between group and 3 groups, no significant difference (P>0.05).The results are shown in Table 1.
1 pain relief situation of table compares (n=60)
Group Effective Effectively Invalid Effective percentage (%) Pain disappearing time (d)
1 group 16 29 15 75.00 19.6±2.3
2 groups 21 30 9 85.00▲ 17.6±1.9▲
3 groups 20 34 6 90.00▲ 11.8±1.5▲
Note：Compare with 1 group,▲P<0.05
Indomethacin is a kind of NSAID (non-steroidal anti-inflammatory drug), is prostaglandin synthesis inhibitors, is that Western medicine commonly used in the art stops Pain medicine；Diclofenac is usually used in the mild to moderate pain for alleviating muscle, soft tissue and joint, to alleviating what lower back damage caused Pain has good analgesic effect.1 data display of table, effective percentage of the Yao medicinal composition that the present invention is provided to prolapse of lumbar intervertebral disc With indomethacin, diclofenac without significant difference, illustrate that the Yao medicinal composition of present invention offer has obvious analgesic effect, and can To substitute Western medicine and external treatment of Chinese medicine therapeutic alliance prolapse of lumbar intervertebral disc.
2.2 ODI, VAS scorings are compared
Compare with 1 group, 2,3 groups of ODI scoring, VAS score before the treatment, 2 monthly no difference of science of statistics (P after treatment> 0.05), then reduce substantially within 6 months after treatment, difference has statistical significance (P<0.05).Compare between 2 groups and 3 groups, difference Not statistically significant (P>0.05).Concrete outcome
It is shown in Table 2.
(n=60) is compared in table 2 ODI, VAS scoring
Note：Compare with 1 group,▲P<0.05.
As a result show, the therapeutic effect of the Yao medicinal composition joint external treatment of Chinese medicine that the present invention is provided is relative to external treatment with Chinese medicine Method is used individually the ODI after can significantly improving 6 months and VAS scorings, and combines the treatment of external treatment of Chinese medicine with Western medicine Without significant difference, effect shows that the Yao medicinal composition of present invention offer can substitute Western medicine with external treatment of Chinese medicine combination treatment loins Disc protrusion.
2.3 electromyograms compare
Compare with 1 group, the F ripples conduction velocity of 2,3 groups of common peroneal nerve and posterior tibial nerve before the treatment, 2 months after treatment No difference of science of statistics (P>0.05), then raise substantially within 6 months after treatment, difference has statistical significance (P<0.05).2 groups and 3 Compare between group, no significant difference (P>0.05).The results are shown in Table 3.
3 electromyogram of table compares (n=60)
Note：Compare with 1 group,▲P<0.05
2.4 untoward reaction
1 group, 2 groups is showed no untoward reaction, 3 groups of appearance, 4 (6.67%) untoward reaction.As a result show, the present invention is provided Yao medicinal composition clinical treatment when have no adverse reaction, can improve patient's relative to Western medicine and external treatment of Chinese medicine therapeutic alliance Quality of life.
Embodiment 5
Economic health evaluation
1 data and method
Main analysis according to minimum treatment cost is analyzed with cost-effectiveness analysis (CEA) two, wherein minimum treatment Cost analyses mainly include expenses for medicine in therapeutic process, fee of material, Laboratory Fee, treatment cost；The mesh of cost-effectiveness analysis (CEA) Be find the minimum therapeutic scheme of cost when reaching a certain therapeutic effect, wherein cost determines that (C) refers to the angle from patient Degree sets out, and calculates the cost of all cases, makes economic health evaluation with the obvious effective rate (E) of Bariatric as criterion.
1.1 minimum treatment cost analyses
Result of study in embodiment 4 is shown, is combined the oral group 2 of precious jade medicine with massage rehabilitation with lumbar traction and treat lumbar vertebra The effective percentage of disc herniation is 85.00%, and lumbar traction combines the treatment prolapse of lumbar intervertebral disc of group 3 of Western medicine with massage rehabilitation Effective percentage be 90.00%, two groups compare difference have statistical significance (P>0.05).Therefore, with the group 2 in embodiment 4 For observation group, 3 matched groups of group in embodiment 4, minimum treatment cost statistics is carried out.
1.2 CEA are analyzed
E determines：According to the research of embodiment 4, observation group's effective percentage is 85.00%, and matched group is 90.00%, and difference is not There is statistical significance (P>0.05).
C determines：From the first Affiliated Hospital of Guangxi University of Chinese Medicine and the information of attached Rui Kang hospitals since pressing in January, 2014 The correlative charges real price that management system is directly derived is calculated.
2 results
2.1 minimum treatment costs compare
The minimum treatment cost analytic statisticss result of observation group's treatment is that (721.3 ± 14.8) are first, and matched group minimum is treated into This analysis statistical result is that (1221.2 ± 25.1) are first, two groups for the treatment of cost significant differences.
Statistical result showed, Yao medicinal composition are combined with external treatment of Chinese medicine relative to Western medicine with external treatment of Chinese medicine therapeutic alliance The treatment cost for the treatment of prolapse of lumbar intervertebral disc is significantly reduced.
2.2 CEA analysis results
Cost of drugs, observation group are (345.2 ± 30.6) unit；Matched group is (589.7 ± 53.8) unit.
Other costs：Observation group is 110.3 yuan；Matched group is 251.4 yuan.
Untoward reaction and complication cost：Observation group's mean treatment cost is that (12.3 ± 1.6) are first, and matched group is (78.4 ± 31.6) unit.
Totle drilling cost, observation group are (750.9 ± 40.6) unit, and matched group is (1056.5 ± 90.8) unit.
Two groups for the treatment of cost-effect analysis results show that observation group is less than matched group, and difference tool is statistically significant (P<0.05).Concrete outcome is shown in Table 4.
The cost-effectiveness analysis of 4 two groups of patients of table
Group C E C/E (%)
Observation group 751 85.00 8.83
Matched group 1064 90.00 11.82▲
Note：Compare with matched group,▲P<0.05.
The result of table 4 shows that the Yao medicinal composition that the present invention is provided cost-effectiveness when being combined with external treatment of Chinese medicine is notable When being combined with external treatment of Chinese medicine less than Western medicine, i.e., the Yao medicinal composition treatment cost that the present invention is provided under identical curative effect is more Low.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should It is considered as protection scope of the present invention.

