CN100536816C - Cozymase Q10 nano microcapsule emulsions and preparation and application thereof - Google Patents
Cozymase Q10 nano microcapsule emulsions and preparation and application thereof Download PDFInfo
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- CN100536816C CN100536816C CNB2007103045235A CN200710304523A CN100536816C CN 100536816 C CN100536816 C CN 100536816C CN B2007103045235 A CNB2007103045235 A CN B2007103045235A CN 200710304523 A CN200710304523 A CN 200710304523A CN 100536816 C CN100536816 C CN 100536816C
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- 239000003094 microcapsule Substances 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000000839 emulsion Substances 0.000 title claims description 66
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 title claims description 43
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims abstract description 71
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 50
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims abstract description 28
- 235000017471 coenzyme Q10 Nutrition 0.000 claims abstract description 28
- 229940110767 coenzyme Q10 Drugs 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 13
- 239000002537 cosmetic Substances 0.000 claims abstract description 10
- 125000005456 glyceride group Chemical group 0.000 claims description 26
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 26
- 238000003756 stirring Methods 0.000 claims description 26
- 239000002245 particle Substances 0.000 claims description 13
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 11
- 229940083466 soybean lecithin Drugs 0.000 claims description 11
- 239000002202 Polyethylene glycol Substances 0.000 claims description 10
- 229920001223 polyethylene glycol Polymers 0.000 claims description 10
- 239000005515 coenzyme Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 5
- 102000002322 Egg Proteins Human genes 0.000 claims description 5
- 108010000912 Egg Proteins Proteins 0.000 claims description 5
- 241000287828 Gallus gallus Species 0.000 claims description 5
- 229940067606 lecithin Drugs 0.000 claims description 5
- 239000000787 lecithin Substances 0.000 claims description 5
- 235000010445 lecithin Nutrition 0.000 claims description 5
- 210000004681 ovum Anatomy 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 150000004678 hydrides Chemical class 0.000 claims description 3
- 239000000463 material Substances 0.000 abstract description 2
- 239000004816 latex Substances 0.000 abstract 4
- 229920000126 latex Polymers 0.000 abstract 4
- 230000001804 emulsifying effect Effects 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 abstract 1
- 229940093633 tricaprin Drugs 0.000 abstract 1
- 229940093609 tricaprylin Drugs 0.000 abstract 1
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 230000015572 biosynthetic process Effects 0.000 description 7
- 239000008367 deionised water Substances 0.000 description 7
- 229910021641 deionized water Inorganic materials 0.000 description 7
- 238000005303 weighing Methods 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 239000004530 micro-emulsion Substances 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 1
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical group CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 description 1
- 206010051246 Photodermatosis Diseases 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 230000008845 photoaging Effects 0.000 description 1
- 125000004151 quinonyl group Chemical group 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000003019 stabilising effect Effects 0.000 description 1
Abstract
The present invention provides coenzyme Q10 nanometer microcapsule latex, a preparation method and application thereof and concretely relates to coenzyme Q10 nanometer microcapsule latex, a preparation method and application thereof. The present invention is characterized by mixing and emulsifying the coenzyme Q10 with the weight percentage of 1 percent to 10 percent, 1 percent to 20 percent of tricaprylin or tricaprin, 1 percent to 10 percent of phospholipid, 50 percent to 94 percent of glycerin, 2 percent to 20 percent of water, etc., orderly and uniformly under the temperature condition of 50 DEG C to 60 DEG C. Finally, a high pressure viscolizer is used for processing the materials to obtain the transparent or semitransparent coenzyme Q10 nanometer microcapsule latex with average grain size less than 100nm. The coenzyme Q10 nanometer microcapsule latex has the characteristics of high stability, water dispersibility, biological compatibility, etc., which ensures that the cosmetic containing the coenzyme Q10 is convenient and simple to be confected.
Description
Technical field
The present invention relates to a kind of nano micro-capsule emulsion, particularly a kind of is the nano micro-capsule emulsion of active component with the coenzyme Q10, belongs to the cosmetics preparing technical field.
