CN100522147C - 5,6,7-三羟基庚酸及其类似物在制备治疗干眼病和眼色素层炎药物中的应用 - Google Patents

5,6,7-三羟基庚酸及其类似物在制备治疗干眼病和眼色素层炎药物中的应用 Download PDF

Info

Publication number
CN100522147C
CN100522147C CNB2005800154047A CN200580015404A CN100522147C CN 100522147 C CN100522147 C CN 100522147C CN B2005800154047 A CNB2005800154047 A CN B2005800154047A CN 200580015404 A CN200580015404 A CN 200580015404A CN 100522147 C CN100522147 C CN 100522147C
Authority
CN
China
Prior art keywords
dry eye
uveitis
treatment
compound
analogs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2005800154047A
Other languages
English (en)
Chinese (zh)
Other versions
CN1953740A (zh
Inventor
P·G·科林寇
M·R·赫勒贝格
D·A·盖玛彻
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Alcon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc filed Critical Alcon Inc
Publication of CN1953740A publication Critical patent/CN1953740A/zh
Application granted granted Critical
Publication of CN100522147C publication Critical patent/CN100522147C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
CNB2005800154047A 2004-05-14 2005-05-12 5,6,7-三羟基庚酸及其类似物在制备治疗干眼病和眼色素层炎药物中的应用 Expired - Fee Related CN100522147C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57116204P 2004-05-14 2004-05-14
US60/571,162 2004-05-14

Publications (2)

Publication Number Publication Date
CN1953740A CN1953740A (zh) 2007-04-25
CN100522147C true CN100522147C (zh) 2009-08-05

Family

ID=34968761

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2005800154047A Expired - Fee Related CN100522147C (zh) 2004-05-14 2005-05-12 5,6,7-三羟基庚酸及其类似物在制备治疗干眼病和眼色素层炎药物中的应用

Country Status (19)

Country Link
US (1) US20050256189A1 (https=)
EP (1) EP1744736B1 (https=)
JP (2) JP4993299B2 (https=)
KR (1) KR101170885B1 (https=)
CN (1) CN100522147C (https=)
AT (1) ATE448779T1 (https=)
AU (1) AU2005244839B2 (https=)
BR (1) BRPI0511125A (https=)
CA (1) CA2563659C (https=)
CY (1) CY1109666T1 (https=)
DE (1) DE602005017762D1 (https=)
DK (1) DK1744736T3 (https=)
ES (1) ES2334368T3 (https=)
MX (1) MXPA06013170A (https=)
PL (1) PL1744736T3 (https=)
PT (1) PT1744736E (https=)
SI (1) SI1744736T1 (https=)
WO (1) WO2005112905A1 (https=)
ZA (1) ZA200609220B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7879905B2 (en) * 2004-11-09 2011-02-01 Alcon, Inc. 5,6,7-trihydroxyheptanoic acid and analogs for the treatment of ocular diseases and diseases associated with hyperproliferative and angiogenic responses
US7687539B1 (en) 2005-11-07 2010-03-30 Alcon Research, Ltd. Method of treating ocular allergy
TW201010727A (en) * 2008-09-03 2010-03-16 Alcon Res Ltd Pharmaceutical composition having relatively low ionic strength
WO2011096941A1 (en) * 2010-02-08 2011-08-11 Alcon Research, Ltd. Method of treating ocular allergy
JP2013521230A (ja) * 2010-02-25 2013-06-10 アルコン リサーチ， リミテッド 角膜創傷治癒を促進する方法
KR101931395B1 (ko) 2011-02-18 2018-12-20 쓰리엠 이노베이티브 프로퍼티즈 컴파니 가요성 발광 반도체 디바이스
KR102593305B1 (ko) * 2020-11-25 2023-10-25 서울대학교 산학협력단 인공지능 기반 의류 사이즈 추천 방법 및 시스템

