CN100536826C - Sheep oil nano emulsions and preparation and application thereof - Google Patents
Sheep oil nano emulsions and preparation and application thereof Download PDFInfo
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- CN100536826C CN100536826C CNB2007103045254A CN200710304525A CN100536826C CN 100536826 C CN100536826 C CN 100536826C CN B2007103045254 A CNB2007103045254 A CN B2007103045254A CN 200710304525 A CN200710304525 A CN 200710304525A CN 100536826 C CN100536826 C CN 100536826C
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- sheep oil
- nanometer emulsion
- oil nanometer
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Abstract
The present invention provides sheep oil nanometer latex, a preparation method and an application thereof and concretely relates to the sheep oil nanometer latex and the preparation method and the application thereof, which is characterized by mixing and emulsifying the following materials according to the weight percentage: 1 percent to 20 percent of the sheep oil, 1 percent to 10 percent of tricaprylin or tricaprin, 1 percent to 10 percent of phospholipid, 50 percent to 94 percent of glycerin, 2 percent to 20 percent of water, etc., orderly and uniformly under the temperature condition of 40 DEG C to 60 DEG C. Finally, a high pressure viscolizer is used for processing the materials to obtain the transparent or semitransparent sheep oil nanometer latex with average grain size less than 100nm. The sheep oil nanometer latex has the characteristics of high stability, water dispersibility, biological compatibility, etc., and being widely applied to the cosmetic field.
Description
Technical field
The present invention relates to a kind of sheep oil nanometer emulsion liquid, belong to the cosmetics technical field.
Background technology
Sheep oil is the fat secretion thing that is deposited on the Pilus Caprae seu Ovis, and Main Ingredients and Appearance is a sterols, and aliphatic alcohols and triterpene alcohols and fatty acid ester thereof contain free alcohol and a spot of free fatty etc. in addition.About 35～45 ℃ of the fusing point of sheep oil, water-soluble hardly, good with the compatibility of other base material of cosmetics; But regrettably special thickness, viscous sense are big especially, and have special abnormal flavour and color and luster not good enough, bring very big inconvenience for the preparation of its cosmetics, have limited its extensive use.
Summary of the invention
The object of the invention provides the sheep oil nanometer emulsion liquid of a kind of stability height, the compatibility and good water solubility.
The technical solution adopted in the present invention is:
A kind of sheep oil nanometer emulsion liquid is characterized in that: this sheep oil nanometer emulsion liquid contains following component by weight percentage:
Sheep oil 1～20%
Caprylic/capric glyceride 1～10%
Phosphatidase 11～10%
Glycerol 50～94%
Water 1～20%,
Through mixing and handling by high pressure homogenizer, mean diameter is less than 100nm with said components, and outward appearance is transparent or semitransparent shape.
Contain 0.1～2.5% Polyethylene Glycol caprylic/capric glyceride in the sheep oil nanometer emulsion liquid of the present invention.
The phospholipid that sheep oil nanometer emulsion liquid of the present invention is adopted is one or more the mixture in soybean lecithin, Ovum Gallus domesticus Flavus lecithin or their hydride.
The phospholipid that sheep oil nanometer emulsion liquid of the present invention is adopted is the soybean lecithin of PC content 〉=70%.
The preparation method of sheep oil nanometer emulsion liquid of the present invention is carried out as follows:
1) 1～20% sheep oil, 1～10% caprylic/capric glyceride and 1～10% phospholipid are made the homogeneous mixed liquor under 40 ℃～60 ℃ temperature and stirring condition;
2) add 50～94% glycerol successively and 1～20% water stirs to above-mentioned mixed liquor, handle by high pressure homogenizer at last, high pressure homogenize pressure is 500bar～1500bar, and cycle-index is 4 times～8 times, obtains the sheep oil nanometer emulsion liquid of a kind of transparent or semitransparent particle diameter less than 100nm.