Background technology
Coenzyme Q10 (CoQ10) is a kind of quinone lopps chemical compound, has long isoprene side chains, is soluble in chloroform, benzene and carbon tetrachloride, is dissolved in acetone, petroleum ether and ether, is slightly soluble in ethanol, water insoluble and methanol.It is easily decomposed by illumination, is subjected to temperature, humidity effect then less.The biological activity of CoQ10 mainly comes from the physicochemical property of redox characteristic He its side chain of its quinone ring.It is the Natural antioxidant and the cellular metabolism activator that cell self produces, the effects such as integrity, stabilising membrane current potential and enhance immunity reaction that have protection and recover biofilm structure.
According to the literature, with advancing age, the content of CoQ10 descends gradually in the human body skin, and CoQ10 is applied to the skin field has good effect for the reparation of defying age and photoaging skin, (U.Hoppe, J.Bergemann, W.Diembeck etal.Coenzyme Q10, a cutaneous antioxidant and energizer, BioFactors 9 (1999) 371-378).Patent CN1738548A, CN1256939C and CN1633245A etc. provide food CoQ10 compositions, patent CN1857239A provides CoQ10 injectable emulsion, patent CN101015524 provides CoQ10 Orally taken emulsion, and patent CN1525850 provides CoQ10 microemulsion preconcentrate for oral use and microemulsion etc.
Along with the extensive use of nanotechnology at cosmetic field, adopt the cosmetics of nanotechnology development, unique distinction is that the composition of tool effect in the cosmetics is carried out special handling becomes nano level micro-structure, and the deep layer that penetrates to the skin is smoothly better brought into play effects such as skin protection.
Summary of the invention
The object of the invention provides the water-soluble coenzyme Q10 nano micro-capsule emulsion that a kind of stability is high, the compatibility is good, makes itself and any interworking of required skin care item preparation; Give full play to the effect of coenzyme Q10 isoreactivity composition, to reach the effect of long-time cosmetology.
The technical solution adopted in the present invention is:
A kind of cozymase Q 10 nano microcapsule emulsions is characterized in that: this nano micro-capsule emulsion contains following component by weight percentage:
Coenzyme Q10 1～10%
Caprylic/capric glyceride 1～20%
Phosphatidase 11～10%
Glycerol 50～94%
Water 2～20%,
Through mixing and handling by high pressure homogenizer, mean diameter is less than 100nm with said components, and outward appearance is transparent or semitransparent shape.
Can contain 0.1～2% Polyethylene Glycol caprylic/capric glyceride in the cozymase Q 10 nano microcapsule emulsions of the present invention.
The phospholipid that cozymase Q 10 nano microcapsule emulsions of the present invention adopted is one or more the mixture in soybean lecithin, Ovum Gallus domesticus Flavus lecithin or their hydride.
The phospholipid that cozymase Q 10 nano microcapsule emulsions of the present invention adopted is the soybean lecithin of PC content 〉=72%.
The preparation method of cozymase Q 10 nano microcapsule emulsions of the present invention is carried out as follows:
1) 1～10% coenzyme Q10,1～20% caprylic/capric glyceride and 1～10% phospholipid are made the homogeneous mixed liquor under 50 ℃～60 ℃ temperature and stirring condition;
2) adding 50～94% glycerol and 2～20% successively to above-mentioned mixed liquor stirs under water, handle by high pressure homogenizer at last, high pressure homogenize pressure is 500bar～1500bar, cycle-index is 4 times～8 times, obtains the cozymase Q 10 nano microcapsule emulsions of a kind of transparent or semitransparent particle diameter less than 100nm.
The preparation method of cozymase Q 10 nano microcapsule emulsions of the present invention is carried out as follows:
1) 1～10% coenzyme Q10,1～20% caprylic/capric glyceride, 0.1～2% Polyethylene Glycol caprylic/capric glyceride and 1～10% phospholipid are made the homogeneous mixed liquor under 50 ℃～60 ℃ temperature and stirring condition;
2) adding 50～94% glycerol and 2～20% successively to above-mentioned mixed liquor stirs under water, handle by high pressure homogenizer at last, high pressure homogenize pressure is 500bar～1500bar, cycle-index is 4 times～8 times, obtains the cozymase Q 10 nano microcapsule emulsions of a kind of transparent or semitransparent particle diameter less than 100nm.