Claims (8)

1. a kind of Yao medicinal composition, is obtained through ethanol water extraction by the solid material for including following weight portion：Enter mountain tiger 1～ 4 parts, go up a hill 1～4 part of tiger, and 1～4 part of operculina turpethum, day bore 1～4 part, and calabash bores 1～4 part, and 1～4 part of DAJIEGU wind walks blood wind 1 ～4 parts, 0.5～3 part of the Cortex Eucommiae, 0.5～3 part of Radix Cyathulae, 0.5～3 part of Herba Taxilli, 0.5～3 part of Rhizoma Cibotii, 0.5～3 part of Flos Carthami, soil 0.1～1 part of Trionyx sinensis Wiegmann worm, 0.1～1 part of Semen Persicae, 0.1～1 part of Olibanum, 0.1～1 part of Myrrha.
2. Yao medicinal composition according to claim 1, it is characterised in that by including the solid material of following weight portion through second Alcohol-water solution extraction is obtained：Enter 2 parts of mountain tiger, go up a hill 2 parts of tiger, 2 parts of operculina turpethum, day bore 2 parts, and calabash bores 2 parts, 2 parts of DAJIEGU wind, Walk 2 parts of blood wind, 1 part of the Cortex Eucommiae, 1 part of Radix Cyathulae, 1 part of Herba Taxilli, 1 part of Rhizoma Cibotii, 1 part of Flos Carthami, 0.5 part of Eupolyphaga Seu Steleophaga, 0.5 part of Semen Persicae, 0.5 part of Olibanum, 0.5 part of Myrrha.
3. a kind of preparation method of Yao medicinal composition described in claim 1 or 2, comprises the following steps：
(1) dry after crush solid material；
(2) volumetric concentration is adopted to extract 28～42d, institute for 35～50% ethanol water to the dried solid material It is Yao medicinal composition to state and extract the lixiviating solution for obtaining.
4. preparation method according to claim 3, it is characterised in that the granularity that crushes in step (1) is 18～35 Mesh.
5. the preparation method according to claim 3 or 4, it is characterised in that it is infrared drying to dry in step (1).
6. preparation method according to claim 3, it is characterised in that the volume of ethanol water is dense in step (2) Spend for 40～45%.
7. the preparation method according to claim 3 or 6, it is characterised in that ethanol water and solid in step (2) The volume ratio of raw material is 8～13:1.
8. preparation method according to claim 3, it is characterised in that in the leaching process of step (2), in 1～7d per It is stirred 1 time to acid soil, and 8d starts to stir acid soil 1 time every 7d.
CN201611216487.2A 2016-12-26 2016-12-26 A kind of Yao medicinal composition and preparation method thereof Pending CN106491882A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115252704A (en) * 2022-06-10 2022-11-01 广西中医药大学 Yao medicine composition for treating skin diseases and preparation method thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101703662A (en) * 2009-11-13 2010-05-12 秦中文 Oral Chinese medicament for treating hyperosteogeny
CN105362491A (en) * 2015-11-25 2016-03-02 张立 External-use medicine for treating cervical vertebra hyperosteogeny

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101703662A (en) * 2009-11-13 2010-05-12 秦中文 Oral Chinese medicament for treating hyperosteogeny
CN105362491A (en) * 2015-11-25 2016-03-02 张立 External-use medicine for treating cervical vertebra hyperosteogeny

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115252704A (en) * 2022-06-10 2022-11-01 广西中医药大学 Yao medicine composition for treating skin diseases and preparation method thereof

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Application publication date: 20170315