CN100522147C - 5,6,7-三羟基庚酸及其类似物在制备治疗干眼病和眼色素层炎药物中的应用 - Google Patents

5,6,7-三羟基庚酸及其类似物在制备治疗干眼病和眼色素层炎药物中的应用 Download PDF

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Publication number
CN100522147C
CN100522147C CNB2005800154047A CN200580015404A CN100522147C CN 100522147 C CN100522147 C CN 100522147C CN B2005800154047 A CNB2005800154047 A CN B2005800154047A CN 200580015404 A CN200580015404 A CN 200580015404A CN 100522147 C CN100522147 C CN 100522147C
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CN
China
Prior art keywords
dry eye
uveitis
treatment
compound
analogs
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2005800154047A
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English (en)
Chinese (zh)
Other versions
CN1953740A (zh
Inventor
P·G·科林寇
M·R·赫勒贝格
D·A·盖玛彻
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Alcon Inc
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Alcon Inc
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Publication of CN1953740A publication Critical patent/CN1953740A/zh
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Publication of CN100522147C publication Critical patent/CN100522147C/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
CNB2005800154047A 2004-05-14 2005-05-12 5,6,7-三羟基庚酸及其类似物在制备治疗干眼病和眼色素层炎药物中的应用 Expired - Fee Related CN100522147C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57116204P 2004-05-14 2004-05-14
US60/571,162 2004-05-14

Publications (2)

Publication Number Publication Date
CN1953740A CN1953740A (zh) 2007-04-25
CN100522147C true CN100522147C (zh) 2009-08-05

Family

ID=34968761

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2005800154047A Expired - Fee Related CN100522147C (zh) 2004-05-14 2005-05-12 5,6,7-三羟基庚酸及其类似物在制备治疗干眼病和眼色素层炎药物中的应用

Country Status (19)

Country Link
US (1) US20050256189A1 (enExample)
EP (1) EP1744736B1 (enExample)
JP (2) JP4993299B2 (enExample)
KR (1) KR101170885B1 (enExample)
CN (1) CN100522147C (enExample)
AT (1) ATE448779T1 (enExample)
AU (1) AU2005244839B2 (enExample)
BR (1) BRPI0511125A (enExample)
CA (1) CA2563659C (enExample)
CY (1) CY1109666T1 (enExample)
DE (1) DE602005017762D1 (enExample)
DK (1) DK1744736T3 (enExample)
ES (1) ES2334368T3 (enExample)
MX (1) MXPA06013170A (enExample)
PL (1) PL1744736T3 (enExample)
PT (1) PT1744736E (enExample)
SI (1) SI1744736T1 (enExample)
WO (1) WO2005112905A1 (enExample)
ZA (1) ZA200609220B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005020178D1 (de) * 2004-11-09 2010-05-06 Alcon Inc 5,6,7-trihydroxyheptansäure und analoge zur behandlung von augenkrankheiten und mit hyperproliferativen und angiogenen reaktionen verbundenen krankheiten
US7687539B1 (en) 2005-11-07 2010-03-30 Alcon Research, Ltd. Method of treating ocular allergy
TW201010727A (en) * 2008-09-03 2010-03-16 Alcon Res Ltd Pharmaceutical composition having relatively low ionic strength
WO2011096941A1 (en) * 2010-02-08 2011-08-11 Alcon Research, Ltd. Method of treating ocular allergy
CA2788333A1 (en) * 2010-02-25 2011-09-01 Alcon Research, Ltd. Method of accelerating corneal wound healing
WO2012112873A2 (en) 2011-02-18 2012-08-23 3M Innovative Properties Company Flexible light emitting semiconductor device
KR102593305B1 (ko) * 2020-11-25 2023-10-25 서울대학교 산학협력단 인공지능 기반 의류 사이즈 추천 방법 및 시스템