The application of cozymase Q 10 nano microcapsule emulsions of the present invention in the preparation cosmetics.
Cozymase Q 10 nano microcapsule emulsions of the present invention has the following advantages: appearance transparent, viscous liquid; Constant product quality has good water solublity, makes that the preparation of the cosmetics contain coenzyme Q10 is convenient, simple, can with any interworking of required skin care item preparation; Because the material that this nano-microcapsule adopted is lipoids such as phospholipid, with the skin lipid structural similarity, be easy to coenzyme Q10 isoreactivity composition is infiltrated into deep skin, be easy to the Skin Cell film and merge, give full play to the effect of coenzyme Q10 isoreactivity composition, to reach the effect of long-time cosmetology.
The specific embodiment
Cozymase Q 10 nano microcapsule emulsions provided by the invention, this nano micro-capsule emulsion contains following component by weight percentage:
Coenzyme Q10 1～10%
Caprylic/capric glyceride 1～20%
Phosphatidase 11～10%
Glycerol 50～94%
Water 2～20%,
Through mixing and handling by high pressure homogenizer, mean diameter is less than 100nm with said components, and outward appearance is transparent or semitransparent shape.
The phospholipid that is adopted in the cozymase Q 10 nano microcapsule emulsions of the present invention is one or both and the above mixture in soybean lecithin, Ovum Gallus domesticus Flavus lecithin or its hydride, can preferably adopt the soybean lecithin of PC content 〉=72%.
Also can contain 0.1～2% Polyethylene Glycol caprylic/capric glyceride in the cozymase Q 10 nano microcapsule emulsions described in the present invention.
The invention also discloses the preparation method of described cozymase Q 10 nano microcapsule emulsions, this method is carried out as follows:
1) 1～10% coenzyme Q10,1～20% caprylic/capric glyceride and 1～10% phospholipid are made the homogeneous mixed liquor under 50 ℃～60 ℃ temperature and stirring condition;
2) adding 50～94% glycerol and 2～20% successively to above-mentioned mixed liquor stirs under water, handle by high pressure homogenizer at last, high pressure homogenize pressure is 500bar～1500bar, cycle-index is 4 times～8 times, obtains the cozymase Q 10 nano microcapsule emulsions of a kind of transparent or semitransparent particle diameter less than 100nm.
For the preparation method of the cozymase Q 10 nano microcapsule emulsions that contains Polyethylene Glycol caprylic/capric glyceride, carry out as follows in the said method:
1) 1～10% coenzyme Q10,1～20% caprylic/capric glyceride, 0.1～2% Polyethylene Glycol caprylic/capric glyceride and 1～10% phospholipid are made the homogeneous mixed liquor under 50 ℃～60 ℃ temperature and stirring condition;
2) adding 50～94% glycerol and 2～20% successively to above-mentioned mixed liquor stirs under water, handle by high pressure homogenizer at last, high pressure homogenize pressure is 500bar～1500bar, cycle-index is 4 times～8 times, obtains the cozymase Q 10 nano microcapsule emulsions of a kind of transparent or semitransparent particle diameter less than 100nm.
Cozymase Q 10 nano microcapsule emulsions of the present invention can be used to prepare cosmetics; Because this nano micro-capsule emulsion constant product quality, have good water solublity, can be easily, simply with any interworking of required skin care item preparation, can make with the coenzyme Q10 is the cosmetic product of active component.
The invention will be further described below to enumerate several embodiment.
Embodiment 1 takes by weighing 1% soybean lecithin, 1% coenzyme Q10 and 1% caprylic/capric glyceride and stirs formation homogeneous mixed liquor at 50 ℃, the deionized water and stirring that adds 94% glycerol and 3% then in mixed liquor forms homogenous emulsion, at last this emulsion is promptly obtained the transparence cozymase Q 10 nano microcapsule emulsions through 8 processing of high pressure homogenizer circulation under the 500bar pressure condition, this cozymase Q 10 nano microcapsule emulsions is measured its grain through laser particle analyzer and is about 55nm.
