CN100502833C - 藏药青鹏膏剂的新制备方法 - Google Patents
藏药青鹏膏剂的新制备方法 Download PDFInfo
- Publication number
- CN100502833C CN100502833C CNB2003101189224A CN200310118922A CN100502833C CN 100502833 C CN100502833 C CN 100502833C CN B2003101189224 A CNB2003101189224 A CN B2003101189224A CN 200310118922 A CN200310118922 A CN 200310118922A CN 100502833 C CN100502833 C CN 100502833C
- Authority
- CN
- China
- Prior art keywords
- phase
- water
- glycerol
- time
- pure water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title claims abstract description 63
- 239000002674 ointment Substances 0.000 title claims description 15
- 238000000034 method Methods 0.000 title description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 71
- 239000007788 liquid Substances 0.000 claims abstract description 14
- 238000002360 preparation method Methods 0.000 claims abstract description 13
- 238000003756 stirring Methods 0.000 claims abstract description 13
- 230000006837 decompression Effects 0.000 claims abstract description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 87
- 239000012071 phase Substances 0.000 claims description 57
- 229940079593 drug Drugs 0.000 claims description 30
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 24
- 229940057995 liquid paraffin Drugs 0.000 claims description 23
- 238000000605 extraction Methods 0.000 claims description 17
- 239000000203 mixture Substances 0.000 claims description 15
- 241000196324 Embryophyta Species 0.000 claims description 14
- 238000010438 heat treatment Methods 0.000 claims description 12
- 239000003921 oil Substances 0.000 claims description 12
- -1 polyoxyethylene Polymers 0.000 claims description 12
- 239000003871 white petrolatum Substances 0.000 claims description 11
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 10
- 238000009835 boiling Methods 0.000 claims description 9
- 235000019198 oils Nutrition 0.000 claims description 9
- 229910019142 PO4 Inorganic materials 0.000 claims description 8
- 239000010452 phosphate Substances 0.000 claims description 8
- 239000011591 potassium Substances 0.000 claims description 8
- 229910052700 potassium Inorganic materials 0.000 claims description 8
- 235000021355 Stearic acid Nutrition 0.000 claims description 7
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 7
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 7
- 239000008117 stearic acid Substances 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 6
- 239000007858 starting material Substances 0.000 claims description 6
- 238000010792 warming Methods 0.000 claims description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 5
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 5
- 239000008346 aqueous phase Substances 0.000 claims description 5
- 235000014121 butter Nutrition 0.000 claims description 5
- 238000005516 engineering process Methods 0.000 claims description 5
- 229940075507 glyceryl monostearate Drugs 0.000 claims description 5
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims description 5
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 5
- 229920000053 polysorbate 80 Polymers 0.000 claims description 5
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 5
- 241000972155 Moschus Species 0.000 claims description 4
- 241000147945 Oxytropis kansuensis Species 0.000 claims description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 150000001408 amides Chemical class 0.000 claims description 4