The preparation method of sheep oil nanometer emulsion liquid of the present invention is carried out as follows:
1) 1～20% sheep oil, 1～10% caprylic/capric glyceride, 0.1～2.5% Polyethylene Glycol caprylic/capric glyceride and 1～10% phospholipid are made the homogeneous mixed liquor under 40 ℃～60 ℃ temperature and stirring condition;
2) add 50～94% glycerol successively and 1～20% water stirs to above-mentioned mixed liquor, handle by high pressure homogenizer at last, high pressure homogenize pressure is 500bar～1500bar, and cycle-index is 4 times～8 times, obtains the sheep oil nanometer emulsion liquid of a kind of transparent or semitransparent particle diameter less than 100nm.
The application of sheep oil nanometer emulsion liquid of the present invention in the preparation cosmetic product.
Sheep oil nanometer emulsion liquid of the present invention forms the phospholipid molecule protective layer on sheep oil particles surface, has the following advantages and the salience effect: appearance transparent, constant product quality, room temperature have good water solublity down for flowable liquid; Be easy to form the breathable lipid membrane at skin surface; In the cosmetic formulations process, can under cryogenic conditions, add in the product, can with any interworking of required skin care item preparation, bring great convenience for the preparation of sheep oil cosmetics.
The specific embodiment
Sheep oil nanometer emulsion liquid provided by the invention, this sheep oil nanometer emulsion liquid contains following component by weight percentage:
Sheep oil 1～20%
Caprylic/capric glyceride 1～10%
Phosphatidase 11～10%
Glycerol 50～94%
Water 1～20%,
Through mixing and handling by high pressure homogenizer, mean diameter is less than 100nm with said components, and outward appearance is transparent or semitransparent shape.
Contain 0.1～2.5% Polyethylene Glycol caprylic/capric glyceride among the present invention in the sheep oil nanometer emulsion liquid.
The phospholipid that sheep oil nanometer emulsion liquid is adopted among the present invention is one or more the mixture in soybean lecithin, Ovum Gallus domesticus Flavus lecithin or their hydride.
The phospholipid that sheep oil nanometer emulsion liquid is adopted among the present invention is the soybean lecithin of PC content 〉=70%.
The preparation method of sheep oil nanometer emulsion liquid provided by the invention is carried out as follows:
1) 1～20% sheep oil, 1～10% caprylic/capric glyceride and 1～10% phospholipid are made the homogeneous mixed liquor under 40 ℃～60 ℃ temperature and stirring condition;
2) add 50～94% glycerol successively and 1～20% water stirs to above-mentioned mixed liquor, handle by high pressure homogenizer at last, high pressure homogenize pressure is 500bar～1500bar, and cycle-index is 4 times～8 times, obtains the sheep oil nanometer emulsion liquid of a kind of transparent or semitransparent particle diameter less than 100nm.
Carry out as follows for the preparation method of the sheep oil nanometer emulsion liquid that contains Polyethylene Glycol caprylic/capric glyceride in the said method:
1) 1～20% sheep oil, 1～10% caprylic/capric glyceride, 0.1～2.5% Polyethylene Glycol caprylic/capric glyceride and 1～10% phospholipid are made the homogeneous mixed liquor under 40 ℃～60 ℃ temperature and stirring condition;
2) add 50～94% glycerol successively and 1～20% water stirs to above-mentioned mixed liquor, handle by high pressure homogenizer at last, high pressure homogenize pressure is 500bar～1500bar, and cycle-index is 4 times～8 times, obtains the sheep oil nanometer emulsion liquid of a kind of transparent or semitransparent particle diameter less than 100nm.
Steady quality of the present invention, room temperature for flowable liquid, have good water solublity down; Be easy to form the breathable lipid membrane at skin surface; In the cosmetic formulations process, can under cryogenic conditions, add this product, can with any interworking of required skin care item preparation, so this sheep oil nanometer emulsion liquid can be widely used in the cosmetic product in preparation.
The invention will be further described below to enumerate several specific embodiments.
Embodiment 1 takes by weighing 1% soybean lecithin, 1% sheep oil and 1% caprylic/capric glyceride and stirs formation homogeneous mixed liquor at 40 ℃, the deionized water and stirring that adds 94% glycerol and 3% then in mixed liquor forms homogenous emulsion, at last this emulsion is promptly obtained transparence sheep oil nanometer emulsion liquid through 8 processing of high pressure homogenizer circulation under the 500bar pressure condition, this sheep oil nanometer emulsion liquid is measured its grain through laser particle analyzer and is about 49nm.