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4131651A (en) * 1977-10-25 1978-12-26 Barnes-Hind Pharmaceuticals, Inc. Treatment of dry eye
US4409205A (en) * 1979-03-05 1983-10-11 Cooper Laboratories, Inc. Ophthalmic solution
US4370325A (en) * 1979-03-30 1983-01-25 Dermik Laboratories Pharmaceutical compositions and method of treatment
US4744980A (en) * 1986-04-28 1988-05-17 Holly Frank J Ophthalmic solution for treatment of dry eye syndrome
US4883658A (en) * 1986-04-28 1989-11-28 Holly Frank J Ophthalmic solution for treatment of dry-eye syndrome
US4818537A (en) * 1986-10-21 1989-04-04 Liposome Technology, Inc. Liposome composition for treating dry eye
US4966773A (en) * 1986-11-25 1990-10-30 Alcon Laboratories, Inc. Topical ophthalmic compositions containing microfine retinoid particles
US5278151A (en) * 1987-04-02 1994-01-11 Ocular Research Of Boston, Inc. Dry eye treatment solution
US4914088A (en) * 1987-04-02 1990-04-03 Thomas Glonek Dry eye treatment solution and method
US5075104A (en) * 1989-03-31 1991-12-24 Alcon Laboratories, Inc. Ophthalmic carboxy vinyl polymer gel for dry eye syndrome
US5174988A (en) * 1989-07-27 1992-12-29 Scientific Development & Research, Inc. Phospholipid delivery system
US5041434A (en) * 1991-08-17 1991-08-20 Virginia Lubkin Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
DE69115990T2 (de) * 1990-05-29 1996-05-30 Ocular Res Of Bonton Inc Zusammensetzung zur Behandlung von Dry Eye Erkrankungen
ZA912797B (en) * 1990-05-29 1992-12-30 Boston Ocular Res Dry eye treatment process and solution
ZA927277B (en) * 1991-10-02 1993-05-19 Boston Ocular Res Dry eye treatment process and solution.
US5958912A (en) * 1992-04-21 1999-09-28 The Schepens Eye Research Institute, Inc. Ocular therapy in keratoconjunctivitis sicca using topically applied androgens of TGF-β
US5290572A (en) * 1992-08-06 1994-03-01 Deo Corporation Opthalmic composition for treating dry eye
US5441951A (en) * 1994-06-15 1995-08-15 Brigham & Women's Hospital Lipoxin compounds
US5696166A (en) * 1995-10-31 1997-12-09 Yanni; John M. Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders
WO1997020578A1 (en) * 1995-12-04 1997-06-12 University Of Miami Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance
US5800807A (en) * 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
ES2215752T3 (es) 1999-11-09 2004-10-16 Alcon, Inc Lipoxina a4 y analogos para el tratamiento del ojo seco.

Also Published As

Publication number Publication date
JP4993299B2 (ja) 2012-08-08
DK1744736T3 (da) 2010-02-15
JP2007537282A (ja) 2007-12-20
ATE448779T1 (de) 2009-12-15
CY1109666T1 (el) 2014-08-13
US20050256189A1 (en) 2005-11-17
EP1744736A1 (en) 2007-01-24
AU2005244839B2 (en) 2009-12-24
EP1744736B1 (en) 2009-11-18
KR101170885B1 (ko) 2012-08-07
BRPI0511125A (pt) 2007-11-27
AU2005244839A1 (en) 2005-12-01
AU2005244839A2 (en) 2005-12-01
ES2334368T3 (es) 2010-03-09
ZA200609220B (en) 2009-02-25
MXPA06013170A (es) 2007-02-13
CA2563659A1 (en) 2005-12-01
PL1744736T3 (pl) 2010-03-31
JP2012107053A (ja) 2012-06-07
WO2005112905A1 (en) 2005-12-01
CN1953740A (zh) 2007-04-25
SI1744736T1 (sl) 2010-01-29
PT1744736E (pt) 2010-01-05
KR20070011582A (ko) 2007-01-24
CA2563659C (en) 2012-03-20
DE602005017762D1 (de) 2009-12-31

Similar Documents

Publication Publication Date Title
EP2175858B1 (en) Pharmaceutical compositions and methods of treating dry eye disorders
US20060189541A1 (en) Methods of treating dry eye disorders
EP0391909A1 (en) COMPOSITION OF EYE CYCLOSPORIN.
AU2005229006B9 (en) Use of loteprednol etabonate for the treatment of dry eye
JP2012107053A (ja) ドライアイ障害およびブドウ膜炎を処置するための方法
US20110130451A1 (en) Method of treating dry eye disorders and uveitis
US20050182039A1 (en) Use of Loteprednol etabonate for the treatment of dry eye
DE60218153T2 (de) Verwendung von proteasom-inhibitoren zur behandlung des trockenen auges
US20020009507A1 (en) Use of polyethoxylated castor oil for the treatment of dry eye
ZA200402356B (en) Methods for treating dry eye by a combination of an anti-inflammatory steroid and a MUC-1 secretagogue.
JP2026004313A (ja) ４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの結晶形態及びその製剤
US6645994B1 (en) Method of treating dry eye disorders
US7745461B1 (en) Method of treating dry eye disorders
US7235556B2 (en) Methods of treating dry eye disorders
US6696453B2 (en) Use of NF-κB inhibitors to treat dry eye disorders
US20030008853A1 (en) Method for treating dry eye disorders
JP2004175749A (ja) ドライアイおよびドライアイを伴う疾病の治療剤
EP1790338A1 (en) Therapeutic agent for keratoconjunctiva disorder

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20090805

Termination date: 20170512