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4131651A (en) * 1977-10-25 1978-12-26 Barnes-Hind Pharmaceuticals, Inc. Treatment of dry eye
US4409205A (en) * 1979-03-05 1983-10-11 Cooper Laboratories, Inc. Ophthalmic solution
US4370325A (en) * 1979-03-30 1983-01-25 Dermik Laboratories Pharmaceutical compositions and method of treatment
US4883658A (en) * 1986-04-28 1989-11-28 Holly Frank J Ophthalmic solution for treatment of dry-eye syndrome
US4744980A (en) * 1986-04-28 1988-05-17 Holly Frank J Ophthalmic solution for treatment of dry eye syndrome
US4818537A (en) * 1986-10-21 1989-04-04 Liposome Technology, Inc. Liposome composition for treating dry eye
US4966773A (en) * 1986-11-25 1990-10-30 Alcon Laboratories, Inc. Topical ophthalmic compositions containing microfine retinoid particles
US5278151A (en) * 1987-04-02 1994-01-11 Ocular Research Of Boston, Inc. Dry eye treatment solution
US4914088A (en) * 1987-04-02 1990-04-03 Thomas Glonek Dry eye treatment solution and method
US5075104A (en) * 1989-03-31 1991-12-24 Alcon Laboratories, Inc. Ophthalmic carboxy vinyl polymer gel for dry eye syndrome
US5174988A (en) * 1989-07-27 1992-12-29 Scientific Development & Research, Inc. Phospholipid delivery system
US5041434A (en) * 1991-08-17 1991-08-20 Virginia Lubkin Drugs for topical application of sex steroids in the treatment of dry eye syndrome, and methods of preparation and application
ATE132366T1 (de) * 1990-05-29 1996-01-15 Boston Ocular Res Zusammensetzung zur behandlung von dry eye erkrankungen
ZA912797B (en) * 1990-05-29 1992-12-30 Boston Ocular Res Dry eye treatment process and solution
ZA927277B (en) * 1991-10-02 1993-05-19 Boston Ocular Res Dry eye treatment process and solution.
US5958912A (en) * 1992-04-21 1999-09-28 The Schepens Eye Research Institute, Inc. Ocular therapy in keratoconjunctivitis sicca using topically applied androgens of TGF-β
US5290572A (en) * 1992-08-06 1994-03-01 Deo Corporation Opthalmic composition for treating dry eye
US5441951A (en) * 1994-06-15 1995-08-15 Brigham & Women's Hospital Lipoxin compounds
US5696166A (en) * 1995-10-31 1997-12-09 Yanni; John M. Compositions containing hydroxyeicosatetraenoic acid derivatives and methods of use in treating dry eye disorders
WO1997020578A1 (en) * 1995-12-04 1997-06-12 University Of Miami Non-preserved topical corticosteroid for treatment of dry eye, filamentary keratitis, and delayed tear clearance
US5800807A (en) * 1997-01-29 1998-09-01 Bausch & Lomb Incorporated Ophthalmic compositions including glycerin and propylene glycol
PT1237549E (pt) * 1999-11-09 2004-06-30 Alcon Inc Lipoxina a4 e seus analogos para o tratamento de olho seco

Also Published As

Publication number Publication date
AU2005244839B2 (en) 2009-12-24
KR20070011582A (ko) 2007-01-24
JP4993299B2 (ja) 2012-08-08
DK1744736T3 (da) 2010-02-15
AU2005244839A2 (en) 2005-12-01
CY1109666T1 (el) 2014-08-13
ZA200609220B (en) 2009-02-25
JP2007537282A (ja) 2007-12-20
PL1744736T3 (pl) 2010-03-31
ES2334368T3 (es) 2010-03-09
KR101170885B1 (ko) 2012-08-07
MXPA06013170A (es) 2007-02-13
AU2005244839A1 (en) 2005-12-01
BRPI0511125A (pt) 2007-11-27
CA2563659C (en) 2012-03-20
CN1953740A (zh) 2007-04-25
US20050256189A1 (en) 2005-11-17
ATE448779T1 (de) 2009-12-15
DE602005017762D1 (de) 2009-12-31
JP2012107053A (ja) 2012-06-07
EP1744736A1 (en) 2007-01-24
PT1744736E (pt) 2010-01-05
SI1744736T1 (sl) 2010-01-29
CA2563659A1 (en) 2005-12-01
WO2005112905A1 (en) 2005-12-01
EP1744736B1 (en) 2009-11-18

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Granted publication date: 20090805

Termination date: 20170512