Embodiment 2 takes by weighing 5% Ovum Gallus domesticus Flavus lecithin, 10% sheep oil and 5% caprylic/capric glyceride and stirs formation homogeneous mixed liquor at 55 ℃, the deionized water and stirring that adds 70% glycerol and 10% then in mixed liquor forms homogenous emulsion, at last this emulsion is promptly obtained translucent sheep oil nanometer emulsion liquid through 4 processing of high pressure homogenizer circulation under the 1000bar pressure condition, this sheep oil nanometer emulsion liquid is measured its grain through laser particle analyzer and is about 58nm.
Embodiment 3 takes by weighing 5% soybean lecithin, 5% Ovum Gallus domesticus Flavus lecithin, 20% sheep oil and 10% caprylic/capric glyceride and stirs formation homogeneous mixed liquor at 60 ℃, the deionized water and stirring that adds 50% glycerol and 10% then in mixed liquor forms homogenous emulsion, at last this emulsion is promptly obtained translucent sheep oil nanometer emulsion liquid through 3 processing of high pressure homogenizer circulation under the 1500bar pressure condition, this sheep oil nanometer emulsion liquid is measured its grain through laser particle analyzer and is about 53nm.
Embodiment 4 takes by weighing 4% hydrogenated soy phosphatidyl choline, 10% sheep oil, 5% caprylic/capric glyceride and 1% Polyethylene Glycol caprylic/capric glyceride and stirs formation homogeneous mixed liquor at 55 ℃, the deionized water and stirring that adds 65% glycerol and 15% then in mixed liquor forms homogenous emulsion, at last this emulsion is promptly obtained translucent sheep oil nanometer emulsion liquid through 4 processing of high pressure homogenizer circulation under the 800bar pressure condition, this sheep oil nanometer emulsion liquid is measured its grain through laser particle analyzer and is about 44nm.
Embodiment 5 takes by weighing 4% soybean lecithin, 20% sheep oil, 5% caprylic/capric glyceride and 2.5% Polyethylene Glycol caprylic/capric glyceride and stirs formation homogeneous mixed liquor at 55 ℃, the deionized water and stirring that adds 60% glycerol and 8.5% then in mixed liquor forms homogenous emulsion, at last this emulsion is promptly obtained translucent sheep oil nanometer emulsion liquid through 4 processing of high pressure homogenizer circulation under the 1000bar pressure condition, this sheep oil nanometer emulsion liquid is measured its grain through laser particle analyzer and is about 48nm.
Embodiment 6 takes by weighing 1% soybean lecithin, 3% sheep oil, 1% caprylic/capric glyceride and 0.1% Polyethylene Glycol caprylic/capric glyceride and stirs formation homogeneous mixed liquor at 55 ℃, the deionized water and stirring that adds 80% glycerol and 14.9% then in mixed liquor forms homogenous emulsion, at last this emulsion is promptly obtained translucent sheep oil nanometer emulsion liquid through 4 processing of high pressure homogenizer circulation under the 700bar pressure condition, this sheep oil nanometer emulsion liquid is measured its grain through laser particle analyzer and is about 39nm.
Claims (6)
1. sheep oil nanometer emulsion liquid, it is characterized in that: this sheep oil nanometer emulsion liquid contains following component by weight percentage:
Sheep oil 1～20%
Sad caprin 1～10%
Phosphatidase 11～10%
Glycerol 50～94%
Water 1～20%,
Through mixing and handling by high pressure homogenizer, mean diameter is less than 100nm with said components, and outward appearance is transparent or semitransparent shape; The phospholipid that is adopted is one or more the mixture in soybean lecithin, Ovum Gallus domesticus Flavus lecithin or their hydride.
2. according to the described sheep oil nanometer emulsion of claim 1 liquid, it is characterized in that: also contain 0.1～2.5% the sad caprin of Polyethylene Glycol in the described sheep oil nanometer emulsion liquid.
3. according to the described sheep oil nanometer emulsion of claim 1 liquid, it is characterized in that: the phospholipid that is adopted is the soybean lecithin of phosphatidylcholine content 〉=70%.