Embodiment 2 takes by weighing 5% Ovum Gallus domesticus Flavus lecithin, 5% coenzyme Q10 and 10% caprylic/capric glyceride and stirs formation homogeneous mixed liquor at 55 ℃, the deionized water and stirring that adds 70% glycerol and 10% then in mixed liquor forms homogenous emulsion, at last this emulsion is promptly obtained translucent cozymase Q 10 nano microcapsule emulsions through 4 processing of high pressure homogenizer circulation under the 1000bar pressure condition, this cozymase Q 10 nano microcapsule emulsions is measured its grain through laser particle analyzer and is about 66nm.
Embodiment 3 takes by weighing 5% soybean lecithin, 5% Ovum Gallus domesticus Flavus lecithin, 10% coenzyme Q10 and 20% caprylic/capric glyceride and stirs formation homogeneous mixed liquor at 60 ℃, the deionized water and stirring that adds 52% glycerol and 8% then in mixed liquor forms homogenous emulsion, at last this emulsion is promptly obtained translucent cozymase Q 10 nano microcapsule emulsions through 3 processing of high pressure homogenizer circulation under the 1500bar pressure condition, this cozymase Q 10 nano microcapsule emulsions is measured its grain through laser particle analyzer and is about 62nm.
Embodiment 4 takes by weighing 6% soybean lecithin, 3% coenzyme Q10 and 6% caprylic/capric glyceride and stirs formation homogeneous mixed liquor at 55 ℃, the deionized water and stirring that adds 65% glycerol and 20% then in mixed liquor forms homogenous emulsion, at last this emulsion is promptly obtained translucent cozymase Q 10 nano microcapsule emulsions through 3 processing of high pressure homogenizer circulation under the 1500bar pressure condition, this cozymase Q 10 nano microcapsule emulsions is measured its grain through laser particle analyzer and is about 43nm.
Embodiment 5 takes by weighing 3% hydrogenated soy phosphatidyl choline, 4% coenzyme Q10,5% caprylic/capric glyceride and 1% Polyethylene Glycol caprylic/capric glyceride and stirs formation homogeneous mixed liquor at 55 ℃, the deionized water and stirring that adds 80% glycerol and 7% then in mixed liquor forms homogenous emulsion, at last this emulsion is promptly obtained the transparence cozymase Q 10 nano microcapsule emulsions through 4 processing of high pressure homogenizer circulation under the 1000bar pressure condition, this cozymase Q 10 nano microcapsule emulsions is measured its grain through laser particle analyzer and is about 36nm.
Embodiment 6 takes by weighing 2% soybean lecithin, 4% coenzyme Q10,6% caprylic/capric glyceride and 2% Polyethylene Glycol caprylic/capric glyceride and stirs formation homogeneous mixed liquor at 55 ℃, the deionized water and stirring that adds 70% glycerol and 16% then in mixed liquor forms homogenous emulsion, at last this emulsion is promptly obtained the transparence cozymase Q 10 nano microcapsule emulsions through 5 processing of high pressure homogenizer circulation under the 800bar pressure condition, this cozymase Q 10 nano microcapsule emulsions is measured its grain through laser particle analyzer and is about 48nm.
Embodiment 7 takes by weighing 1% soybean lecithin, 2% coenzyme Q10,1% caprylic/capric glyceride and 0.1% Polyethylene Glycol caprylic/capric glyceride and stirs formation homogeneous mixed liquor at 55 ℃, the deionized water and stirring that adds 90% glycerol and 5.9% then in mixed liquor forms homogenous emulsion, at last this emulsion is promptly obtained the transparence cozymase Q 10 nano microcapsule emulsions through 4 processing of high pressure homogenizer circulation under the 1000bar pressure condition, this cozymase Q 10 nano microcapsule emulsions is measured its grain through laser particle analyzer and is about 41nm.
Claims (6)
1. cozymase Q 10 nano microcapsule emulsions, it is characterized in that: this nano micro-capsule emulsion contains following component by weight percentage:
Coenzyme Q10 1～10%
Caprylic/capric glyceride 1～20%
Phosphatidase 11～10%
Glycerol 50～94%
Water 2～20%,
Through mixing and handling by high pressure homogenizer, mean diameter is less than 100nm with said components, and outward appearance is transparent or semitransparent shape;
The phospholipid that is adopted is one or more the mixture in soybean lecithin, Ovum Gallus domesticus Flavus lecithin and their hydride.