- 239000007766 cera flava Substances 0.000 claims description 4
- 230000001804 emulsifying effect Effects 0.000 claims description 4
- 230000007159 enucleation Effects 0.000 claims description 4
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 4
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 4
- 239000009609 fructus phyllanthi Substances 0.000 claims description 4
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 4
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 4
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims description 3
- ZEMPKEQAKRGZGQ-AAKVHIHISA-N 2,3-bis[[(z)-12-hydroxyoctadec-9-enoyl]oxy]propyl (z)-12-hydroxyoctadec-9-enoate Chemical compound CCCCCCC(O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(O)CCCCCC)COC(=O)CCCCCCC\C=C/CC(O)CCCCCC ZEMPKEQAKRGZGQ-AAKVHIHISA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims description 3
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 3
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 3
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- 239000012153 distilled water Substances 0.000 claims description 3
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 3
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 3
- 229920001282 polysaccharide Polymers 0.000 claims description 3
- 239000005017 polysaccharide Substances 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 235000015112 vegetable and seed oil Nutrition 0.000 claims description 3
- 239000008158 vegetable oil Substances 0.000 claims description 3
- BCCIONUUXPFCLW-UHFFFAOYSA-N C[Na].C1=CC=CC=C1 Chemical compound C[Na].C1=CC=CC=C1 BCCIONUUXPFCLW-UHFFFAOYSA-N 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 229920000136 polysorbate Polymers 0.000 claims description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 2
- 230000003285 pharmacodynamic effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 6
- 239000011159 matrix material Substances 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 2
- 241000402754 Erythranthe moschata Species 0.000 abstract 1
- 239000000047 product Substances 0.000 description 7
- 239000002552 dosage form Substances 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 239000000843 powder Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000012567 medical material Substances 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000003317 industrial substance Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000012372 quality testing Methods 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 235000020681 well water Nutrition 0.000 description 1
- 239000002349 well water Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2003101189224A CN100502833C (zh) | 2003-11-12 | 2003-11-12 | 藏药青鹏膏剂的新制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2003101189224A CN100502833C (zh) | 2003-11-12 | 2003-11-12 | 藏药青鹏膏剂的新制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1615934A CN1615934A (zh) | 2005-05-18 |
CN100502833C true CN100502833C (zh) | 2009-06-24 |
Family
ID=34761244
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2003101189224A Expired - Lifetime CN100502833C (zh) | 2003-11-12 | 2003-11-12 | 藏药青鹏膏剂的新制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100502833C (zh) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100355430C (zh) * | 2005-07-06 | 2007-12-19 | 甘肃奇正藏药有限公司 | 一种治疗眼部疾病的藏药制剂及其制备方法 |
CN100402079C (zh) * | 2006-04-19 | 2008-07-16 | 西藏央科生物科技有限公司 | 风痛贴膏及其制备方法 |