4. the preparation method of a sheep oil nanometer emulsion liquid as claimed in claim 1 is characterized in that this method carries out as follows:
1) 1～20% sheep oil, 1～10% sad caprin and 1～10% phospholipid are made the homogeneous mixed liquor under 40 ℃～60 ℃ temperature and stirring condition;
2) add 50～94% glycerol successively and 1～20% water stirs to above-mentioned mixed liquor, handle by high pressure homogenizer at last, high pressure homogenize pressure is 500bar～1500bar, and cycle-index is 4 times～8 times, obtains the sheep oil nanometer emulsion liquid of a kind of transparent or semitransparent particle diameter less than 100nm.
5. the preparation method of a sheep oil nanometer emulsion liquid as claimed in claim 2 is characterized in that this method carries out as follows:
1) 1～20% sheep oil, 1～10% sad caprin, the sad caprin of 0.1～2.5% Polyethylene Glycol and 1～10% phospholipid are made the homogeneous mixed liquor under 40 ℃～60 ℃ temperature and stirring condition;
2) add 50～94% glycerol successively and 1～20% water stirs to above-mentioned mixed liquor, handle by high pressure homogenizer at last, high pressure homogenize pressure is 500bar～1500bar, and cycle-index is 4 times～8 times, obtains the sheep oil nanometer emulsion liquid of a kind of transparent or semitransparent particle diameter less than 100nm.
6. the application of sheep oil nanometer emulsion liquid as claimed in claim 1 or 2 in the preparation cosmetic product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007103045254A CN100536826C (en) | 2007-12-28 | 2007-12-28 | Sheep oil nano emulsions and preparation and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2007103045254A CN100536826C (en) | 2007-12-28 | 2007-12-28 | Sheep oil nano emulsions and preparation and application thereof |
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| Publication Number | Publication Date |
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| CN101214215A CN101214215A (en) | 2008-07-09 |
| CN100536826C true CN100536826C (en) | 2009-09-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2007103045254A Expired - Fee Related CN100536826C (en) | 2007-12-28 | 2007-12-28 | Sheep oil nano emulsions and preparation and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019233552A1 (en) * | 2018-06-05 | 2019-12-12 | Pm-International Ag | Two-phase system |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664369B (en) * | 2009-05-27 | 2011-04-20 | 董萍 | Trimethylglyine compound nanoemulsion used for nourishing and moisturizing skin and preparation method thereof |
| CN101978942B (en) * | 2010-10-27 | 2012-01-11 | 中国科学院西双版纳热带植物园 | Omega-3 fatty acid oil skin care lotion and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO65292A2 (en) * | 1975-06-27 | 1978-12-15 | Miraj Cosmetice | COMPOSITION FOR FARD |
| JP2001039815A (en) * | 1999-07-27 | 2001-02-13 | Nippon Fine Chem Co Ltd | Cosmetic and preparation for external use |
| US20030190347A1 (en) * | 1998-05-11 | 2003-10-09 | Andreas Werner Supersaxo | Use of nanodispersions in pharmaceutical end formulations |
| CN1633983A (en) * | 2004-11-02 | 2005-07-06 | 黄扶民 | Camellia chrysantha containing skin-care, washing product |
-
2007
- 2007-12-28 CN CNB2007103045254A patent/CN100536826C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RO65292A2 (en) * | 1975-06-27 | 1978-12-15 | Miraj Cosmetice | COMPOSITION FOR FARD |
| US20030190347A1 (en) * | 1998-05-11 | 2003-10-09 | Andreas Werner Supersaxo | Use of nanodispersions in pharmaceutical end formulations |
| JP2001039815A (en) * | 1999-07-27 | 2001-02-13 | Nippon Fine Chem Co Ltd | Cosmetic and preparation for external use |
| CN1633983A (en) * | 2004-11-02 | 2005-07-06 | 黄扶民 | Camellia chrysantha containing skin-care, washing product |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019233552A1 (en) * | 2018-06-05 | 2019-12-12 | Pm-International Ag | Two-phase system |
| CN112399800A (en) * | 2018-06-05 | 2021-02-23 | Pm国际股份公司 | Two-phase system |
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| CN101214215A (en) | 2008-07-09 |
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