2. according to the described cozymase Q 10 nano microcapsule emulsions of claim 1, it is characterized in that: also contain 0.1～2% Polyethylene Glycol caprylic/capric glyceride in the cozymase Q 10 nano microcapsule emulsions.
3. according to the described cozymase Q 10 nano microcapsule emulsions of claim 1, it is characterized in that: the phospholipid that is adopted is the soybean lecithin of PC content 〉=72%.
4. the preparation method of a cozymase Q 10 nano microcapsule emulsions as claimed in claim 1 is characterized in that this method carries out as follows:
1) 1～10% coenzyme Q10,1～20% caprylic/capric glyceride and 1～10% phospholipid are made the homogeneous mixed liquor under 50 ℃～60 ℃ temperature and stirring condition;
2) in above-mentioned mixed liquor, add 50～94% glycerol and 2～20% water successively, stir, handle by high pressure homogenizer at last, high pressure homogenize pressure is 500bar～1500bar, cycle-index is 4 times～8 times, obtains the cozymase Q 10 nano microcapsule emulsions of a kind of transparent or semitransparent particle diameter less than 100nm.
5. the preparation method of a cozymase Q 10 nano microcapsule emulsions as claimed in claim 2 is characterized in that this method carries out as follows:
1) 1～10% coenzyme Q10,1～20% caprylic/capric glyceride, 0.1～2% Polyethylene Glycol caprylic/capric glyceride and 1～10% phospholipid are made the homogeneous mixed liquor under 50 ℃～60 ℃ temperature and stirring condition;
2) in above-mentioned mixed liquor, add 50～94% glycerol and 2～20% water successively, stir, handle by high pressure homogenizer at last, high pressure homogenize pressure is 500bar～1500bar, cycle-index is 4 times～8 times, obtains the cozymase Q 10 nano microcapsule emulsions of a kind of transparent or semitransparent particle diameter less than 100nm.
6. the application of cozymase Q 10 nano microcapsule emulsions as claimed in claim 1 or 2 in the preparation cosmetic product.
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101658468B (en) * | 2009-09-09 | 2013-03-06 | 苏州纳康生物科技有限公司 | Coenzyme Q nanostructured lipid carrier and preparation method thereof |
| CN102258474B (en) * | 2010-05-24 | 2012-10-10 | 富阳科兴生物化工有限公司 | Preparation method of self-microemulsifying coenzyme Q10 powdery dry emulsion |
| CN102258473B (en) * | 2010-05-24 | 2013-03-13 | 富阳科兴生物化工有限公司 | Self-microemulsion coenzyme Q10 powdery dry emulsion and application thereof |
| CN103732214B (en) * | 2011-06-17 | 2017-04-12 | 博格有限责任公司 | Inhalable pharmaceutical compositions |
| CN104367569A (en) * | 2014-11-06 | 2015-02-25 | 江苏隆力奇生物科技股份有限公司 | Nano coenzyme Q10 oral liquid |
| CN104666102A (en) * | 2015-03-20 | 2015-06-03 | 江苏隆力奇生物科技股份有限公司 | Dihydro-sphingosine nanocapsule emulsion as well as preparation method and application thereof |
| CN105662974A (en) * | 2016-03-10 | 2016-06-15 | 江苏隆力奇生物科技股份有限公司 | Preparation with skin light aging prevention function and application of preparation |
| CN105748313A (en) * | 2016-03-10 | 2016-07-13 | 江苏隆力奇生物科技股份有限公司 | Method of using coenzyme Q10 to prevent skin photoage |
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| CN1256939C (en) * | 2001-04-12 | 2006-05-24 | 维西费克特公司 | Coenzyme Q10 containing microemulsion preconcentrates and microemulsions |
| CN1857239A (en) * | 2006-03-22 | 2006-11-08 | 杭州宇泰医药科技有限公司 | Coenzyme Q10 injection emulsion and its preparing process |
| CN1994275A (en) * | 2006-11-17 | 2007-07-11 | 清华大学 | A nano micro-capsule emulsion of snake oil and method for preparing same |
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