CN1969969B (zh) * | 2006-07-20 | 2010-07-28 | 甘肃奇正藏药有限公司 | 一种用于止痛消肿的软膏剂及其制备方法 |
CN101181372B (zh) * | 2007-11-17 | 2011-09-21 | 甘肃奇正藏药有限公司 | 藏药青鹏膏剂的醇提制备方法 |
CN101926858B (zh) * | 2009-06-26 | 2012-07-25 | 西藏自治区藏医院 | 一种治疗湿疹皮炎的外用药物组合物及其制备方法 |
CN102058687B (zh) * | 2010-12-29 | 2012-05-16 | 西藏奇正藏药股份有限公司 | 一种用于止痛消肿的青鹏口服制剂及其制备方法 |
CN102038763B (zh) * | 2010-12-29 | 2012-02-22 | 西藏奇正藏药股份有限公司 | 一种用于止痛消肿的青鹏鼻用制剂及其制备方法 |
CN102048843B (zh) * | 2010-12-29 | 2013-03-20 | 西藏奇正藏药股份有限公司 | 一种用于止痛消肿的青鹏贴膏剂及其制备方法 |
CN102038765B (zh) * | 2010-12-29 | 2012-02-22 | 西藏奇正藏药股份有限公司 | 一种用于止痛消肿的青鹏膏药及其制备方法 |
CN102058686B (zh) * | 2010-12-29 | 2012-03-07 | 西藏奇正藏药股份有限公司 | 一种用于止痛消肿的青鹏酒剂或酊剂及其制备方法 |
CN102038764B (zh) * | 2010-12-29 | 2012-03-07 | 西藏奇正藏药股份有限公司 | 一种用于止痛消肿的青鹏散剂或颗粒剂及制备方法 |
CN102100757B (zh) * | 2010-12-29 | 2012-12-19 | 西藏奇正藏药股份有限公司 | 用于止痛消肿的青鹏喷射制剂及其制备方法 |
CN102038766B (zh) * | 2010-12-29 | 2012-02-15 | 西藏奇正藏药股份有限公司 | 一种用于止痛消肿的青鹏搽剂或洗剂及其制备方法 |
CN102100758B (zh) * | 2010-12-29 | 2013-05-01 | 西藏奇正藏药股份有限公司 | 一种用于止痛消肿的青鹏凝胶剂及其制备方法 |
-
2003
- 2003-11-12 CN CNB2003101189224A patent/CN100502833C/zh not_active Expired - Lifetime
Non-Patent Citations (3)
Title |
---|
中华人民共和国卫生部药品标准. 中华人民共和国卫生部,322. 1995 中药药剂学. 张兆旺,306,中国中医药出版社. 2003 |
中华人民共和国卫生部药品标准. 中华人民共和国卫生部,322. 1995 * |
中药药剂学. 张兆旺,306,中国中医药出版社. 2003 * |
Also Published As
Publication number | Publication date |
---|---|
CN1615934A (zh) | 2005-05-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN100502833C (zh) | 藏药青鹏膏剂的新制备方法 | |
RU2362578C1 (ru) | Лекарственный препарат для лечения сахарного диабета и метод его приготовления | |
CN102895432A (zh) | 开心散新剂型处方工艺及其制备方法 | |
KR20070054222A (ko) | 진통 작용이 있는 약제 조성물 | |
CN106214668B (zh) | 丙泊酚柔性纳米脂质体贴剂及其应用 | |
CN102178733B (zh) | 一种治疗糖尿病的中药制剂及其制备方法 | |
CN104352624A (zh) | 蒙药芯芭正丁醇提取物在制备防治糖尿病药物中的应用 | |
CN102018852A (zh) | 参连消渴降糖胶囊及制作工艺 | |
CN102793767B (zh) | 一种治疗失眠症的三七药物组合物及其制备方法与应用 | |
CN100348170C (zh) | 一种治疗疼痛的伊痛舒滴丸及其制备方法 | |
CN1246016C (zh) | 一种治疗更年期综合征的中药复方制剂及制备方法 | |
CN100453073C (zh) | 复方半边莲滴丸及其制备方法 | |
CN101716323B (zh) | 抗疲劳的药物组合物及其制备方法 | |
CN1839931B (zh) | 一种治疗心脑血管疾病的药物组合物及其制备方法 | |
CN101584719B (zh) | 刺五加果提取物在制备治疗高血脂症药物中的应用 | |
CN114392321B (zh) | 一种防脱、生发的中药组合物及其制备方法 | |
CN115645497B (zh) | 一种降尿酸的中药组合物及其制备方法和应用 | |
CN103565956B (zh) | 一种治疗消渴病的中药组合物及其制备 | |
CN101934061B (zh) | 一种治疗腹泻的中药咀嚼片及其制备方法 | |
CN109498737B (zh) | 一种治疗代谢性疾病的药物组合物及其制备方法和用途 | |
CN101554399B (zh) | 一种具有免疫增强作用的补骨脂提取物及应用 | |
CN101214302A (zh) | 一组治疗抑郁症伴生功能性消化不良的药物组合物及制法 | |
CN1315464C (zh) | 一种治疗癌症疼痛的乌头滴丸及其制备方法 | |
CN100358550C (zh) | 一种治疗心动过缓的中药 | |
CN100389753C (zh) | 一种具有清热解毒作用的口服滴丸制剂 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: TIBET QIZHENG TIBETAN MEDICINE CO., LTD. Free format text: FORMER OWNER: LEI JUFANG Effective date: 20100517 |
|
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 730000 NO.105, KEJI STREET, LANZHOU CITY, GANSU PROVINCE TO: 850000 NO.C8, HOLY CITY GARDEN VILLA (MAILBOX NO.14-081), NO.6, ZHAJI WEST ROAD, LHASA CITY, TIBET AUTONOMOUS REGION |
|
TR01 | Transfer of patent right |
Effective date of registration: 20100517 Address after: 850000 C8 Les Loges Du Park Hotel, 6 West Zaki Road, Lhasa, Tibet, China (P.O. Box 14-081) Patentee after: Tibetan Cheezheng Tibetan Medicine Co.,Ltd. Address before: 730000 No. 105 science street, Gansu, Lanzhou Patentee before: Lei Jufang |
|
CX01 | Expiry of patent term |
Granted publication date: 20090624 |
|
CX01 | Expiry of patent term |